检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

微透镜阵列注射压缩成型的残余应力

中南大学学报（自然科学版） 2017年第10期48卷 2636-2641页

作者：孙磊磊蒋炳炎陈磊蒋丰泽中南大学机电工程学院高性能复杂制造国家重点实验室湖南长沙410083

利用Autodesk Moldflow Insight软件,通过正交实验仿真分析熔体温度、模具温度、压缩速度、压缩距离、压缩压力和压缩延迟时间这6个因素的工艺特性,并进行极差分析。按照压缩框主轴压缩的方式制作注射压缩模具,采用单因素实验设计研究... 详细信息

利用Autodesk Moldflow Insight软件,通过正交实验仿真分析熔体温度、模具温度、压缩速度、压缩距离、压缩压力和压缩延迟时间这6个因素的工艺特性,并进行极差分析。按照压缩框主轴压缩的方式制作注射压缩模具,采用单因素实验设计研究熔体温度、模具温度、压缩速度这3个主要因素的工艺特性,运用应力-光学定律,根据测量所得光程差间接得到平均残余应力。研究结果表明:模具温度对残余应力的影响最大,其次是压缩延迟时间和熔体温度;残余应力随模具温度的升高而降低,随熔体温度的升高先减小后增大,随压缩延迟时间的增加而上升。

关键词：微透镜阵列注射压缩成型残余应力

Gnas methylation in the basolateral amygdala regulates reconsolidation of morphine associated memory in rats

在线全文

学校读者我要写书评

暂无评论

Gnas methylation in the basolateral amygdala regulates recon...

工艺参数对注射压缩成型微透镜阵列基板双折射率的影响

第六届心理健康学术年会

作者： Jianjun Zhang Peng Liu fengze jiang Nan Sui CAS Key Laboratory of Mental Health Institute of Psychology Department of Psychology University of Chinese Academy of Sciences

Recently, we and other laboratories reported that DNA methyltransferases(Dnmts)were involved in the reconsolidation of addiction related memory, but how DNA methylation regulates reconsolidation of opiate reward memory remain to be found. Here, using morphine induced conditioned place preference(mCPP) in rats, we showed that Dnmts inhibition in basolateral amygdala(BLA), but not in central amygdala or nucleus accumbens, disrupted reconsolidation of morphine reward memory. Moreover, the disruption effects were retrieval-and time-window-dependent. Concordant with this, the mRNA levels of Dnmt 3 a and Dnmt 3 b but not Dnmt 1 in the BLA were significantly upregulated since one hour after memory retrieval. Thus, we further explored the target genes of DNA methylation in the BLA at one hour after retrieval and found 75 differentially methylated regions. Then, we verified the DNA methylation and the roles of three genes(Pik3 r1, Gnas and Sox10) whose promoter were hypermethylated in *** DNA methylation level of these genes were upregulated and the mRNA levels were downregulated. Intra-BLA injection of the PI3 K agonist 740 Y-P immediately after memory retrieval impaired the reconsolidation, and BLA-specific overexpression of Gnas significantly disrupted the reconsolidation. However, overexpression of Sox10 in BLA did not affect this process. These data demonstrated that DNA methylation in BLA, mediated by Dnmt 3 a and/or Dnmt 3 b, regulated reconsolidation of morphine reward memory via hypermethylation of Gnas promotor.

关键词： DNA methylation reconsolidation morphine basolateral amygdala Dnmts Gnas

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中南大学学报（自然科学版） 2014年第8期45卷 2610-2616页

作者：蒋丰泽刘义伦陈磊 Stefan Kirchberg 中南大学机电工程学院高性能复杂制造国家重点实验室湖南长沙410083 克劳斯塔尔工业大学聚合物材料与塑料工程系

采用注射压缩成型工艺,研究压缩距离、压缩速度和压缩压力对微透镜陈列基板双折射率的影响规律。研究结果表明:与注射成型制件相比,注射压缩成型制件在工作平面内双折射率显著降低约42%;双折射率随压缩速度、压缩压力的增大而减小,随压... 详细信息

采用注射压缩成型工艺,研究压缩距离、压缩速度和压缩压力对微透镜陈列基板双折射率的影响规律。研究结果表明:与注射成型制件相比,注射压缩成型制件在工作平面内双折射率显著降低约42%;双折射率随压缩速度、压缩压力的增大而减小,随压缩距离的增大先减后增;压缩参数对双折射率的影响从大到小依次为压缩速度、压缩压力、压缩距离。

关键词：注射压缩工艺参数微透镜阵列双折射率

在线全文

学校读者我要写书评

暂无评论

大模型分布式训练方法研究综述

深圳信息职业技术学院学报 2023年第6期21卷 9-15页

作者：蒋丰泽深圳信息职业技术学院软件学院广东深圳518172

随着ChatGPT的问世,各种大模型(Large Language Model,LLM)产品不断涌现,一个属于大模型的时代正在来临。然而,由于大模型面临着参数规模大、训练时间长的难点,现有传统机器学习模型训练方法并不适用于大模型的训练,亟需探索新的分布式... 详细信息

随着ChatGPT的问世,各种大模型(Large Language Model,LLM)产品不断涌现,一个属于大模型的时代正在来临。然而,由于大模型面临着参数规模大、训练时间长的难点,现有传统机器学习模型训练方法并不适用于大模型的训练,亟需探索新的分布式训练方法与策略。针对这些问题,从三个方面综述大模型分布式训练方法在过去十几年里的进展,包含分布式训练的架构并行加速策略以及内存和计算优化方面的内容,最后提出了未来可以探索的研究方向。

关键词：大模型分布式训练并行处理

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2025年第1期68卷 1-18页

作者： Masataka Iwai Chen jiang Haidong Liu Department of Mathematics Graduate School of ScienceOsaka University Shanghai Center for Mathematical Sciences & School of Mathematical Sciences Fudan University Department of mathematics Sun Yat-sen University

In this paper,we study Miyaoka-type inequalities on Chern classes of terminal projective 3-folds with nef anti-canonical *** X be a terminal projective 3-fold such that-KXis *** show that if c1（X） · c2（X）≠0,then c1（X） · c2（X） ≥ 1/252;if further X is not rationally connected,then c1（X） · c2（X） ≥ 4/5 and this inequality is *** order to prove this,we give a partial classification of such varieties along with many *** also study the nonvanishing of c1（X）dim X-2· c2（X） for terminal weak Fano varieties and prove a Miyaoka-Kawamata-type inequality.

关键词： terminal threefolds Miyaoka-type inequality boundedness

Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan Chen Yuan jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system

Constraints on holographic QCD phase transitions from PTA observations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Effects of carbon content on the microstructure and tensile properties of a low-density steel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu Fan Shuyong jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior