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Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING ZHENG jianfeng cai JIE GAO LIE DONG XIANGBIN ZHANG YINGHUI HUANG Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)

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SOLVING SYSTEMS OF PHASELESS EQUATIONS VIA RIEMANNIAN OPTIMIZATION WITH OPTIMAL SAMPLING COMPLEXITY

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Journal of Computational Mathematics 2024年第3期42卷 755-783页

作者： jianfeng cai Ke Wei Department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina School of Data Science Fudan UniversityShanghaiChina

A Riemannian gradient descent algorithm and a truncated variant are presented to solve systems of phaseless equations|Ax|^(2)=*** algorithms are developed by exploiting the inherent low rank structure of the problem based on the embedded manifold of rank-1 positive semidefinite *** recovery guarantee has been established for the truncated variant,showing that the algorithm is able to achieve successful recovery when the number of equations is proportional to the number of *** key ingredients in the analysis are the restricted well conditioned property and the restricted weak correlation property of the associated truncated linear *** evaluations show that our algorithms are competitive with other state-of-the-art first order nonconvex approaches with provable guarantees.

关键词： Phaseless equations Riemannian gradient descent Manifold of rank-1 and positive semidefinite matrices Optimal sampling complexity

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Using proteomimetics to switch angiogenic signaling

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1534-1535页

作者： Peng Teng jianfeng cai College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Department of Chemistry University of South FloridaTampaFL 33620USA

Angiogenesis is a vital process in the event of various healthy and diseased conditions especially in the tumor metastatic pathway,and it is one of the key hallmarks of cancer cells^(1,2),therefore,angiogenesis inhibitors are potential anti-cancer ***,silenced angiogenesis on the other hand could result in stroke,heart attack,and other cardiovascular diseases^(3).Yet,the precise manipulation of contradictory pro-angiogenic and anti-angiogenic signaling remains extremely challenging in both molecular biology and *** the recent issue of J Am Chem Soc.

关键词： Proteomimetics AApeptides VEGF VEGFR

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Editorial of Special Column“Novel Peptides and Peptidomimetics in Drug Discovery”

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2606-2608页

作者： jianfeng cai Lulu Wei Department of Chemistry University of South Florida

Since insulin,a natural peptide composed of 51 amino acids,was first isolated and commercialized in the 1920s,peptide drugs have greatly reshaped our modern drug discovery area^(1).To date,the total number of approved peptide drugs for human use worldwide has exceeded 60^(2).Popular peptide drugs such as liraglutide(Victoza)^(2) and glucagon-like peptide 1(GLP-1)^(3) are the topselling drugs for type 2 ***,significant hurdles associated with natural peptide sequences as therapeutics,such as metabolic instability and,consequently,have low oral bioavailability and shorter half-life^(4),are still *** overcome the limitations of natural peptides and further optimize their advantages,peptidomimetics emerged as an alternative strategy.

关键词： drugs Popular overcome

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Abundance and biomass of heterotrophic microbes in the Kongsfjorden, Svalbard

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Acta Oceanologica Sinica 2005年第6期24卷 143-152页

作者： JIANG Xiaodong HE jianfeng cai Minghong State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China

Abundance and biomass of heterotrophic microbes were investigated usingepifluorescense microscopy in August 2004 along a transect in the Kongsfjorden, a glacial fjord inthe high arctic, located in the north-western part of Svalbard. A bacterial abundance was low atouter fjord stations (on average 2.29 x 10~8 ind./dm^3) and was higher at inner fjord stations (onaverage 3.52 x 10~8 ind./dm^3).The biomass of bacteria ranged from 3.69 to 8.01 mg/m^*** abundanceof bacteria was low at the surface of water(0 m), whereas the higher abundances often occurred atdepths of 30～50 *** abundance of heterotrophic flagellates varied from 2.785 to 8.891 x 10~4 ind./dm^3. The assemblage was numerically dominated by less than 5 μm heterotrophic flagellates(78.67%～94.80%).The biomass of heterotrophic flagellates varied from 0.37 to 2.30 mg/m^*** meanbiomass distribution for all stations was 4.91% for less than 5 μm heterotrophic flagellates,86.74% for 6～20 μm flagellates and 8.35% for greater than 20 μm sized *** low biomassof heterotrophic flagellates often occurred at the surface of water (0 m),while the maximum valueof biomass occurred at different depths. The biomass of total heterotrophic microbial communityranged from 4.20 to 10.03 mg/m^*** mean biomass distribution for all stations was 82.58% forbacteria, 15.77% for flagellates and 1.66% for ciliates.

关键词： abundance biomass bacteria flagellate kongsfjorden

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Long-term variability of the carbon balance in a large irrigated area along the lower Yellow River from 1984 to 2006

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Science China Earth Sciences 2013年第4期56卷 671-683页

作者： LEI HuiMin YANG DaWen cai jianfeng WANG FengJiao State Key Laboratory of Hydroscience and Engineering Department of Hydraulic Engineering Tsinghua University Management Office of the Weishan Irrigation District Binzhou Bureau of Meteorology

The irrigated areas in the northern region of China are important food production areas. Therefore, studies on the variability of the carbon balance in these agro-ecosystems are fundamental for the management of carbon sequestration. This paper simulated the long-term variability of the carbon balance in a typical irrigated area along the lower Yellow River from 1984 to 2006, using a process-based ecosystem model called the Simple Biosphere Model, version 2. The mean annual gross primary production (GPP), mean annual net assimilation rate (NAR), mean annual soil respiration (Rs ), and mean annual net ecosystem exchange (NEE) were 1733, 1642, 1304, and 338g C m-2 a-1 , respectively. A significant increasing trend in the seasonal total NAR during the wheat growing season, and a significant decreasing trend in the seasonal total NAR during the maize growing season were detected. However, no significant trend was found in the annual NAR, R s , and NEE. The average carbon sequestration was 1.93 Tg C a-1 when the grain harvest was not taken into account, and the carbon sequestration amount during the maize season was higher than that during the wheat season. However, the agro-ecosystem was a weak carbon source with a value of 0.23 Tg C a-1 , when the carbon in the grain was assumed emitted into the atmosphere.

关键词： carbon balance winter wheat summer maize process-based ecosystem model irrigated area

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IMPROVED HARMONIC INCOMPATIBILITY REMOVAL FOR SUSCEPTIBILITY MAPPING VIA REDUCTION OF BASIS MISMATCH

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Journal of Computational Mathematics 2022年第6期40卷 913-935页

作者： Chenglong Bao jianfeng cai Jae Kyu Choi Bin Dong Ke Wei Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China Department of Mathematics The Hong Kong University of Science and TechnologyHongkongChina School of Mathematical Sciences Tongji UniversityShanghai 200092China Beijing International Center for Mathematical Research and Laboratory for Biomedical Image Analysis Beijing Institute of Big Data Research Peking UniversityBeijing 100871China School of Data Science Fudan UniversityShanghai 200433China

In quantitative susceptibility mapping(QSM),the background field removal is an essential data acquisition step because it has a significant effect on the restoration quality by generating a harmonic incompatibility in the measured local field *** though the sparsity based first generation harmonic incompatibility removal(1GHIRE)model has achieved the performance gain over the traditional approaches,the 1GHIRE model has to be further improved as there is a basis mismatch underlying in numerically solving Poisson’s equation for the background *** this paper,we propose the second generation harmonic incompatibility removal(2GHIRE)model to reduce a basis mismatch,inspired by the balanced approach in the tight frame based image *** results shows the superiority of the proposed 2GHIRE model both in the restoration qualities and the computational efficiency.

关键词： Quantitative susceptibility mapping Magnetic resonance imaging Deconvolution Partial differential equation Harmonic incompatibility removal (Tight)wavelet frames Sparse approximation

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Anomalous Thermopower and High ZT in GeMnTe2 Driven by Spin’s Thermodynamic Entropy

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Research 2021年第1期2021卷 61-69页

作者： Sichen Duan Yinong Yin Guo-Qiang Liu Na Man jianfeng cai Xiaojian Tan Kai Guo Xinxin Yang Jun Jiang Ningbo Institute of Materials Technology and Engineering Chinese Academy of ScienceNingbo 315201China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049China

NaxCoO_(2)was known 20 years ago as a unique example in which spin entropy dominates the thermoelectric ***,however,little has been learned about how to manipulate the spin degree of freedom in ***,we report the enhanced thermoelectric performance of GeMnTe_(2)by controlling the spin’s thermodynamic *** anomalously large thermopower of GeMnTe_(2)is demonstrated to originate from the disordering of spin orientation under finite *** on the careful analysis of Heisenberg model,it is indicated that the spin-system entropy can be tuned by modifying the hybridization between Te-p and Mn-d *** a consequent strategy,Se doping enlarges the thermopower effectively,while neither carrier concentration nor band gap is *** measurement of magnetic susceptibility provides a solid evidence for the inherent relationship between the spin’s thermodynamic entropy and *** further introducing Bi doing,the maximum ZT in Ge_(0.94)Bi_(0.06)MnTe_(1.94)Se_(0.06)reaches 1.4 at 840 K,which is 45%higher than the previous report of Bi-doped GeMnTe_(2).This work reveals the high thermoelectric performance of GeMnTe_(2)and also provides an insightful understanding of the spin degree of freedom in thermoelectrics.

关键词： temperature entropy thermodynamic

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Peptidomimetic-based antibody surrogate for HER2

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2645-2654页

作者： Mengmeng Zheng Chunpu Li Mi Zhou Ru Jia Fengyu She Lulu Wei Feng Cheng Qi Li jianfeng cai Yan Wang Department of Chemistry University of South FloridaTampaFL 33620USA Department of Medical Oncology&Cancer Institute of Medicine Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmaceutical Science College of PharmacyUniversity of South FloridaTampaFL 33612USA

Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive *** monoclonal antibodies are currently used as marketed drugs,their large molecular weight,high cost of production and susceptibility to proteolysis could be a hurdle for long-term *** this study,we reported a strategy for the development of artificial antibody based on y-AApeptides to target HER2 extracellular domain(ECD).To achieve this,we synthesized a one-bead-two-compound(OBTC)library containing 320,000 cyclic y-AApeptides,from which we identified a y-AApeptide,M-3-6,that tightly binds to HER2 ***,we designed an antibody-like dimer of M-3-6,named M-3-6-D,which showed excellent binding affinity toward HER2 comparable to monoclonal ***,M-3-6-D was completely resistant toward enzymatic *** addition,it could effectively inhibit the phosphorylation of HER2,as well as the downstream signaling pathways of AKT and ***,M-3-6-D also efficiently inhibited cell proliferation in vitro,and suppressed tumor growth in SKBR3 xenograft model in vivo,implying its therapeutic potential for the treatment of *** small molecular weight,antibody-like property,resistance to proteolysis,may enable it a new generation of artificial antibody ***,our strategy of artificial antibody surrogate based on dimers of cyclicγ-AApeptides could be applied to a myriad of disease-related receptor targets in future.

关键词： HER2 Anti-cancer Peptidomimetics γ-AApeptides Antibody-surrogate

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Poly(α-L-lysine)-based nanomaterials for versatile biomedical applications:Current advances and perspectives

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Bioactive Materials 2021年第7期6卷 1878-1909页

作者： Maochao Zheng Miao Pan Wancong Zhang Huanchang Lin Shenlang Wu Chao Lu Shijie Tang Daojun Liu jianfeng cai Shantou University Medical College 22 Xinling RoadShantou515041China The Second Affiliated Hospital of Shantou University Medical College 69 Dongxiabei RoadShantou515041China College of Pharmacy Jinan UniversityGuangzhou511443China Department of Chemistry University of South FloridaTampaFL33620USA

Poly(α-L-lysine)(PLL)is a class of water-soluble,cationic biopolymer composed ofα-L-lysine structural *** previous decade witnessed tremendous progress in the synthesis and biomedical applications of PLL and its ***-based polymers and copolymers,till date,have been extensively explored in the contexts such as antibacterial agents,gene/drug/protein delivery systems,bio-sensing,bio-imaging,and tissue *** review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last *** review first describes the synthesis of PLL and its derivatives,followed by the main text of their recent biomedical applications and translational ***,the challenges and perspectives of PLL-based nanomaterials in biomedical fields are addressed.

关键词： Poly(α-L-lysine) Antimicrobial agents Delivery systems Bio-sensing Bio-imaging

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