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AlphaFold-guided redesign of a plant pectin methylesterase inhibitor for broad-spectrum disease resistance

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Molecular Plant 2024年第9期17卷 1344-1368页

作者： Yeqiang Xia Guangzheng Sun Junhua Xiao Xinyi He haibin jiang Zhichao Zhang Qi Zhang Kainan Li Sicong Zhang Xuechao Shi Zhaoyun Wang Lin Liu Yao Zhao Yuheng Yang Kaixuan Duan Wenwu Ye Yiming Wang Suomeng Dong Yan Wang Zhenchuan Ma Yuanchao Wang Department of Plant Pathology Nanjing Agricultural UniversityNanjingJiangsu 210095China Key Laboratory of Soybean Disease and Pest Control(Ministry of Agriculture and Rural Affairs) Nanjng Agricultural UniversityNanjngJiangsu 210095China Anhui Province Key Laboratory of Crop Integrated Pest Management Anhui Agricultural UniversityHefei 230036China School of Bioengineering Dalian University of TechnologyDalian 116024China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBejing 100193China These authors contributed equally to the article.

Plant cell walls are a critical site where plants and pathogens continuously struggle for physiological *** we show that dynamic remodeling of pectin methylesterification of plant cell walls is a compo-nent of the physiological and co-evolutionary struggles between hosts and pathogens.A pectin methyles-terase(PsPME1)secreted by Phytophthora sojae decreases the degree of pectin methylesterification,thus synergizing with an endo-polygalacturonase(PsPG1)to weaken plant cell *** counter PsPME1-mediated susceptibility,a plant-derived pectin methylesterase inhibitor protein,GmPMl1,protects pectin to maintain a high methylesterification ***1 protects plant cell walls from enzymatic degrada-tion by inhibiting both soybean and *** pectin methylesterases during ***,constitutive expression of GmPMl1 disrupted the trade-off between host growth and defense *** therefore used AlphaFold structure tools to design a modified form of GmPMI1(GmPMI1R)that specifically targets and inhibits pectin methylesterases secreted from pathogens but notfrom *** expression of GmPMi1R enhanced plant resistance to oomycete and fungal *** summary,our work highlights the biochemical modification of the cell wall as an important focal point in the physiological and co-evolutionary conflict between hosts and microbes,providing an important proof of concept that Al-driven structure-based tools can accelerate the development of new strategies for plant protection.

关键词： apoplastic immunity AlphaFold-guided redesign broad-spectrum disease resistance pectin methyl-esteraseinhibitor cell wall

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反常电子粘滞性引起的双撕裂模非线性演化

南方能源建设 2024年第3期11卷 36-46页

作者：何志雄董家齐蒋海斌福建理工大学电子电气与物理学院福建福州350118 中国核工业集团公司核工业西南物理研究院四川成都610041

[目的]在常规电阻撕裂模方程的基础上加入反常电子粘滞性,用圆柱位形的磁流体动力学,对由反常电子粘滞性引起的双撕裂模的非线性发展做了数值研究。[方法]通过对非线性发展阶段磁岛和磁力线的演化分析,详细研究了两个有理面间距分别为... 详细信息

[目的]在常规电阻撕裂模方程的基础上加入反常电子粘滞性,用圆柱位形的磁流体动力学,对由反常电子粘滞性引起的双撕裂模的非线性发展做了数值研究。[方法]通过对非线性发展阶段磁岛和磁力线的演化分析,详细研究了两个有理面间距分别为较大、中等、较小3种情况下,由反常电子粘滞性引起的双撕裂模非线性发展的不同阶段的磁场拓扑结构的变化以及相关动力学特征,探讨了非线性发展的驱动问题。[结果]研究表明,两个有理面的间距的大小,对双撕裂模非线性发展有很大影响。间距中等时,会发生快速磁重联,对位形破坏最快最大。[结论]研究结果对托卡马克的位形设计和运行时的控制提供了参考。

关键词：双撕裂模反常电子粘滞性非线性演化等离子体模拟磁重联

GF-2 Satellite 1m/4m Camera Design and In-Orbit Commissioning

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Chinese Journal of Electronics 2018年第6期27卷 1316-1321页

作者： HUANG Wei SUN shunrong jiang haibin GAO Chao ZONG Xiaoying Beijing Institute of Space Mechanics and Electricity

GF-2(Gaofen-2) is the second high resolution imaging satellite of China high resolution earth observation system(CHEOS) and it is the first civilian high resolution imager with Ground sample distance(GSD) under1 m in China. The two 1 m/4 m cameras represent a breakthrough in comparison with the previous GF-1 camera. Recent advances in small relative aperture optics system design, vibration reduction, and high accuracy thermal control make it possible for this camera work perfect with high resolution, lihgtweight and high image quality performance. The in-orbit commissioning demonstrates that the performance of the cameras meets all the design requirements. The components of 1 m/4 m camera, the novel techniques adopted and in-orbit commissioning results are illustrated.

关键词： Small relative aperture Vibration reduction High accuracy thermal control In-orbit commissioning

Different influences of nucleating agents on crystallization behavior of polyethylene and polypropylene

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Science China Chemistry 2012年第6期55卷 1140-1147页

作者： jiang haibin ZHANG XiaoHong QIAO JinLiang College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China SINOPEC Beijing Research Institute of Chemical Industry Beijing 100013 China

The crystallization behavior of polyethylene (PE) and polypropylene (PP), including the neat ones and the ones nucleated with the same nucleating agent (NA), was studied by DSC. It was found that the nucleating agent decelerated the PE nonisothermal crystallization process. NA did enhance the nucleating rates for both PE and PP, but the linear growth rate dominated the volumetric growth rate for PE, and the volumetric growth rate dominated the overall crystallization rate. That is why PE nucleated with NA had a slower overall crystallization rate than the neat one.

关键词： nucleating agent crystallization polyethylene polypropylene

硬膜外分娩镇痛相关发热对产妇分娩方式和助产方式的影响

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中国医学前沿杂志（电子版） 2024年第8期16卷 64-68页

作者：刘洋赵天天李彦东江海滨张成栋济宁医学院附属医院麻醉科山东济宁272000

目的研究硬膜外分娩镇痛引起的发热对产科分娩方式和助产方式的影响。方法对2020年1-6月于济宁医学院附属医院接受硬膜外分娩镇痛的孕妇病例进行回顾性队列研究。孕妇行硬膜外分娩镇痛后,根据有无发热将其分为发热组和非发热组。研究主... 详细信息

目的研究硬膜外分娩镇痛引起的发热对产科分娩方式和助产方式的影响。方法对2020年1-6月于济宁医学院附属医院接受硬膜外分娩镇痛的孕妇病例进行回顾性队列研究。孕妇行硬膜外分娩镇痛后,根据有无发热将其分为发热组和非发热组。研究主要结局是硬膜外分娩镇痛相关发热对产科分娩方式,助产方式的影响,次要结局是抗生素使用情况以及新生儿因呼吸窘迫综合征或脓毒症收入重症医学病房(intensive care unit,ICU)的发生情况。结果本研究开始纳入856例孕妇,最终574例孕妇符合标准并对其临床资料进行了分析,其中硬膜外分娩镇痛相关发热128例(发热组),未发热446例(未发热组)。发热组剖宫产发生率为16.4%,未发热组剖宫产发生率7.3%,二者差异具有统计学意义(P0.05)。结论硬膜外分娩镇痛引起的非感染性发热会增加产妇剖宫产发生率以及孕妇围产期抗生素使用率,但对于经阴助产需求以及新生儿因呼吸窘迫综合征或脓毒血症入ICU情况影响差异无统计学意义。

关键词：硬膜外分娩镇痛发热剖宫产

高职临床医学专业《内科学》课程思政教学案例研究——以“消化性疾病”为例

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临床研究 2024年第10期32卷 193-195,198页

作者：姜海斌陈延唐峰杨丽洁蒋锐常德职业技术学院内科教研室湖南常德415000

目的探究高职临床医学专业《内科学》的课程思政教学案例。方法研究时间为2020年9月至2023年6月,选择常德职业技术学院2020级临床医学专业不同班级的450名学生,分为两组,观察组实施《内科学》课程思政教学(n=225);对照组采用传统教学... 详细信息

目的探究高职临床医学专业《内科学》的课程思政教学案例。方法研究时间为2020年9月至2023年6月,选择常德职业技术学院2020级临床医学专业不同班级的450名学生,分为两组,观察组实施《内科学》课程思政教学(n=225);对照组采用传统教学方式(n=225),比较两组间的考试成绩,并采用问卷调查评价教学模式的满意程度及课堂思政效果。结果观察组平时成绩、期末考核成绩及总成绩均高于对照组,差异均有统计学意义(P <0.05)。观察组的学生对教学设计、学业成绩、授课方式的满意度,及职业认同感、社会责任感和爱国情怀方面的思政效果均高于对照组,差异均有统计学意义(P <0.05)。结论将思政元素融入高职临床医学专业《内科学》课程能有效提高学生的学习效果和对教学模式的满意度,这为高职医学教育提供了新的思路和方法,有助于培养具有高度社会责任感和爱国情怀的医学人才。

关键词：高职临床医学专业课程思政教学案例消化性疾病

Histological Observation of Germ Cell Development and Discovery of Spermatophores in Ovoviviparous Black Rockfish(Sebastes schlegeli Hilgendorf) in Reproductive Season

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Journal of Ocean University of China 2014年第5期13卷 830-836页

作者： FENG Junrong LIU Liming jiang haibin WANG Maojian DU Rongbin Ocean College Yantai University Shandong Marine Fisheries Research Institute

Black rockfish(Sebastes schlegeli) is an important species for culture; however, its reproductive characteristics have not been fully documented. In this study, we investigated the morphology and developmental process of germ cells in this ovoviviparous rockfish in reproductive season(October 2011–November 2012) with histological methods. We found that the gonad of mature fish showed notable seasonal changes in developmental characteristics and morphological structure. The sperm cells matured during a period lasting from October to December, significantly earlier than the oocytes did. A large number of spermatozoa and other cells occurred in testis at different developmental stages. Vitellogenesis in oocytes began in October, and gestation appeared in April next year. Spermatophores were discovered for the first time in Sebastes, which assembled in testis, main sperm duct, oviduct and genital tract, as well as ovarian cavity in October and April. These organs may serve either as production or hiding places for spermatophores and spermatozoa which were stored and transported in form of spermatophores. Testicular degeneration started from the distal part of testis in April, with spermatophores assembled in degenerating testis and waiting for transportation. The copulation probably lasted for a long period, during which the spermatozoa were discharged in batches as spermatophores. These spermatophores were coated with sticky materials secreted from the interstitial areas of testis and the main sperm duct, then transported into ovary.

关键词： Sebastes schlegeli germ cell development spermatophore copulation period

A Microsatellite Genetic Linkage Map of Black Rockfish(Sebastes schlegeli)

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Journal of Ocean University of China 2014年第6期13卷 1078-1086页

作者： CHU Guannan jiang Liming HE Yan YU Haiyang WANG Zhigang jiang haibin ZHANG Quanqi College of Marine Life Science Key Laboratory of Marine Genetics and Breeding of Ministry of EducationOcean University of China Shandong Marine Fisheries Research Institute

Ovoviviparous black rockfish(Sebastes schlegeli) is an important marine fish species for aquaculture and fisheries in China. Genetic information of this species is scarce because of the lack of microsatellite markers. In this study, a large number of microsatellite markers of black rockfish were isolated by constructing microsatellite-enriched libraries. Female- and male-specific genetic linkage maps were constructed using 435 microsatellite markers genotyped in a full-sib family of the fish species. The female linkage map contained 140 microsatellite markers, in which 23 linkage groups had a total genetic length of 1334.1 c M and average inter-marker space of 13.3 c M. The male linkage map contained 156 microsatellite markers, in which 25 linkage groups had a total genetic length of 1359.6 c M and average inter-marker distance of 12.4 c M. The genome coverage of the female and male linkage maps was 68.6% and 69.3%, respectively. The female-to-male ratio of the recombination rate was approximately 1.07:1 in adjacent microsatellite markers. This paper presents the first genetic linkage map of microsatellites in black rockfish. The collection of polymorphic markers and sex-specific linkage maps of black rockfish could be useful for further investigations on parental assignment, population genetics, quantitative trait loci mapping, and marker-assisted selection in related breeding programs.

关键词： black rockfish Sebastes schlegeli microsatellite genetic linkage map

Effect of polyamide on selectivity of its supported Raney Ni catalyst

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Science China Chemistry 2016年第6期59卷 776-780页

作者： haibin jiang Shuliang Lu Xiaohong Zhang Baoliang Tian Hui Peng Wei Dai Jinliang Qiao SINOPEC Beijing Research Institute of Chemical Industry Beijing 100013 China

A newly-developed polyamide supported Raney Ni catalyst, which is suitable for use in fix-bed reactions with high selectivity, was studied in this paper. Selective hydrogenation of acetone to isopropanol was chosen as a probe reaction. It has been found that clean preparation of isopropanol could be achieved, that is to say, the two main byproducts(isopropyl ether and methyl-iso-butyl carbinol) could be eliminated with the newly-developed polyamide supported Raney Ni catalyst. The elimination of these side reactions was attributed to the adsorption effect of polyamide support and a model was proposed. The proposed model was further proved by hydroamination reaction of acetone. According to this model, catalyst support can play an important role in chemical reactions. Different products could be produced when different catalyst support is used, the main reaction and side reactions can even be reversed sometimes when the chemicals, active component of catalyst and reaction condition are the same. This model could help to improve catalytic selectivity of many Raney metal catalysts used routinely in chemical and oil refining industry, and is also useful for hydrogenation reactions in pharmaceutical and food industry.

关键词： polyamide Raney Ni acetone