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The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

Cell Research 2001年第2期11卷 89-94页

作者： LIAO JIN HUI, JUN song CHEN, MIN QIANG CHAI, SHENG ZHAO, jian guo song State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shan 1State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 1State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 1State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 1State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 1State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China

We reported in this manuscript that TGF-β1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-β1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-β1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-β1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-β1-mediated gene expression and apoptosis.

关键词： Transforming growth factor β apoptosis p38 hepatocyte signal transduction.

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Mutual-structure weighted guided image filtering for depth map restoration

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Optoelectronics Letters 2025年第1期21卷 51-56页

作者： LIU Zijian song jian CHEN Quanmin XU jiangtao Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology School of Microelectronics Tianjin University Spikesee Technology Co. Ltd.

Although guided image filtering(GIF) is known for preserving edges and fast computation, it may produce inaccurate outputs in depth map restoration. In this paper, a novel confidence-weighted GIF called mutual-structure weighted GIF(MSWGIF) is proposed, which replaces the mean filtering strategy in GIF during handling overlapping windows. The confidence value is composed of a depth term and a mutual-structure term, where the depth term is utilized to protect the edges of the output, and the mutual-structure term helps to select accurate windows during the structure characteristics of the guidance image are transferred to the output. Experimental results show that MSWGIF reduces the root mean square error(RMSE) by an average of 12.37%, and the average growth rate of correlation(CORR) is 0.07% on average. Additionally, the average growth rate of structure similarity index measure(SSIM) is 0.34%.

关键词： Wiener filtering

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Activation of phospholipase D activity in transforming growth factor-beta-induced cell growth inhibition

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Cell Research 2000年第2期10卷 139-149页

作者： SHENG ZHAO JUN LIANG HE HUA CHEN jian guo song(E-mail: sonaj@***)(State Key Laboratory of Molecular Biology, Shanghai Instituteof Biochemistry, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China) harmacy.ankara.edu.tr

Cells regulate phospholipase D （PLD） activity in response to numerous extracellular signals. Here, we investigated the involvement of PLD activity in transforming growth factor-β（TGF-β1）-mediated growth inhibition of epithelial cells. TGFβ1 inhibits the growth of MDCK, Mv1Lu, and A-549 cells. In the presence of 0.4 % butanol, TGF-β1 induces an increase in the formation of phosp hat idylbutanol, a unique product catalyzed by PLD. TGF-β1 also induces an increase in phosphatidic acid （PA） level in A-549 and MDCK cells. TGF-β1 induces an increase in the levels of DAG labeled with [3H]-myristic acid in A-549 and MDCK cells but not in Mv1Lu cells- No increase of DAG was observed in cells prelabeled with [3H]-arachidonic *** data presented suggest that PLD activation is involved in the TGF-β1-induced cell growth inhibition.

关键词： Transforming growth factor-β phospholiapse D signaling phosphatidic acid diacylglycerol

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng song Yuhang song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

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Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah song jian Muhammad Naeem Ul Hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

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中美休闲体育的比较研究

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河北体育学院学报 2008年第2期22卷 25-26,38页

作者：郭建松周口职业技术学院河南周口466001

对中美休闲体育进行了比较研究,找出了当前我国休闲体育与美国存在的差距,为中国休闲体育的快速、健康发展提供对策。

关键词：休闲体育中国美国比较

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EMT与肿瘤

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生命的化学 2008年第5期28卷 523-526页

作者：张可华宋建国中国科学院上海生命科学研究院生物化学与细胞生物学研究所分子细胞生物学重点实验室上海200031

上皮细胞向间质细胞的转变(epithelial to mesenchymal transition,EMT)是哺乳动物胚胎发育过程中的生理现象,也是维系生命体组织平衡的基本生物事件。目前的研究表明成熟组织中不适当的EMT对多种肿瘤的发展进程具有重要的影响。EMT可... 详细信息

上皮细胞向间质细胞的转变(epithelial to mesenchymal transition,EMT)是哺乳动物胚胎发育过程中的生理现象,也是维系生命体组织平衡的基本生物事件。目前的研究表明成熟组织中不适当的EMT对多种肿瘤的发展进程具有重要的影响。EMT可促进肿瘤细胞的浸润以及肿瘤的转移,还可能使肿瘤细胞逃逸某些因素诱导的凋亡。本文综合目前的研究进展,旨在阐述EMT与肿瘤的关系以及EMT发生的分子机制。

关键词： EMT 肿瘤浸润肿瘤转移 β-转化生长因子

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流化床反应器中生物质的催化裂解气化研究

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燃料化学学报 2001年第4期29卷 319-322页

作者：郭建维宋晓锐崔英德广东工业大学轻工化工学院广东广州510090

利用木材加工废弃的白木屑在自行开发的流化床生物质气化系统上进行了非传统气化新方法实验研究 ,制备了多种镍基催化剂并对不同催化剂的裂解气化性能进行了评价。结果表明 ,共沉淀镍铝催化剂性能最佳 ,镍铝比在 0 5～ 1 0之间催化剂... 详细信息

利用木材加工废弃的白木屑在自行开发的流化床生物质气化系统上进行了非传统气化新方法实验研究 ,制备了多种镍基催化剂并对不同催化剂的裂解气化性能进行了评价。结果表明 ,共沉淀镍铝催化剂性能最佳 ,镍铝比在 0 5～ 1 0之间催化剂活性、稳定性最好。该催化剂连续使用 2 0 0min活性无显著降低 ,失活催化剂可采用在65 0℃～ 70 0℃的混合气N2 ∶CO2 ∶O2 ∶H2 O( 4 0∶5 0∶5∶5 )中焙烧的方法有效再生。

关键词：生物质气化流化床催化裂解气体燃料能源镍基催化剂

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Polarization-encoded neural networks with simplified grating patch

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Science China Technological Sciences 2025年

作者： Chengyan ZHONG Xiang WANG Lingfei LI Yuanchi CUI Lei XIAO Dawei song Junxiong guo Wen HUANG Yufeng guo Yu LIU College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Nanjing Mumusili Technology Co. LTD School of Integrated Circuits Tsinghua University Institute of Advanced Study School of Electronic Information and Electrical Engineering Chengdu University State Key Laboratory of Electronic Thin Films and Integrated Devices School of Integrated Circuit Science and EngineeringUniversity of Electronic Science and Technology of China

Optical neural networks (ONNs) offer a promising solution for high-performance, energy-efficient artificial intelligence hardware by leveraging the parallelism and speed of light. However, the large-scale implementation of ONNs remains challenging due to the bulky footprint and complex control of optical synapses. In this work, we propose and simulate a plasmonic polarized synaptic architecture that overcomes the diffraction limit and enables ultra-compact ONNs. By tuning the polarization state of incident light, the optical transmittance through each plasmonic unit can be dynamically adjusted to represent a synaptic weight. Our plasmonic structures, with features as small as 40 nm, operate well below this limit in the visible spectrum (400–750 nm). Compared with diffraction and interference-based circuit designs, our proposed method achieves a substantial reduction in synaptic density by factors of 150000-fold and 1500-fold, respectively. Furthermore, we successfully demonstrate a proof-of-concept plasmonic ONN applied to the Canadian Institute for Advanced Research—10classes (CIFAR-10) dataset using a Visual Geometry Group network with 16 layers (VGG16) model. After training for 80epochs, the network achieves an accuracy of 93%. The polarization-tunable plasmonics paves the way towards scalable ONNs for next-generation artificial intelligence (AI) accelerators and smart sensors.

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中国奥运旅游可持续发展对策研究

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河北体育学院学报 2006年第2期20卷 10-12页

作者：郭瑞华郭建松周口师范学院体育系河南周口466000 周口职业技术学院河南周口466000

采用文献资料法、逻辑分析法和数理统计法对奥运旅游的效应进行了分析,并从旅游环境的破坏、旅游安全危机、后奥运时期旅游经济低谷、旅游客流排挤效应四个方面重点探讨了奥运旅游的负效应,旨在减少2008年北京奥运会对旅游业的负效应,... 详细信息

采用文献资料法、逻辑分析法和数理统计法对奥运旅游的效应进行了分析,并从旅游环境的破坏、旅游安全危机、后奥运时期旅游经济低谷、旅游客流排挤效应四个方面重点探讨了奥运旅游的负效应,旨在减少2008年北京奥运会对旅游业的负效应,为中国旅游业的可持续发展提供借鉴。

关键词：奥运旅游效应持续发展对策

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