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BIOCELL 2020年第3期44卷 431-441页

作者： XINGXING ZHU TIANFENG HUA MINGFEI WU JIATIAN WU jianchao hong MIN YANG The Second Affiliated Hospital of Anhui Medical University HefeiChina The Laboratory of Cardiopulmonary Resuscitation and Critical Care Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiChina School of Pharmacy Anhui Province Key Laboratory of Major Autoimmune DiseasesAnhui Medical UniversityHefeiChina

Post-resuscitation myocardial dysfunction(PRMD)is the most severe myocardial ischemia-reperfusion injury(MIRI)and is characterized by difficult treatment and poor *** has shown the protective effects of the rational use of ivabradine(IVA)against PRMD,however,the molecular mechanisms of IVA remain *** this study,an ischemia-reperfusion injury(IRI)model was established using hypoxic *** results demonstrated that pretreatment with IVA reduced IRI-induced cytotoxicity and *** attenuated mitochondrial damage,eliminated excess reactive oxygen species(ROS),suppressed IRI-induced ATP and NAD+,and increased the AMP/ATP *** further found that IVA increased the mRNA levels of sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α)and upregulated the expression levels of phosphorylated AMP-activated protein kinase(p-AMPK)/AMPK,SIRT1,and PGC-1α***,no change in AMPK mRNA levels was *** energy metabolism significantly changed after *** aim of this study was to demonstrate the cardioprotective effect of Ivabradine via the AMPK/SIRT1/PGC-1αsignaling pathway in myocardial ischemia/reperfusion injury-induced in H9c2 cell.

关键词： Ivabradine Myocardial ischemia reperfusion injury Energy metabolism Oxidative stress AMPK/SIRT1/PGC-1α pathway

2020年欧洲重症医学会非出血性重症成人患者的输血策略临床实践指南解读

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中国循证医学杂志 2020年第10期20卷 1136-1141页

作者：吴颖洪健超张金肖文艳杨旻安徽医科大学第二附属医院重症医学二科合肥230601 安徽医科大学第二附属医院心肺复苏与危重病实验室合肥230601

贫血和凝血障碍是重症监护病房(ICU)患者的常见问题,科学使用血液制品有助于重症患者救治,但也存在可能危及生命的不良反应风险。欧洲重症医学会(ESICM)于2020年发布了非出血性重症成人患者的输血策略临床实践指南,目的在于解决非出血... 详细信息

贫血和凝血障碍是重症监护病房(ICU)患者的常见问题,科学使用血液制品有助于重症患者救治,但也存在可能危及生命的不良反应风险。欧洲重症医学会(ESICM)于2020年发布了非出血性重症成人患者的输血策略临床实践指南,目的在于解决非出血性重症成人患者的输血策略问题。本文对其重点内容进行解读,以帮助我国医务人员更好地学习和使用该指南。

关键词：非出血性重症成人患者输血临床实践指南指南解读

《美国心脏协会远程通讯心肺复苏术指南》摘译与解读

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中华危重病急救医学 2020年第6期32卷 658-663页

作者：洪健超陆宗庆吴颖华天凤杨旻安徽医科大学第二附属医院心肺复苏与危重病实验室合肥230601 安徽医科大学第二附属医院重症医学二科合肥230601

院外心搏骤停(OHCA)救治一直是困扰全球的医学挑战,及早识别与启动生存链与患者预后相关。2020年3月,美国心脏协会(AHA)在总结以往研究的基础上发布了远程通讯心肺复苏术(T-CPR)指南,详细介绍了T-CPR的具体流程、标准及注意事项。为帮... 详细信息

院外心搏骤停(OHCA)救治一直是困扰全球的医学挑战,及早识别与启动生存链与患者预后相关。2020年3月,美国心脏协会(AHA)在总结以往研究的基础上发布了远程通讯心肺复苏术(T-CPR)指南,详细介绍了T-CPR的具体流程、标准及注意事项。为帮助国内医生更好地了解T-CPR,为我国OHCA的急救提供参考,本文对该指南进行了摘译与解读。

关键词：远程通讯心肺复苏术院外心搏骤停美国心脏协会指南

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一种耦合电感零纹波高增益DC/DC变换器

电器与能效管理技术 2021年第2期 88-93页

作者：洪建超林国庆福州大学电气工程与自动化学院福建福州350108

针对新能源发电系统中直流升压变换器输入电流纹波大的问题,提出了一种耦合电感零纹波高增益直流变换器。变换器在Boost变换器基础上,引入耦合电感和二极管电容升压单元提高电压增益;同时在理论上实现输入电流零纹波,有助于提高发电效... 详细信息

针对新能源发电系统中直流升压变换器输入电流纹波大的问题,提出了一种耦合电感零纹波高增益直流变换器。变换器在Boost变换器基础上,引入耦合电感和二极管电容升压单元提高电压增益;同时在理论上实现输入电流零纹波,有助于提高发电效率。详细分析了变换器的工作原理和稳态特性,最后搭建了1台100 W的实验样机,验证了变换器的零输入电流特性和高增益特性。

关键词：新能源发电零纹波高增益耦合电感

基于深度卷积神经检测网络与显著性图像的遥感图像检测研究

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自动化与仪器仪表 2018年第12期 50-53,57页

作者：普措才仁洪建超西北民族大学数学与计算机科学学院

通过深度显著性图像检测算法,包括模型构建、二值化处理、模型训练方法等研究;实现将深度显著性算法与深度对象检测模型相结合的遥感图像目标检测模型,包括实现可靠的检测模型设计、精准的对象标定方法,实现较强鲁棒性的模型等;最终将... 详细信息

通过深度显著性图像检测算法,包括模型构建、二值化处理、模型训练方法等研究;实现将深度显著性算法与深度对象检测模型相结合的遥感图像目标检测模型,包括实现可靠的检测模型设计、精准的对象标定方法,实现较强鲁棒性的模型等;最终将该模型应用于检测遥感图像中的飞机自动检测,实现的软件能够应用于相关行业。

关键词：深度学习卷积神经网络遥感图像检测模型

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加强围术期质量管理

中国卫生质量管理 2011年第4期18卷 21-23页

作者：樊宏胡剑超阳红谭旭芬王乃俊杨叶生成都军区昆明总医院质量管理科云南昆明650032

加强围术期质量管理,确保手术安全,具有重要的现实意义。总结了以医院信息技术为平台,优化围术期质量管理流程,坚持依法管理,强化基础质量管理,加强关键环节质控,营造和谐氛围等做法。提出围术期质量管理需全体人员共同参与;质量管理要... 详细信息

加强围术期质量管理,确保手术安全,具有重要的现实意义。总结了以医院信息技术为平台,优化围术期质量管理流程,坚持依法管理,强化基础质量管理,加强关键环节质控,营造和谐氛围等做法。提出围术期质量管理需全体人员共同参与;质量管理要持续改进;质量管理要"以病人为中心"等建议。

关键词：质量管理围术期质量控制

Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases

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Bioactive Materials 2024年第9期39卷 14-24页

作者： Hang Zhou Chunyan Zhu Qing Zhao Jinliang Ni Haipeng Zhang Guangcan Yang jianchao Ge Chao Fang hong Wei Xianli Zhou Kun Zhang In-Patient Ultrasound Department Second Affiliated Hospital of Harbin Medical UniversitySurgeons’HallNo.246.XuefuRoadNangang DistrictHarbin CityHeilongjiang ProvPR China Department of Laboratory Medicine and Central Laboratory Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of Chin1No.32West Second SectionFirst Ring RoadChengdu610072SichuanPR China Ultrasound Research and Education Institute Shanghai Tenth People’s HospitalTongji University School of MedicineNo.301 Yan-chang-zhong RoadShanghai

Tumor-promoting niche after incomplete surgery resection(SR)can lead to more aggressive local progression and distant metastasis with augmented angiogenesis-immunosuppressive tumor microenvironment(TME).Herein,elevated neutrophil extracellular traps(NETs)and cancer-associated neurotransmitters(CANTs,e.g.,catecholamines)are firstly identified as two of the dominant ***,an injectable fibrin-alginate hydrogel with high tissue adhesion has been constructed to specifically co-deliver NETs inhibitor(DNase I)-encapsulated PLGA nanoparticles and an unselectiveβ-adrenergic receptor blocker(propranolol).The two components(i.e.,fibrin and alginate)can respond to two triggers(thrombin and Ca2+,respectively)in postoperative bleeding to gelate,shaping into an interpenetrating network(IPN)featuring high *** continuous release of DNase I and PR can wreck NETs and antagonize catecholamines to decrease microvessel density,blockade myeloid-derived suppressor cells,secrete various proinflammatory cytokines,potentiate natural killer cell function and hamper cytotoxic T cell *** reprogrammed TME significantly suppress locally residual and distant tumors,induce strong immune memory effects and thus inhibit lung ***,targetedly degrading NETs and blocking CANTs enabled by this in-situ IPN-based hydrogel drug depot provides a simple and efficient approach against SR-induced cancer recurrence and metastasis.

关键词： Neutrophil extracellular traps Cancer-associated neurotransmitters Interpenetrating network hydrogels Postsurgical cancer relapse and metastases Immunosuppressive tumor microenvironment

Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation

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Chinese Chemical Letters 2018年第7期29卷 1119-1122页

作者： Ci Xu jianchao Xu Han Liu Xuechen Li Department of Chemistry State Key Laboratory of Synthetic ChemistryThe University of Hong Kong

Based on a mechanism analogous to the serine/threonine ligation, the aspartic acid ligation, which is facilitated by the γ-amino alcohol based ligation and oxidation, is developed and applied to the synthesis of cyclic peptides. The γ-hydroxyl group triggers the ring-chain tautomerization via a 6-endo-trig process,while the δ-hydroxyl group facilitates the oxidative cleavage of the vicinal diol to give carboxylic acid.

关键词： Aspartic acid ligation Peptide cyclization Serine/threonine ligation Ring-chain tautomerization Acyl transfer Selective oxidation

ACCELERATED SYMMETRIC ADMM AND ITS APPLICATIONS IN LARGE-SCALE SIGNAL PROCESSING

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Journal of Computational Mathematics 2024年第6期42卷 1605-1626页

作者： jianchao Bai Ke Guo Junli Liang Yang Jing H.C.So Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an 710129China Key Laboratory of Optimization Theory and Applications at China West Normal University of Sichuan Province School of Mathematics and InformationChina West Normal UniversityNanchong 637009China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China Department of Electrical Engineering City University of Hong KongHong KongSARChina

The alternating direction method of multipliers(ADMM)has been extensively investigated in the past decades for solving separable convex optimization problems,and surprisingly,it also performs efficiently for nonconvex *** this paper,we propose a symmetric ADMM based on acceleration techniques for a family of potentially nonsmooth and nonconvex programming problems with equality constraints,where the dual variables are updated twice with different *** proper assumptions instead of the socalled Kurdyka-Lojasiewicz inequality,convergence of the proposed algorithm as well as its pointwise iteration-complexity are analyzed in terms of the corresponding augmented Lagrangian function and the primal-dual residuals,*** of our algorithm is verified by numerical examples corresponding to signal processing applications in sparse nonconvex/convex regularized minimization.

关键词： Nonconvex optimization Symmetric ADMM Acceleration technique Complexity Signal processing

Advancement in QDs for optoelectronic applications and beyond

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Nano Research 2024年第12期17卷 10426-10445页

作者： Memoona Qammar Max J.H.Tan Pengbo Ding jianchao Ge Yinthai Chan Jonathan E.Halpert Department of Chemistry Hong Kong University of Science and Technology(HKUST)Hong Kong 999077China Department of Chemistry Northwestern UniversityEvanstonIllinois 60208USA Cosmic Discovery Sdn Bhd 10 Jalan Wawasan 3/KU7Sungai Kapar Indah42200 KlangSelangorMalaysia

This review focuses on the history and current state of the art optoelectronic applications of quantum dots involving light *** focus mainly on three areas of commercial,or potential commercial interest,including quantum dot light emitting devices(QLEDs,sometimes called QD-LEDs),lasing applications,and quantum computing *** main connection between these areas is the development of the science and engineering needed to achieve electrical excitation of the quantum dot in an optoelectronic device in order to achieve emission with characteristics particularly suited to the application in *** to the special physics of quantum dots,these materials are particularly well suited for both existing commercial applications,and potentially for future applications,such as single photon sources,spin cubits,or polarized *** conclude with an analysis of the future prospects for these exciting *** 30 years of progress since the Nobel Prize winning work on monodisperse samples of QDs,our goal is to highlight the current start of the art,discuss the current issues for each technology,and suggest future goals for the next 30 years for quantum dot research.

关键词： quantum dots quantum confinement optoelectronic properties color purity lasing quantum coherence quantum computing