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Study on MiRNA Epigenetic Intervention for Epilepsy

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Journal of Biosciences and Medicines 2022年第10期10卷 144-151页

作者： Jiao Hu jialu mo Xianglin Cheng The First Affiliated Hospital of Yangtze University Jingzhou China

MiRNAs are a family of small non-coding RNAs that control levels of multiple proteins by post-transcriptionally decreasing messenger RNA stability and translation. MiRNA is a part of the epigenetic machinery. In addition to post-transcriptional gene silencing by miRNAs, the epigenetic mechanisms also include DNA methylation, histone modifications and their crosstalk. Epigenetic modifications were reported to play an important role in many disease onsets and progressions and can be used to explain several features of epilepsy. However, miRNA not only function as a part of epigenetic machinery, but are also epigenetically modified by DNA methylation and histone modification like any other protein-coding gene. There is a strong connection between epigenetic and MiRNA, and any dysregulation of this complex system can result in various physiological and pathological conditions. Currently, there is an unmet need for antiepileptic drugs that truly prevent the development of epilepsy in high-risk populations. New findings in animal models and human brain tissue suggest that microRNAs play a crucial role in epileptogenesis and the pathophysiology of chronic epilepsy. Objectives: This paper focuses on the epigenetic role of miRNA in the development of epilepsy and potential targets for drug therapy. Methods: In this paper, through the keywords epilepsy, epigenetic, methylation, miRNA, non-coding RNA search in PubMed, SPIS, GeenMedical, Google Scholar and Web of Science, to study the potential application of miRNA epigenetic regulation in the treatment of epilepsy. Results: Future treatments that manipulate miRNA epigenetic processes, such as Anti-oligonucleotides, DNA methylation and Nucleic Acid Aptamers, to treat or prevent epilepsy. Conclusion: Overall, miRNA epigenetic drugs have become a new frontier target to achieve a cure for epilepsy.

关键词： MiRNA Epigenetic Epilepsy Treatment

Progress of Autophagy in Epilepsy Research

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Journal of Biosciences and Medicines 2022年第10期10卷 182-191页

作者： jialu mo Jiao Hu Xianglin Cheng The First Affiliated Hospital of Yangtze University Jingzhou China

Epilepsy is a clinical syndrome caused by highly synchronized abnormal discharges of neurons in the brain. It is a common disease of the nervous system. The pathogenesis of epilepsy has not been fully understood yet. The main pathological changes after seizures are programmed neuronal death and glial proliferation. Autophagy is a catabolic process. moderate autophagy is critical to maintain the homeostasis and cell health, while abnormal autophagy can lead to disease. A number of studies have proved that abnormal autophagy mechanism can lead to epilepsy, and there are also literatures that autophagy induced by endoplasmic reticulum stress can reduce the neuronal damage triggered by epilepsy, thus playing a protective role in neurons. This article reviews the relationship between autophagy and epilepsy in order to provide basis for further study of autophagy pathway and pathophysiology of epilepsy.

关键词： Epilepsy Autophagy mTOR Endoplasmic Reticulum Stress

A design of high-precision positioning system of UAV based on the Qianxun location network

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A design of high-precision positioning system of UAV based o...

Recent Advances in molybdenum-Based Materials for Lithium-Sulfur Batteries

第37届中国控制会议

作者： jialu Luo Bo mo Jin Lin School of Aerospace Engineering Beijing Institute of Technology

To deal with the problem that the traditional single-point positioning method cannot meet the application demands of positioning precision, this paper designs a high-precision positioning system of unmanned aerial vehicle（UAV） based on the Qianxun location network by means of the network Real-Time Kinematic（RTK） technology. As the first commercial Bei Dou ground based augmentation system（GBAS）, Qianxun location network provides embedded software development kit（SDK） to obtain differential data which can correct positioning data with errors. As a result, the positioning information of high precision can be acquired. To demonstrate the performance of the designed system, several tests are conducted. It is concluded that the designed positioning system has the characteristics of low cost, small size and high precision, along with the convenient installation on UAV.

关键词： Qianxun location network High-precision positioning Network RTK technology

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Research 2021年第1期2021卷 235-264页

作者： Henghan Dai Lumin Wang Yue Zhao jialu Xue Ruicong Zhou Chenyang Yu Jianing An Jinyuan Zhou Qiang Chen Gengzhi Sun Wei Huang Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China Institute of Photonics Technology Jinan UniversityGuangzhou 510632China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454003China Institute of Flexible Electronics(IFE) Northwestern Polytechnical University(NPU)Xi’an 710072China

Lithium-sulfur(Li-S)batteries as power supply systems possessing a theoretical energy density of as high as 2600 Wh kg−1 are considered promising alternatives toward the currently used lithium-ion batteries(LIBs).However,the insulation characteristic and huge volume change of sulfur,the generation of dissolvable lithium polysulfides(LiPSs)during charge/discharge,and the uncontrollable dendrite formation of Li metal anodes render Li-S batteries serious cycling issues with rapid capacity *** address these challenges,extensive efforts are devoted to designing cathode/anode hosts and/or modifying separators by incorporating functional materials with the features of improved conductivity,lithiophilic,physical/chemical capture ability toward LiPSs,and/or efficient catalytic conversion of *** all candidates,molybdenum-based(mo-based)materials are highly preferred for their tunable crystal structure,adjustable composition,variable valence of mo centers,and strong interactions with soluble ***,the latest advances in design and application of mo-based materials for Li-S batteries are comprehensively reviewed,covering molybdenum oxides,molybdenum dichalcogenides,molybdenum nitrides,molybdenum carbides,molybdenum phosphides,and molybdenum *** the end,the existing challenges in this research field are elaborately discussed.

关键词： molybdenum lithium render

喉额侧窗式切除术治疗侵及前联合的T1b期声门型喉癌疗效分析

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听力学及言语疾病杂志 2017年第6期25卷 615-618页

作者：钟兆棠梁敏志陈泽莫玲飞梁珈璐广东省高州市人民医院耳鼻喉科茂名525200

目的探讨喉额侧窗式切除术结合甲状软骨外膜瓣修复术治疗侵及前联合的T1b期声门型喉癌的疗效。方法对确诊为前联合受侵的T1b期声门型喉癌患者22例,均行喉额侧窗式切除术结合甲状软骨外膜瓣修复术治疗;随访5年,观察患者术后呼吸功能、吞... 详细信息

目的探讨喉额侧窗式切除术结合甲状软骨外膜瓣修复术治疗侵及前联合的T1b期声门型喉癌的疗效。方法对确诊为前联合受侵的T1b期声门型喉癌患者22例,均行喉额侧窗式切除术结合甲状软骨外膜瓣修复术治疗;随访5年,观察患者术后呼吸功能、吞咽功能、发音功能、复发率及生存率。结果所有患者手术均顺利完成,术后二周拔除气管套管,拔管率100%;无一例发生误咽;术后患者发声功能(G分级)较术前改善者为86.4%(19/22),与术前相同者为13.6%(3/22);肿瘤复发2例,1例为原位复发,1例为颈部淋巴结转移复发,复发率为9.1%(2/22);5年生存率为95.5%(21/22)。结论喉额侧窗式切除术结合甲状软骨外膜瓣修复术式适用于前联合受侵的T1b期声门型喉癌,该术式能相对完整地保留喉的骨架及生理功能,不易引起喉狭窄,且修复组织稳定,能有效改善发声质量。

关键词：声门型喉癌喉窗式切除术甲状软骨外膜瓣

支撑喉镜下针状电刀喉肿瘤切除术治疗早期喉癌与喉癌前病变的疗效以及安全性分析

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系统医学 2023年第12期8卷 91-94页

作者：莫玲飞梁广志梁珈璐高州市人民医院耳鼻喉科广东高州525200

目的探讨支撑喉镜下针状电刀喉肿瘤切除术治疗早期喉癌与喉癌前病变的疗效以及安全性。方法选取2020年6月—2022年6月在高州市人民医院接受支撑喉镜下针状电刀喉肿瘤切除术治疗的120例早期喉癌与喉癌前病变患者,以数字随机表法分为两组,... 详细信息

目的探讨支撑喉镜下针状电刀喉肿瘤切除术治疗早期喉癌与喉癌前病变的疗效以及安全性。方法选取2020年6月—2022年6月在高州市人民医院接受支撑喉镜下针状电刀喉肿瘤切除术治疗的120例早期喉癌与喉癌前病变患者,以数字随机表法分为两组,各60例。对照组采用传统开放手术切除术,研究组采用喉镜下针状电刀切除术,对比两组的术后并发症、术后复发率以及声带修复情况变化。结果与对照组相比,研究组治疗后的气道灼烧、吞咽不适、声带粘连和呼吸困难等术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。与对照组相比,研究组在治疗后复发率的患者比例(0)低于对照组(10.00%),差异有统计学意义(χ^(2)=4.386,P<0.05)。对照组患者声带基本恢复率低于研究组,瘢痕或缺损率高于研究组,差异有统计学意义(P<0.05)。结论在早期喉癌与喉癌前病变的治疗过程中,支撑喉镜下针状电刀喉肿瘤切除术疗效显著,有一定的优越性和发展力,是一种高效的治疗方法。

关键词：喉镜电刀喉肿瘤切除术喉癌与喉癌前病变

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氨苄西林胁迫下阪崎克罗诺杆菌维持连续休眠态的转录组学分析

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现代食品科技 2023年第5期39卷 72-80页

作者：莫云少张竟丰敖嘉璐刘园园陈楚欣赵力超华南农业大学食品学院广东广州510642 广东省功能食品活性物重点实验室广东广州510642

阪崎克罗诺杆菌是奶粉中常见的食源致病菌,在压力胁迫下会进入连续休眠态。该研究通过转录组测序技术分析氨苄西林压力胁迫下形成的连续休眠态菌的基因表达变化差异,共筛选出220个显著上调基因和416个显著下调基因;并对差异表达基因进... 详细信息

阪崎克罗诺杆菌是奶粉中常见的食源致病菌,在压力胁迫下会进入连续休眠态。该研究通过转录组测序技术分析氨苄西林压力胁迫下形成的连续休眠态菌的基因表达变化差异,共筛选出220个显著上调基因和416个显著下调基因;并对差异表达基因进行GO和KEGG富集分析。结果表明,与代谢活性、运动能力(鞭毛合成)、细胞分裂相关基因表达整体显著下调;与药物外排泵、细胞形态改变相关的部分基因表达显著上调;GO富集分析结果还提示严谨反应、毒素抗毒素系统(TAS)相关基因表达显著上调,TAS可能通过调控下游mRNA和NAD+促进连续休眠态的形成。因此,在氨苄西林胁迫下严谨反应可能通过级联调节激活TAS表达,从而促进连续休眠态形成。在该状态下,阪崎克罗诺杆菌通过降低代谢活性、减弱运动能力、抑制细胞分裂,同时改变细胞形态,并增强药物外排能力,从而维持连续休眠态。研究结果为防控压力胁迫下产生的连续休眠态阪崎克罗诺杆菌奠定了理论基础。

关键词：氨苄西林阪崎克罗诺杆菌连续休眠态转录组

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沉积速率对直流脉冲溅射钼薄膜微结构与光学性能的影响

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光学学报 2016年第9期36卷 325-332页

作者：赵娇玲贺洪波王虎郭佳露贺婷中国科学院上海光学精密机械研究所强激光重点材料实验室上海201800 中国科学院大学北京100049

用脉冲直流磁控溅射方法在硅片衬底上制备了厚度相同的单层钼薄膜,结合台阶仪、X射线衍射仪、场发射扫描电镜、原子力学显微镜和紫外-可见分光光度计分别研究了不同沉积速率对钼薄膜微结构、表面形貌和光学性能的影响。掠入射X射线反射... 详细信息

用脉冲直流磁控溅射方法在硅片衬底上制备了厚度相同的单层钼薄膜,结合台阶仪、X射线衍射仪、场发射扫描电镜、原子力学显微镜和紫外-可见分光光度计分别研究了不同沉积速率对钼薄膜微结构、表面形貌和光学性能的影响。掠入射X射线反射谱拟合的钼薄膜厚度与设计厚度一致,说明当前钼薄膜制备工艺成熟稳定。沉积速率通过改变薄膜生长模式与薄膜形核率影响钼薄膜表面形貌演化。随着沉积速率的增大,薄膜越来越致密,钼(110)面的衍射峰强度逐渐增大,平均晶粒尺寸增大,表面粗糙度先降低后增加。

关键词：薄膜光学性能材料制备与表征其他性能

原发于蝶窦外侧隐窝囊肿的诊断与鼻内镜手术治疗

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中国耳鼻咽喉头颈外科 2017年第1期24卷 35-38页

作者：钟兆棠陈泽梁敏志莫玲飞梁珈璐高州市人民医院耳鼻咽喉科广东茂名525200

目的探讨原发于蝶窦外侧隐窝囊肿的临床特征及鼻内镜治疗的疗效。方法回顾性分析我院2007~2015年间收治的9例原发于蝶窦外侧隐窝囊肿患者的临床资料及术后随访结果。其中7例患者以面颊部麻木感为主诉,2例患者进行性视力下降为主诉;头面... 详细信息

目的探讨原发于蝶窦外侧隐窝囊肿的临床特征及鼻内镜治疗的疗效。方法回顾性分析我院2007~2015年间收治的9例原发于蝶窦外侧隐窝囊肿患者的临床资料及术后随访结果。其中7例患者以面颊部麻木感为主诉,2例患者进行性视力下降为主诉;头面部均无明显阳性体征。均于全麻内镜下经蝶窦入路行囊肿开窗引流术。结果所有患者术中及术后均无并发症发生,术后症状均消失。随访6~24个月,所有患者的囊肿引流口均与蝶窦相通形成永久性引流口,无闭塞或复发。结论 1原发于蝶窦外侧隐窝囊肿的有其独有的症状及影像学特征,区别于一般的蝶窦囊肿;2鼻内镜下经蝶窦入路行囊肿开窗切除术是治疗原发于蝶窦外侧隐窝囊肿的微创、安全、有效术式。

关键词：内窥镜检查囊肿蝶窦外侧隐窝