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Synthesis and Crystal Structure of a New One-dimensional Double Helical-chain Polymer, {Zn(O_2CC_(12)H_8CO_2)(H_2O)}_n

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1107-1110页

作者： YIN Pei-Xiu ZHANG jian wen Yi-Hang cheng jian-Kai LI Zhao-Ji YAO Yuan-Gen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

A new zinc polymer, {Zn（O2CC12H8CO2）（H2O）}, or {Zn（DPHA）（H2O）}n （O2CC12H8CO2, DPHA = 1,1′ -biphenyl-2,2′-dicarboxylate dianion） has been synthesized under hydrothermal conditions. The crystal is of monoclinic, space group P21/c with a = 12.8418（5）, b = 5.9505（2）, c = 17.2989（5） A, β = 104.020（2）°, V = 1282.52（8） A^3, C14H10O5Zn, Mr= 323.61, Z = 4, Dc = 1.676 g/cm^3,μ = 1.930 mm^-1, F（000） = 656, R = 0.0766 and wR = 0.1871 for 1775 observed reflections （I 〉 2σ（I））. It consists of Zn2（DPHA）2（H2O）2 units, which are further extended into a one-dimensional double helical-chain polymer via Zn-O bonding. The hydrogen bonding interactions extend the helical chains into a two-dimensional layer structure.

关键词： zinc polymer DPHA ligand one-dimensional double helical-chain,two-dimensional layer structure

Recent progress in ultraviolet and deep-ultraviolet nonlinear optical aluminoborates

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Chinese Journal of Structural Chemistry 2023年第3期42卷 47-55页

作者： Qing-Fen Li Wei-Feng Chen You-Zhao Lan jian-wen cheng Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical ChemistryZhejiang Normal UniversityJinhuaZhejiang321004China

Aluminoborates(ABOs)show wide ultraviolet(UV)transmittance,and are one of the important types of UV and deep-UV nonlinear optical(NLO)*** recent years,the combination of AlO_(n)(n=4,5,6)polyhedra or their fluorinated analogues with different polyborate anions leads to a rich variety of crystalline *** this review,we summarize the recent developments of UV and deep-UV NLO inorganic *** ABOs can be grouped into three types in terms of their compositions:(i)aluminum oxyborates,(ii)alkali/alkaline earth metal aluminoborates,and(iii)alkali/alkaline earth metal aluminoborate fluorides and *** discuss the synthesis,structural features,NLO properties,as well as related structure-performance relationships of these non-centrosymmetric ***,the future perspectives in this field are discussed.

关键词： Aluminum borate Nonlinear optical Ultraviolet Deep-ultraviolet

Detection of circulating tumor cells in hepatocellular carcinoma: applications in diagnosis, prognosis prediction and personalized treatment

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Hepatoma Research 2020年第9期6卷 65-79页

作者： Peng-Xiang Wang jian-wen cheng Xin-Rong Yang Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan University/Key Laboratory of Carcinogenesis and Cancer InvasionMinistry of EducationShanghai 200032P.R.China.

Hepatocellular carcinoma(HCC)is one of the most common malignant tumors worldwide and is associated with poor clinical prognosis,which is mainly caused by tumor recurrence and *** tumor cells(CTCs)are tumor cells shed into the bloodstream and regarded as the“seeds”of tumor recurrent or metastatic *** the past decade,the clinical value of CTC analysis has been extensively *** analysis is a representative form of liquid biopsy,offering a novel solution that can bypass the problems of invasive biopsy procedures,enabling comprehensive,non-invasive,and real-time disease *** HCC,CTC analysis has facilitated early detection and prognosis prediction,as well as treatment monitoring and therapeutic intervention *** this review,we summarize available literature and provide an overview of CTC biology,detection technologies,and clinical applications in the diagnosis,prognosis prediction,and personalized treatment of HCC.

关键词： Hepatocellular carcinoma liquid biopsy circulating tumor cells biomarkers personalized medicine

A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

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Genes & Diseases 2019年第4期6卷 419-430页

作者： Wei Wang Bo Hu jiang-jiang Qin jian-wen cheng Xin Li Mehrdad Rajaei Jia Fan Xin-Rong Yang Ruiwen Zhang Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTX77204USA Drug Discovery Institute University of HoustonHoustonTX77204USA Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai200032China Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Fudan UniversityShanghai200032China

Overexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor commonly occur in hepatocellular carcinoma(HCC)and are associated with increased mortality due to this *** MDM2 has been demonstrated to be a valid approach for the treatment of ***,most of the MDM2 inhibitors evaluated to date have been designed to block the MDM2 and p53 binding,and have limited efficacy against tumors with mutant or deficient *** the present study,we developed a novel MDM2 inhibitor(termed SP141)that has direct effects on MDM2 and exerts anti-HCC activity independent of the p53 status of the cancer *** demonstrate that SP141 inhibits cell growth and prevents cell migration and invasion,independent of ***,SP141 directly binds the MDM2 protein and promotes MDM2 *** inhibition of MDM2 by SP141 also increases the sensitivity of HCC cells to *** addition,in orthotopic and patient-derived xenograft models,SP141 inhibits MDM2 expression and suppresses tumor growth and metastasis,without any host ***,the inhibition of MDM2 by SP141 is essential for its anti-HCC *** results provide support for the further development of SP141 as a lead candidate for the treatment of HCC.

关键词： CRISPR/Cas9 Hepatocellular carcinoma MDM2 p53-independent Patient-derived xenograft

Approximation Algorithms for Solving the 1-Line Minimum Steiner Tree of Line Segments Problem

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Journal of the Operations Research Society of China 2024年第3期12卷 729-755页

作者： jian-Ping Li Su-Ding Liu Jun-Ran Lichen Peng-Xiang Pan wen-cheng Wang Department of Mathematics Yunnan UniversityKunming650504YunnanChina School of Mathematics and Physics Beijing University of Chemical TechnologyBeijing650504China

We address the 1-line minimum Steiner tree of line segments(1L-MStT-LS)***,given a set S of n disjoint line segments in R^(2),we are asked to find the location of a line l and a set E_(l) of necessary line segments(i.e.,edges)such that a graph consisting of all line segments in S ∪ E_(l) plus this line l,denoted by T_(l)=(S,l,E_(l)),becomes a Steiner tree,the objective is to minimize total length of edges in E_(l) among all such Steiner ***,we are asked to find a set E_(0) of necessary edges such that a graph consisting of all line segments in S ∪ E_(0),denoted by T_(S)=(S,E_(0)),becomes a Steiner tree,the objective is to minimize total length of edges in E_(0) among all such Steiner trees,we refer to this new problem as the minimum Steiner tree of line segments(MStT-LS)*** addition,when two endpoints of each edge in Eo need to be located on two different line segments in S,respectively,we refer to that problem as the minimum spanning tree of line segments(MST-LS)*** obtain three main results:(1)Using technique of Voronoi diagram of line segments,we design an exact algorithm in time O(n log n)to solve the MST-LS problem;(2)we show that the algorithm designed in(1)is a 1.214-approximation algorithm to solve the MStT-LS problem;(3)using the combination of the algorithm designed in(1)as a subroutine for many times,a technique of finding linear facility location and a key lemma proved by techniques of computational geometry,we present a 1.214-approximation algorithm in time O(n^(3) log n)to solve the 1L-MStT-LS problem.

关键词： 1-Line minimum Steiner tree of line segments Minimum spanning tree of line segments Voronoi diagram of line segments Steiner ratio Approximation algorithms

Substantial increase of heat-induced labor and economic loss in China under rapid economic and environmental temperature growth

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Advances in Climate Change Research 2024年第4期15卷 708-716页

作者： Bo-wen CHU jian-Feng LUO Ke-Xin WANG Zhen-cheng XING Hai-Kun WANG Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric SciencesNanjing UniversityNanjing 210023China Collaborative Innovation Center of Climate Change Jiangsu ProvinceNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China Nanjin-Helski Insiute in Amosperc and Earth System Sciences Nanjing UniversityNanjing 210023China

Exposure to heat stress causes diminished work performance and leads to economic *** the last two decades,China has experienced both rapid economic development and environmental warming;however,the spatiotemporal variations of association between environmental heat and labor loss have been rarely investigated behind this double ***,we evaluated the variation in China's heat-induced labor productivity loss and related economic cost from 2001 to 2019 and investigated the effect of economic development and regional *** found that decline in labor productivity because of heat stress increased significantly(p<0.05 for heavy-intensity work),and the corresponding economic loss also exhibited a drastic increase by 6-to *** relative economic loss showed a slight but nonsignificant increase with an average value of 0.54%of the annual total *** the sub-regional and sectoral level,adverse effects were more prominent in the southeast region,and the secondary industry sectors,such as construction and manufacturing,contributed to larger proportions of economic *** transformation of industrial structure made economic sectors more vulnerable to heat exposure,and increasingly preventive effects of air-conditioning use were noted on economic damage due to heat-induced productivity decline(36.0%relative economic benefits in 2019 compared to 9.7%in 2001).Our findings could provide a deep insight into heat burden on occupational health and heat adaptation strategies regionally under climate change,especially in developing areas with higher temperature and humidity environment.

关键词： Heat stress Labor loss Wet bulb globe temperature China Economic impact

Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2727-2741页

作者： Hui-Ying jian Zi-cheng Liang Huan wen Zhen Zhang Pu-Hua Zeng Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Hospital of Integrated Traditional Chinese and Western Cancer Research Institute of Hunan Academy of Traditional Chinese MedicineHunan Academy of Chinese MedicineChangsha 410006Hunan ProvinceChina

BACKGROUND Previous studies have shown that the Shi-pi-xiao-ji(SPXJ)herbal decoction formula is effective in suppressing hepatocellular carcinoma(HCC),but the underlying mechanisms are not ***,this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1(ACAT1)-regulated cellular *** a series of experiments,we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1,lowering the level of cholesterol in the cell membrane,and altering the cellular stiffness,which provides a new idea for the research of traditional Chinese medicine against *** To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of *** HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type *** apoptotic rate and proliferative,invasive,and migratory abilities of control and SPXJ-treated HCC cells were *** force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC *** membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection ***1 protein levels were estimated using western *** Compared with the vehicle group,SPXJ serum considerably reduced proliferation of HCC cells,increased stiffness and apoptosis of HCC cells,inhibited migration and invasion of HCC cells,decreased plasma membrane cholesterol levels,and upregulated ACAT1 protein ***,treatment of HCC cells with the water-soluble cholesterol promoted proliferation,migration,and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels,but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle *** SPXJ formula inhibited proliferation,invasion,and migration

关键词： Shi-pi-xiao-ji formula Hepatocellular carcinoma Cellular stiffness Plasma membrane cholesterol level AcetylcoA acetyltransferase 1

Flow characteristics and bubble statistics during the fragmentation process of the ingested main cavity in plunging breaking waves

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Journal of Hydrodynamics 2024年第3期36卷 546-555页

作者： wen-bin Zhang Wei-wen Zhao De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

Plunging breaking waves play an important role in the exchange of heat,momentum,and mass between the atmosphere and *** this paper,a series of direct numerical simulations is conducted to investigate the fragmentation process of the ingested main cavity in plunging breaking *** two-phase Navier-Stokes equations are solved using the finite-volume method based on adaptive refinement *** free surface is captured using a geometrical volume of fluid *** 2-D,3-D simulations are *** flow fields at different stages of wave breaking are presented and quantitative analysis for bubbles is *** 2-D instantaneous vorticity field and local velocity field are visualized to discuss the general flow characteristics during the fragmentation *** a 2-D parametric study is conducted to investigate the differences in the flow characteristics during the fragmentation process under different wave parameters including initial wave steepness(ε),Bond number(Bo),and Reynolds number(Re).3-D vortex structures are shown to further investigate the mechanisms behind the differences in the flow *** bubble size distributions under two different initial wave steepness are also discussed with their relationship to the fragmentation process of the ingested main *** research offers a significant understanding of the distinct procedures and fundamental dynamics involved in wave breaking,enhancing our comprehension of this intricate event.

关键词： Plunging breaking waves multiphase flow bubble statistics

In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： Wei-jian Guo Ao Zhou wen-wen Cai Jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry(Ministry of Education) School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO_(2))into high-value chemicals,thereby presenting a promising avenue toward achieve carbon ***,addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting *** this study,the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ *** porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer,thus enhancing their electrocatalytic activity and ***,nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions,thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical ***,Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential ***,its faradaic efficiency(FE)of formate reaches 92.7%in H-cell and94.9%in flow cell,respectively,with good electrocatalytic *** in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Porous carbon nanofiber N-doping Electron delocalization Carbon dioxide reduction