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Notch signaling pathway in cancer:from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy 2024年第6期9卷 2527-2563页

作者： Qingmiao Shi Chen Xue Yifan Zeng Xin Yuan Qingfei chu Shuwen jiang Jinzhi Wang Yaqi Zhang Danhua Zhu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Notch signaling,renowned for its role in regulating cell fate,organ development,and tissue homeostasis across metazoans,is highly conserved throughout *** Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences,typically necessitating receptor-ligand interaction to initiate classical Notch signaling *** evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer *** of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies,closely linked to cancer proliferation,invasion,and ***,the Notch signaling pathway contributes to maintaining stem-like properties in cancer cells,thereby enhancing cancer *** regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive ***,the Notch signaling pathway is implicated in conferring chemoresistance to tumor ***,a comprehensive understanding of these biological processes is crucial for developing innovative therapeutic strategies targeting Notch *** review focuses on the research progress of the Notch signaling pathway in cancers,providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence and progression of ***,the review summarizes pharmaceutical clinical trials targeting Notch signaling for cancer therapy,aiming to offer new insights into therapeutic strategies for human malignancies.

关键词： Notch invasion involvement

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玉米丁醇生命周期温室气体排放

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北京工业大学学报 2015年第10期41卷 1591-1595页

作者：姜莉储江伟东北林业大学交通学院哈尔滨150040

采用一种油井到车轮（well to wheel,WTW）的分析方法,确定生物丁醇相关WTW活动包括玉米种植、玉米的运输、丁醇生产、丁醇运输、车辆运行.采用3种不同的副产品分配方法,计算并比较了玉米丁醇在生命周期内的温室气体排放量.研究结果表... 详细信息

采用一种油井到车轮（well to wheel,WTW）的分析方法,确定生物丁醇相关WTW活动包括玉米种植、玉米的运输、丁醇生产、丁醇运输、车辆运行.采用3种不同的副产品分配方法,计算并比较了玉米丁醇在生命周期内的温室气体排放量.研究结果表明：根据能值法和产品替代法,玉米丁醇生命周期温室气体（GHG）排放量与同等热值汽油相比可以减少26.0%～49.5%;用生物丁醇联产的丙酮替代以石油为基础的丙酮,可以显著降低丁醇生命周期GHG排放量;玉米丁醇生命周期中,GHG排放的主要来源是使用天然气、柴油和氮肥,分别占到总GHG排放的53.00%、21.40%和13.38%.

关键词：丁醇 ABE发酵温室气体生命周期玉米

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对LNG冷能利用中几个问题的讨论

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天然气工业 2008年第9期28卷 126-128页

作者：江楚标四川空分设备厂厂长及中国空分设备公司

我国已规划建设10个以上从国外进口LNG的大型接收站,还在不断建设一些中小型LNG气化站。进口LNG不仅进口了燃料,同时也进口了宝贵的冷能。不同气化管输压力下LNG的可利用冷能和冷能的品位或利用价值有很大的不同。阐述了常压LNG和加压LN... 详细信息

我国已规划建设10个以上从国外进口LNG的大型接收站,还在不断建设一些中小型LNG气化站。进口LNG不仅进口了燃料,同时也进口了宝贵的冷能。不同气化管输压力下LNG的可利用冷能和冷能的品位或利用价值有很大的不同。阐述了常压LNG和加压LNG气化时可利用冷能的数量和冷能的品位或低温价值所发生的变化。讨论了LNG冷能的梯级利用和LNG加压气化后天然气的外输压力问题。认为目前我国最应关注的是以成熟的LNG冷能利用技术为基础,在现有和即将建设的LNG接收站尽可能充分地利用冷能。接收站在规划之初就应同时把冷能的利用给予通盘考虑。对接收站的建设提出了建议。

关键词：液化天然气冷能利用温位梯级利用输气压力

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中国古代的敏速司法研究

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北方法学 2020年第4期14卷 141-150页

作者：蒋铁初杭州师范大学沈钧儒法学院

敏速司法是指司法者凭借个人能力又快又准地办理案件,其意义在于节省办案时间与成本,从而减少淹滞之弊。实践中的敏速司法具有智慧、宽仁、察情、勤政四个方面特征。片面追求敏速司法会导致滥纵之弊。为了应对淹滞与滥纵,中国古代立法... 详细信息

敏速司法是指司法者凭借个人能力又快又准地办理案件,其意义在于节省办案时间与成本,从而减少淹滞之弊。实践中的敏速司法具有智慧、宽仁、察情、勤政四个方面特征。片面追求敏速司法会导致滥纵之弊。为了应对淹滞与滥纵,中国古代立法与司法实践努力在敏速司法与详慎司法之间保持平衡。

关键词：敏速司法详慎司法淹滞滥纵

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非圆弧滑面滑坡中满足平衡条件的预应力锚索设计拉力的确定方法

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铁道学报 2006年第5期28卷 125-128页

作者：蒋楚生周德培西南交通大学土木工程学院成都610031

近20年来预应力锚索广泛用于加固滑坡或高边坡,但在以往的设计计算中,为简化起见,对非圆弧滑坡预应力锚索的设计一般采用指定设计外力而根据力的投影来确定锚索根数,并认为锚索作用力以集中荷载作用在滑面上。实际上,由于作用在地面的... 详细信息

近20年来预应力锚索广泛用于加固滑坡或高边坡,但在以往的设计计算中,为简化起见,对非圆弧滑坡预应力锚索的设计一般采用指定设计外力而根据力的投影来确定锚索根数,并认为锚索作用力以集中荷载作用在滑面上。实际上,由于作用在地面的荷载经滑体传递后发生了很大的扩散作用,不满足力及力矩的平衡条件,其公式具有一定的缺陷,因而不尽合理,甚至由于锚设置不当造成其超载受荷而发生破坏,引起严重后果。本文根据其受力特点采用Morgenstern-Price法的基本假定从平衡条件出发,导出了确定锚索设计外力的迭代算法公式,对工程实际具有较大的理论意义。

关键词：非圆弧滑面滑坡锚索设计拉力平衡条件

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GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1222-1240页

作者： Paipai Guo Ji jiang Rui chu Feng He Mingli Ge Ruhong Fang Qiuyun Guan Huijuan Cheng chunru jiang Tiantian Su Zhenduo Zhu Hao Liu Wei Wei Shihao Zhang Qingtong Wang Institute of Clinical Pharmacology Anhui Medical UniversityKey Laboratory of Anti-inflammatory and Immune MedicineMinistry of EducationCollaborative Innovation Center of Anti-inflammatory and Immune MedicinesHefei 230032China School of Pharmacy Bengbu Medical CollegeBengbu 233030China The Third Affiliated Hospital of Anhui Medical University(the First People’s Hospital of Hefei) Hefei 230061China

Hyperplasia and migration of fibroblast-like synoviocytes(FLSs)are the key drivers in the pathogenesis of rheumatoid arthritis(RA)and joint *** Yes-associated protein(YAP),which is a powerful transcription co-activator for proliferative genes,was observed in the nucleus of inflammatory FLSs with unknown upstream *** Gene Expression Omnibus database analysis,it was found that Salvador homolog-1(SAV1),the pivotal negative regulator of the Hippo-YAP pathway,was slightly downregulated in RA ***,SAV1 protein expression is extremely ***,it was revealed that SAV1 is phosphorylated,ubiquitinated,and degraded by interacting with an important serine-threonine kinase,G protein-coupled receptor(GPCR)kinase 2(GRK2),which was predominately upregulated by GPCR activation induced by ligands such as prostaglandin E2(PGE2)in *** process further contributes to the decreased phosphorylation,nuclear translocation,and transcriptional potency of YAP,and leads to aberrant FLSs *** depletion of GRK2 or inhibition of GRK2 by paroxetine rescued SAV1 expression and restored YAP phosphorylation and finally inhibited RA FLSs proliferation and ***,paroxetine treatment effectively reduced the abnormal proliferation of FLSs in a rat model of collagen-induced arthritis which was accompanied by a significant improvement in clinical ***,these results elucidate the significance of GRK2 regulation of Hippo-YAP signaling in FLSs proliferation and migration and the potential application of GRK2 inhibition in the treatment of FLSs-driven joint destruction in RA.

关键词： Rheumatoid arthritis Fibroblast-like synoviocytes G protein-coupled receptor kinase 2 Salvador homolog-1 Yes-associated protein

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Underestimated benefits of NO_(x) control in reducing SNA and O_(3) based on missing heterogeneous HONO sources

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 57-67页

作者： Shuping Zhang Haotian Zheng Jun Liu Yao Shi Tianzeng Chen Chaoyang Xue Fenfen Zhang Yueqi jiang Xiangping Zhang Shovan Kumar Sahu Biwu chu Jia Xing State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China China Academy of Civil Aviation Science and Technology Beijing 100028China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Yellow River Institute of Hydraulic Research Zhengzhou 450003China Centre for Climate Research Singapore Meteorological Service SingaporeSingapore 537054Singapore

Substantial NO_(x) emission mitigation is crucial for the synergistic reduction of particulate matter and ozone(O_(3))pollution in *** traditional air quality model does not consider heterogeneous HONO chemistry,leading to uncertainties in estimating the benefits of NO_(x) *** studies have shown that the parameterization of heterogeneous HONO formation increases both the simulated value of sulfate–nitrate–ammonium(SNA)and that of O_(3),thus adding the heterogeneous reactions of HONO into air quality models inevitably leads to changes in the estimated benefits of NO_(x) *** we investigated the changes in SNA and O_(3)concentrations from NO_(x) emission reduction before and after adding heterogeneous HONO reactions in the Community Multi-Scale Air Quality(CMAQ)*** heterogeneous HONO reactions in the simulation improved the benefits of NO_(x) reduction in terms of SNA control in *** 80%NO_(x) reduction,the reduction in SNA increased from 36.9%without considering heterogeneous HONO reactions to 42.8%with heterogeneous HONO *** reduction in the maximum daily 8h average(MDA8)O_(3)in summer caused by NO_(x) reduction increased slightly from 4.7%to 5.2%after adding heterogeneous HONO *** results in this study highlight the enhanced effectiveness of NO_(x) controls for the reduction of SNA and O_(3)after considering heterogeneous HONO formation in a complex chemical ambient,demonstrating the importance of NO_(x) controls in reducing PM2.5 and O_(3)pollution in China.

关键词： Heterogeneous HONO NO_(x) reduction PM_(2.5) O_(3)

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Tunning the bandgap of MnO_(2)homojunction by building active high-index facet to achieve rapid electron transfer for enhanced photocatalytic sterilization

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Journal of Materials Science & Technology 2024年第1期168卷 265-275页

作者： Tao Zhang Bo Li Chaofeng Wang Shuilin Wu Shengli Zhu Hui jiang Yufeng Zheng Zhaoyang Li Zhenduo Cui Yu Zhang Paul K chu Xiangmei Liu Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science and Engineering Hubei UniversityWuhan 430062China School of Health Science&Biomedical Engineering Hebei University of TechnologyTianjin 300401China School of Materials Science&Engineering Peking UniversityBeijing 100871China School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Physics Department of Materials Science and Engineering and Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Photocatalysis has been a research hotspot in recent years,and the design and modification of photocat-alysts have been the key *** methods for designing photocatalysts,including constructing heterojunctions and homojunctions,have been developed on the basis of *** this study,two homojunctions of manganese dioxide(MnO_(2)),including a high-index crystal plane homojunction and a general homojunction,are prepared using a stepwise hydrothermal *** a capping agent,the high-index crystal surface of the MnO_(2)is *** is found that the electron transport efficiency be-tween the two components of the homojunction with high-index planes is higher and the adsorption capacity of the oxygen is stronger,which leads to higher photocatalytic *** addition,the newly designed high-index homojunction is used for the treatment of bacterial infections,and it kills Staphy-lococcus aureus(***)and Escherichia coli(***)at rates of 99.95%±0.04%and 99.31%±0.25%,*** also has excellent therapeutic effects on mouse wounds,which implies superb practical application *** work provides a new strategy for the improved design of homojunctions and the application of photocatalytic materials.

关键词： Photocatalysis Homojunction Bandgap High-index facet Antibacterial

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Coupling of Adhesion and Anti‑Freezing Properties in Hydrogel Electrolytes for Low‑Temperature Aqueous‑Based Hybrid Capacitors

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Nano-Micro Letters 2024年第2期16卷 15-31页

作者： Jingya Nan Yue Sun Fusheng Yang Yijing Zhang Yuxi Li Zihao Wang chuchu Wang Dingkun Wang Fuxiang chu chunpeng Wang Tianyu Zhu Jianchun jiang Institute of Chemical Industry of Forest Products Chinese Academy of ForestryKey Laboratory of Biomass Energy and MaterialJiangsu ProvinceNanjing 210042JiangsuPeople’s Republic of China Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Clemson UniversityClemsonSC 29634USA

Solid-state zinc-ion capacitors are emerging as promising candidates for large-scale energy storage owing to improved safety,mechanical and thermal stability and easy-to-direct *** electrolytes are appealing solid-state electrolytes because of eco-friendliness,high conductivity and intrinsic ***,the electrolyte/electrode interfacial contact and anti-freezing properties of current hydrogel electrolytes are still challenging for practical applications of zinc-ion ***,we report a class of hydrogel electrolytes that couple high interfacial adhesion and anti-freezing *** synergy of tough hydrogel matrix and chemical anchorage enables a well-adhered interface between hydrogel electrolyte and ***,the cooperative solvation of ZnCl2 and LiCl hybrid salts renders the hydrogel electrolyte high ionic conductivity and mechanical elasticity simultaneously at low *** significantly,the Zn||carbon nanotubes hybrid capacitor based on this hydrogel electrolyte exhibits low-temperature capacitive performance,delivering high-energy density of 39 Wh kg^(-1)at-60°C with capacity retention of 98.7%over 10,000 *** the benefits of the well-adhered electrolyte/electrode interface and the anti-freezing hydrogel electrolyte,the Zn/Li hybrid capacitor is able to accommodate dynamic deformations and function well under 1000 tension cycles even at-60°*** work provides a powerful strategy for enabling stable operation of low-temperature zinc-ion capacitors.

关键词： Interfacial adhesion Anti-freezing Hydrogel electrolytes Low-temperature hybrid capacitors Dynamic deformati

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Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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Regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng Zhang Yuan jiang Yijun He iawei Cai Lin Liang Zhaohuan Chen Sicheng Pan chu Hua Keke Wu Le Wang Zhiyong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

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