检索结果-南通市图书馆

Measurement of the Mass Excess of ^(158)Sm

在线全文

学校读者我要写书评

暂无评论

Chinese journal of nuclear physics 1995年第3期17卷 234-238页

作者： Zhao Kui Guo Ji-yu Lu Xiu-qin cheng Ye-hao Huang Xiao-lin Ma Yong Li Shu-yuan Ruan Ming Li Zhi-chang jiang cheng-lie China Institute of Atomic Energy,P.O.Box 275(10),Beijing 102413 中国原子能科学院北京

A Q-value of —4.076±0.151 MeV has been determined for the two-proton transfer reaction160Gd(18O,20Ne)158Sm,which yields a first experimental measured value of —65.764±0.151 MeV forthe mass excess of 158Sm,the nucl... 详细信息

关键词： Heavy ion reaction Q-value Mass excess

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2018年第3期5卷 204-219页

作者： jiang-jiang Qin Xin Li Courtney Hunt Wei Wang Hui Wang Ruiwen Zhang Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTX77204USA Center for Drug Discovery University of HoustonHoustonTX77204USA School of Public Health Shanghai Jiao Tong University School of MedicineShanghai200025China

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest,apoptosis,senescence,and DNA *** MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein ***2,p53,and the p53-MDM2 pathway represent welldocumented targets for preventing and/or treating *** products,especially those from medicinal and food plants,are a rich source for the discovery and development of novel therapeutic and preventive agents against human *** natural product-derived MDM2 inhibitors have shown potent efficacy against various human *** contrast to synthetic small-molecule MDM2 inhibitors,the majority of which have been designed to inhibit MDM2-p53 binding and activate p53,many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability,exerting their anticancer activity in both p53-dependent and p53-independent *** recently,several natural products have been reported to target mutant p53 in ***,identification of natural products targeting MDM2,mutant p53,and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic *** this review,we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway,emphasizing several emerging issues,such as the efficacy,mechanism of action,and specificity of these natural products.

关键词： MDM2 Natural products Oncogene p53 Tumor suppressor

Studies on the Synthesis, Crystal Structure and Quantum Chemistry of Di(o-cyanobenzyl)tin Bis(quinoline-2-carboxylate)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2008年第2期27卷 220-224页

作者： KUANG Dai-Zhi jiang jiang-Ping ZHANG Fu-Xing WANG Jian-Qiu LUO Yi-Ming FENG Yong-Lan Department of Chemistry and Materials Science Hengyang Normal University Hengyang 421008 China School of Chemistry and Chemical Engineering Central South University Changsha 410083 China

Di（o-cyanobenzyl）tin bis（quinoline-2-carboxylate） was synthesized by the reaction of tri（o-cyanobenzyl）tin chloride with quinoline-2-carboxylic acid. The molecular structure of the compound was characterized by elemental analysis, IR, 1H NMR and X-ray diffraction. Crystal data for the compound： tficlinic, space group P1, a = 0.80734（7）, b = 1.00681（9）, c = 1.04811（9） nm, a = 81.7570（10）, β = 7.7240（10）,γ = 81.2850（10）°, V = 0.77581（12） nm3, Z = 1, Dc = 1.488 g/cm3, μ（MoKa） = 0.870 mm^-1 and F（000） = 350. The final R= 0.0204 and wR= 0.0530 for 2677 observed reflections with I 〉2σ（I）, and R = 0.0208 and wR = 0.0532 for all reflections. The molecular structure adopts a distorted octahedral geometry around the Sn atom. The title compound molecules are connected via hydrogen bonding interactions to form a 3D network structure. Quantum chemistry calculation study on the title compound has been performed by means of G98W package at the Lanl2dz basis set. The stability of the compound, orbital energies and some frontier molecular orbital composition characteristics have also been investigated.

关键词： di(o-cyanobenzyl)tin bis(quinoline-2-carboxylate) synthesis crystal structure

Influence of Procedure Parameters on Rheological Property of Semi-Solid AZ91D Magnesium Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2004年第z2期22卷 47-49页

作者： jiang Yunxi Xie Shuisheng Li Xinggang Li Lei General Research Institute for Non-Ferrous Metals Beijing 100088China General Research Institute for Non-Ferrous MetalsBeijing 100088China General Research Institute for Non-Ferrous MetalsBeijing 100088China General Research Institute for Non-Ferrous MetalsBeijing 100088China

Semi-solid AZ91D magnesium alloy was investigated in isothermal steady-state condition. The influence of stirring technological parameters such as stirring temperature and shear rate to apparent viscosity of semi-solid alloy slurry was discussed. Apparent viscosity increases with stirring temperature decreases at the same shear rate. At the same stirring temperature, apparent viscosity decreases rapidly at first with shear rate increases, and then apparent viscosity decreases slowly with shear rate increases, when shear rate reaches a certain value, apparent viscosity appears tiny increase. According to the experimental data, the relation between solid volume fraction and apparent viscosity of semi-solid AZ9l D alloy at shear rate 238 s- 1 is fitted by regression method, it supplies useful data to the numerical simulation of semi-solid AZ91D alloy die casting process.

关键词： AZ91D alloy semi-solid rheological property procedure parameter

Eutectic nucleation in Al-25wt.% Si alloy through DSC

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2010年第1期29卷 62-65页

作者： WU Yuying LIU Xiangfa jiang Binggang HUANG Chuanzhen Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of Education Shandong University Jinan 250061 China School of Mechanical Engineering Shandong University Jinan 250061 China

Eutectic nucleation in hypereutectic Al-25wt.%Si alloy with the addition of P was studied by calculating the activation energy and nucleation work. The results indicate that P refinement, which can decrease the activation energy as well as nucleation work of eutectic solidification, can increase the eutectic nucleation frequency of Al-25wt.%Si alloy, so the addition of P can refme the eutectic structures of hypereutectic Al-Si alloys. According to the calculations, there is a certain relationship between the precipitation of primary silicon and eutectic solidification, and the eutectic nucleation mode is independent of morphology transition.

关键词： aluminum alloys refinement differential scanning calorimeter eutectic silicon eutectic nucleation

Intravenous tirofiban therapy for patients with capsular warning syndrome

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2019年第1期4卷 22-27页

作者： Wei Li Ya Wu Xiao-Shu Li cheng-Chun Liu Shu-Han Huang Chun-Rong Liang Huan Wang Li-Li Zhang Zhi-Qiang Xu Yan-jiang Wang Meng Zhang Department of Neurology Daping Hospital&Research Institute of SurgeryThe Army Military Medical UniversityChongqingChina

Background Capsular warning syndrome(CWS)is defined as recurrent episodes of transient ischaemic attacks≥3 times during a short time *** is no effective therapy to stop these ***,herein,report our experience of using intravenous tirofiban to treat *** All patients with CWS in our hospital from January 2013 to September 2017 were *** in tirofiban group(T-group)were treated by intravenous tirofiban at 0.4μg/kg/min for 30 min followed by 0.1-0.15μg/kg/min *** treatments(non-T-group)included thrombolytic,oral antiplatelet agents and *** haemorrhage(ICH),systematic bleeding,new attacks after treatment,National Institutes of Health Stroke Scale(NIHSS)scores at 24 hours and modified Rankin Scales(mRSs)at 3 months were *** statistics were used for *** Of 23 patients qualified(15 in T-group,8 in non-T-group),the duration of symptoms ranged from 2 to 100 min before *** treatment,in T-group,four patients(26.7%)had recurrent attacks,and NIHSS scores were 0 in 11 patients(73.3%)at 24 *** patients reached a favourable outcome(mRS≤2) at 3 *** non-T-group,five patients(62.5%)had new *** scores were 0 in two patients(25%)at 24 *** 3 months,seven patients(87.5%)reached a favourable *** ICH nor systematic bleeding or thrombocytopaenia occurred in both groups of *** Intravenous tirofiban can be a potentially effective and safe therapy to stop early symptomatic fluctuations and shorten the duration of functional deficits in patients with CWS.

关键词： patients Intravenous intravenous

Isolation and identification of bacteria responsible for simultaneous anaerobic ammonium and sulfate removal

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2010年第3期53卷 644-649页

作者： Cai, Jing jiang, Jian Xiang Zheng, Ping Department of Environmental Engineering Zhejiang University Hangzhou 310029 China

Sulfate-dependent anaerobic ammonium oxidation is a novel biological reaction,in which ammonium is oxidized with sulfate as the electron acceptor under anoxic *** and sulfate are cosmopolitan chemical species which are an integral part of the global nitrogen and sulfur cycles.A detailed exploration of sulfate-dependent anaerobic ammonium oxidation is quite *** this work,a bacterial strain named ASR has been isolated from an anaerobic ammonia and sulfate removing reactor working under *** the basis of electron microscopy,physiological tests and 16S rDNA phylogenetic sequence analysis,the strain ASR is found to be related to Bacillus *** to the biological carbon source utilization test,the strain ASR could use many carbon *** optimum pH value and temperature were 8.5 and 30 °C,*** test proves that the strain ASR is able to use sulfate to oxidize ammonia *** maximum ammonia and sulfate removal rates were 44.4% and 40.0%,*** present study provided biological evidence for the confirmation and development of sulfate-dependent anaerobic ammonium oxidation and brought new insights into the global nitrogen and sulfur cycles.

关键词： bacillus ammonia sulfate isolation and identification

MSISE90大气密度模型及其在GPS无线电掩星中的应用

在线全文

学校读者我要写书评

暂无评论

云南天文台台刊 2001年第2期 26-30页

作者：蒋虎 HUANG cheng 中国科学院上海天文台上海200030

本文简略介绍了MSISE90大气密度模型，它是以提高低高度大气密度计算精度为目标，基于MSIS86模式，采用不相干散射雷达和卫星质谱仪测量资料，在半经验公式的基础上进行拟合处理而成；并指出了Hedin对该模型的修正之处。并将该模型应用... 详细信息

本文简略介绍了MSISE90大气密度模型，它是以提高低高度大气密度计算精度为目标，基于MSIS86模式，采用不相干散射雷达和卫星质谱仪测量资料，在半经验公式的基础上进行拟合处理而成；并指出了Hedin对该模型的修正之处。并将该模型应用于GPS无线电掩星反演中性地球大气参数的先验温度序列的生成。

关键词： MSISE90大气密度模型无线电掩星 GPS 地球大气参数先验温度序列

Theoretical study on the reaction mechanism of ozone addition to the double bonds of keto-limonene

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第1期24卷 147-151页

作者： Lei jiang Yisheng Xu Baohui Yin Zhipeng Bai College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

The reaction mechanism of ozone （O 3） addition to the double bonds of gas phase keto-limonene was investigated using ab initio *** different possibilities for O 3 addition to the double bond were considered and two corresponding van der Waals complexes （Complex 1 and Complex 2） were found for 1-endo and *** rate constants were calculated using the transition state theory at the CCSD（T）/6-31G（d）＋ CF//B3LYP/6-31G（d,p） *** high-pressure limit of the total rate constant at 298 K was 3.51×10-16 cm 3/（molecule·sec）,which was in a good agreement with the experimental data.

关键词： keto-limonene O3 transition state theory