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武汉工程大学学报 2008年第5期30卷 28-31页

作者：司江伟郑其绪河海大学商学院江苏南京210098 中国石油大学(华东)经济管理学院山东东营257061

人才才能三态的关系表现为正相关性、循环性、反常性和超常性。这些理论探讨有利于人才的选拔、任用和评价,有利于创新型国家的构建,有利于提高人才的使用效能、优化人才环境。

关键词：人才管理知识能力业绩

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael Qjiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu Fan Shuyong jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior

LC-MRM-MS法同时测定香槟方10个成分的含量

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中华中医药杂志 2017年第5期32卷 2226-2229页

作者：徐方方漆睿江斯炜王伟陈志强果德安刘博广州中医药大学第二附属医院广东省中医药科学院广州510006

目的:建立运用液相色谱-多反应监测扫描模式-质谱法(LC-MRM-MS)同时测定香槟方中10个成分(人参皂苷Rc,人参皂苷Rd,人参皂苷Rg1,槲皮素,槲皮苷,异槲皮苷,乌药醚内酯,槟榔碱,去甲异波尔定,苦杏仁苷)含量的分析方法。方法:采用Waters BEH C... 详细信息

目的:建立运用液相色谱-多反应监测扫描模式-质谱法(LC-MRM-MS)同时测定香槟方中10个成分(人参皂苷Rc,人参皂苷Rd,人参皂苷Rg1,槲皮素,槲皮苷,异槲皮苷,乌药醚内酯,槟榔碱,去甲异波尔定,苦杏仁苷)含量的分析方法。方法:采用Waters BEH C_(18)色谱柱(2.1mm×100mm,1.7μm),以0.5‰甲酸-水-乙腈为流动相,梯度洗脱,流速0.2mL/min,柱温为室温;采用电喷雾离子源(Esi),正负离子检测,多反应监测扫描模式(MRM)分析,毛细管电压为3.5k V,去溶剂化温度600℃,去溶剂化气流量为550L/Hr,雾化器压力为6.2Bar。结果:10个成分在质量浓度范围内线性良好,平均加样回收率为94.52%-111.15%,RSD均小于3.01%。结论:该分析方法特异、快速、灵敏,重复性好,可为香槟方的质量控制提供依据。

关键词：香槟方多反应监测扫描模式人参皂苷槲皮素乌药醚内酯槟榔碱苦杏仁苷

UPLC-QqQ-MS/MS同时测定香槟方中4个生物碱成分

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中国实验方剂学杂志 2019年第17期25卷 152-159页

作者：江斯炜郑作亮徐方方陈伟英汤丽鹏陈志强刘博黎奔广州中医药大学第二临床医学院广州510006 广州中医药大学广东省中医证候临床研究重点实验室广州510006

目的:建立超高效液相色谱-三重四极杆质谱法(UPLC-QqQ-MS/MS)同时测定香槟方中槟榔次碱、槟榔碱、去甲异波尔定、波尔定碱的含量,比较槟榔、乌药单煎液与香槟方合煎液中4种生物碱成分的含量变化,为香槟方制剂研究提供实验基础。方法:采... 详细信息

目的:建立超高效液相色谱-三重四极杆质谱法(UPLC-QqQ-MS/MS)同时测定香槟方中槟榔次碱、槟榔碱、去甲异波尔定、波尔定碱的含量,比较槟榔、乌药单煎液与香槟方合煎液中4种生物碱成分的含量变化,为香槟方制剂研究提供实验基础。方法:采用Waters ACQUITY UPLC BEH Shield RP18色谱柱(2.1 mm×150 mm,1.7μm);流动相0.1%甲酸水溶液-乙腈梯度洗脱,流速0.2 mL·min-1,柱温30℃;采用电喷雾离子源(Esi),正离子模式扫描,多反应监测(MRM)模式检测;各化合物的定量离子对分别为m/z 142.10/44.11(槟榔次碱),156.20/44.07(槟榔碱),314.29/265.12(去甲异波尔定),328.13/265.10(波尔定碱)。结果:槟榔次碱、槟榔碱、去甲异波尔定、波尔定碱分别在0.479 0~57.48,0.976 0~78.08,0.812 0~64.96,0.091 2~18.24μg·L-1线性关系良好(r≥0.994 8),平均加样回收率为93.73%~104.34%,RSD均<5%(n=6)。香槟方中槟榔次碱、槟榔碱、去甲异波尔定、波尔定碱的质量分数分别为(90.07±1.26),(445.27±12.39),(742.35±38.39),(38.50±3.33)μg·g-1,均显著低于单煎液中的含量。结论:该方法快速、灵敏、准确、重复性好,可用于香槟方中生物碱成分的含量测定,为香槟方的质量控制及深入研究提供参考依据;香槟方配伍对槟榔次碱、槟榔碱、去甲异波尔定、波尔定碱的溶出量具有显著影响。

关键词：香槟方生物碱超高效液相色谱-串联质谱法槟榔次碱槟榔碱去甲异波尔定波尔定碱

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu Dong Zhouhua jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

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“四史教育”融入课程思政的探究

化工管理 2022年第31期 11-13页

作者：姜思维宋春雨潘柯重庆化工职业学院化学工程学院重庆401228

“四史教育”是新时代职业院校思想政治工作的重要内容,如何有效地开展“四史教育”是近几年的重要研究内容。将“四史”教育与课程思政、专业学习有机融合,能够更好的实现“立德树人”的根本任务。本文根据化妆品技术专业的专业特色和... 详细信息

“四史教育”是新时代职业院校思想政治工作的重要内容,如何有效地开展“四史教育”是近几年的重要研究内容。将“四史”教育与课程思政、专业学习有机融合,能够更好的实现“立德树人”的根本任务。本文根据化妆品技术专业的专业特色和人才培养目标,分析课程内容,挖掘“四史”元素,探究将“四史”元素融入课程思政的策略。

关键词：化妆品四史教育课程思政化妆品技术专业

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou wei-Jin jiang Ji Yu Mao-Jun Yao Yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(Psisted extraction significantly increased the DMY content of the extracts(Psis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant