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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou Yuan-yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun yan han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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Recent advances in geosynthetic-reinforced retaining Nails for highway applications

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Frontiers of Structural and Civil Engineering 2018年第2期12卷 239-247页

作者： Jie han yan jiang Chao XU Department of Civil Environmental and Architectural Engineering University of Kansas Lawrence KS 66044 USA Terracon Consultants Inc. 2201 Rowland Ave Savannah Georgia 31404 USA Department of Geotechnical Engineering College of Civil Engineering Tongji University Shanghai 200092 China

Geosynthetic-reinforced retaining （GRR） walls have been increasingly used to support roadways and bridge abutments in highway projects. In recent years, advances have been made in construction and design of GRR walls for highway applications. For example, piles have been installed inside GRR walls to support bridge abutments and sound barrier walls. Geosynthetic layers at closer spacing are used in GRR walls to form a composite mass to support an integrated bridge system. This system is referred to as a geosynthetic-reinforced soil （GRS）-integrated bridge systems （IBS） or GRS-IBS. In addition, short geosynthetic layers have been used as secondary reinforcement in a GRR wall to form a hybrid GRR wall （HGRR wall） and reduce tension in primary reinforcement and facing deflections. These new technologies have improved performance of GRR walls and created more economic solutions; however, they have also created more complicated problems for analysis and design. This paper reviews recent studies on these new GRR wall systems, summarizes key results and findings including but not limited to vertical and lateral earth pressures, wall facing deflections, and strains in geosynthetic layers, discusses design aspects, and presents field applications for these new GRR wall systems.

关键词： bridge geosynthetic highway reinforced wall

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TRAJECTORY GENERATION AND CONTROL FOR NON-CIRCULAR CNC TURNING

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Chinese Journal of Mechanical Engineering 2008年第5期21卷 23-28页

作者： jiang Simin yan han WANG Xiankui Douglas Machine Inc. Alexandria MN 56308 USA Department of Precision Instruments and Mechanology Tsinghua University Beijing 100084 China

A trajectory generation method which is based on NURBS interpolation is studied to improve the fitting accuracy and smoothness of non-circular cross section and obtain higher accuracy of the final non-circular profile control. After using the NURBS, the most optimized and smooth trajectory for the linear actuator can be obtained. For the purpose of machining the non-circular cross section by CNC turning, the fast response linear actuator has been used. The control algorithm which is compound control of proportional-integral-differential （PID） and iterative learning control has been developed for non-circular profile generation. By using the NURBS interpolation and the compound control of PID and iterative learning control, the final motion accuracy of linear actuator has been improved, therefore, the machining accuracy of the non-circular turning can be improved.

关键词： Trajectory generation Iterative learning control Non-circular turning

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二茂铁甲酸及其衍生物的研究进展

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应用化工 2014年第4期43卷 713-717页

作者：韩江燕乔庆东李琪王艳菊辽宁石油化工大学化学化工与环境学部辽宁抚顺113001

阐述了二茂铁甲酸衍生物在聚合物材料、生物传感器、电分析化学、修饰电极、功能性材料等方面应用现状。分析了二茂铁甲酸类金属有机化合物的特点,即电子传递可逆,容易产生特征官能团,化学稳定性好,所含茂环的位阻作用可以很好的保护氧... 详细信息

阐述了二茂铁甲酸衍生物在聚合物材料、生物传感器、电分析化学、修饰电极、功能性材料等方面应用现状。分析了二茂铁甲酸类金属有机化合物的特点,即电子传递可逆,容易产生特征官能团,化学稳定性好,所含茂环的位阻作用可以很好的保护氧化还原中心的铁离子,具有良好的生物活性和亲脂性。最后对这类化合物在各方面的应用,发展趋势进行展望。

关键词：二茂铁甲酸生物传感器修饰电极电子探针综述

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AN INDEFINITE-PROXIMAL-BASED STRICTLY CONTRACTIVE PEACEMAN-RACHFORD SPLITTING METHOD

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Journal of Computational Mathematics 2023年第6期41卷 1017-1040页

作者： yan Gu Bo jiang Deren han Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing210016China Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles(NUAA) MIITNanjing210016China School of Mathematical Sciences Key Laboratory for NSLSCS of Jiangsu ProvinceNanjing Normal UniversityNanjing210023China LMIB School of Mathematics and Systems ScienceBeihang UniversityBeijing100191China Key Laboratory for NSLSCS of jiangsu Province China

The Peaceman-Rachford splitting method is efficient for minimizing a convex optimization problem with a separable objective function and linear ***,its convergence was not guaranteed without extra *** et al.(SIAM ***.24:1011-1040,2014)proved the convergence of a strictly contractive Peaceman-Rachford splitting method by employing a suitable underdetermined relaxation *** this paper,we further extend the so-called strictly contractive Peaceman-Rachford splitting method by using two different relaxation ***,motivated by the recent advances on the ADMM type method with indefinite proximal terms,we employ the indefinite proximal term in the strictly contractive Peaceman-Rachford splitting *** show that the proposed indefinite-proximal strictly contractive Peaceman-Rachford splitting method is convergent and also prove the o(1/t)convergence rate in the nonergodic *** numerical tests on the l 1 regularized least square problem demonstrate the efficiency of the proposed method.

关键词： Indefinite proximal Strictly contractive Peaceman-Rachford splitting method Convex minimization Convergence rate

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面向重大突发事件的高校智库动态知识服务策略

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大学图书情报学刊 2025年第1期43卷 115-121页

作者：蒋艳河海大学图书馆南京210024

面向社会重大突发事件的智库应对需要高效的动态知识服务体系做支撑。根据动态能力理论,知识协同、知识生产和知识流构成了动态知识服务体系三要素,动态能力通过知识协同要素、知识生产环节和知识流转效率来表现动态知识服务能力。动态... 详细信息

面向社会重大突发事件的智库应对需要高效的动态知识服务体系做支撑。根据动态能力理论,知识协同、知识生产和知识流构成了动态知识服务体系三要素,动态能力通过知识协同要素、知识生产环节和知识流转效率来表现动态知识服务能力。动态知识服务体系中的知识协同要素、知识生产环节和知识流转效率与智库服务重大突发事件的知识需求还不相适应。为了提高应对突发事件的智库动态知识服务水平,要在知识协同要素的有序化、知识生产环节匹配的精准化和知识流治理的高效化等方面提升服务策略。

关键词：高校智库重大突发事件动态知识服务动态能力理论

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Effects of heat treatment and Re-content on the TCP-phase in two Ni-Mo-Cr-Re superalloys

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Acta Metallurgica Sinica(English Letters) 2009年第5期22卷 365-372页

作者： Pingli MAO yan XIN Ke han Weiguo jiang School of Materials Science and Engineering Shenyang Univers-ity of Technology Shenyang 110023 China National High Magnetic Field Laboratory Florida State University Tallahassee Florida USA Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

The volume fraction and morphology of the TCP-phase formed in two kinds of Ni- Mo-Cr-Re superalloys under different heat treatment conditions were investigated in this paper. In Re-5% alloy, with increasing of the heat treatment temperature and prolonging the holding time, the volume fraction of TCP-phase decreased and the TCP-phase size increased. At relatively lower temperature, the TCP-phase prefers to present in the dendrite cores. In Re-10% alloy, the volume fraction and size have the same change tendency as that of in Re-5% alloy, but the morphology will change from needle-like and block-like to sphere when the temperature increases. The TCP-phases formed in these two Ni-Mo-Cr-Re alloys are σ and P phase.

关键词： Heat treatment TCP-phase Superalloy

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电动拖拉机驱动电机系统故障诊断模型研究

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农机化研究 2025年第2期47卷 234-238页

作者：蒋延莲刘艳南京交通技师学院南京210049 南京理工大学泰州科技学院江苏泰州225300

驱动电机系统的故障可能导致电动拖拉机失控或发生意外情况,从而危及驾驶员和周围环境的安全,准确诊断故障可以帮助驾驶员及时采取措施,避免潜在的危险。为了进一步提高电动拖拉机驱动电机系统的故障诊断准确率,基于驱动电机系统的数据... 详细信息

驱动电机系统的故障可能导致电动拖拉机失控或发生意外情况,从而危及驾驶员和周围环境的安全,准确诊断故障可以帮助驾驶员及时采取措施,避免潜在的危险。为了进一步提高电动拖拉机驱动电机系统的故障诊断准确率,基于驱动电机系统的数据特征及故障类型,以BP人工神经网络模型为基础,通过PSO-BP优化后的人工神经网络模型构建电动拖拉机电机驱动电机系统故障诊断模型,并对传统BP神经网络模型的阈值和权重进行优化,以更快地收敛到全局最优解。通过采集驱动电机系统的数据,对基于PSO-BP故障诊断模型进行试验验证,结果表明:模型对5种故障状态诊断准确率较高,特别是退磁故障和IGBT故障这两种复杂的故障类型。研究内容能够为电动拖拉机驱动电机系统的故障诊断提供一种有效的方法和技术支持,可提高诊断准确率、保障驾驶员和周围环境的安全,提高了工作效率,降低了维修成本。

关键词：电动拖拉机驱动电机系统故障诊断准确率 PSO-BP优化算法

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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