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Diabetic macular edema in proliferative stage treated with anti-vascular endothelial growth factor agent and triamcinolone acetonide by laser-based strategies

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1113-1119页

作者： Gang Qiao Wan-jiang Dong Yan Dai Zhen-Hua jiang Hai-Ke Guo Department of Ophthalmology Guangdong General Hospital Affiliated to Southern Medical University Department of Ophthalmology Mianyang Wan-Jiang Eye Hospital Department of Ophthalmology Mianyang Central Hospital

AIM： To appraise the effect of treatment for diabetic macular edema（DME） in proliferative stage with sufficient panrentinal photocoagulation（PRP） therapy and intravitreal injections（IV） Conbercept and posterior subtenon＇s triamcinolone acetonide（STTA） sequential ***： This prospective clinical randomized controlled trial of cross-over design was conducted in three phases. The participants included cases of DME in proliferative stage. They were divided into two groups and treated with PRP before enrollment. Group A were treated with IVConbercept 0.5 mg for one month in the 1^st phase. Group B were treated with STTA 40 mg（twice per two weeks）. The interventions were exchanged in the second phase（2mo） between the two groups. In the third phase（3-6mo） no other treatment was given. Best corrected visual acuity（BCVA）, central macular thickness（CMT） measured by OCT and complications were ***： After phase I： in Group A, BCVA improved from 0.201±0.17 to 0.37±0.24（F=5.88, P=0.004）. CMT changed from 449±155.10 to 304.1±84.70 μm（F=14.9, P〈0.01）. In Group B, BCVA changed from 0.195±0.19 to 0.26±0.20（F=0.76, P=0.41） while CMT changed from 463.82±152.92 to 366.00±115.40 μm（F=3.70, P〈0.03）. The improvement of BCVA was better in Group A（P〈0.05）. After phase II： in Group A, BCVA raised to 0.47±0.27（F=0.26, P〈0.01）, CMT reduced to 260.67±62.97 μm（F=-188.3, P〈0.01）; in Group B, BCVA raised to 0.51±0.26（F=0.31, P〈0.01）, CMT reduced to 261.93±50.15 μm（F=-201.9, P〈0.01）. But there were no difference between two groups（P〉0.05）. After phase III： in Group A, BCVA maintained 0.42±0.25（F=0.22, P=0.001）, CMT maintained 267.8±58.34 μm,（F=-0.27, P〈0.01）; in Group B, BCVA was 0.47±0.25（F=-0.27, P〈0.01）, CMT was 272.71±49.16 μm（F=-191.1, P〈0.01）. No serious complications happened in all ***： PRP＋Conbercept is better than PRP＋STTA in DME with proliferative stage but PRP＋Conbercept＋STTA sequential therapy may be a wiser choice for persistent effectiveness on anat

关键词： Conbercept sequential therapy cross-over design diabetic macular edema

Quadcopter UAV Modeling and Automatic Flight Control Design

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第6期34卷 627-636页

作者： Bhatia Ajeet Kumar jiang Ju Zhen Ziyang College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016.P.R.China jiangsu Key Laboratory of Internet of Things and Control Technologies Nanjing 210016.P.R.China

The mathematical model of quadcopter-unmanned aerial vehicle （UAV） is derived by using two approaches： One is the Newton-Euler approach which is formulated using classical meehanics; and other is the Euler-Lagrange approach which describes the model in terms of kinetic （translational and rotational） and potential energy. The proposed quadcopter＇s non-linear model is incorporated with aero-dynamical forces generated by air resistance, which helps aircraft to exhibits more realistic behavior while hovering. Based on the obtained model, the suitable control strategy is developed, under which two effective flight control systems are developed. Each control system is created by cascading the proportional-derivative （PD） and T-S fuzzy controllers that are equipped with six and twelve feedback signals individually respectively to ensure better tracking, stabilization, and response. Both pro- posed flight control designs are then implemented with the quadcopter model respectively and multitudinous simulations are conducted using MATLAB/Simulink to analyze the tracking performance of the quadcopter model at various reference inputs and trajectories.

关键词： quadcopter unmanned aerial vehicle (UAV) flight control desigm T-S fuzzy inference system propotional-derivative (PD) controller

Dosage Effects of Fadrozole on Growth and Development of Sex-Reversed Genetic Female Chickens

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Journal of Integrative Agriculture 2013年第6期12卷 1049-1053页

作者： YANG Xiu-rong jiang He-sheng ZHENG jiang-xia QU Lu-jiang CHEN Si-rui LI Jun-ying XU Gui- yun YANG Ning Department of Animal Genetics and Breeding Guangxi University Department of Animal Genetics and Breeding National Engineering Laboratory for Animal Breeding China Agricultural University

Fadrozole, an aromatase inhibitor, can masculinize genetic female chickens and high-dose decreases the hatchability. Therefore, it is important to study the growth and development of sex-reversed females after hatch. Chick embryos from a population of CAU3 egg-type were treated with different concentrations of Fadrozole prior to the sexual differentiation at E3.0 （st18）. At hatch, the phenotypic sex and genetic sex were identified by vent sexing and genetic diagnosis with CHD1, respectively. Body weight and shank length of sex reversal were tested at 8 and 20 wk, respectively. Testicular development, oviduct and ovarian degeneration were observed and serum concentration of estradiol and testosterone were tested with radioimmunoassay （RIA） at 30 wk. The results showed that body weight and shank length of sex- reversed females were not significantly different between low-dose groups （0.1, 0.3, and 0.5 mg for F1, F2, and F3, respectively） and high-dose groups （1.0 and 1.3 mg for F4 and F5, respectively）（P〉0.05）. Left and right testes or ovotestes in F2, F3, F4, and F5 groups were heavier than that of in F1 group （P〈0.05）. While the gonad weight of treatment groups were less than that in male control （P〈0.05）, oviduct weight in F2, F3, F4, and F5 groups were significant differences compared with female control and F1 group （P〈0.05）. Egg number from onset of laying egg to 30 wk in F4 and F5 groups were less than in female control, F1 and F2 groups （P〈0.05）. Serum testosterone level in F5 group was significant higher compared with female control, F1, F2, F3, and F4 groups （P〈0.05）, but significant lower compared with male control （P〈0.05）. While concentration of serum estradiol in F5 group was significant lower compared with female control, F1, F2, and F4 groups （P〈0.05）. In conclusion, the concentration of Fadrozole do not affect postnatal growth of sex-reversed female chicken and the degree of sex-reversed females elevate with the increase of Fadrozole concentration at

关键词： chicken Fadrozole growth and development reproductive system sex reversals

温度对线路覆冰监测光纤光栅倾角传感器性能的影响

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高电压技术 2010年第7期36卷 1704-1709页

作者：马国明李成榕蒋建全江涛程养春华北电力大学高电压与电磁兼容北京市重点实验室北京102206

针对现有架空输电线路覆冰在线监测系统存在的易受电磁干扰、使用寿命短等缺点,开发出了用于输电线路覆冰监测的光纤布喇格光栅(fiber Bragg grating,FBG)拉力倾角传感器;研究了温度对该传感器的影响。利用温控箱试验传感器零点温度影... 详细信息

针对现有架空输电线路覆冰在线监测系统存在的易受电磁干扰、使用寿命短等缺点,开发出了用于输电线路覆冰监测的光纤布喇格光栅(fiber Bragg grating,FBG)拉力倾角传感器;研究了温度对该传感器的影响。利用温控箱试验传感器零点温度影响的结果表明,使用温度内温度变化引起的拉力测量零点变化<±0.1%时,倾角测量零点变化<±0.67%;气候室中试验研究覆冰气候环境下开发的拉力倾角传感器的拉力测量误差<0.17%。户外试验表明研发的光纤布喇格光栅拉力倾角传感器在长期低温环境下(-15°C～+3°C)运行稳定,传感器测量未出现蠕变衰减现象。

关键词：架空输电线路拉力倾角传感器光纤布喇格光栅温度误差可靠性

Alternative Splicing and Differential Expression of Two Transcripts of Nicotine Adenine Dinucleotide Phosphate Oxidase B Gene from Zea mays

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Journal of Integrative Plant Biology 2009年第3期51卷 287-298页

作者： Fan Lin Yun Zhang Ming-Yi jiang College of Life Sciences Nanjing Agricultural University Nanjing 210095 China

With the exception of rice, little is known about the existence of respiratory burst oxidase homolog （rboh） gene in cereals. The present study reports the cloning and analysis of a novel rboh gene, termed ZmrbohB, from maize （Zea mays L.）. The full-length cDNA of ZmrbohB encodes a 942 amino acid protein containing all of the respiratory burst oxidase homolog catalytically critical motifs. Alternative splicing of ZmrbohB has generated two transcript isoforms, ZmrbohB-α and -β. Spliced transcript ZmrbohB-β retains an unspliced intron 11 that carries a premature termination codon and probably leads to nonsense-mediated mRNA decay. Expression analysis showed that two splice isoforms were differentially expressed in various tissues and at different developmental stages, and the major product was ZmrbohB-e. The transcripts of ZmrbohB-α accumulated markedly when the maize seedlings were subjected to various abiotic stimuli, such as wounding, cold （4℃）, heat （40℃）, UV and salinity stress. In addition, several abiotic stimuli also affected the alternative splicing pattern of ZmrbohB except wounding. These results provide new insight into roles in the expression regulation of plant rboh genes and suggest that ZrnrbohB gene may play a role in response to environmental stresses.

关键词： abiotic stress alternative splicing respiratory burst oxidase homolog Zea mays.

Fe_3O_4 nano-whiskers by ultrasonic-aided reduction in concentrated NaOH solution

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Particuology 2011年第1期9卷 86-90页

作者： chenglong Yu Xin Hao Hongtao jiang Lili Wang School of Materials Science and Engineering Shaanxi University of Science & Technology Xi'an 710021 China Research Laboratory of Hydrothermal Chemistry Faculty of Science Kochi University Kochi 7808520 Japan

Fe3O4 nano-whiskers were synthesized via ultrasonic-aided reduction of FeCl2.4H2O with N2H4-H2O in concentrated NaOH solution. Phase identification and morphology observation were conducted by X-ray diffraction （XRD） analysis, transmission electron microscopy （TEM） and field emission scanning electron microscopy （FE-SEM）. Face scanning energy dispersive spectrum （face scanning EDS） and twodimensional fast Fourier transform （2DFFF） for element distribution were carried out for confirming composition homogeneity. From XRD and TEIVI, the synthesized Fe304 nano-whiskers are of cubic phase with average dimension of 20 nm~ 200 nm （average aspect ratio of 10）. FE-SEM shows that the nanowhiskers without dispersion are interconnected into a network at a scale of 20μm. 2DFFT of the distribution of Fe and O from face scanning EDS confirms the composition homogeneity of the synthesized Fe3O4. Hydrazine hydrate determines the formation of the nano-whiskers, while the possible mechanism is the preferred growth along certain orientation with the aid of ultrasonic treatment.

关键词： Fe 3 O 4 nano-whiskers Morphology Homogeneity Two-dimensional fast Fourier transform

Global convergent algorithm for the bilevel linear fractional-linear programming based on modified convex simplex method

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Journal of Systems Engineering and Electronics 2010年第2期21卷 239-243页

作者： Guangmin Wang Bing jiang Kejun Zhu Zhongping Wan School of Economics and Management China University of Geosciences Wuhan 430074 R R. China School of Mathematics and Statistics Wuhan University Wuhan 430072 R R. China

A global convergent algorithm is proposed to solve bilevel linear fractional-linear programming, which is a special class of bilevel programming. In our algorithm, replacing the lower level problem by its dual gap equaling to zero, the bilevel linear fractional-linear programming is transformed into a traditional sin- gle level programming problem, which can be transformed into a series of linear fractional programming problem. Thus, the modi- fied convex simplex method is used to solve the infinite linear fractional programming to obtain the global convergent solution of the original bilevel linear fractional-linear programming. Finally, an example demonstrates the feasibility of the proposed algorithm.

关键词： bilevel linear fractional-linear programming convex simplex method dual problem.

Fabrication and properties of Al matrix composites strengthened by in situ alumina particulates

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Journal of University of Science and Technology Beijing 2006年第3期13卷 263-266页

作者： Gaofeng Fu Lan jiang Ji Liu Yue Wang School of Materials and Metallurgy Northeastern University Shenyang 110004 China

New aluminum matrix composites strengthened by Al2O3 particulates through stirring cast by adding NH4Al（SO4）2 to the molten aluminum have been fabricated. TEM observation shows that in-situ Al2O3 particulates are generally spherical and they are uniformly distributed in the Al matrix. Dry sliding wear test results show that the volume loss of the unreinforced Al matrix is about three times that of the Al2O3 reinforced metal matrix composite （MMC） and the volume loss of the MMC fabricated by adding Al2O3 is larger than that of the MMC by adding NH4Al（SO4）2. Lubricating sliding wear test results show that the volume loss of the MMCs increases more slowly than that of the matrix with the increasing of the load.

关键词： aluminum matrix composite alumina microstructure wear

Current perspectives on mesenchymal stem cells as a potential therapeutic strategy for non-alcoholic fatty liver disease

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World Journal of Stem Cells 2024年第7期16卷 760-772页

作者： Yan jiang Narazah Mohd Yusoff jiang Du Emmanuel Jairaj Moses Jun-Tang Lin School of Nursing Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Advanced Medical and Dental Institute Universiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Henan Joint International Research Laboratory of Stem Cell Medicine School of Medical EngineeringXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Stem Cells and Biotherapy Engineering Research Center of Henan National Joint Engineering Laboratory of Stem Cells and BiotherapySchool of Life Science and TechnologyXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Henan Joint International Research Laboratory of Stem Cell Medicine School of Medical EngineeringXinxiang Medical UniversityXinxiang 453000Henan ProvinceChina

Non-alcoholic fatty liver disease(NAFLD)has emerged as a significant health challenge,characterized by its widespread prevalence,intricate natural progression and multifaceted *** NAFLD initially presents as benign fat accumulation,it may progress to steatosis,non-alcoholic steatohepatitis,cirrhosis,and hepatocellular *** stem cells(MSCs)are recognized for their intrinsic self-renewal,superior biocompatibility,and minimal immunogenicity,positioning them as a therapeutic innovation for liver ***,this review aims to elucidate the potential roles of MSCs in alleviating the progression of NAFLD by alteration of underlying molecular pathways,including glycolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** insights are expected to provide further understanding of the potential of MSCs in NAFLD therapeutics,and support the development of MSC-based therapy in the treatment of NAFLD.

关键词： Non-alcoholic induced fatty liver disease Mesenchymal stem cells Lipid accumulation Inflammation Oxidative stress Endoplasmic reticulum stress Fibrosis