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Competitive sorption between 17α-ethinyl estradiol and bisphenol A/4-n-nonylphenol by soils

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Journal of Environmental Sciences 2013年第6期25卷 1154-1163页

作者： Jianzhong li Lu jiang xi xiang Shuang Xu Rou Wen xiang liu School of Environment Tsinghua University

The sorption of 17α-ethinyl estradiol （EE2）, bisphenol A （BPA）, and 4-n-nonylphenol （NP） in single systems and the sorption of EE2 with different initial aqueous concentrations of BPA or NP were examined using three soils. Results showed that all sorption isotherms were nonlinear and fit the Freundlich model. The degree of nonlinearity was in the order BPA （0.537-0.686）〉 EE2 （0.705-0.858）〉 NP （0.875-0.0.951） in single systems. The isotherm linearity index of EE2 sorption calculated by the Freundlich model for Loam, Silt Loam and Silt increased from 0.758, 0.705 and 0.858, to 0.889, 0.910 and 0.969, respectively, when BPA concentration increased from 0 to 1000 μg/L, but the effect of NP was comparably minimal. Additionally, EE2 significantly suppressed the sorption of BPA, but insignificantly suppressed that of NE These findings can be attributed to the difference of sorption affinity of EE2, NP and BPA on the hard carbon （e.g., black carbon） of soil organic matter that dominated the sorption in the low equilibrium aqueous concentration range of endocrine-disrupting chemicals （EDCs）. Competitive sorption among EDCs presents new challenges for predicting the transport and fate of EDCs under the influence of co-solutes.

关键词： competitive sorption 17α-ethinyl estradiol endocrine-disrupting chemicals distributed reactivity model black carbon

Spatial Variation of Dissolved Organic Carbon in Soils of Riparian Wetlands and Responses to Hydro-geomorphologic Changes in Sanjiang Plain, China

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Chinese Geographical Science 2015年第2期25卷 174-183页

作者： xi Min KONG Fanlong LYU xianguo jiang Ming li Yue College of Chemical and Environmental Engineering Qingdao University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences

Spatial variation of dissolved organic carbon(DOC) in soils of riparian wetlands and responses to hydro-geomorphologic changes in the Sanjiang Plain were analyzed through in situ collecting soil samples in the Naoli River and the Bielahong River. The results showed that the average contents of DOC for soil layer of 0–100 cm were 730.6 mg/kg, 250.9 mg/kg, 423.0 mg/kg and 333.1 mg/kg respectively from riverbed to river terrace along the transverse directions of the Naoli watershed. The content of the soil DOC was the highest in the riverbed, lower in the high floodplain and much lower in the river terrace, and it was the lowest in the low floodplain. The difference in the content and vertical distribution of DOC between the riverbed and the three riparian wetlands was significant, while it was not significant among the low floodplain, the high floodplain and the river terrace. The variability of soil DOC was related to the hydrological connectivity between different landscape position of the riparian wetlands and the adjacent stream. Extremely significant correlations were observed between DOC and total organic carbon(TOC), total iron(TFe), ferrous iron(Fe(II)) whose correlation coefficients were 0.819, –0.544 and –0.709 in riparian wetlands of the Naoli River. With the increase of wetland destruction, soil p H increased and soil DOC content changed. The correlation coefficients between soil DOC and TOC, TFe, Fe(II) also changed into 0.759, –0.686 and –0.575 respectively in the Bielahong River. Under the impact of drainage ditches, the correlations between soil DOC and TFe, Fe(II) were not obvious, while the soil p H was weakly alkaline and was negatively correlated with soil DOC in the previous high floodplain. It indicates that riparian hydro-geomorphology is the main factor that could well explain this spatial variability of soil DOC, and the agricultural environmental hydraulic works like ditching also must be considered.

关键词： dissolved organic carbon(DOC) riparian wetlands spatial variation hydro-geomorphologic changes Sanjiang Plain

Estradiol Induced Estrogen Receptor-mediated Transcription and Expression of Aquaporin5

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Chemical Research in Chinese Universities 2019年第2期35卷 239-244页

作者： WEI Wei HE xi liU xintong LAN Chuanjian li jiang Dental Hospital Jilin UniversityChangchun 130021P.R.China

In this study,we constructed the recombinant plasmid of pGL2/Aquaporin5(AQP5)promoter(pGL2/AQP5p)luciferase reporter,then found estadiol(E2)induced AQP5 promoter activation in a dose-dependent ***,we identified endogenous estrogen receptors(ER),including ERαand ERβ,expressed in human submandibular gland(HSG)cells,which responded to *** demonstrated by the stimulation of E2,AQP5 was upregulated in protein level,meanwhile AQP5 located in cytomembrane was elevated in ***,we revealed the roles of ERαand ERβin AQP5 upregulation by *** ERαand ERβwere overexpressed,the AQP5 transcription level and protein expression were augmented *** when knockdown ER by ERα-shRNA or ERβ-shRNA,AQP5 transcription and expression ***,we detected the effect of E2 in Sjogren's syndrome(SS)mice model in *** mice models were constructed by injecting submandibular gland antigen immune induction combined with estrogen deprivation,which were administoted with saline and *** salivary secretion was decreased,and the AQP5 expression downregulated in the submandibular gland in the SS model *** SS mice were administrated with E2,the salivary secretion was significantly increased,and the AQP5 expression upregulated in the submandibular *** results suggest E2 activates AQP5p transcription and upregulates AQP5 protehi expression,mid E2 promotes salivary secretion in SS model in *** together,we provided the evidence that E2 increased salivary secretion by activating AQP5 transcription and expression.

关键词： Aquaporin 5(AQP5) Sjogren's syndrome(SS) Estradiol

Comprehensive analysis of antibacterial and anti-hepatoma activity of metabolites from jujube fruit

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Food Bioscience 2022年第3期47卷 474-483页

作者： Qianqian Shi xi li Dajun Zhu Junjun jiang xingang li College of Forestry Northwest A&F UniversityYangling712100ShaanxiChina Key Comprehensive Laboratory of Forestry of Shaanxi Province Northwest A&F UniversityYangling712100ShaanxiChina Research Center for Jujube Engineering and Technology of State Forestry Administration Northwest A&F UniversityYangling712100ShaanxiChina

Jujube is one of the most produced dried fruits in China,and it is also a traditional Chinese medicine that enhances immunity and has anti-cancer *** fruit is rich in phenolic compounds,but few reports are available on its biological *** evaluate the biological activities of the phenolic compounds in dried jujube fruit,the composition and content of metabolites in dried jujube fruit were determined by metabolomics,and the antibacterial and anticancer activities of the phenolic compounds were analyzed in dried jujube *** results showed that 463 compounds were identified in dried‘Junzao’fruit,including 102 phenolic *** in vitro activity test showed that the jujube phenolic metabolites had extensive antibacterial effects and caused disruption and nuclear sclerosis of hepatocellular carcinoma(HepG2)*** correlation analysis showed that total phenolic content,quercetin-3-rutinose,and procyanidin B1 were the main active antibacterial and anticancer *** study provides data supporting the application of dried jujube fruit in the development of functional foods,pharmaceuticals and cosmetics.

关键词： Anticancer activity HepG2 cell Phenolic metabolites Chinese jujube Pharmaceutical development

Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-Jie Quan Hao liang Yong-Hong Tang li jiang xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Partial P-Type Metal Ions Doping Induced Variation of Both Crystal Structure and Oxygen Vacancy Within Cu/SnO_(2) Metastable Solid Solution Nanofibers for Highly Sensitive C_(2)H_(2) Sensor

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Chemical Research in Chinese Universities 2021年第3期37卷 584-588页

作者： WANG Ruifang YU xi li Zhenyu CHEN Jingyu jiang Tingting State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500P.R.China Center of Functional Materials for Working Fluids of Oil and Gas Field School of New Energy and MaterialsSouthwest Petroleum UniversityChengdu610500P.R.China School of Engineering Southwest Petroleum UniversityNanchong637001P.R.China School of Chemical Engineering Northeast Electric Power UniversityJilin132012P.R.China

Partial P-type metal ions doping(PPMID)is an alternative method to further enhance the gas sensing performance of N-type metal oxides(NMOs)in contrast to that of P-N metal oxides heterojunctions,but the influences of the introduction of PPMID on the grain size and oxygen vacancies of NMOs have been rarely ***,a simple and effective route has been demonstrated to address this problem with Cu^(2+)-doped SnO_(2) metastable solid solution nanofibers(CSMSSNs)as model and C_(2)H_(2) as target molecule by combining electrospinning and calcination *** seems that the introduction of PPMID can also affect crystal structure and oxygen vacancies of NMOs,proven by combining X-ray diffraction(XRD)and X-ray photoelectron spectra(XPS).Thus,PPD,crystal structure and oxygen vacancies have been combined to clarify the enhanced sensing performance of Cu-doped SnO_(2) metastable solid solution nanofibers angainst C_(2)H_(2).

关键词： P-Type doping P-N heterojunction Electrospinning Metastable solid solution nanofiber C_(2)H_(2)sensor

Machine learning accelerated DFT research on platinum-modified amorphous alloy surface catalysts

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Chinese Chemical Letters 2023年第5期34卷 645-649页

作者： xi Zhang Kangpu li Bo Wen jiang Ma Dongfeng Diao Institute of Nanosurface Science and Engineering Guangdong Provincial Key Laboratory of Micro/NanoShenzhen UniversityShenzhen 518060China College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China Research Center of Medical Plasma Technology Shenzhen UniversityShenzhen 518060China

Pt-modified amorphous alloy(Pt@PdNiCuP)catalyst exhibits excellent electro-catalytic activity and high experimental durability for hydrogen evolution reaction(HER).However,the physical origin of the catalytically active remains *** this paper,we constructed a distance contribution descriptor(DCD)for the feature engineering of machine learning(ML)potential,and calculated the Gibbs free energies(ΔGH)of 46,000*H binding sites on the Pt@Pd Ni Cu P surface by ML-accelerated density functional theory(DFT).The relationship betweenΔGHand DCD revealed that in the H-Pt distance region of 2.0-2.5 A where the parabolic tail and disordered scatters coexist,the H-metal bonding configuration is mainly the bridge-or hollow-bonding *** contribution analysis of DCD indicates that the joint effect of Pt,Pd and Ni atoms determines the catalytical behavior of amorphous alloy,which agrees well with experimental *** counting atomic percentages in different energy intervals,we obtained the atomic ratio for the best catalytic performance(Pt:Pd:Ni:Cu:P=0.33:0.17:0.155:0.16:0.185).Projected density of states(PDOS)show that H 1s orbital,Pt 5d orbital,and Pd 4d orbital form a bonding state at-2 e *** results provide new ideas for designing more active amorphous alloy catalysts.

关键词： Hydrogen evolution reaction Amorphous alloy Density functional theory Machine learning

Gd-DTPA对磁共振扩散张量成像评估晚期鼠脑胶质瘤的影响

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广东医学 2018年第12期39卷 1761-1764页

作者：李香营蒋锡丽袁园陈建强战跃福杨光中南大学湘雅医学院附属海口医院海口市人民医院放射科海南海口570208

目的探讨Gd-DTPA对3.0T磁共振扩散张量成像(diffusion tensor imaging,DTI)评估晚期鼠脑胶质瘤的影响。方法雌性Wistar大鼠35只,通过脑固定装置将C6细胞接种至右尾状核,3~4周后分别于注射对比剂钆喷替酸葡甲胺(Gd-DTPA)前后行DTI扫描,... 详细信息

目的探讨Gd-DTPA对3.0T磁共振扩散张量成像(diffusion tensor imaging,DTI)评估晚期鼠脑胶质瘤的影响。方法雌性Wistar大鼠35只,通过脑固定装置将C6细胞接种至右尾状核,3~4周后分别于注射对比剂钆喷替酸葡甲胺(Gd-DTPA)前后行DTI扫描,选取瘤体、瘤周组织和对侧镜像脑组织多个感兴趣区(ROI)获得FA值,采用配对t检验分析注射对比剂前后相应部位FA值差异。结果 35只晚期C6鼠脑胶质瘤进行了DTI扫描,注射对比剂Gd-DTPA后瘤体及瘤周组织FA值均较注射对比剂前FA值升高,两组差异有统计学意义(P0.05)。结论静脉注射Gd-DTPA 6 min后对大鼠C6脑胶质瘤进行DTI扫描,可人为造成瘤体及瘤周组织FA值升高,而对侧镜像脑组织FA值无明显影响,因而在进行DTI扫描时,应在注射对比剂前完成。

关键词：磁共振成像磁共振弥散张量成像对比剂胶质瘤大鼠

Structural self-reconstruction strategy empowering Ni-rich layered cathodes with low-strain for superior cyclabilities

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Nano Research 2023年第4期16卷 4950-4960页

作者： Zhouliang Tan Yunjiao li xiaoming xi Shijie jiang xiaohui li xingjie Shen Panpan Zhang Zhenjiang He School of Metallurgy and Environment Central South UniversityChangsha 410083China Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China Changsha Research Institute of Mining and Metallurgy Changsha 410083China Office of Laboratory and Equipment Management Xinjiang UniversityUrumqi 830000China

The key to hindering the commercial application of Ni-rich layered cathode is its severe structural and interface degradation during the undesired phase transition(hexagonal to hexagonal(H2→H3)),degenerating from the build-up of mechanical strain and undesired parasitic ***,a perovskite li_(0.35)La_(0.55)TiO_(3)(LLTO)layer is built onto Ni-rich cathodes crystal to induce layered@spinel@perovskite heterostructure to solve the root cause of capacity *** exploration based on structure characterizations,in situ X-ray diffraction techniques,and first-principles calculations demonstrate that such a unique heterostructure not only can improve the ability of the host structure to withstand the mechanical strain but also provides fast diffusion channels for lithium ions as well as provides a protective barrier against electrolyte ***,the LLTO modified liNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)cathode manifests an unexpected cyclability with an extremely high-capacity retention of≈94.6%after 100 cycles,which is superior to the pristine liNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)(79.8%).Furthermore,this modified electrode also shows significantly enhanced cycling stability even withstanding a high cut-off voltage of 4.6 *** surface self-reconstruction strategy provides deep insight into the structure/interface engineering to synergistically stabilize structure stability and regulate the physicochemical properties of Ni-rich cathodes,which will also unlock a new perspective of surface interface engineering for layered cathode materials.

关键词： Ni-rich layered oxides cathode structural self-reconstruction phase transition mechanical strain first-principal calculation