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Real-Variable Theory of Local Variable Hardy Spaces

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Acta Mathematica Sinica,English Series 2023年第7期39卷 1229-1262页

作者： jian TAN School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Mathematics Nanjing UniversityNanjing 210093China

In this paper, we give a complete real-variable theory of local variable Hardy ***, we present various real-variable characterization in terms of several local maximal ***, the new atomic and the finite atomic decomposition for the local variable Hardy spaces are established. As an application, we also introduce the local variable Campanato space which is showed to be the dual space of the local variable Hardy spaces. Analogous to the homogeneous case, some equivalent definitions of the dual of local variable Hardy spaces are also considered. Finally, we show the boundedness of inhomogeneous Calderon–Zygmund singular integrals and local fractional integrals on local variable Hardy spaces and their duals.

关键词： Local Hardy space atom variable exponent analysis local BMO-type space inhomogeneous Calderón–Zygmund singular integrals local fractional integrals

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纳米粒子在骨组织工程化基因修饰治疗中的应用

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中国组织工程研究 2025年第22期29卷 4771-4783页

作者：李光照裴锡波王剑口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院修复科四川省成都市610041

背景:传统的骨组织工程技术治疗临界骨缺损存在成骨效率低、安全性差等问题。而以非病毒纳米粒子为基因载体构建的基因强化型骨组织工程移植物,具有更高的成骨效率和安全性,引起了国内外学者的广泛关注和研究。目的:对当前国内外有关纳... 详细信息

背景:传统的骨组织工程技术治疗临界骨缺损存在成骨效率低、安全性差等问题。而以非病毒纳米粒子为基因载体构建的基因强化型骨组织工程移植物,具有更高的成骨效率和安全性,引起了国内外学者的广泛关注和研究。目的:对当前国内外有关纳米粒子在组织工程成骨基因治疗研究中取得的新技术、新方法以及面临的挑战等进行综述,旨在为纳米粒子介导的骨组织工程基因治疗研究提供参考。方法:第一作者在Pub Med、Web of Science和中国知网数据库上进行文献检索,并以“Bone defect repair,Bone tissue engineering,Gene delivery,Nanoparticles,Non-viral gene vector,Sustained release technology,Sequential release,Targeted delivery”作为英文检索词,以“骨缺损修复,骨组织工程,基因递送,纳米粒子,非病毒基因载体,缓释技术,序贯释放,靶向递送”作为中文检索词,最终纳入84篇文献进行总结。结果与结论:(1)在骨缺损愈合的各个生理阶段进行针对性的基因递送可以显著增强骨修复效果。在早期炎症阶段,通过纳米粒子递送抗炎基因来调节炎症反应,可以为后续骨愈合奠定基础;在血管新生期,向局部递送促血管化基因有助于形成高度组织化、可灌注的血管系统,加快骨愈合速度;随着血管化的进行,骨骼的神经再支配也开始发生,此时递送促神经再生的功能性基因有利于促进神经化骨再生;在成骨阶段,通过构建纳米粒子-成骨基因复合物,可以直接提升支架及体内新骨形成的效率。(2)各种有机、无机纳米颗粒、金属有机框架和外泌体等非病毒纳米载体,在骨组织工程基因治疗中具有巨大的潜力,这些纳米基因载体各有其独特的优势和不足,因此在实际应用时,需要根据基因转染效率、生物安全性和成骨特性等因素选择最合适的类型。(3)为了全面提升递送基因的效果,目前主要通过对纳米载体进行各种功能设计来增强基因转染效率,包括增强缓释性和多基因递送序贯性等时间调控能力、增强对骨组织和成骨相关细胞的空间靶向能力、增强跨膜运输效率和细胞核靶向能力等全过程调控手段。(4)未来要进一步推动纳米粒子介导的骨组织工程基因治疗在临床上的应用,还需要克服诸多技术挑战,包括提高有机纳米基因载体的基因转染效率、降低无机纳米载体的生物安全性风险、优化新型纳米载体的生产工艺以及促进其它生理过程与成骨交互作用等,这些问题也是未来骨组织工程基因治疗的研究热点和潮流。

关键词：骨缺损修复骨组织工程基因递送纳米粒子非病毒基因载体缓释技术序贯释放靶向性递送

影响牙髓干细胞成骨及成牙本质分化的相关物理因素及作用机制

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中国组织工程研究 2025年第7期29卷 1531-1540页

作者：孙玉婷吴家媛张剑遵义医科大学口腔医学院贵州省遵义市563000

背景:牙髓干细胞是口腔颌面部组织工程中极具应用潜力的干细胞之一,较骨髓间充质干细胞具有采集方便、伦理问题少以及增殖分化潜能高等优势。目前,除了生物化学等因素外,物理刺激对于牙髓干细胞的成骨/成牙本质分化也起着关键性的作用... 详细信息

背景:牙髓干细胞是口腔颌面部组织工程中极具应用潜力的干细胞之一,较骨髓间充质干细胞具有采集方便、伦理问题少以及增殖分化潜能高等优势。目前,除了生物化学等因素外,物理刺激对于牙髓干细胞的成骨/成牙本质分化也起着关键性的作用。目的:综述影响牙髓干细胞成骨/成牙本质分化的相关物理因素以及可能涉及的信号传导通路作用机制,寻找影响其分化的最佳诱导条件。方法:检索PubMed和中国知网数据库,以“牙髓干细胞,成骨分化,成牙本质分化,低氧,机械力,激光,磁场,微重力”为中文检索词,以“dental pulp stem cells(DPSCs),osteogenesis differentiation,odontoblastic differentiation,hypoxia,mechanical force,laser therapy,magnetic fields,microgravity”为英文检索词,选取与影响牙髓干细胞成骨/成牙本质分化相关物理因素有关的79篇文献进行综述。结果与结论:(1)微环境中直接或间接的物理信号在调控牙髓干细胞定向分化方面展现出了广阔的应用前景。低氧、力学刺激(动静水压力、机械牵张力及剪切力等)、激光、微重力和磁场等相关物理因素对牙髓干细胞的影响以促进成骨/成牙本质分化为主,因口颌系统拥有复杂的力学环境,力学刺激是细胞环境改变的关键物理因素,同时也是组织工程的一个前沿领域,深入探讨牙髓干细胞对力学环境的响应为口腔疾病的诊断及治疗提供新思路。(2)因该领域比较“年轻”,相关因素涉及的设备参数尚未统一,相关结果存在不一致性,未能达成共识,之后应进一步探索及优化相关物理因素的最佳诱导参数及作用条件。(3)支架材料作为组织工程的三要素之一,在牙髓干细胞成骨/成牙本质分化方面也起到了促进作用,同时也推动了材料学的发展及临床技术的进步。(4)其中涉及到的信号通路有Notch,Wnt,MAPK等,关于物理刺激如何调控牙髓干细胞行为的相关生物学基础尚未明确,未来将进一步探究其具体作用机制,为物理因素影响下的牙髓再生及骨组织工程提供新思路。

关键词：牙髓干细胞成骨分化成牙本质分化物理因素力学因素信号通路干细胞组织工程

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渗透树脂联合美白技术修复微裂氟斑牙

中国组织工程研究 2025年第4期29卷 686-691页

作者：张文怡尹昭张健天津医科大学口腔医院修复科天津市300070 衡水市第四人民医院河北省衡水市053000 天津医科大学口腔医院口腔颌面外科天津市300070

背景:微研磨、家庭美白联合渗透树脂治疗氟斑牙具有良好的效果,但该方法对氟斑牙微裂纹的影响尚不清楚。目的:探究微研磨、家庭美白联合渗透树脂修复微裂氟斑牙的效果。方法:①临床研究:选择2020年7月至2021年3月就诊于天津医科大学口... 详细信息

背景:微研磨、家庭美白联合渗透树脂治疗氟斑牙具有良好的效果,但该方法对氟斑牙微裂纹的影响尚不清楚。目的:探究微研磨、家庭美白联合渗透树脂修复微裂氟斑牙的效果。方法:①临床研究:选择2020年7月至2021年3月就诊于天津医科大学口腔医院修复科的23例微裂氟斑牙患者,包括255颗微裂氟斑牙,均接受牙齿微研磨术、家庭美白与渗透树脂联合治疗,对比治疗前及治疗结束后1周、1个月的牙齿颜色、牙齿敏感程度和牙齿疼痛阈值。②体外实验:收集牙齿表面至少存在一条裂纹的氟斑牙60颗,随机分3组处理:对照组不进行任何处理,美白组进行微研磨与家庭美白处理,联合组进行微研磨、家庭美白和渗透树脂联合处理,每组20颗,测量处理后3组牙齿样本的显微硬度。结果与结论:①临床研究:治疗结束后6个月,255颗微裂氟斑牙中牙齿美白治疗显效207颗、有效48颗,总体治疗有效率为100%。随着治疗时间的延长,中、重度牙齿度敏感程度占比呈下降趋势,治疗结束后6个月,255颗氟斑牙中无重度敏感、15颗为中度敏感、125颗为轻度敏感、115颗无敏感,与治疗前的氟斑牙敏感程度相比差异有显著性意义(P0.05)。②体外实验:美白组牙齿显微硬度值低于对照组、联合组(P0.05)。③结果表明,微研磨、家庭美白联合渗透树脂治疗微裂氟斑牙具有较好的疗效。

关键词：氟斑牙微裂纹渗透树脂牙齿美白治疗效果显微硬度

Coexistence of situs inversus totalis and hepatocellular carcinoma:A series of nine cases and a literature review

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Journal of Interventional Medicine 2022年第1期5卷 46-49页

作者： Xiaowei Li Zhigang Fu Jiaming Zhong Kunkun Cao xiaoxia Chen Ning Ding Li Liu jian Zhai Zengqiang Qu Department Ⅱ of Interventional Radiology Eastern Hepatobiliary Surgery HospitalShanghaiChina

Hepatocellular carcinoma(HCC)is the most commonly diagnosed carcinoma and one of the leading causes of cancer-related deaths *** inversus totalis(SIT)is a congenital condition where in the internal organs of the abdomen and thorax lie in mirror images of their normal *** far,there are very few reports on cases of SIT coexisting with *** case series is probably the largest series in world *** cohort of this retrospective study included a total of nine patients diagnosed with SIT-HCC and treated in our hospital between January 2013 and May *** characteristics,prognostic factors,and outcomes were *** strategies included surgery,transarterial chemoembolization,and microwave *** diagnosis and treatment of patients with SIT are challenging because of organ *** current treatment strategies for different stages of liver cancer are safe and feasible for patients with SIT-HCC.

关键词： Situs inversus totalis Hepatocellular carcinoma Treatment strategies

PARAMETRIC IDENTIFICATION AND SENSITIVITY ANALYSIS FOR AUTONOMOUS UNDERWATER VEHICLES IN DIVING PLANE

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Journal of Hydrodynamics 2012年第5期24卷 744-751页

作者： XU Feng ZOU Zao-jian YIN jian-chuan CAO jian School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240China School of Naval Architecture Ocean and Civil Engineering and State Key Laboratory of Ocean EngineeringShanghai Jiao Tong University Shanghai 200240 China College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China

The inherent strongly nonlinear and coupling performance of the Autonomous Underwater Vehicles （AUV）, maneuvering motion in the diving plane determines its difficulty in parametric identification. The motion parameters in diving plane are obtained by executing the Zigzag-like motion based on a mathematical model of maneuvering motion. A separate identification method is put forward for parametric identification by investigating the motion equations. Support vector machine is proposed to estimate the hydrodynamic derivatives by analyzing the data of surge, heave and pitch motions. Compared with the standard coefficients, the identified parameters show the validation of the proposed identification method. Sensitivity analysis based on numerical simulation demonstrates that poor sensitive derivative gives bad estimation results. Finally the motion simulation is implemented based on the dominant sensitive derivatives to verify the reconstructed model.

关键词： parametric identification Autonomous Underwater Vehicles (AUVs) support vector machine sensitivity analysis

Coupled 3D discrete-continuum numerical modeling of pile penetration in sand

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第1期13卷 44-55页

作者： jian ZHOU Qi-wei jian Jiao ZHANG jian-jun GUO Department of Geotechnical Engineering Tongji University Shanghai 200092 China School of Civil Engineering and Transportation Shanghai Technical College of Urban Management Shanghai 200432 China Sichuan Provincial Chuanjian Investigation and Design Institute Chengdu 610017 China

A coupled discrete-continuum simulation incorporating a 3D aspect and non-circular particles was performed to analyze soil-pile interactions during pile penetration in sand.A self-developed non-circular particle numerical simulation program was used which considered sand near the pile as interacted particles using a discrete element method;the sand away from the pile was simulated as a continuous medium exhibiting linear elastic *** domain analyzed was divided into two *** forces at the interface between the two zones were obtained from a discrete zone and applied to the continuum boundaries as nodal forces,while the interface velocities were obtained from the continuum zone and applied to the discrete *** show that the coupled discrete-continuum simulation can give a microscopic description of the pile penetration process without losing the discrete nature of the zone concerned,and may significantly improve computational efficiency.

关键词： Coupled numerical modeling Discrete-continuum Micro and macro 3D simulation Non-circular particles Pilepenetration mechanism

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基于聚类算法的路径频散曲线拾取方法

中国海洋大学学报（自然科学版） 2025年第1期55卷 149-157页

作者：何建张建中黄忠来中国海洋大学海洋地球科学学院山东青岛266100 中国海洋大学海底科学与探测技术教育部重点实验室山东青岛266100

多道地震资料面波分析方法是目前确定近地表横波速度的有效工具,但由于反演的一维横波速度模型仅反映了检波器排列中点垂直方向上的横波速度变化,因此其横向分辨率较差。与面波分析方法相比,面波层析反演方法具有更大的潜力来提高近地... 详细信息

多道地震资料面波分析方法是目前确定近地表横波速度的有效工具,但由于反演的一维横波速度模型仅反映了检波器排列中点垂直方向上的横波速度变化,因此其横向分辨率较差。与面波分析方法相比,面波层析反演方法具有更大的潜力来提高近地表特征的横向分辨率。但是面波层析反演方法需要从大量检波器对之间(路径)的平均频散能量谱中拾取频散曲线,人工拾取将耗费大量的时间成本。针对这个问题,本文进行了聚类算法自动从路径平均频散能量谱中拾取相速度频散曲线的研究。理论模型正演数据以及实际资料面波数据的实验结果都验证了本文方法的正确性。

关键词：聚类算法频散曲线面波层析反演横波速度

Variable Universe Fuzzy Control for Battery Equalization

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Journal of Systems Science & Complexity 2018年第1期31卷 325-342页

作者： ZHENG jian CHEN jian OUYANG Quan The State Key Laboratory of Industrial Control Technology College of Control Science and Engineering Zhejiang University

In order to avoid the overcharge and overdischarge damages, and to improve the lifetime of the lithium-ion batteries, it is essential to keep the cell voltages in a battery pack at the same level,i.e., battery equalization. Based on the bi-directional modified Cuk converter, variable universe fuzzy controllers are proposed to adaptively maintain equalizing currents between cells of a serially connected battery pack in varying conditions. The inputs to the fuzzy controller are the voltage differences and the average voltages of adjacent cell pairs. A large voltage difference requires large equalizing current while adjacent cells both with low/high voltages can only stand small discharge/charge currents. Compared with the conventional fuzzy control method, the proposed method differs in that the universe can shrink or expand as the effects of the input changes. This is important as the input may change in a small range. Simulation results demonstrate that the proposed variable universe fuzzy control method has fast equalization speed and good adaptiveness for varying conditions.

关键词： Cell equalization lithium-ion battery variable universe fuzzy control