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Genomic profiling of colorectal cancer in large-scale Chinese patients:amplification and somatic mutations in ERBB2

Oncology Research 2024年第9期32卷 1429-1438页

作者： YUZHI LIU EVELYNE BISCHOF ZHIQIN CHEN jiahuan zhou BEI ZHANG DING ZHANG YONG GAO MING QUAN Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghaiChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteDepartment of OncologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Jiangsu Hengrui Pharmaceuticals Co. Ltd.ShanghaiChina D Medicines Inc. ShanghaiChina

Objectives:Human epidermal growth factor receptor 2(HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer(mCRC)patients with HER2 amplification,but are not satisfactory in cases of HER2 mutant ***:Consequently,further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2(ERBB2)is *** genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes,tumor mutational burden,microsatellite instability,and programmed death ligand 1(PD-L1)***:Among 2454 CRC patients,85 cases(3.46%)exhibited ERBB2 amplification,and 55 cases(2.24%)carried ERBB2 mutation.p.R678Q(28%),p.V8421(24%),and p.S310F/Y(12%)were the most prevalent of the 16 detected mutation *** comparison to the ERBB2 altered(alt)group,KRAS/BRAF mutations were more prevalent in ERBB2 wild-type(wt)samples(ERBB2wt ***2alt,KRAS:50.9%vs.25.6%,p<0.05;BRAF:8.5%vs.2.3%,p<0.05).32.7%(18/55)of CRCs with ERBB2 mutation exhibited microsatellite instability high(MSI-H),while no cases with HER2 amplification displayed *** genes varied between ERBB2 copy number variation(CNV)and ERBB2 single nucleotide variant(SNV);TP53 alterations tended to co-occur with ERBB2 amplification(92.3%)as opposed to ERBB2 mutation(58.3%).KRAS and PIK3CA alterations were more prevalent in ERBB2 SNV cases(KRAS/PIK3CA:45.8%/31.2%)compared to ERBB2 amplification cases(KRAS/PIK3CA:14.1%/7.7%).Conclusion:Our study delineates the landscape of HER2 alterations in a large-scale cohort of CRC patients from *** findings enhance our understanding of the molecular features of Chinese CRC patients and offer valuable implications for further investigation.

关键词： Colorectal cancer ERBB2 HER2 Human epidermal growth factor receptor 2 Genetic profiling Precision oncology

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跨模态目标重识别研究综述

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计算机科学 2024年第1期51卷 13-25页

作者：崔振宇周嘉欢彭宇新北京大学王选计算机研究所北京100871 多媒体信息处理国家重点实验室北京100871

目标重识别(ReID)技术旨在匹配不同区域摄像头在不同时间拍摄到的同一目标,其核心是通过目标间的细粒度差异实现不同目标的有效区分。因此,目标重识别技术被广泛应用于安防布控、刑侦监控等领域并发挥了重要作用。传统的目标重识别技术... 详细信息

目标重识别(ReID)技术旨在匹配不同区域摄像头在不同时间拍摄到的同一目标,其核心是通过目标间的细粒度差异实现不同目标的有效区分。因此,目标重识别技术被广泛应用于安防布控、刑侦监控等领域并发挥了重要作用。传统的目标重识别技术通常适用于光照条件良好情况下的可见光模态数据,但在处理黑夜低光照条件下的目标重识别任务时,其性能通常受到严重限制。红外摄像机因其卓越的夜视性能,通常被应用于在低光照条件下采集目标红外图像。因此,跨模态目标重识别技术旨在通过可见光图像匹配红外图像,实现全天候不间断的目标重识别。近年来,跨模态目标重识别技术取得了很大进展,然而,对于现有模型的归纳总结及深入分析仍然欠缺。为此,对跨模态目标重识别领域的相关研究和新颖方法进行了深入调研和总结,讨论了现有方法在实际场景中面临的挑战,并从模型分类和模型评价两个方面对现有方法进行归纳与分析。首先,围绕跨模态目标重识别问题的研究难点,将跨模态目标重识别分为生成式方法和非生成式方法两大类;然后,对当前跨模态重识别领域中广泛使用的评测数据集以及相关评价指标进行了综述与总结;最后,讨论了跨模态重识别领域仍然存在的挑战并对未来发展趋势进行了展望。

关键词：计算机视觉目标重识别跨模态细粒度特征表征学习

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Erratum to“Gravity-Dependent Animacy Perception in Zebrafish”

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Research 2024年第3期6卷 799-800页

作者： Xiaohan Ma Xiangyong Yuan jiahuan Liu Li Shen Yiwen Yu Wen zhou Zuxiang Liu Yi Jiang State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Chinese Institute for Brain Research Beijing 102206China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

In the Research Article“Gravity-Dependent Animacy Perception in Zebrafish”[1],there was an error when calculating the velocity and acceleration of the human and pigeon BM stimuli provided by other researchers in ***... 详细信息

关键词： acceleration finding Zebrafish

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Cutting edge preparation of microdrills by shear thickening polishing for improved hole quality in electronic PCBs

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Frontiers of Mechanical Engineering 2024年第2期19卷 99-107页

作者： jiahuan WANG Mingfeng KE Jiepei LIAO Yu zhou Saurav GOEL Jaya VERMA Xu WANG Weigang GUO Julong YUAN Binghai LYU College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310000China Ultra-precision Machining Center Key Laboratory of Special Purpose Equipment and Advanced Manufacturing TechnologyZhejiang University of TechnologyHangzhou 310000China School of Engineering London South Bank UniversityLondon SE10AAUK Shenzhen Jinzhou Precision Technology Corporation Shenzhen 518116China Department of Mechanical Engineering University of Petroleum and Energy StudiesDehradun 248007India Special Equipment Institute Hangzhou Vocational&Technical CollegeHangzhou 310018China

Printed circuit boards(PCBs)are representative composite materials,and their high-quality drilling machining remains a persistent challenge in the *** finishing of the cutting edge of a microdrill is crucial to drill performance in machining fine-quality holes with a prolonged tool *** miniature size involving submicron scale geometric dimensions,a complex flute shape,and low fracture toughness makes the cutting edge of microdrills susceptible to breakage and has been the primary limiting factor in edge preparation for *** this study,a newly developed cutting edge preparation method for microdrills was tested experimentally on electronic printed circuit *** proposed method,namely,shear thickening polishing,limited the cutting edge burrs and chipping on the cutting edge,and this in turn transformed the cutting edge’s radius from being sharp to ***,the edge–edge radius could be regulated by adjusting the processing *** drilling experiments were conducted to investigate the influence of different cutting edge radii on wear,hole position accuracy,nail head value,and hole wall *** proposed approach showed 20%enhancement in hole position accuracy,33%reduction in the nail head value,and 19%reduction in hole wall roughness compared with the original ***,a threshold is needed;without it,excessive shear thickening polishing will result in a blunt edge,which may accelerate the wear of the *** was identified as the primary factor that reduced hole *** study indicates that in printed circuit board machining,microdrills should effectively eliminate grinding defects and maintain the sharpness of the cutting edge as much as possible to obtain excellent drilling ***,shear thickening polishing is a promising method for cutting edge preparation of *** research and optimization can lead to additional improvements in microdrill performance and contribute to the conti

关键词： microdrill shear thickening polishing cutting edge preparation electronic printed circuit boards hole quality

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Study of the Relationship Between New Ionic Interaction Parameters and Salt Solubility in Electrolyte Solutions Based on Molecular Dynamics Simulation

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Journal of Ocean University of China 2024年第2期23卷 467-476页

作者： SUN Wenting HU Yangdong ZHENG jiahuan SUN Qichao Chen Xia DING Jiakun ZHANG Weitao WU Lianying College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China Institute of Chemical Engineering Guangdong Academy of Science Guangzhou 510665China

Studying the relationship between ionic interactions and salt solubility in seawater has implications for seawater desalination and mineral *** this paper,a new method of expressing ion-to-ion interaction is proposed by using molecular dynamics simulation,and the relationship between ion-to-ion interaction and salt solubility in a simulated seawater water-salt system is *** analyzing the variation of distance and contact time between ions in an electrolyte solution,from both spatial and temporal perspectives,new parameters were proposed to describe the interaction between ions:interaction distance(ID),and interaction time ratio(ITR).The best correlation between characteristic time ratio and solubility was found for a molar ratio of salt-to-water of 10:100 with a correlation coefficient of *** the same salt,a positive correlation was found between CTR and the molar ratio of salt and *** type 1-1,type 2-1,type 1-2,and type 2-2 salts,the correlation coefficients between CTR and solubility were 0.93,0.96,0.92,and 0.98 for a salt-to-water molar ratio of 10:100,*** solubility of multiple salts was predicted by simulations and compared with experimental values,yielding an average relative deviation of 12.4%.The new ion-interaction parameters offer significant advantages in describing strongly correlated and strongly hydrated electrolyte solutions.

关键词： molecular dynamics simulation interaction distance interaction time rate electrolyte aqueous solutions solubility

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新生代农民工居住特征及影响因素分析

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城市发展研究 2017年第9期24卷 109-119页

作者：周加欢冯健唐杰北京大学城市与环境学院中国人民大学公共管理学院

新生代农民工作为农民工群体中的新生力量,是一个值得关注的群体。近年来关于农民工居住状况的研究成果逐渐增多,但关于新生代农民工居住状况的研究数据相对稀缺,尤其是缺乏对于其内部细分群体的居住状况分析。本文基于采集自全国30个... 详细信息

新生代农民工作为农民工群体中的新生力量,是一个值得关注的群体。近年来关于农民工居住状况的研究成果逐渐增多,但关于新生代农民工居住状况的研究数据相对稀缺,尤其是缺乏对于其内部细分群体的居住状况分析。本文基于采集自全国30个省新生代农民工的两千余份问卷调查数据,探讨新生代农民工的居住特点及其影响因素。研究表明,新生代农民工居住具有以下特征:住所获取方式主要依靠单位提供和个人租赁,居住面积和设施条件较过去有所改善,居住状况在不同收入水平、行业和流入地之间存在分异,居住稳定性有所提高,迁居大城市的意愿强于迁居中小城镇。通过进一步分析发现居住特征与就业状况、流动类型和思想观念密切相关。就业、流动和观念三大因素,通过客观支付能力和主观支付意愿两个渠道,对新生代农民工的居住选择产生影响。

关键词：新生代农民工居住状况居住环境流动人口

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论辅导员如何有效引导学生正确处理宿舍人际关系

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文化创新比较研究 2021年第18期5卷 40-43页

作者：周佳欢浙江万里学院浙江宁波315000

当代大学生普遍是“00后”,他们有很强的自我意识,对待事情有自己独特的看法。在原生家庭生活中,他们通常拥有过多以自我为中心的权利,以致进入大学校园过集体生活后有着极大的不适应,特别是室友之间,矛盾突显。处理宿舍矛盾已成为高校... 详细信息

当代大学生普遍是“00后”,他们有很强的自我意识,对待事情有自己独特的看法。在原生家庭生活中,他们通常拥有过多以自我为中心的权利,以致进入大学校园过集体生活后有着极大的不适应,特别是室友之间,矛盾突显。处理宿舍矛盾已成为高校辅导员工作中的日常。而大学阶段正是培养纯洁“革命”友谊的最佳时期,辅导员应引导学生正确处理室友间的关系,让他们拥有一段美好的大学时光。文章以两个真实案例为切入点,现身说法如何有效地引导学生解决宿舍矛盾,从而总结实际经验和学生发展特点,做到更好为学生服务,帮助学生成长,实现立德树人。

关键词： “00后” 辅导员宿舍矛盾人际关系

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地质调查信息化建设成果及思路

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国土资源信息化 2005年第5期 2-4页

作者：周家寰中国地质调查局

一、地质调查信息化建设工作概况地质调查信息化建设是新一轮国土资源大调查中数字国土工程的重要组成部分.六年来,总计安排工作项目141项,投入工作经费24330万元.在国土资源部的正确领导下,地质调查信息化建设工作,按照"一条主线,两个... 详细信息

一、地质调查信息化建设工作概况地质调查信息化建设是新一轮国土资源大调查中数字国土工程的重要组成部分.六年来,总计安排工作项目141项,投入工作经费24330万元.在国土资源部的正确领导下,地质调查信息化建设工作,按照"一条主线,两个支撑,一个目标"的建设思路,在扎实地逐步推进.

关键词：信息化建设地质调查国土资源部数字国土工程组成部分工作项目

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Building decarbonization based on building loads flexibility and clusters' collaboration

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National Science Open 2024年第3期3卷 7-12页

作者： Jian Ge Guoquan Lv jiahuan Tang Kang Zhao Department of Architecture Zhejiang University International Research Center for Green Building and Low-Carbon City International CampusZhejiang University

The decarbonization of the building sector is crucial for global sustainable development because it is responsible for about 40%of global carbon emissions and has been growing continuously at a rate of 2%to 3%per year [1].Over time,significant energy-saving milestones have been achieved through technologies such as improving equipment efficiency,building envelope performance,and utilization of sustainable resources.

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TP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer:a clinical next-generation sequencing study

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Precision Clinical Medicine 2024年第2期7卷 122-131页

作者： Yongsheng Huang Shuwei Ren Linxiaoxiao Ding Yuanling jiang jiahuan Luo Jjinghua Huang Xinke Yin Jianli Zhao Sha Fu Jianwei Liao Cellular&Molecular Diagnostics Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Laboratory The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangzhou Regenerative Medicine and Health Guangdong LaboratorySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Background:TP53 mutations and homologous recombination deficiency(HRD)occur frequently in breast ***,the characteristics of TP53 pathogenic mutations in breast cancer patients with/without HRD are not ***:Clinical next-generation sequencing(NGS)of both tumor and paired blood DNA from 119 breast cancer patients(BRCA-119 cohort)was performed with a 520-gene ***,tumor mutation burden(TMB),and genomic HRD scores were assessed from NGS *** data from 47 breast cancer patients in the HRD test cohort were analyzed for further ***:All TP53 pathogenic mutations in patients had somatic origin,which was associated with the protein expression of estrogen receptor and progestogen *** to patients without TP53 pathologic mutations,patients with TP53 pathologic mutations had higher levels of HRD scores and different genomic *** frequency of TP53 pathologic mutation was higher in the HRDhigh group(HRD score≥42)relative to that in the HRD-low group(HRD score<42).TP53 has different mutational characteristics between the HRD-low and HRD-high ***53-specific mutation subgroups had diverse genomic features and ***,TP53 pathogenic mutations predicted the HRD status of breast cancer patients with an area under the curve(AUC)of ***53-specific mutations,namely HRD-low mutation,HRD-high mutation,and HRD common mutation,predicted the HRD status of breast cancer patients with AUC values of 0.32,0.72,and 0.58,***,TP53 HRD-high mutation and HRD common mutation combinations showed the highest AUC values(0.80)in predicting HRD ***:TP53-specific mutation combinations predict the HRD status of patients,indicating that TP53 pathogenic mutations could serve as a potential biomarker for poly-ADP-ribose polymerase(PARP)inhibitors in breast cancer patients.

关键词： next-generation sequencing homologous recombination deficiency TP53 breast cancer

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