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Synthesis of β-Cyclodextrin-[60]fullerene Conjugate and Its DNA Cleavage Performance

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Chinese Journal of Chemistry 2014年第1期32卷 78-84页

作者： Jingjing Wang Zhaoheng Zhang Wei Wu xiqun jiang Department of Polymer Science and Engineering College of Chemistry and Chemical Engineering Nanjing University Nanjing Jiangsu 210093 China College of Pharmacy Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China Email: Wei Wu (wuwei@***) Xiqun Jiang (jiangx@***)[*]Department of Polymer Science and Engineering College of Chemistry and Chemical Engineering Nanjing University Nanjing Jiangsu 210093 China Tel.: 0086-025-83597138

A water soluble β-cyclodextrin (β-CD) functionalized [60]fullerene (C60-CD) was *** C60-CD-induced generation of reactive oxygen species (ROS),and DNA-cleavage ability and cytotoxicity of C60-CD were studied upon visible light irradiation,demonstrating that the compound is very promising in the applications of photodynamic *** histological analyses demonstrate that C60-CD has no acute or subacute toxicity to living body.

关键词： fullerene β-cyclodextrin DNA-cleavage photodynamic therapy

Preparation of porous chitosan-poly(acrylic acid)-calcium phosphate hybrid nanoparticles via mineralization

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Chinese Science Bulletin 2009年第10期54卷 3127-3136页

作者： CHEN ChangJing DENG Yu YAN ErYun HU Yong jiang xiqun Nanjing National Laboratory of Microstructures Department of Material Science and Engineering Nanjing University Nanjing 210093 China Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering College of Chemistry & Chemical Engi- neering Nanjing University Nanjing 210093 China Center for Materials Analysis Nanjing University Nanjing 210093 China

In this work, the preparation of chitosan-poly(acrylic acid)-calcium phosphate hybrid nanoparticles (CS-PAA-CaP NP) based on the mineralization of calcium phosphate (CaP) on the surface of chito-san-poly (acrylic acid) nanoparticles (CS-PAA NPs) was reported. CS-PAA-CaP NPs were achieved by directly adding ammonia to the aqueous solution of CS-PAA nanoparticles or by thermal decomposi-tion of urea in the aqueous solution of CS-PAA nanoparticles, resulting in the mineralization of CaP on the surface of CS-PAA NPs. Through these two routes, especially using urea as a pH-regulator, the precipitation of CS-PAA NPs, a common occurrence in basic environment, was avoided. The size, morphology and ingredient of CS-PAA-CaP hybrid nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), scanning electron microscope (SEM), thermogravimetry analysis (TGA) and X-ray diffractometer (XRD). When urea was used as the pH regulator to facilitate the mineralization during the thermal urea decomposition procedure, regular CS-PAA-CaP hybrid nanoparticles with a porosity-structural CaP shells and 400―600 nm size were obtained. TGA result revealed that the hybrid NPs contained approximately 23% inorganic component, which was consistent with the ratio of starting materials. The XRD spectra of hybrid nanoparticles in-dicated that dicalcium phosphate (DCP: CaHPO4) crystal was a dominant component of mineralization. The porous structure of the CS-PAA-CaP hybrid NPs might be greatly useful in pharmaceutical and other medical applications.

关键词：纳米粒子丙烯酸壳聚糖磷酸钙多孔制备混合矿化

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乏氧光学影像探针的设计与应用

高等学校化学学报 2022年第12期43卷 185-196页

作者：李成周森森蒋锡群南京大学化学化工学院高分子科学与工程系江苏省纳米技术重点实验室南京210023

氧气在生命活动中具有重要意义,为需氧生物提供了重要的能量来源,氧气供应不足会导致组织乏氧.乏氧往往与炎症、慢性伤口及肿瘤等多种疾病密切相关,而组织氧浓度是评估机体健康的重要依据.光学成像在空间分辨率、灵敏性和成本方面的巨... 详细信息

氧气在生命活动中具有重要意义,为需氧生物提供了重要的能量来源,氧气供应不足会导致组织乏氧.乏氧往往与炎症、慢性伤口及肿瘤等多种疾病密切相关,而组织氧浓度是评估机体健康的重要依据.光学成像在空间分辨率、灵敏性和成本方面的巨大优势使其成为炎症、癌症、脑部疾病和手术导航的重要影像诊断工具.本文介绍了数种乏氧响应的光学探针的合成策略,并展示了不同的乏氧光学探针在肿瘤检测、炎症监测、伤口氧含量监测、治疗响应监测和食品包装检测等方面的应用,最后探讨了乏氧光学成像的应用前景.

关键词：乏氧磷光探针荧光探针

Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy

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Nano Research 2018年第11期11卷 6062-6073页

作者： Lei jiang Yang Ding Xialin Xue Sensen Zhou Cheng Li Xiaoke Zhang xiqun jiang State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 China MOE Key Laboratory of High Performance Polymer Materials and Technology and Department of Polymer Science & EngineeringCollege of Chemistry & Chemical Engineering Nanjing University Nanjing 210093 China

Developing multifunctional nanoparticles to support new therapy models is a promising and challenging task to address the current dilemma on antitumor treatment. Herein, we incorporated multifunctional dendritic nanoparticles into a poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers thermosensitive injectable hydrogel matrix to construct a localized drug delivery system for combining chemotherapy and immunotherapy. The multifunctional dendritic nanoparticles were designed with following expectations: i, Dendritic scaffolds provide a hydrophobic interior to load the anticancer drug, doxorubicin (DOX), for chemotherapy; and ii, dendritic scaffolds are used to build arginine-rich molecules to provide the inducible nitric oxide synthase (iNOS) substrate, L-Arg, to M1 macrophages, which can produce the cytotoxic substance nitric oxide (NO) and subsequently induce tumor cell destruction through immunotherapy. It is noteworthy that the dendritic nanoparticles-in-hydrogel delivery system is able to gel at physiological temperature and serves as a warehouse for the sustained release of the drug. Ultimately, this system showed great efficacy in treating 4T1 cells-xenografted BALB/C mice (86.62% tumor growth inhibition). Therefore, this localized drug delivery system combining chemotherapy and immunotherapy provides a novel approach for cancer therapy.

关键词： multifunctional dendritic nanoparticles peptide dendrimer cancer therapy combined chemotherapy and immunotherapy

Biomedical polymers: synthesis, properties, and applications

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Science China Chemistry 2022年第6期65卷 1010-1075页

作者： Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji xiqun jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan UniversityWuhan430072China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Ministry of EducationBeijing Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin300071China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Jinhua Institute of Zhejiang University Jinhua321299China Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai200438China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nano-scienceNational Center for Nanoscience and Technology(NCNST)Beijing100190China School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou510006China Institute of Functional Nano and So

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

关键词： biomedical polymer nanomedicine cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity biocompatibility

基于树状大分子纳米载体的化疗及基因治疗在肿瘤治疗中的应用（英文）

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Science China Materials 2018年第11期61卷 1404-1419页

作者：姜雷周森森张小可武伟蒋锡群 MOE Key Laboratory of High Performance Polymer Materials and Technology and Department of Polymer Science&Engineering College of Chemistry&Chemical Engineering Nanjing University State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University

针对肿瘤组织的微环境,结合树状大分子的特点可以构建定向可控药物、基因传递系统,实现化学或基因治疗中的高效低毒.本综述从树状大分子的结构出发,总结了其纳米载体在肿瘤治疗中的最新进展,尤其重点讨论了传统树状大分子、树状大分子... 详细信息

针对肿瘤组织的微环境,结合树状大分子的特点可以构建定向可控药物、基因传递系统,实现化学或基因治疗中的高效低毒.本综述从树状大分子的结构出发,总结了其纳米载体在肿瘤治疗中的最新进展,尤其重点讨论了传统树状大分子、树状大分子偶联物、可自组装的两亲性树状大分子、杂化树状大分子及自身具有药理活性的树状大分子作为药物或基因递送载体的应用.我们希望本综述将有助于启发未来的相关研究,以进一步拓展这种材料在肿瘤治疗中的新应用.

关键词：树状大分子基因治疗肿瘤组织纳米载体应用化疗传递系统高效低毒

顺序式模拟移动床色谱高效纯化低聚异麦芽糖应用研究

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食品与机械 2024年第7期40卷 163-168+230页

作者：阮圣慧郑喜群刘晓兰李良玉姜彩霞黑龙江八一农垦大学食品学院黑龙江八一农垦大学国家杂粮工程技术研究中心粮食副产物加工与利用教育部工程研究中心齐齐哈尔大学食品与生物工程学院

[目的]提高低聚糖行业的生产效率。[方法]以50型低聚异麦芽糖浆为原料，利用顺式模拟移动床色谱分离技术对其纯化。通过制备色谱单柱试验筛选出钾离子型树脂为合适的分离介质；根据物料平衡原理和顺序式模拟移动床基本原理近似确定分离... 详细信息

[目的]提高低聚糖行业的生产效率。[方法]以50型低聚异麦芽糖浆为原料，利用顺式模拟移动床色谱分离技术对其纯化。通过制备色谱单柱试验筛选出钾离子型树脂为合适的分离介质；根据物料平衡原理和顺序式模拟移动床基本原理近似确定分离工艺的初始操作参数，并对分离条件进行优化。[结果]最佳技术参数为：料液折光率60%、柱温65℃、进样量455 mL、进水量682 mL、进样流量37.4 mL/min、进水流量29.6 mL/min以及总循环流量364 mL/h,在此条件下低聚异麦芽糖出口折光为20.40%,纯度达到90.20%,收率达到85.50%。[结论]自主研制的顺序式模拟移动床色谱分离设备可用于高效纯化低聚异麦芽糖。

关键词：顺序式模拟移动床色谱分离纯化低聚异麦芽糖

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A Novel one-Step Approach to the Fabrication of EHEC-PAA Complex Vesicles in Aqueous Media

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A Novel one-Step Approach to the Fabrication of EHEC-PAA Com...

Ⅻ International Symposium on Small Particles and Inorganic Clusters

作者： Ying Chen xiqun jiang College of Chemistry and Chemical Engineering Nanjing university China

＜正＞ Polymeric vesicles iiave attracted considerable attention in recent years, since they are a model for biological membranes and have versatile structures with several practical applications, such as microreactors, environmental toxin sequesters, and drug delivery vehicles. Here, we proposed a new method for fabricating vesicles with biocompatible and biodegradable macromolecules, which avoids the complicated preparation schemes typically

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高分子钆配合物磁共振造影剂的研究进展

离子交换与吸附 2010年第3期26卷 280-288页

作者：谢晨郭舰武伟蒋锡群南京大学化学化工学院

近年来,高分子磁共振造影剂因其弛豫效率高、体内驻留时间长、器官选择性好和毒副作用小等优点而倍受关注。本文综述用于磁共振造影剂的高分子钆配合物的最新研究进展。讨论了将官能化的配合物与线性、树状聚合物及生物大分子结合制备... 详细信息

近年来,高分子磁共振造影剂因其弛豫效率高、体内驻留时间长、器官选择性好和毒副作用小等优点而倍受关注。本文综述用于磁共振造影剂的高分子钆配合物的最新研究进展。讨论了将官能化的配合物与线性、树状聚合物及生物大分子结合制备高分子钆配合物的合成方法,并介绍了高分子钆配合物磁共振造影剂的性能、应用和发展前景。

关键词：磁共振造影剂钆配合物弛豫性能