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Potential role of the compound Eucommia bone tonic granules in patients with osteoarthritis and osteonecrosis: A retrospective study

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World Journal of Clinical Cases 2020年第1期8卷 46-53页

作者： Cheng-Xia Hu Ke-Yao Hu jian-feng wang Department of Pain Haiyang People’s HospitalYantai 265100Shandong ProvinceChina Department of Urology Yantaishan HospitalYantai 264001Shandong ProvinceChina Department of Pain Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Osteoarthritis is a major source of pain,disability,and socioeconomic cost *** is a disabling disorder that frequently occurs in the younger population aged from 20-50 *** compound Eucommia bone tonic granules,a traditional Chinese medicine,can alleviate the damage of osteoarthritis and *** To investigate the potential role of the compound Eucommia bone tonic granules(Eucommia)in the treatment of patients with osteoarthritis and *** One-hundred forty osteoarthritis and osteonecrosis cases admitted to our hospital from January 2013 to December 2017 were *** were divided into two groups:Eucommia-meloxicam group and meloxicam *** efficacy and the Western Ontario and McMaster Universities Arthritis Index(WOMAC)score were evaluated according to the evaluation criteria of orthopedic *** levels of bone-GLA protein,interleukin-17,recombinant human S100 calcium binding protein A12,sphingosine 1-phosphate,cystatin C,creatinine,and hemoglobin in peripheral blood were *** The total effective rate in the two osteoarthritis groups was not different,but the total effective rate in the two osteonecrosis groups was significantly *** overall efficacy of Eucommia-meloxicam group was superior to that of the meloxicam *** showed that pain,stiffness,and dysfunction in the two groups of osteoarthritis and osteonecrosis before and after treatment were significantly *** concentration of recombinant human S100 calcium binding protein A12,sphingosine 1-phosphate,cystatin C,creatinine,and hemoglobin before and after treatment in the Eucommia-meloxicam group and meloxicam group of osteoarthritis and osteonecrosis were significantly different,and the two treatment groups were significantly different from each other for *** Our findings indicate that Eucommia can effectively enhance the curative effect of meloxicam,and the combinat

关键词： Osteoarthritis Osteonecrosis Eucommia Patients Meloxicam Drug

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Synergistic silver-mediated and palladium-catalyzed nondirected olefination of aryl C–H bond: quick access to multi-substituted aryl olefins

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Science China Chemistry 2024年第3期67卷 882-889页

作者： jian Yao Lili Shao Xiaohong Huo Xiaoming wang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 20032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Transition metal-catalyzed olefination of aryl C-H bond is a powerful tool for the synthesis of alkenes. While the Pd-catalyzed oxidative C-H olefination of arenes, also known as Fujiwara-Moritani reaction, has been established as one of the most efficient methods, the substrates are largely limited to terminal olefins with electron-withdrawing group(s). Herein, we report a synergistic silver-mediated and palladium-catalyzed non-directed C-H olefination of arenes with vinyl(pseudo)halides, which offers a complementary strategy to the typical Fujiwara-Moritani reaction. The reactions proceeded well for a variety of halogenated arenes, heteroarenes, and olefin substrates, providing an efficient access to various multi-substituted aryl olefins, including trisubstituted/tetrasubstituted olefins and several complex olefins derived from medicines or natural products. Mechanistic studies indicated a bimetallic Pd/Ag cooperation is operative in the catalysis, i.e., the reaction is initiated by aryl C-H bond cleavage via ligation with phosphine/Ag species, followed by transferring of the aryl moiety to a vinyl palladium intermediate,which is in turn formed by oxidative addition of vinyl(pseudo)halide to a Pd complex. This method enables the synthesis of a wide range of challenging multi-substituted vinyl products from simple arenes(directing-group free) in a streamlined and controllable fashion.

关键词： direct C–H olefination multi-substituted aryl alkenes bimetallic Pd/Ag cooperation C–H functionalization

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Advancing mid-infrared microdisk laser emission with Tm:YAG

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 91-96页

作者： Zhaocong wang Huiqi Li Lei wang Yang Tan feng Chen School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

Mid-infrared microcavity lasers have important applications in biosensing,mid-infrared spectroscopy,and environmental ***,the low output power of existing mid-infrared microcavity lasers hinders their practical *** drawback is attributed to the insufficient laser gain medium,which limits the development of mid-infrared whispering-gallerymode(WGM)*** address this issue,we have employed ion implantation-enhanced etching to fabricate Tm:YAG thin films as effective gain media for mid-infrared WGM *** Tm:YAG thin film,with a thickness of 2μm,exhibits excellent fluorescence ***,the Tm:YAG thin film is processed using focused ion beam to form microdisks with a diameter of 30μ*** 785 nm laser pumping,the maximum output power of the Tm:YAG microdisk at 2023.1 nm is229μW,with a slope efficiency of 2.9%.This work demonstrates the outstanding potential of Tm:YAG as a mid-infrared laser gain medium,providing a new option for the development of mid-infrared lasers.

关键词： microdisk microlaser ultrathin film

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Pd-catalyzed asymmetric carbonyl alkynylation:Synthesis of axial chiral ynones

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Chinese Chemical Letters 2024年第6期35卷 293-297页

作者： Long Jin jian Han Dongmei Fang Min wang jian Liao Natural Products Research Center Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China College of Chemical Engineering Sichuan UniversityChengdu 610065China University of Chinese Academy of Sciences Beijing 100049China

Ynones are important skeletons in bioactive molecules and valuable building blocks for organic synthesis,thus great efforts have been devoted to their ***,introducing prochiral substrates to construct ynones bearing a chiral framework is unrealized to ***,we reported the first example of Pd/SOP-catalyzed asymmetric carbonylative alkynylation via a non-classical carbonylative Sonogashiratype approach(acyl-Pd(Ⅱ)species generated from nucleophiles).By using cyclic diaryliodonium salts as prochiral substrates,various axial chiral ynones with good functional group tolerance(39 examples),satisfied yields(71%-96%)and excellent enantioselectivities(generally 94%-99%ee)were *** of bioactive compounds,scale-up experiment and useful transformations were also conducted to demonstrate the utility of this process.

关键词： Pd-catalyzed Axial chiral ynones Cyclic diaryliodonium High-valent palladium catalyzed Asymmetric carbonyl alkynylation

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Covariate-Assisted Matrix Completion with Multiple Structural Breaks

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Journal of Systems Science & Complexity 2024年第2期37卷 692-728页

作者： MENG Jing feng Long ZOU Changliang wang Zhaojun School of Statistics and Data Science KLMDASRLEBPSand LPMCNankai UniversityTianjin 300071China

In matrix completion,additional covariates often provide valuable information for completing the unobserved entries of a high-dimensional low-rank matrix *** this paper,the authors consider the matrix recovery problem when there are multiple structural breaks in the coefficient matrix β under the column-space-decomposition model A=Xβ+B.A cumulative sum(CUSUM)statistic is constructed based on the penalized estimation of β.Then the CUSUM is incorporated into the Wild Binary Segmentation(WBS)algorithm to consistently estimate the location of ***,a nearly-optimal recovery of A is *** findings are further corroborated via numerical experiments and a real-data application.

关键词： Additional covariates matrix completion multiple structural breaks wild Binary Segmentation

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Creep constitutive model considering nonlinear creep degradation of fractured rock

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International Journal of Mining Science and Technology 2024年第1期34卷 105-116页

作者： wang Chunping Liu jianfeng Chen Liang Liu jian wang Lu Liao Yilin Beijing Research Institute of Uranium Geology Beijing 100029China CAEA Innovation Center for Geological Disposal of High-Level Radioactive Waste Beijing 100029China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China School of Architecture and Civil Engineering Xihua UniversityChengdu 610039China

Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fractured at 30° and 45° angles. The experimental results indicate that the steady creep strain rates of intact and fractured rock present an exponential increase trend with the increase of stress level. A nonlinear creep model is developed based on the experimental results, in which the initial damage caused by fracture together with the damage caused by constant load have been taken into consideration. The fitting analysis results indicated that the model proposed is more accurate at identifying the full creep regions in fractured granite, especially the accelerated stage of creep deformation. The least-square fit error of the proposed creep model is significantly lower than that of Nishihara model by almost an order of magnitude. An analysis of the effects of elastic modulus, viscosity coefficient, and damage factors on fractured rock strain rate and creep strain is conducted. If no consideration is given to the effects of the damage, the proposed nonlinear creep model can degenerate into to the classical Nishihara model.

关键词： Fractured rock Damage Creep Beishan granite Geological disposal

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A new method for identifying flow pattern of spouted fluidized bed by coupling Hilbert-Huang transform characteristics of differential pressure signals in different zones

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Particuology 2024年第6期89卷 67-78页

作者： Yongzhi Mei Yang wang Lihui Zhang feng Duan School of Energy and Environment Anhui University of TechnologyMaanshan243002China Wuhu Technology and Innovation Research Institute Wuhu241000China Wuhu Cigarette Factory of China Tobacco Anhui Industrial Co. Ldt.Wuhu241002China

On a cold spouted fluidized bed,this study compares the characteristic differences in intrinsic mode function(IMF)energy and Hilbert–Huang spectrum between the spout zone and annulus zone under different combinations of spouted gas and fluidized gas flow rates for five typical flow *** energy distribution characteristics under different flow patterns are also *** Hilbert–Huang spectrum and IMF energy of pressure difference signals exhibit distinct variations in different zones as the flow pattern ***,there exists a correlation between the energy in the middle-frequency range and the flow *** the K-means algorithm,the middle-frequency range energy of IMFs in the spout zone and annulus zone is subjected to clustering analysis,leading to the identification of partition boundaries for each flow *** on this,a flow pattern identification method of spouted fluidized bed coupled with middle-frequency range energy in spout zone and annulus zone is proposed,which has very high identification accuracy.

关键词： Spouted fluidized bed Flow pattern Zoning signal Flow pattern transition Hilbert-Huang transform

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Securing multi-chain consensus against diverse miner behavior attacks in blockchain networks

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 540-554页

作者： Wenbo ZHANG Tao wang Chaoyang ZHANG Jingyu feng School of Cyberspace Security Xi’an University of Posts and TelecommunicationsXi’an 710121China Postal Savings Bank of China Xi’an 710000China

As cross-chain technologies enable interactions among different blockchains(hereinafter“chains”),multi-chain consensus is becoming increasingly important in blockchain ***,more attention has been paid to single-chain consensus ***-chain consensus schemes with trusted miner participation have not been considered,thus offering opportunities for malicious users to launch diverse miner behavior(DMB)attacks on different *** attackers can be friendly in the consensus process on some chains,called mask chains,to enhance their trust value,while on others,called kill chains,they engage in destructive behaviors on the *** this paper,we propose a multi-chain consensus scheme named Proof-of-DiscTrust(PoDT)to defend against DMB *** idea of distinctive trust(DiscTrust)is introduced to evaluate the trust value of each user across different *** trustworthiness of a user is split into local and global trust values.A dynamic behavior prediction scheme is designed to enforce DiscTrust to prevent an intensive DMB attacker from maintaining strong trust by alternately creating true or false blocks on the kill *** trusted miner selection algorithms for multi-chain environments can be implemented to select network miners,chain miners,and chain miner leaders,*** results show that PoDT is secure against DMB attacks and more effective than traditional consensus schemes in multi-chain environments.

关键词： Blockchain Cross-chain Trust mechanism Multi-chain consensus

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High-efficiency crystalline white organic lightemitting diodes

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Light(Science & Applications) 2024年第4期13卷 747-759页

作者： Yijun Liu feng Zhu Yue wang Donghang Yan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China. School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China. State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

Crystalline white organic light-emitting diodes(C-WOLEDs)are promising candidates for lighting and display *** is urgently necessary,however,to develop energy-saving and high-efficiency C-WOLEDs that have stable and powerful emission to meet commercial ***,we report a crystalline host matrix(CHM)with embedded nanoaggregates(NA)structure for developing high-performance C-WOLEDs by employing a thermally activated delayed fluorescence(TADF)material and orange phosphorescent dopants(Phos.-D).The CHM-TADFNA-D WOLED exhibit a remarkable EQE of 12.8%,which is the highest performance WOLEDs based on crystalline *** device has a quick formation of excitons and a well-designed energy transfer process,and possesses a fast ramping of luminance and current *** to recently reported high-performance WOLEDs based on amorphous material route,the C-WOLED achieves a low series-resistance Joule-heat loss ratio and an enhanced photon output,demonstrating its significant potential in developing the next-generation WOLEDs.

关键词： diodes dopant crystalline

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Research on performances of back-illuminated scientific CMOS for astronomical observations

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Research in Astronomy and Astrophysics 2021年第10期21卷 268-278页

作者： Peng Qiu Yong Zhao Jie Zheng jian-feng wang Xiao-Jun jiang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of ScienceBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

To evaluate performances of a back-illuminated scientific CMOS(sCMOS)camera for astronomical observations,comparison tests between Andor Marana s CMOS and Andor iKon-L 936 CCD cameras were conducted in a laboratory and on a *** laboratory tests showed that the readout noise of the sCMOS camera is about half lower,the dark current is about 17 times higher,the dynamic range is lower in the 12-bit setting and higher in the 16-bit setting,and the linearity and bias stability are comparable relative to those of the CCD *** field tests,we observed the open cluster M67 with the sCMOS and CCD cameras on a 60 cm *** the CCD camera,the sCMOS camera has a dual-amplifier *** a 16-bit image of the sCMOS camera is composed of two 12-bit images sampled with 12-bit high gain and low gain amplifiers simultaneously,it is not real 16-bit output *** evaluation tests indicated that the dual-amplifier architecture of the s CMOS camera leads to a decline of photometric stability by about six times around specific pixel *** photometry of bright objects with similar magnitudes that require high frame rates,the s CMOS camera under 12-bit setting is a good ***,the sCMOS camera is fitted with survey observations of variable objects requiring short exposure times,mostly less than 1 s,and high frame *** also satisfies the requirements for an offset guiding instrument owing to its high sensitivity,high temporal resolution and high stability.

关键词： detectors photometric observational

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