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Highly efficient photo-thermal synergistic catalysis of CO_(2)methanation over La_(1-x)Ce_(x)NiO_(3)perovskite-catalyst

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Nano Research 2024年第9期17卷 7945-7956页

作者： Ting Li Zhen-Yu Zhang De-Cun Luo Bo-Yu Xu rong-jiang Zhang Ji-Long Yao Dan Li Tao Xie Institute of Industrial Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Solar-driven photo-thermal catalytic CO_(2)methanation reaction is a promising technology to alleviate the problems posed by greenhouse gases ***,designing advanced photo-thermal catalysts remains a research challenge for CO_(2)methanation *** this work,a series of ABO3(A=lanthanide,B=transition metal)perovskite catalysts with Ce-substituted LaNiO3(La_(1-x)Ce_(x)NiO_(3),x=0,0.2,0.5,0.8,1)were synthesized for CO_(2)*** La_(0.2)Ce_(0.8)NiO_(3) exhibited the highest CH_(4) formation rate of 258.9 mmol·g^(-1)·hcat-1,CO_(2)conversion of 55.4%and 97.2%CH_(4) selectivity at 300℃with the light intensity of 2.9 W·cm^(-2).Then the catalysts were thoroughly analyzed by physicochemical structure and optical properties *** partial substitution of the A-site provided more active sites for the adsorption and activation of CO_(2)/H_(2).The sources of the active sites were considered to be the oxygen vacancies(O_(v))created by lattice distortions due to different species of ions(La^(3+),Ce^(4+),Ce^(3+))and exsolved Ni0 by H_(2)*** catalysts have excellent light absorption absorbance and low electron-hole(e^(-)/h^(+))recombination rate,which greatly contribute to the excellent performance in photo-thermal synergistic catalysis(PTC)CO_(2)*** results of in situ irradiated electron paramagnetic resonance spectrometer(ISI-EPR)and ISI-X-ray photoelectron spectroscopy(XPS)indicated that the aggregation of unpaired electrons near the defects and Ni metal(from La and Ce ions to Ov and Ni0)accelerated adsorption and activation of CO_(2)/H_(2).At last,the catalyst properties and structure were correlated with the proposed reaction mechanism from the in situ diffuse reflection infrared Fourier transform spectrum(DRIFTS)*** in situ precipitation of the B-site enhanced the dispersion of Ni,while its enriched photoelectrons upon illumination further promote hydrogen *** H^(*)spillover accelerated t

关键词： photo-thermal catalysis CO_(2)methanation perovskite A-site substitution in situ diffuse reflection infrared Fourier transform spectrum(DRIFTS)

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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-rong jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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Continuous wave and active Q-switched operation of Watt-level LED-pumped two-rod Nd,Ce:YAG laser

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Chinese Physics B 2024年第7期33卷 361-366页

作者：沈建平芦鹏徐少聪江容容陈阳陈亮邢凤阳 College of Electronic and Optical Engineering&College of Flexible Electronics Nanjing University of Posts and TelecommunicationsNanjing 210023China

A high-performance LED-side-pumped two-rod Nd,Ce:YAG laser with continuous-wave(CW) and acousto–optical(A-O) Q-switched operation is demonstrated in this work. A symmetrically shaped flat–flat cavity with two identical LEDside-pumped laser modules is employed for power scalability. In the CW regime, the maximum output average power of laser at 1064 nm is 4.41 W, corresponding to a maximum optical conversion efficiency of 5.3% and a slope efficiency is 12.4%. In the active Q-switched regime, the pulse energy of laser reaches as high as 0.89 m J at a repetition rate of 800 Hz with a pulse width of 457.2 ns, the corresponding highest peak output power is 1.94 k W and the M~2 factor is measured to be about 8.8. To the best of the authors' knowledge, this is the first demonstration and the highest performance of a CW LED-side-pumped two-rod laser Nd,Ce:YAG with Watt-level output reported so far.

关键词： Watt-level LED-pumped CW Nd Ce:YAG actively Q-switched operation

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IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

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Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian Fan Nana Geng Xingyue Li Danyang Yin Yuyou Yang rong jiang Cheng Chen Naibo Feng Li Liang Xiaoli Li Fengtao Luo Huabing Qi Qiaoyan Tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is *** inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage ***,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains ***,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone ***1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth *** deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and ***1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage ***,ER stress cannot be activated normally in ERN1-deficient *** conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER ***1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH PTHrP/PTH1R

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CircPMS1 promotes proliferation of pulmonary artery smooth muscle cells,pulmonary microvascular endothelial cells,and pericytes under hypoxia

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Animal Models and Experimental Medicine 2024年第3期7卷 310-323页

作者： Xiaoyi Hu Shang Wang Hui Zhao Yaqin Wei Ruowang Duan rong jiang Wenhui Wu Qinhua Zhao Sugang Gong Lan Wang Jinming Liu Ping Yuan Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Bismuth Science University of Shanghai for Science and TechnologyShanghaiChina Department of Geriatrics Shanghai Institute of GeriatricsHuadong HospitalFudan UniversityShanghaiChina Department of Anesthesiology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Background:Circular RNAs(circRNAs)have been recognized as significant regulators of pulmonary hypertension(PH);however,the differential expression and function of circRNAs in different vascular cells under hypoxia remain ***,we identified co-differentially expressed circRNAs and determined their putative roles in the proliferation of pulmonary artery smooth muscle cells(PASMCs),pulmonary microvascular endothelial cells(PMECs),and pericytes(PCs)under ***:Whole transcriptome sequencing was performed to analyze the differential expression of circRNAs in three different vascular cell *** analysis was used to predict their putative biological *** real-time polymerase chain reaction,Cell Counting Kit-8,and EdU Cell Proliferation assays were carried out to determine the role of circular postmeiotic segregation 1(circPMS1)as well as its potential sponge mechanism in PASMCs,PMECs,and ***:PASMCs,PMECs,and PCs exhibited 16,99,and 31 differentially expressed circRNAs under hypoxia,***1 was upregulated in PASMCs,PMECs,and PCs under hypoxia and enhanced the proliferation of vascular ***1may upregulate DEP domain containing 1(DEPDC1)and RNA polymerase II subunit D expression by targeting microRNA-432-5p(miR-432-5p)in PASMCs,upregulate MAX interactor 1(MXI1)expression by targeting miR-433-3p in PMECs,and upregulate zinc finger AN1-type containing 5(ZFAND5)expression by targeting miR-3613-5p in ***:Our results suggest that circPMS1 promotes cell proliferation through the miR-432-5p/DEPDC1 or miR-432-5p/POL2D axis in PASMCs,through the miR-433-3p/MXI1 axis in PMECs,and through the miR-3613-5p/ZFAND5 axis in PCs,which provides putative targets for the early diagnosis and treatment of PH.

关键词： circular postmeiotic segregation 1 circular RNAs hypoxia pulmonary hypertension vascular cells

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政策工具视角下省(市)级生物医药产业高质量发展政策文本分析

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中国新药杂志 2024年第12期33卷 1194-1200页

作者：盛天翊蒋蓉邵蓉中国药科大学药品监管科学研究院南京211198 国家药品监督管理局药品监管创新与评价重点实验室南京211198

目的:从政策工具视角,结合产业创新价值链维度,总结我国生物医药产业高质量发展政策制定现状,分析政策工具使用偏好,为政策优化调整提供参考。方法:以政策工具为X维度,产业创新价值链为Y维度,采用Rothwell和Zegveld政策工具分类法对我... 详细信息

目的:从政策工具视角,结合产业创新价值链维度,总结我国生物医药产业高质量发展政策制定现状,分析政策工具使用偏好,为政策优化调整提供参考。方法:以政策工具为X维度,产业创新价值链为Y维度,采用Rothwell和Zegveld政策工具分类法对我国生物医药产业高质量发展政策文件进行编码和分类,并采用SPSS,Ucinet等工具结合产业创新价值链进行统计分析。结果:在X维度中,环境型政策工具的使用频率最高(50.2%),需求型政策工具的使用频率最低(11.1%)。在Y维度中,产业推广阶段的政策工具使用频率最高(44.2%),成果转化阶段的政策工具使用频率最低(27.2%)。在双维度视角下,成果转化和产业推广阶段环境型政策工具使用频次最多,在研究开发阶段则是供给型政策工具最多。结论:各省(市)生物医药产业高质量发展政策文件中环境型政策工具使用较多,供给型和需求型政策工具使用相对较少。建议相关部门加强各类型政策工具平衡应用,重点增加需求型政策工具的使用频次,加大信息化投入,并发挥研究主体的创新作用。

关键词：政策工具生物医药产业高质量发展社会网络文本编码

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Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

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Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： Shang Wang Yi Yan Jian Zhang Ping Yuan Ci-Jun Luo Hong-Ling Qiu Hui-Ting Li Jian Xu Lan Wang Tian-Lan Li rong jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

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“两个结合”视域下新时代价值观教育的守正创新之道

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民族教育研究 2024年第1期35卷 55-62页

作者：姜术容清华大学社会科学学院北京100084

“两个结合”是一种结合了中华文明突出特性的坚实价值立场。在打牢中华文化根基、拓展中华文化空间、巩固中华文化主体性的意义上,“两个结合”彰显出接续固本、创新包容、和谐统一的价值导向,从而为新时代价值观教育提供了守正创新之... 详细信息

“两个结合”是一种结合了中华文明突出特性的坚实价值立场。在打牢中华文化根基、拓展中华文化空间、巩固中华文化主体性的意义上,“两个结合”彰显出接续固本、创新包容、和谐统一的价值导向,从而为新时代价值观教育提供了守正创新之道。一方面,在守正要义上,依托“两个结合”的价值要求,新时代价值观教育需要对中华文明的优秀价值理想予以传承守护、对中华文明的美好价值意义予以精神守望、对中华文明的主导价值规范予以认同坚守,从而以更有理想、更有意义、更有原则的价值追求,化解现代人在价值虚无化、价值稀薄化、价值碎片化处境中面临的价值观困境。另一方面,在创新理路上,依照“两个结合”的价值取向,新时代价值观教育需要在愈加频繁的现代化交往实践和生活体验中,通过教育理念革新、教育生态营造以及教育机制建构,解决现代人在做什么样的人、为什么而活、应当怎样去活等方面存在的价值观难题。在“两个结合”的指引下,新时代价值观教育通过明确价值导向、改善价值处境、解决价值难题,以守正创新的方式,为中华文化传承发展、中华民族现代文明建设提供良好的价值支撑。

关键词： “两个结合” 价值立场价值观教育守正创新中华民族现代文明

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“大写的科学革命”的科学思想史叙事何以可能?

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自然辩证法研究 2024年第7期40卷 3-9页

作者：王荣江南京财经大学马克思主义学院南京210023

肖显静教授的《科学思想史》是一本极具史料性、研究性、综合性和创新性的科学思想史新著,是中国科学思想史研究有了自己独特的研究视角、方法和观点而走向成熟的标志性成果,展现了国内科学思想史研究从最初的恩格斯的自然辩证法研究传... 详细信息

肖显静教授的《科学思想史》是一本极具史料性、研究性、综合性和创新性的科学思想史新著,是中国科学思想史研究有了自己独特的研究视角、方法和观点而走向成熟的标志性成果,展现了国内科学思想史研究从最初的恩格斯的自然辩证法研究传统发展到利用西方科学哲学理论研究科学思想史的研究传统之后出现的新阶段和新范式——综合论的科学思想史研究。但是,这样的研究和叙事似乎存在一些较难克服的矛盾和问题:作为核心概念“大写的科学革命”的建构性过强,也不够清晰;该概念与“小写的科学革命”概念之间关系可能存在逻辑顺序颠倒使用的问题;从自然观变革到方法论创新再到科学革命的递进和变化关系并非作者论述的那么简单,恰恰是要展开、解释并加以说明的。这种“大写的科学革命”的科学思想史叙事可能是此书的最大亮点,但也可能成为人们热烈关注的争议点和突出问题。

关键词：大写的科学革命建构解释项与被解释项逻辑问题

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Treatment of fat-poor renal angiomyolipoma with ectopic blood supply by fluorescent laparoscopy:A case report and review of literature

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World Journal of Clinical Oncology 2024年第11期15卷 1435-1443页

作者： Jian-Er Tang rong-jiang Wang Zhi-Hai Fang Ping-Ya Zhu Jian-Xiang Yao Hua Yang Department of Urology First Affiliated Hospital of Huzhou Normal CollegeHuzhou 313000Zhejiang ProvinceChina Department of Andrology Huzhou Women and Children's HospitalHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in treatment ***-poor renal angiomyolipoma is a relatively rare type of in renal *** fat imaging features are not obvious,and it is easily misdiagnosed as renal cell *** SUMMARY We report the case of a 41-year-old man who complained of *** abdominal computed tomography scans revealed that a heterogeneous mass was seen in the lower pole of the right kidney,with the size of about 53 mm×47 *** showed two right renal arteries,with the mass supplied by an ectopic vessel from the abdominal *** laparoscopic blockade of the right renal heterotopic artery and partial nephrectomy was *** on histological and immunohistochemical findings,the tumor was diagnosed as fatpoor renal *** The use of fluorescent laparoscopy can effectively help intraoperative management,and the fluorescence pattern provided by intravenous indocyanine green can help suggest the final diagnosis,effectively guide the surgical decisionmaking,and avoid preoperative imaging diagnosis leading to nephrectomy for benign renal tumors,through fluorescent navigation of tumor supply vessel precise block,minimize the loss of renal function.

关键词： Renal angiomyolipoma Renal cell carcinoma Ectopic blood supply luorescent laparoscopic Partial nephrectom Case report

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