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Jaffe-Campanacci syndrome resulted in amputation: A case report

World Journal of Clinical Cases 2024年第10期12卷 1785-1792页

作者： Jun jiang min Liu Department of Pediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Jaffe-Campanacci syndrome(JCS)is a very rare syndrome.The treatment of JCS is more conservative,and most authors recommend that no surgery should be done in asymptomatic patients.The conventional concept holds that the natural course of non-ossifying fibromas(NOFs)grows with the development of bones,and the osteolytic region gradually stops expanding and self-healing through bone ossifying around the lesion and ossification within the lesion.But in this case,the bone lesions were potentially biologically aggressive,which led to severe limb deformities and pain.CASE SUMMARY We present the case of a 5-year-old girl with JCS presenting with not only NOF sand café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in amputation.She was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretching or being touched.Skin examination revealed multiple café-au-lait macules on the neck,arm,axilla,and torso,including the nipples and perineum.Radiographs revealed multiple lytic lesions in the proximal part of the right humerus,distal part of the right clavicle,proximal and distal parts of the right femur,and proximal parts of the right tibia and fibula.Curettage and biopsy were performed on the distal part of the right femur.At the age of 7,the girl was re-admitted to our hospital for a pathological fracture in the middle in the right femur and underwent Intralesional excision,internal fixation,bone grafting,and spica casting.At the age of 10,the girl came to our hospital again for severe pain of the right leg.Amputation from the middle level of the right femur was performed.We present the case of a 5-year-old girl with JCS presenting with not only NOFs and café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in amputation.She was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretchi

关键词： Jaffe-Campanacci syndrome Multiple non-ossifying fibromas Café-au-lait macule Amputation Case report

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蒋小敏运用气血双补汤治疗气血两虚型缺铁性贫血验案2则

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江西中医药 2022年第12期53卷 29-31页

作者：郑冉蒋小敏江西中医药大学南昌330004 江西中医药大学附属医院南昌330006

缺铁性贫血是临床常见的一种贫血类型,蒋小敏对治疗缺铁性贫血颇有见解,认为排除原发病因与辨证论治同等重要,主张该病的病位在于脾胃肝肾,与饮食劳倦、先天不足、久病体虚等有关,关键病机在于脾胃气血生化乏源导致气血两虚,自拟气血双... 详细信息

缺铁性贫血是临床常见的一种贫血类型,蒋小敏对治疗缺铁性贫血颇有见解,认为排除原发病因与辨证论治同等重要,主张该病的病位在于脾胃肝肾,与饮食劳倦、先天不足、久病体虚等有关,关键病机在于脾胃气血生化乏源导致气血两虚,自拟气血双补汤健脾养心、滋补肝肾,资化源助运化,补气以生血,补血助气运。通过追溯缺铁性贫血的中医历史源流及病因病机、方药分析以及具体临床医案等方面来介绍蒋小敏临床运用此方之思路和经验。

关键词：蒋小敏缺铁性贫血气血双补汤气血两虚

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姜敏教授中医体质调理治疗恶性肿瘤经验

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光明中医 2021年第2期36卷 201-203页

作者：任静姜敏首都医科大学附属北京世纪坛医院北京100038 首都医科大学附属北京世纪坛医院中医科北京100038

姜敏教授师从国医大师王琦教授,从事中医临床30余年,擅长在中医体质学的基础上运用中医药治疗各种恶性肿瘤及其并发症。姜敏教授认为恶性肿瘤的发生是一种体质性变化,强调从整体和本质上把握疾病,根据肿瘤患者的体质特征,寻找恶性肿瘤... 详细信息

姜敏教授师从国医大师王琦教授,从事中医临床30余年,擅长在中医体质学的基础上运用中医药治疗各种恶性肿瘤及其并发症。姜敏教授认为恶性肿瘤的发生是一种体质性变化,强调从整体和本质上把握疾病,根据肿瘤患者的体质特征,寻找恶性肿瘤的发病规律,注意要以"人"为背景,"辨体-辨病-辨证相结合"治疗疾病。

关键词：中医体质调理恶性肿瘤临证经验姜敏

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Full composition granules of Huanglian (Rhizoma Coptidis) decrease the serum monocyte chemotactic protein-1 and connective tissue growth factor levels and inhibit kidney nuclear factor-κB expression in rats with high-fat diet-induced diabetes

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Journal of Traditional Chinese Medicine 2021年第3期41卷 424-431页

作者： GUO Yangzhi DU Juan JIANG Min GUO Wei Department of Traditional Chinese Medicine Capital Medical University Affiliated Beijing Shijitan HospitalBeijing 100038China Department of Obstetrics and Gynecology Beijing Changping Hospital of Integrated Chinese and Western MedicineBeijing 102208China Department of Traditional Chinese Medicine the Mongolian Medical and Traditional Chinese Medicine Hospital of WuhaiWuhai 016000China

OBJECTIVE: To investigate the efficacy of the full composition granules of Huanglian(Rhizoma Coptidis)(FGC) on the serum monocyte chemotactic protein-1(MCP-1) and connective tissue growth factor(CTGF) levels and kidney nuclear factor-κB(NF-κB) expression in rats with high-fat diet-induced diabetes.METHODS: Diabetes was induced in rats by feeding a high-fat chow combined with intravenous streptozotocin injection. Forty diabetic SpragueDawley rats were randomly assigned to a normal group(NG), model group(MG), irbesartan group(IG), and low-, middle-, and high-dosage FGC groups(LFGC, MFGC, HFGC), with eight rats per group. The IG rats received 31.25 mg·kg^(-1)·d^(-1) irbesartan tablets, whereas those in the LFGC, MFGC,and HFGC were administered 52, 312.5, and 625 mg·kg^(-1)·d^(-1) FGC, respectively. After 12 weeks,bodyweight(BW), left kidney weight(KW), hemoglobin A1c(HbA1c), serum creatinine(Scre), blood urea nitrogen(BUN), and serum MCP-1 and CTGF levels were determined, pathological changes of the kidney were recorded, and kidney NF-κB p65(A) expression was measured.RESULTS: The 24-h urine albumin and levels of HbA1c, Scre, BUN, and serum MCP-1 and CTGF were significantly increased in in the MG compared with the NG, as was the kidney NF-κB(p65) expression(P ministration,the 24-h urine albumin and the levels of HbA1c,Scre, and serum MCP-1 and CTGF were significantly decreased in FCG groups compared with those in the MG, which is in agreement with the change in the kidney NF-κB(p65) expression, whereas the similarly significant decrease only exist in 24-h urine albumin and the levels of serum CTGF after irbesartan administration. Hematoxylin-eosin(HE)staining results indicated that the fibrosis observed in the MG samples was alleviated through FGC treatment.CONCLUSION: FGC may alleviate potential kidney injury by decreasing the serum MCP-1 and CTGF levels and inhibiting NF-k B expression i

关键词： Huanglian(Rhizoma Coptidis) diabetic nephropathies chemokine CCL2 connective tissue growth factor NF-kappa B

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Acupuncture on intrauterine growth restriction associated brain injury:case study including use of magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2023年第3期43卷 602-605页

作者： XIN Zhixiong LI Jiyuan XU Yanni LING Jing JIANG Min YU Yutian Department of Pediatrics People's Hospital of Sanshui DistrictFoshan 528000China Department of MRI Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Ninth School of Clinical Medicine Peking UniversityBeijing 100038China Foshan minfound Medical Imaging Diagnostic Center Foshan 528000China Department of Gynecology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China Acupuncture Department Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Brain injury due to intrauterine growth restriction(IUGR) is a thorny clinical problem that often leads to permanent neurological deficits such as cerebral palsy.Few practical therapies can treat an IUGR-associated brain injury.We employed acupuncture to treat a 6-month-old male patient with severe hypoxic-ischemic encephalopathy(HIE) due to IUGR,as confirmed by magnetic resonance imaging(MRI).Three courses of acupuncture treatment significantly improved some of the patient’s clinical characteristics,such as his insensitive responsiveness and motor deficits,with remarkably reversed HIE features on MRI at 1-year of age.This case suggests that acupuncture is a potential treatment option for an IUGRassociated brain injury and warrants further investigation.

关键词： acupuncture fetal growth retardation brain injuries hypoxia-ischemia brain magnetic resonance imaging neuronal plasticity

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蒋小敏运用桂枝汤类方治疗痹证经验

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江西中医药 2023年第11期54卷 41-43,46页

作者：马俊鹏蒋小敏江西中医药大学岐黄国医书院南昌330006 江西中医药大学附属医院南昌330006

蒋小敏灵活应用桂枝汤及其类方以外和营卫、内调阴阳,辨证精准,善于加减化裁及合方使用,能有效针对痹证营卫不和,复感风寒湿邪,致使气血运行不畅、经络痹阻的病因病机,临床运用黄芪桂枝五物汤、桂枝芍药知母汤、桂枝附子汤等治疗痹证,... 详细信息

蒋小敏灵活应用桂枝汤及其类方以外和营卫、内调阴阳,辨证精准,善于加减化裁及合方使用,能有效针对痹证营卫不和,复感风寒湿邪,致使气血运行不畅、经络痹阻的病因病机,临床运用黄芪桂枝五物汤、桂枝芍药知母汤、桂枝附子汤等治疗痹证,疗效显著。

关键词：痹证桂枝汤桂枝汤类方蒋小敏

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Improving the prognosis of pancreatic cancer:insights from epidemiology,genomic alterations,and therapeutic challenges

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Frontiers of Medicine 2023年第6期17卷 1135-1169页

作者： Zhichen jiang Xiaohao Zheng min Li mingyang Liu State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Division of Gastroenterology and PancreasZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou 310014China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Medicine The University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

Pancreatic cancer,notorious for its late diagnosis and aggressive progression,poses a substantial challenge owing to scarce treatment alternatives.This review endeavors to furnish a holistic insight into pancreatic cancer,encompassing its epidemiology,genomic characterization,risk factors,diagnosis,therapeutic strategies,and treatment resistance mechanisms.We delve into identifying risk factors,including genetic predisposition and environmental exposures,and explore recent research advancements in precursor lesions and molecular subtypes of pancreatic cancer.Additionally,we highlight the development and application of multi-omics approaches in pancreatic cancer research and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy.We also dissect the primary mechanisms underlying treatment resistance in this malignancy,illustrating the latest therapeutic options and advancements in the field.Conclusively,we accentuate the urgent demand for more extensive research to enhance the prognosis for pancreatic cancer patients.

关键词： pancreatic cancer cancer screening single cell molecular alterations precancerous lesion therapy resistance

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Review of noble-gas spin amplification via the spin-exchange collisions

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Science China(Information Sciences) 2022年第10期65卷 5-23页

作者： Haowen SU min jiang Xinhua PENG CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China

Due to isolation from the environment with the protection of the full electronic shells, nuclear spins of noble gas typically feature extraordinary long coherence times, high polarization and good chemical inertness, which makes themselves attractive in extensive scientific applications. Recently, the noble-gas spin amplification via the spin-exchange collisions between overlapping noble-gas spins and alkali-atom spins has been theoretically and experimentally demonstrated in various quantum techniques including maser, Floquet maser, spin-based amplifier, and Floquet spin amplifier. The noble-gas spin amplification can enhance the external oscillating magnetic field by a factor of more than 100 and realize ultrasensitive magnetometry,which is important for the detection of weak electromagnetic fields and hypothetical particles. Based on the spin amplification, experiments have been conducted to search for axion-like dark matter and exotic spindependent forces and new constraints have been established. This review summarizes the recent progress on noble-gas spin amplification, including the basic principles, methods, different types, the related applications ranging from magnetic-field sensing to searches for new physics, and prospects for further improvements.

关键词： nuclear spin noble gas maser spin amplification Floquet system

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The significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease

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PRECISION CLINICAL MEDICINE 2023年第4期6卷 pbad031页

作者： jiang, Fei Wu, min Li, Rongpeng jiangsu Normal Univ Jiangsu Prov Engn Res Ctr Cardiovasc Drugs Targeti Sch Life Sci Xuzhou 221000 Peoples R China Xuzhou Med Univ Affiliated Hosp Dept Lab Med Xuzhou 221000 Peoples R China Univ Chinese Acad Sci Wenzhou Inst Drug Discovery Sect Wenzhou 325000 Peoples R China Med Coll Wisconsin Dept Neurol Milwaukee WI 53226 USA

Inflammatory bowel diseases (IBD) are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence. Although the pathomechanism of IBD has been extensively investigated, several aspects of its pathogenesis remain unclear. Long non-coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides in length that have potential protein-coding functions. LncRNAs play important roles in biological processes such as epigenetic modification, transcriptional regulation and post-transcriptional regulation. In this review, we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment, as well as their potential roles as immune regulators, diagnostic biomarkers and therapeutic targets or agents for IBD.

关键词： lncRNAs inflammatory bowel diseases intestinal barrier intestinal microenvironment immune regulator diagnostic biomarker therapeutic target INTESTINAL BARRIER DYSFUNCTION ATTENUATE EXPERIMENTAL COLITIS ULCERATIVE-COLITIS CROHNS-DISEASE GUT MICROBIOTA EXTRACELLULAR VESICLES EPITHELIAL BARRIER CELLS INNATE HOMEOSTASIS

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蒋小敏从血分瘀热论治湿疹经验

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江西中医药大学学报 2017年第5期29卷 27-28页

作者：占亮生陈江敏蒋小敏江西中医药大学 2014级硕士研究生南昌330004 江西中医药大学附属医院南昌330006

目的:通过整理总结蒋小敏治疗湿疹的临床验案,发掘其治疗湿疹的临床思路和用药规律,为中医治疗湿疹提高临床疗效。方法:通过跟师门诊,收集整理蒋小敏治疗湿疹的病案。结果:临床上由血分瘀热导致的湿疹较为常见。结论:从血分瘀热论治湿... 详细信息

目的:通过整理总结蒋小敏治疗湿疹的临床验案,发掘其治疗湿疹的临床思路和用药规律,为中医治疗湿疹提高临床疗效。方法:通过跟师门诊,收集整理蒋小敏治疗湿疹的病案。结果:临床上由血分瘀热导致的湿疹较为常见。结论:从血分瘀热论治湿疹可取得较好疗效。

关键词：湿疹血分瘀热蒋小敏

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