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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG Xin ZHANG Zhao-xin LI Li-fei HE feng CHEN Ming-long LIU Ying-ze huang jian-mei MO Kong-lan LUO Juan-juan XIAO feng ZHU Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

A Transparent Photoresist Made of Titanium Dioxide Nanoparticle-Embedded Acrylic Resin with a Tunable Refractive Index for UV-Imprint Lithography

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Engineering 2024年第6期37卷 96-104页

作者： Yinglu Liu Dan Wang Changlin Liu Qianqian Hao jian Li Jie-Xin Wang Xiuyun Chen Peng Zhong Xibin Shao jian-feng Chen State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China BOE Technology Group Co. Ltd.Beijing 100176China

Transparent photoresists with a high refractive index(RI)and high transmittance in visible wavelengths have promising functionalities in optical *** work reports a kind of tunable optical material composed of titanium dioxide nanoparticles embedded in acrylic resin with a high RI for ultraviolet(UV)-imprint *** hybrid film exhibits a tunable RI of up to 1.67(589 nm)after being cured by UV light,while maintaining both a high transparency of over 98%in the visible light range and a low haze of less than 0.05%.The precision machining of optical microstructures can be imprinted easily and efficiently using the hybrid resin,which acts as a light guide plate(LGP)to guide the light from the side to the top in order to conserve the energy of the display *** preliminary studies based on both laboratory and commercial experiments pave the way for exploiting the unparalleled optical properties of nanocomposite resins and promoting their industrial application.

关键词： Photoresist Tunable refractive index Hanson solubility Ultraviolet imprint Organic-inorganic composites

A fibrous hydroelectric generator derived from eco-friendly sodium alginate for low-grade energy harvesting

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Frontiers in Energy 2024年第4期18卷 474-482页

作者： feng GONG Jiaming SONG Haotian CHEN Hao LI Runnan huang Yuhang JING Peng YANG Junjie feng Rui XIAO Key Laboratory of Energy Thermal Conversion and Control of the Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

With the development of renewable energy technologies,the recovery and utilization of low-grade energy based on hydroelectric effect have drawn much attention owing to its environmental ***,a novel hydroelectric generator utilizing sodium alginategraphene oxide(SA-GO)fibers is proposed,which is ecofriendly and *** fibers with a length of 5 cm and a diameter of 0.15 mm can generate an open circuit voltage(Voc)of approximately 0.25 V and a short circuit current(Isc)of 4µ*** connecting SA-GO fibers in either series or parallel,this combination can power some electronic ***,these fibers enable the recovery of low-grade energy from the atmosphere or around the human *** experimental and theoretical analysis confirm that the directional flow of protons driven by water molecules is the main mechanism for power generation of SA-GO *** study not only presents a simple energy transformation method that is expected to be applied to our daily life,but also provides a novel idea for the design of humidity electricity-generation devices.

关键词： fibrous hydroelectric generator sodium alginate(SA) graphene oxide(GO) power generation

Combination of methylthio-chemistry with living crystallization-driven self-assembly toward uniformπ-conjugated nanostructures with antibacterial activity,surface tailorability,tunable morphology and dimension

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Science China Chemistry 2024年第7期67卷 2341-2352页

作者： Chuyu Duan Binbin Xu Ruru Li Xiaoyu huang Shaoliang Lin Chun feng Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Living crystallization-driven self-assembly(CDSA)provides robust access to uniformπ-conjugated nanostructures(CNSs)from block copolymers(BCPs)containing a crystallineπ-conjugated segment with controlled dimension,morphology and composition,which show appealing applications in biomedicine,photocatalysis and *** further expand the application spectrum of these CNSs,the development of facile strategies toward diverse CNSs with varying structures/functionalities is highly ***,BCPs consisting of oligo(p-phenylene ethynylene)-b-poly(polypropyl-3-methanethiol acrylate)(OPE_(9)-bPMTPA35and OPE_(9)-b-PMTPA_(58);the subscript represents the number of repeat unit of each block)consisting of a crystallineπ-conjugated core-forming OPE_(9)segment and a corona-forming PMTPA block are *** efficient“click-type”alkylation of methylthio groups,OPE_(9)-b-PMTPA with varying contents of sulfonium unit is *** ribbon-like micelles with different widths and lengths can then be generated in a controlled manner via the self-seeding approach of living ***,negatively charged polymeric and Ag nanoparticles can be immobilized on sulfonium/methylthio-containing shells by taking advantage of electrostatic attraction and coordination interaction,***,the ribbon-like micelles with positively charged shells exhibit antibacterial activity against *** the ease of modification of PMTPA-based shell and attractive opto-electronic/photocatalytic properties ofπ-conjugated units,the combination of methylthio-chemistry and living CDSA opens a new avenue to generate multi-functional CNSs for widespread applications from biomedicine to photocatalysis.

关键词： crystallization-driven self-assembly block copolymer π-conjugated nanostructure methylthio-chemistry

Traceable Lactate-Fueled Self-Acting Photodynamic Therapy against Triple-Negative Breast Cancer

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Research 2024年第3期2024卷 723-733页

作者： Yifan Zhang Guangle feng Ting He Min Yang Jing Lin Peng huang Marshall Laboratory of Biomedical Engineering International Cancer CenterShenzhen Key Laboratory of Tumor Visualization Molecular MedicineLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen518055China.

The depth of light penetration and tumor hypoxia restrict the efficacy of photodynamic therapy(PDT)in triple-negative breast cancer(TNBC),while the overproduction of lactate(LA)facilitates the development,aggressiveness,and therapy resistance of *** address these issues,a self-acting PDT nanosystem(HL@hMnO_(2)-LO_(x)@HA)is fabricated by loading 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha(HPPH),luminol,and LA oxidase(LO_(x))in a hyaluronic acid(HA)-coated hollow manganese dioxide(hMnO_(2))***_(x) catalyzes the oxidation of LA into pyruvate and hydrogen peroxide(H_(2)O_(2)),thus depleting the overproduced intratumoral *** the acidic tumor microenvironment,H_(2)O_(2) reacts with luminol and hMnO_(2) to yield blue luminescence as well as O_(2) and Mn^(2+),***^(2+)could further enhance this *** is then excited by the chemiluminescence through chemiluminescence resonance energy transfer for self-illuminated *** generated O_(2) alleviates the hypoxia state of the TNBC tumor to produce sufficient 1O_(2) for self-oxygenation *** Mn^(2+)performs T1 magnetic resonance imaging to trace the self-acting PDT *** work provides a biocompatible strategy to conquer the limits of light penetration and tumor hypoxia on PDT against TNBC as well as LA overproduction.

关键词： Breast Therapy manganese

Effect of Frequency on Degradation in BOPP Films Under Repetitively Pulsed Voltage

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1280-1290页

作者： Chuansheng Zhang Yu feng Fei Kong Bangdou huang Cheng Zhang Tao Shao Beijing International S&T Cooperation Base for Plasma Science and Energy Conversion Institute of Electrical EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Operating conditions of film capacitors are complex,and the problem of film insulation failure caused by repetitively pulsed voltage is becoming ever *** of the film under repetitively pulsed voltage cannot be accurately evaluated by the average breakdown electric *** this paper,the effects of pulsed electric field and pulse repetition frequency on the breakdown in biaxially oriented polypropylene(BOPP)films are *** phases of BOPP degradation are proposed based on the voltage amplitude,i.e.,maintenance(M),decline(D),and near-zero(N).Evolution of the BOPP film from degradation to breakdown at different frequencies is ***,transition of discharge mode and elemental composition of the film are *** results show continuous heat generation under repetitive microsecond pulses is the dominant factor for degradation of BOPP *** number of applied pulses and the repetitive stressing time decrease exponentially with increase of *** research can be contributed to the safe and reliable operation of capacitors.

关键词： Aging breakdown film capacitor polypropylene repetitive pulse

Algorithmic approach to discrete fracture network flow modeling in consideration of realistic connections in large-scale fracture networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3798-3811页

作者： Qihua Zhang Shan Dong Yaoqi Liu Junjie huang feng Xiong Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China SINOPEC Shanghai Engineering Co. Ltd.Shanghai200120China Faculty of Engineering China University of GeosciencesWuhan430074China

Analyzing rock mass seepage using the discrete fracture network(DFN)flow model poses challenges when dealing with complex fracture *** paper presents a novel DFN flow model that incorporates the actual connections of large-scale ***,this model efficiently manages over 20,000 fractures without necessitating adjustments to the DFN *** geometric analyses,such as identifying connected fractures,dividing the two-dimensional domain into closed loops,triangulating arbitrary loops,and refining triangular elements,are fully *** analysis processes are comprehensively introduced,and core algorithms,along with their pseudo-codes,are outlined and explained to assist readers in their programming *** accuracy of geometric analyses is validated through topological graphs representing the connection relationships between *** practical application,the proposed model is employed to assess the water-sealing effectiveness of an underground storage cavern *** analysis results indicate that the existing design scheme can effectively prevent the stored oil from leaking in the presence of both dense and sparse ***,following extensive modification and optimization,the scale and precision of model computation suggest that the proposed model and developed codes can meet the requirements of engineering applications.

关键词： Discrete fracture network(DFN)flow model Geometric algorithm Fracture flow Water-sealing effect

Centrifuge study on behavior of raft foundation after tunnelling in soft clay

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Underground Space 2024年第4期17卷 161-169页

作者： jian Yu Jiaming Liu Chun Fai Leung Maosong huang Qi Wen Jorgin Tan Department of Geotechnical Engineering Key Laboratory of Geotechnical and Underground Engineering of Ministry of EducationTongji UniversityShanghai 200092China Centre for Offshore Research and Engineering Department of Civil and Environmental EngineeringNational University of Singapore119077Singapore Land Transport Authority 219428Singapore

Ground losses due to tunneling would induce settlement of nearby raft *** study the change in behavior of the raft foundations over time due to tunnel excavation in soft clay,a series of centrifuge model tests were *** results reveal that the raft stiffness has a significant influence on the development of the gap between the raft and the *** width of the gap beneath the flexible foundation would increase over time,leading to a further increase in tensile strain after excavation,whereas the gap for raft foundations with a large stiffness would reduce with time,causing a gradual decrease in tensile *** modification factor(MF)design approach is also evaluated with the test results and demonstrates that the MF design approach would underestimate the tensile strain of the flexible raft and provide a relatively conservative prediction for larger stiffnesses.

关键词： Tunnelling Raft Clay Deflection ratio Centrifuge test

Charge-controlled compositional/microstructural regulations and electrochemical actuation performance of bulk nanoporous Ni-Pd alloys

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Rare Metals 2024年第10期43卷 5305-5317页

作者： Fu-Quan Tan Qing-Guo Bai Bin Yu jian-feng Wang Zhong-Hua Zhang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University School of Applied Physics and Materials Wuyi University Ira A.Fulton School of Engineering Arizona State University

Bulk nanoporous （np） metallic actuators have attracted increasing attention due to their large strain and low stimulation ***,studies focusing upon the combined effect of composition and structure on the actuation performance of metallic actuators are relatively scarce,and its underlying mechanism needs to be clarified Herein,a series of bulk np-NiPd samples with differen compositions and microstructures were fabricated using a dealloying-coarsening-dealloying strategy and chargecontrolled electrochemical dealloying,and the process involves only one component of precursor *** has been found that the np-NiPd cubes show a composition/structure-dependent mechanical property and electrochemical actuation ***,the npNi70Pd30sample with a homogeneously porous structure and good network connectivity exhibits significantly larger strain amplitude and faster strain rate than other hierarchically porous NiPd samples (np-Ni50Pd50and npNi20Pd80).Moreover,the np-Ni70Pd30sample demonstrates good actuation stability with high strain retention after hundreds of ***,the maximum strain amplitude （1.17%） is even comparable to that of advanced leadfree piezoceramic,and the maximum strain rate exceeds those of many reported metallic actuator *** work indicates that good network connectivity plays a vita role in facilitating large/fast strain response in metallic actuators.

关键词： Actuation stability Bulk nanoporous NiPd Electrochemical dealloying Good network connectivity Metallic actuators