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Expression and clinical significance of S100A2 and p63 in esophageal carcinoma

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World Journal of Gastroenterology 2009年第33期15卷 4183-4188页

作者： Li-Yu cao Yu Yin Hao Li Yan jiang hong-fu Zhang Department of Pathology Anhui Medical University Hefei 230032 Anhui Province China

AIM： TO investigate the expression and clinical significance of S100A2 mRNA and protein, p63 protein in esophageal squamous cell carcinoma （ESCC） and their roles in carcinogenesis and progression of esophageal carcinoma （EC）. METHODS： Immunohistochemical staining （S-P method） for S100A2 and p63 protein were performed in 40 samples of ESCC and 40 samples of normal esophageal mucosa. In situ hybridization （ISH） was used to detect the expression of S100A2 mRNA. RESULTS： Expression of S100A2 mRNA in ESCC was positive in 77.5% of samples, which was lower than that in normal mucosa （100%） by ISH （P = 0.002）. The expression level of S100A2 mRNA was closely related to differentiation and and node-metastasis （P = 0.012, P = 0.008）. Expression of $100A2 protein was positive in 72.5% of ESCC samples and expression of p63 protein was positive in 37.5% of ESCC samples, and was lower than that in normal mucosa （100%）（P = 0.000）. The expression of S100A2 protein was correlated with the differentiation and node-metastasis （P = 0.007, P = 0.001）, but no relationship was observed between the expression of p63 protein and clinical pathological manifestations. S100A2 protein was positively correlated with the expression of S100A2 mRNA, and negatively associated with the expression of p63 protein （P = 0.000, P = 0.002）. CONCLUSION： S100A2 and p63 protein both play important roles in the carcinogenesis of ESCC. An investigation into the combined expression of S100A2 and p63 may be helpful in early diagnosis and in evaluating the prognosis of ESCC.

关键词： Immunohistochemistry In situ hybridization Esophageal carcinoma p63 S100A2

Comparison of cell wall changes of two different types of apple cultivars during fruit development and ripening

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农业科学学报:英文版 2023年第9期22卷 2705-2718页

作者： LI Xiang-lu SU Qiu-fang JIA Rong-jian WANG Zi-dun fu jiang-hong GUO Jian-hua YANG Hui-juan ZHAO Zheng-yang College of Horticulture Northwest A&F UniversityYangling 712100P.R.China Apple Engineering and Technology Research Center of Shaanxi Province Yangling 712100P.R.China

Fruit development and ripening is a complex procedure(Malus×domestica Borkh.)and can be caused by various factors such as cell structure,cell wall components,and cell wall hydrolytic *** our study,we focused on the variations in fruit firmness,cell wall morphology and components,the activity of cell wall hydrolytic enzymes and the expression patterns of associated genes during fruit development in two different types of apple cultivars,the hard-crisp cultivar and the loose-crisp *** this paper,the aim was to find out the causes of the texture variations between the different type *** wall materials(CWMs),hemicellulose and cellulose content were strongly associated with variations in fruit firmness during the fruit *** content of water soluble pectin(WSP)and chelator soluble pectin(CSP)gradually increased,while the content of ionic soluble pectin(ISP)showed inconsistent trends in the four *** activities of polygalacturonase(PG),β-galactosidase(β-gal),cellulase(CEL),and pectate lyase(PL)gradually increased in four *** the activities of PG,β-gal,and CEL were higher in‘fuji’and‘Honeycrisp’fruit with the fruit development,while the activity of PL of‘fuji’and‘Honeycrisp’was lower than that of‘ENVY’and‘Modi’.Both four cultivars of fruit cells progressively became bigger as the fruit expanded,with looser cell arrangements and larger cell *** to the qRT-PCR,the relative expression levels of MdACO and Mdβ-gal were notably *** study showed that there were large differences in the content of ISP and hemicellulose,the activity of PL and the relative expression of Mdβ-gal between two different types of apple cultivars,and these differences might be responsible for the variations in the texture of the four cultivars.

关键词： apple(Malus×domestica Borkh.) fruit softening cell wall firmness

Ultrafast optical investigation of carrier and spin dynamics in low-dimensional perovskites

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Science China(Technological Sciences) 2024年第1期67卷 2-18页

作者： fu JinYue jiang Ying FANG hongHua Key Laboratory for Micro-Nano Physics and Technology of Hunan Province School of Physics and ElectronicsHunan UniversityChangsha 410012China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

Low-dimensional perovskite(PVK)materials have attracted significant research interest,because of their quantum-confined effect,tunable band gap structures,and higher stability than that of three-dimensional(3D)*** semiconductor optoelectronic devices,high speed and small size are closely *** development of high-speed devices requires researchers to fully understand the properties of materials,especially the dynamic processes such as carrier recombination,separation,and transport,which often play a crucial role in the performance of *** an indispensable part of dynamic research,spin relaxation is also of great significance in studying the properties of materials and explore possible *** halide PVK materials have strong spin-orbit coupling(SOC),which provides a basis for information storage and processing by using spin degrees of ***,studying the carrier and spin dynamics of low-dimensional PVKs is an effective way to understand the internal properties of low-dimensional PVKs *** paper summarizes the latest research progress on the ultrafast carrier and spin dynamics in low-dimensional PVKs,to comprehensively understand their carrier and spin behaviors and present an outlook for relevant studies in this area.

关键词： low-dimensional perovskites carrier dynamics spin dynamics optoelectronic devices

Segregation of Mg-6Gd alloy under natural convection:From macro solute distribution to micro dendrite growth

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China Foundry 2024年第5期21卷 613-624页

作者： hong-xu Chen Ang Zhang Hao Li Yu Gao Yu-hong Cui Guang-sheng Huang Bin jiang fu-sheng Pan National Engineering Research Center for Magnesium Alloys National Key Laboratory of Advanced Casting TechnologiesCollege of Materials Science and EngineeringChongqing UniversityChongqing 400044China

Segregation is a serious defect in alloy ingots which severely deteriorates materials *** segregation defect in Mg-6Gd alloy is studied by coupling macro thermal-solutal-convection transport and micro dendrite *** macroscopic fluid dynamics and mass transfer equations are resolved to forecast the segregation behavior under conditions of continuous temperature variation during the solidification *** numerical model is validated by testing double-diffusive natural convection in a closed square cavity.A phase field model is then applied to simulate the micro dendrite growth,using macro undercooling and liquid flow velocity as boundary *** show that the multiscale segregation behavior,including macro solute distribution and micro dendritic morphology,is strongly dependent on the temperature condition and the liquid convection,which provides guidance for reducing and eliminating the segregation defect.

关键词： magnesium alloy segregation numerical simulation phase-field simulation multiscale

Response of ocean acidification to atmospheric carbon dioxide removal

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Journal of Environmental Sciences 2024年第6期140卷 79-90页

作者： Jiu jiang Long Cao Xiaoyu Jin Zechen Yu Han Zhang Jianjie fu Guibin jiang School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Geoscience Big Data and Deep Resources of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhou 310058China Zhejiang Climate Center Hangzhou 310052China

Artificial CO_(2)removal from the atmosphere(also referred to as negative CO_(2)emissions)has been proposed as a potential means to counteract anthropogenic climate *** we use an Earth system model to examine the response of ocean acidification to idealized atmospheric CO_(2)removal *** our simulations,atmospheric CO_(2)is assumed to increase at a rate of 1%per year to four times its pre-industrial value and then decreases to the pre-industrial level at a rate of 0.5%,1%,2%per year,*** results show that the annual mean state of surface ocean carbonate chemistry fields including hydrogen ion concentration([H^(+)]),pH and aragonite saturation state respond quickly to removal of atmospheric CO_(2).However,the change of seasonal cycle in carbonate chemistry lags behind the decline in atmospheric CO_(2).When CO_(2)returns to the pre-industrial level,over some parts of the ocean,relative to the pre-industrial state,the seasonal amplitude of carbonate chemistry fields is substantially *** results also show that changes in deep ocean carbonate chemistry substantially lag behind atmospheric CO_(2)*** CO_(2)returns to its pre-industrial value,the whole-ocean acidity measured by[H^(+)]is 15%-18%larger than the pre-industrial level,depending on the rate of CO_(2)*** study demonstrates that even if atmospheric CO_(2)can be lowered in the future as a result of net negative CO_(2)emissions,the recovery of some aspects of ocean acidification would take decades to centuries,which would have important implications for the resilience of marine ecosystems.

关键词： Carbon dioxide removal Net negative CO_(2)emission Ocean acidification Climate change Earth system modeling

Multi-Objective Optimization of VBHF in Deep Drawing Based on the Improved QO-Jaya Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 189-202页

作者： Xiangyu jiang Zhaoxi hong Yixiong Feng Jianrong Tan State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province Zhejiang UniversityHangzhou 310027China Ningbo Innovation Center Zhejiang UniversityNingbo 315100China

Blank holder force(BHF)is a crucial parameter in deep drawing,having close relation with the forming quality of sheet ***,there are different BHFs maintaining the best forming effect in different stages of deep *** variable blank holder force(VBHF)varying with the drawing stage can overcome this problem at an *** optimization of VBHF is to determine the optimal BHF in every deep drawing *** this paper,a new heuristic optimization algorithm named Jaya is introduced to solve the optimization *** improved“Quasi-oppositional”strategy is added to Jaya algorithm for improving population ***,an innovated stop criterion is added for better ***,the quality evaluation criteria for wrinkling and tearing are ***,the Kriging models are developed to approximate and quantify the relation between VBHF and forming defects under random ***,the optimization models are established and solved by the improved QO-Jaya algorithm.A VBHF optimization example of component with complicated shape and thin wall is studied to prove the effectiveness of the improved Jaya *** optimization results are compared with that obtained by other algorithms based on the TOPSIS method.

关键词： Variable blank holder force Multi-objective optimization QO-Jaya algorithm Algorithm stop criterion

Coupling analysis method of grouting construction with deformation response of adjacent existing tunnel

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Underground Space 2024年第2期15卷 312-330页

作者： Ping-wei jiang Zhi-hong Zhang hong Zheng Jin-kun Huang Key Laboratory of Urban Security and Disaster Engineering of China Ministry of Education Beijing University of TechnologyBeijing 100124China China MCC17 Group Co.LTD MaanshanAnhui 243000China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In the new tunnel under close distance through the existing tunnel risk source,the grouting scheme developed to compensate for stratum losses is still based on empirical methods,relying on the overburden thickness of existing *** can potentially lead to an excessively high or low probability of uplift of existing *** a coupled deformation analysis method between the grouting construction and adjacent existing tunnels is of great theoretical significance for developing grouting *** order to reasonably limit the design parameters of grouting construction,based on the theory of fluid–solid coupling elastic pore-column expansion and the theory of random media,the calculation method of stratum displacement which simultaneously considers the coexistence of grout compaction expansion and permeability diffusion mode is derived,and the accuracy of the calculation method is verified by engineering *** accuracy of this calculation method was verified through engineering *** with the deformation coordination condition,the existing tunnel is regarded as an elastic Euler-Bernoulli continuous beam,and the finite element coupling balance equation of the interaction between the existing tunnel and the surrounding soil is *** on this,a coupling calculation model of the grouting construction and the deformation response of the adjacent existing tunnel is *** with three times of grouting construction examples in the shield tunneling project of Beijing Metro Line 12 under the existing airport line,the reliability of the coupling calculation model to determine the grouting construction parameters is *** calculation parameters in the coupling calculation model have clear physical meanings,which can provide a theoretical basis for the grouting design of similar risk source projects.

关键词： Grouting Close-range underpass Tunnel Random medium theory Euler-Bernoulli continuous beam

Echo State Network Based on Improved Knowledge Distillation for Edge Intelligence

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Chinese Journal of Electronics 2024年第1期33卷 101-111页

作者： Jian ZHOU Yuwen jiang Lijie XU Lu ZHAO fu XIAO College of Computer Nanjing University of Posts and Telecommunications jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks

Echo state network(ESN) as a novel artificial neural network has drawn much attention from time series prediction in edge intelligence. ESN is slightly insufficient in long-term memory, thereby impacting the prediction performance. It suffers from a higher computational overhead when deploying on edge devices. We firstly introduce the knowledge distillation into the reservoir structure optimization, and then propose the echo state network based on improved knowledge distillation(ESN-IKD) for edge intelligence to improve the prediction performance and reduce the computational overhead. The model of ESN-IKD is constructed with the classic ESN as a student network, the long and short-term memory network as a teacher network, and the ESN with double loop reservoir structure as an assistant network. The student network learns the long-term memory capability of the teacher network with the help of the assistant network. The training algorithm of ESN-IKD is proposed to correct the learning direction through the assistant network and eliminate the redundant knowledge through the iterative pruning. It can solve the problems of error learning and redundant learning in the traditional knowledge distillation process. Extensive experimental simulation shows that ESN-IKD has a good time series prediction performance in both long-term and short-term memory, and achieves a lower computational overhead.

关键词： Knowledge engineering Training Performance evaluation Computational modeling Time series analysis Artificial neural networks Reservoirs

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Semi-mature MyD88-silenced bone marrow dendritic cells prolong the allograft survival in a rat model of intestinal transplantation

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Chinese Medical Journal 2011年第2期124卷 268-272页

作者： YANG Xiao-jun MENG Song Zhu Chun-fu jiang hong WU Wen-xi Department of General Surgery First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China

Background Semi-mature dendritic cells （DCs） may induce tolerance rather than ***,little is known about the regulatory mechanism by which these DCs induce transplant *** differentiation factor 88 （MyD88） is a key adaptor of Toil-like receptor signaling,which plays a critical role in DC *** of MyD88-silenced immature DCs results in the generation of semi-mature *** explored the possibility of using these DCs to induce intestinal transplant tolerance in *** MyD88 expression was silenced in bone marrow DCs （F344 rats） using small interfering RNAs for 24 hours,at which point,lipopolysaccharide （LPS） was added to the culture for another 48 *** cells were analyzed for their in vitro and in vivo tolerizing *** Semi-mature DCs expressing moderate levels of MHC class Ⅱ and low levels of co-stimulatory molecules were found to produce interleukin （IL）-10,while IL-12 production was *** vitro co-culture with completely allogeneic T cells from Wistar rats led to a significant decrease in alloreactive T-cell *** vivo,the transfer of semi-mature DCs （1×106 ceils） followed by the transplantation of fully mismatched intestinal grafts （F344 rats） led to significantly prolonged survival compared to rats receiving immature and mature *** from semi-mature DC-treated rats contained lower concentrations of the pro-inflammatory cytokines IL-2 and interferon-Y 5 days after *** Semi-mature DCs may promote inducible allograft tolerance and this study suggests a new strategy by which to facilitate the induction of transplant tolerance.

关键词： dendritic cell immune tolerance intestinal transplantation