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Study on specific interaction of new ferrocene-substituted carborane conjugates with hemoglobin protein

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Science China Chemistry 2012年第4期55卷 594-603页

作者： WU Chunhui1,3, YE HongDe2, jiang hui1, WANG XueMei1 & YAN Hong2 1State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, Nanjing 210096, China 2State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China 3School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China State Key Lab of Bioelectronics (Chien-Shiung Wu Lab) Southeast University Nanjing China School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing China

The interactions between the new organometallic complexes, ferrocenesubstituted dithioocarborane conjugates （denoted as FcSB1, FcSB2 and FcSBCO） and hemoglobin （Hb） are investigated by electrochemistry, fluorescence and UVvis absorption spectroscopy. The results demonstrate that FcSB1, FcSB2 and FcSBCO can bind to the heme iron center through the replacement of the weakly bound H20/02 in the distal heme pocket of Hb by their sulfur donor atoms, inducing the allosteric change from the R state （oxygenated conformation, relax） to T state （deoxygenated conformation, tense）. The binding affinity is in the order of FcSBCO〉FeSB2〉FeSB1. Moreover, the fluorescence study illustrates that the three ferrocenecarborane conjugates differently affect the quarterly and tertiary structures as well as the polarity in the surrounding of the Trp and Tyr residues in Hb. Typically, FcSB2 mainly induces alterations of the microenvironment around the 1337Trp residue which is located on the cql32 interface of Hb. Such distinct influences are attributed to the structural features of FcSB1, FcSB2 and FcSBCO containing hydrophobic ferrocenyl and carboranyl units as well as C=O group. Screening the proteinbinding behavior can signify the potential bioactivity of such molecules and may be helpful in the future development of promising multifunctional metallodrugs.

关键词： fluorescence – UV vis absorption spectroscopy – differential pulse voltammetry – biomolecular interaction – ferrocene substituted carborane conjugates – hemoglobin

Studies of low-lying states of even-even Xe isotopes within the nucleon pair approximation

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 103-108页

作者： ZHANG LiHua1, jiang hui1,2 & ZHAO YuMin1,3,4 1Institute of Nuclear, Particle, Astrophysics and Cosmology, Department of Physics, Shanghai Jiao Tong University, Shanghai 200240, China 2School of Arts and Sciences, Shanghai Maritime University, Shanghai 200135, China 3Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator, Lanzhou 730000, China 4CCAST, World Laboratory, P.O. Box 8730, Beijing 100080, China Institute of Nuclear Particle Astrophysics and Cosmology Department of Physics Shanghai Jiao Tong University Shanghai China School of Arts and Sciences Shanghai Maritime University Shanghai China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou China CCAST World Laboratory Beijing China

We study the relevance of nucleon pairs with higher spins, in addition to spin-zero and spin-two pairs (i.e., S D pairs), in low-lying states of even-even Xe nuclei. By including those higher-spin pairs in our configuration, we recalculate energy level schemes, elec trical quadrupole moments, magnetic moments and electric quadrupole transition rates, for low-lying states of even-even 128-142Xe nuclei. The agreement between our calculated results and the experimental data is substantially improved in comparison with previous studies.

关键词： nucleon pair approximation shell model configuration space low-lying states

Adversarial attacks against dynamic graph neural networks via node injection

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High-Confidence Computing 2024年第1期4卷 43-51页

作者： Yanan jiang hui Xia School of Computer Science and Technology Ocean University of ChinaQingdao 266100China

Dynamic graph neural networks(DGNNs)have demonstrated their extraordinary value in many practical ***,the vulnerability of DNNs is a serious hidden danger as a small disturbance added to the model can markedly reduce its *** the same time,current adversarial attack schemes are implemented on static graphs,and the variability of attack models prevents these schemes from transferring to dynamic *** this paper,we use the diffused attack of node injection to attack the DGNNs,and first propose the node injection attack based on structural fragility against DGNNs,named Structural Fragility-based Dynamic Graph Node Injection Attack(SFIA).SFIA firstly determines the target time based on the period ***,it introduces a structural fragile edge selection strategy to establish the target nodes set and link them with the malicious node using serial ***,an optimization function is designed to generate adversarial features for malicious *** on datasets from four different fields show that SFIA is significantly superior to many comparative *** the graph is injected with 1%of the original total number of nodes through SFIA,the link prediction Recall and MRR of the target DGNN link decrease by 17.4%and 14.3%respectively,and the accuracy of node classification decreases by 8.7%.

关键词： Dynamic graph neural network Adversarial attack Malicious node Vulnerability

Study on a conical bearing for acceleration-sensitive equipment

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 103-128页

作者： Pang hui Xu Wen Dai Junwu jiang Tao Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China School of Civil Engineering and Transportation Beihua UniversityJilin 132013China

Seismic isolation effectively reduces seismic demands on building structures by isolating the superstructure from ground vibrations during ***,isolation strategies give less attention to acceleration-sensitive systems or ***,as the isolation layer’s displacement grows,the stiffness and frequency of traditional rolling and sliding isolation bearings increases,potentially causing self-centering and resonance *** a result,a new conical pendulum bearing has been selected for acceleration-sensitive equipment to increase self-centering capacity,and additional viscous dampers are incorporated to enhance system ***,the theoretical formula for conical pendulum bearings is supplied to analyze the device’s dynamic parameters,and shake table experiments are used to determine the proposed device’s isolation efficiency under various *** to the test results,the newly proposed devices have remarkable isolation performance in terms of minimizing both acceleration and displacement ***,a numerical model of the isolation system is provided for further research,and the accuracy is demonstrated by the aforementioned experiments.

关键词： seismic isolation acceleration-sensitive equipment the conical pendulum bearing shake table tests isolation performance,numerical model

The fast method and convergence analysis of the fractional magnetohydrodynamic coupled flow and heat transfer model for the generalized second-grade fluid

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Science China Mathematics 2024年第4期67卷 919-950页

作者： Xiaoqing Chi hui Zhang Xiaoyun jiang School of Mathematics and Statistics Shandong UniversityWeihai 264209China School of Mathematics Shandong UniversityJinan 250100China

In this paper,we first establish a new fractional magnetohydrodynamic(MHD)coupled flow and heat transfer model for a generalized second-grade *** coupled model consists of a fractional momentum equation and a heat conduction equation with a generalized form of Fourier *** second-order fractional backward difference formula is applied to the temporal discretization and the Legendre spectral method is used for the spatial *** fully discrete scheme is proved to be stable and convergent with an accuracy of O(τ^(2)+N-r),whereτis the time step-size and N is the polynomial *** reduce the memory requirements and computational cost,a fast method is developed,which is based on a globally uniform approximation of the trapezoidal rule for integrals on the real *** strict convergence of the numerical scheme with this fast method is *** present the results of several numerical experiments to verify the effectiveness of the proposed ***,we simulate the unsteady fractional MHD flow and heat transfer of the generalized second-grade fluid through a porous *** effects of the relevant parameters on the velocity and temperature are presented and analyzed in detail.

关键词： fractional MHD coupled flow and heat transfer model generalized second-grade fuid fast method convergence analysis numerical simulation

Neg-Entropy Mechanism as a Target for Natural Medicines

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Engineering 2024年第7期38卷 11-12页

作者： Tian-Le Gao hui-hui Guo Jian-Dong jiang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target *** principle of this approach is the presumed molecular mechanism or genetic background of the disease being *** this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so *** newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关键词： drugs diseases cardiovascular

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新丰江水库大坝贯穿裂缝及其稳定性分析

震灾防御技术 2017年第2期12卷 298-305页

作者：宋晓春姜慧王立新刘智朱敏广东省地震局广州510070 中国地震局地震监测与减灾技术重点实验室广州510070 广东省地震预警与重大工程安全诊断重点实验室广州510070 防灾科技学院北京101601

1962年3月19日新丰江水库大坝附近发生MS 6.1级强烈地震后,13—17#坝段在108.5m高程处出现了长达82m的贯穿裂缝,导致水库渗漏,其后虽进行了加固处理,但经过50多年的运营,贯穿裂缝的现状如何,备受各级政府及专家学者的关注。本文利用近... 详细信息

1962年3月19日新丰江水库大坝附近发生MS 6.1级强烈地震后,13—17#坝段在108.5m高程处出现了长达82m的贯穿裂缝,导致水库渗漏,其后虽进行了加固处理,但经过50多年的运营,贯穿裂缝的现状如何,备受各级政府及专家学者的关注。本文利用近些年大坝上的多次小震观测记录,通过对有无贯穿裂缝坝段的地震加速度时程傅氏谱及上下坝体传递函数的对比分析,对14#坝段的整体性和稳定性进行了系统研究。结果表明,到目前为止,大坝贯穿裂缝没有明显恶化,但整体性依然较差,仍然是大坝稳定性的最大隐患。

关键词：新丰江水库大坝贯穿裂缝稳定性

THE HARM OF CROFTON WEED AND EXOTIC PEST INVASION

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THE HARM OF CROFTON WEED AND EXOTIC PEST INVASION

Critical Role of Ethylene-Propylene Block Copolymer in Impact Polypropylene Copolymer

The ⅩⅤth International Plant Protection Congress

作者： jiang hui1 ZHOU Su2 and CHEN Su-qing1 1Sichuan Phytosanitary Station No.4 Wuhouci Street Chengdu 610041 China 2Sichuan Provincial General Station for Grassland Management Chengdu 610041 China

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Chinese Journal of Polymer Science 2024年第3期42卷 344-351,I0007页

作者： Yu-hui Tang Na Zhang Wei Bao Wei jiang Yuan Lin Zhao-hui Su State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Ethylene-propylene block copolymer(EbP) is a vital component in impact polypropylene copolymer(IPC), yet its distribution in the multiphase composite material and how it influences the phase structure and the mechanical properties are not well understood. In this work,four IPCs were investigated by atomic force microscopy-infrared(AFM-IR) to assess the phase compositions in situ, based on which in conjunction with the chain microstructure information obtained ex situ the distributions of the copolymer components were derived for each alloy. For the IPCs whose EbP comprises long P and long E segments, the EbP fraction was found to phase separate from the rubber and the PP matrix to form the cores of the disperse particles with the E-P segmented copolymer(EsP). In contrast, in the IPC with EbP composed of long P and short E segments, the EbP fraction formed an outer shell for the rubber particles with the cores comprising the EsP alone, and this IPC, containing a lower E comonomer content than its counterpart, exhibited both better impact resistance and higher flexural modulus. These results clarify how the chain structure of EbP governs the phase morphology in IPC, which in turn impacts the properties of the composite material.

关键词： Impact polypropylene copolymers AFM-IR Ethylene-propylene block copolymers Core-shell rubber particles