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Analysis of CLARANS Algorithm for Weather Data Based on Spark

Computers, Materials & Continua 2023年第8期76卷 2427-2441页

作者： jiahao zhang Honglin Wang College of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjing210044China

With the rapid development of technology,processing the explosive growth of meteorological data on traditional standalone computing has become increasingly time-consuming,which cannot meet the demands of scientific research and ***,this paper proposes the implementation of the parallel Clustering Large Application based upon RANdomized Search(CLARANS)clustering algorithm on the Spark cloud computing platformto cluster China’s climate regions usingmeteorological data from1988 to *** aim is to address the challenge of applying clustering algorithms to large *** this paper,the morphological similarity distance is adopted as the similarity measurement standard instead of Euclidean distance,which improves clustering ***,the issue of local optima caused by an improper selection of initial clustering centers is addressed by utilizing the max-distance *** to the k-means clustering algorithm already implemented in the Spark platform,the proposed algorithm has strong robustness,can reduce the interference of outliers in the dataset on clustering results,and has higher parallel performance than the frequently used serial algorithms,thus improving the efficiency of big data *** experiment compares the clustered centroid data with the annual average meteorological data of representative cities in the five typical meteorological regions that exist in China,and the results show that the clustering results are in good agreement with the meteorological data obtained from the National Meteorological Science Data *** algorithm has a positive effect on the clustering analysis of massive meteorological data and deserves attention in scientific research activities.

关键词： Clustering analysis cloud computing platform parallel algorithm

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An Interactive Perception Method Based Collaborative Rating Prediction Algorithm

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Chinese Journal of Electronics 2023年第1期32卷 97-110页

作者： YAN Wenjie zhang jiahao LI Ziqi School of Artificial Intelligence Hebei University of Technology

To solve the rating prediction problems of low accuracy and data sparsity on different datasets,we propose an interactive perception method based collaborative rating prediction algorithm named DCAE-MF,by fusing dual convolutional autoencoder(DCAE) and probability matrix factorization(PMF). Deep latent representations of users and items are captured simultaneously by DCAE and are deeply integrated with PMF to collaboratively make rating predictions based on the known rating history of users. A global multi-angle collaborative optimization learning method is developed to effectively optimize all the parameters of DCAE-MF. Extensive experiments are performed on seven real-world datasets to demonstrate the superiority of DCAE-MF on key rating accuracy metrics of the root mean squared error(RMSE) and mean absolute error(MAE).

关键词： Measurement Learning systems Collaboration Prediction algorithms History Optimization

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Bio-organic adaptive photonic crystals enable supramolecular solvatochromism

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Nano Research 2023年第10期16卷 12092-12097页

作者： jiahao zhang Yan zhang Yancheng Wang Sigal Rencus-Lazar Deqing Mei Ehud Gazit Kai Tao State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials Hangzhou Global Scientific and Technological Innovation CentreZhejiang UniversityHangzhou 311200China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China The Shmunis School of Biomedicine and Cancer Research George S.Wise Faculty of Life SciencesTel Aviv UniversityTel Aviv 6997801Israel Department of Materials Science and Engineering Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel Aviv 6997801Israel

Photonic crystals(PCs)exhibit promising structural coloration properties and possess extensive application prospects in diverse optical ***,state-of-the-art inorganic or polymeric PCs show limited adaptivity as their configurations are fixed once ***,bio-organic adaptive PCs are fabricated via drop-casting of amphiphilic guanine-based peptide nucleic acid selfassembled *** high formation activation energy of up to 81.8 kJ·mol−1 suggests that the self-assembly step dominates the entire ***,the configurations along with the structural coloration of the supramolecular PCs are sensitive to self-assembly influencing parameters,showing temperature-encoded structural color evolution and solvent polaritydependent *** findings demonstrate that the supramolecular PCs are adaptive,thus showing promising potential for detection of organic solvents of different polarities in a visual and real-time manner for environmental protection or optical applications.

关键词： peptide nucleic acids molecular manufacturing supramolecular photonic crystals solvatochromic effects adaptivity

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黄芪甲苷可缓解MC3T3-E1细胞氧化应激损伤并促进成骨

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中国组织工程研究 2025年第17期29卷 3529-3536页

作者：张加豪李嘉程温明韬郭艳波骆帝李刚山东中医药大学第一临床医学院山东省济南市250014 山东中医药大学附属医院山东省济南市250014

背景:氧化应激是导致骨质疏松症的主要原因之一,减少氧化应激水平与增加抗氧化防御是治疗骨质疏松症的重要研究方向。研究证实黄芪甲苷具有抗骨质疏松作用,但其作用机制尚不明确。目的:探讨黄芪甲苷对氧化应激条件下MC3T3-E1细胞成骨的... 详细信息

背景:氧化应激是导致骨质疏松症的主要原因之一,减少氧化应激水平与增加抗氧化防御是治疗骨质疏松症的重要研究方向。研究证实黄芪甲苷具有抗骨质疏松作用,但其作用机制尚不明确。目的:探讨黄芪甲苷对氧化应激条件下MC3T3-E1细胞成骨的作用。方法:将MC3T3-E1细胞分4组培养:对照组加入完全培养基,模型组加入含过氧化氢的完全培养基干预24 h后更换为完全培养基,黄芪甲苷组加入含过氧化氢、黄芪甲苷的完全培养基干预24 h后更换为含黄芪甲苷的完全培养基,抑制剂组加入含过氧化氢、黄芪甲苷、细胞外信号调节激酶(extracellular signal-regulated kinases,ERK)抑制剂的完全培养基干预24 h后更换为含黄芪甲苷、ERK抑制剂的完全培养基。过氧化氢干预48 h后,通过丙二醛含量检测黄芪甲苷对MC3T3-E1细胞氧化应激的缓解作用;过氧化氢干预48 h后进行成骨诱导培养,通过碱性磷酸酶染色、茜素红染色验证MC3T3-E1细胞成骨及矿化能力,通过RT-qPCR检测成骨相关基因的表达,Western blot检测成骨相关蛋白及ERK/腺苷酸激活蛋白激酶(AMP-activated protein kinase,AMPK)信号通路蛋白的表达。结果与结论:(1)模型组细胞内碱性磷酸酶含量与矿化结节形成均少于对照组(P<0.05),黄芪甲苷组细胞内碱性磷酸酶含量与矿化结节形成均多于模型组(P<0.05)。(2)与对照组比较,模型组细胞内丙二醛含量增加(P<0.05),骨钙素、RUNX2、Ⅰ型胶原蛋白的mRNA与蛋白表达均降低(P<0.05),AMPK mRNA与p-AMPK蛋白表达升高(P<0.05);与模型组比较,黄芪甲苷组细胞内丙二醛含量减少(P<0.05),骨钙素、RUNX2、Ⅰ型胶原蛋白的mRNA与蛋白表达均升高(P<0.05),ERK1/2、AMPK mRNA表达升高(P<0.05),p-AMPK、p-ERK1/2蛋白表达均升高(P<0.05);ERK抑制剂可部分抑制黄芪甲苷的上述作用。(3)结果表明,黄芪甲苷可通过激活ERK/AMPK信号通路促进氧化应激条件下MC3T3-E1细胞的成骨分化。

关键词：黄芪甲苷骨质疏松症 MC3T3-E1细胞氧化应激 ERK/AMPK信号通路成骨工程化骨材料

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Microfluidic platform for circulating tumor cells isolation and detection

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BIOCELL 2023年第7期47卷 1439-1447页

作者： jiahao zhang JIE REN ZIRUI LI YIXING GOU School of Mechanical Engineering Hebei University of TechnologyTianjin300401China State Key Lab of Reliability and Intelligence of Electrical Equipment Tianjin300401China National Engineering Research Center for Technological Innovation Method and Tool Tianjin300401China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing314001China

Circulating tumor cells(CTCs)are essential biomarkers for liquid biopsies,which are important in the early screening,prognosis,and real-time monitoring of ***,CTCs are less abundant in the peripheral blood of patients,therefore,their isolation is ***,the use of microfluidics for CTC sorting has become a research hotspot owing to its low cost,ease of integration,low sample consumption,and unique advantages in the manipulation of micron-sized ***,we review the latest research on microfluidics-based CTC ***,we consider active sorting using external fields(electric,magnetic,acoustic,and optical tweezers)and passive sorting using the flow effects of cells in specific channel structures(microfiltration sorting,deterministic lateral displacement sorting,and inertial sorting).The advantages and limitations of each method and their recent applications are summarized *** conclude,a forward-looking perspective is presented on future research on the microfluidic sorting of CTCs.

关键词： Circulating tumor cells Microfluidics Cell sorting

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Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells

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Chinese Chemical Letters 2024年第2期35卷 451-454页

作者： jiahao zhang Haiyue Peng Zi'an Chen Guorui Li Jing Huang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Animal Models and Molecular MedicineSchool of Biomedical SciencesHunan UniversityChangsha 410082China

Protein S-sulfenylation(protein sulfenic acid),as one of the most significant oxidative post-translational modifications(OxiPTMs),plays a vital role in regulating protein function.A variety of activity-based probes have been developed to profile sulfenic acid in living ***,due to the transient presence and low content of sulfenic acid in living cell,high doses of probes are needed to achieve efficient *** importantly,current probes have no temporal control over sulfenic acid *** overcome these limitations,two caged cysteine sulfenic acid probes DYn-2-ONB and DYn-2-Cou with either an o-nitrobenzyl or coumarin protecting group were developed in this *** probes can be efficiently uncaged via irradiation to produce the active C-nucleophile probe *** assay in living cells demonstrated DYn-2-ONB exhibited better labeling capacity compared with DYn-2,providing it as a powerful tool for improved monitoring of protein S-sulfenylation in living cells.

关键词： Cysteine Sulfenic acid Activity-based probe Photocage Light activation Protein S-sulfenylation

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Enhanced damage mechanism of reinforced concrete targets impacted by reactive PELE: An analytical model and experimental validation

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Defence Technology（防务技术） 2024年第12期42卷 12-30页

作者： jiahao zhang Mengmeng Guo Sheng Zhou Chao Ge Pengwan Chen Qingbo Yu China State Key Laboratory of Explosion Science and Safety Protection Beijing Institute of TechnologyBeijing100081China

Compared with PELE with inert fillings such as polyethylene and nylon,reactive PELE(RPELE)shows excellent damage effects when impacting concrete targets due to the filling deflagration *** present work,an analytical model describing the jacket deformation and concrete target damage impacted by RPELE was presented,in which the radial rarefaction and filling deflagration reaction were *** impact tests of RPELE on concrete target in the 592-1012 m/s were carried out to verify the analytical *** on the analytical model,the angle-length evolution mechanism of the jacket bending-curling deformation was revealed,and the concrete target damage was further *** can find out that the average prediction errors of the front crater,opening and back crater are 6.8%,8.5%and 7.1%,***,the effects of radial rarefaction and deflagration were *** was found that the neglect of radial rarefaction overestimates the jacket deformation and concrete target damage,while the deflagration reaction of filling increases the diameter of the front crater,opening and back crater by 25.4%,24.3%and 31.1%,*** research provides a valuable reference for understanding and predicting the jacket deformation and concrete target damage impacted by RPELE.

关键词： Reactive PELE Concrete target Jacket deformation Radial rarefaction Enhanced damage mechanism

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Quantum phase transitions in CePdAl probed by ultrasonic and thermoelectric measurements

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Chinese Physics B 2022年第11期31卷 470-473页

作者： Hengcan Zhao Meng Lyu jiahao zhang Shuai zhang Peijie Sun Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Science University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

CePdAl has been recently recognized as a frustrated antiferromagnetic heavy-fermion compound with a pressureor field-tuned,extended quantum critical phase at zero *** characteristic signatures of the emerging quantum critical phase,which are expected to be distinct from those near a quantum critical point,remains *** this work,by performing ultrasonic and thermoelectric measurements down to very low temperatures in a^(3)He–^(4)He dilution refrigerator in the presence of magnetic field,we are able to obtain some crucial thermodynamic and thermal transport features of the quantum critical phase,including a frustration-related elastic softening detected by ultrasound and a Fermi-surface change probed by thermoelectric effect.

关键词： quantum phase transition ultrasound elastic constant thermoelectric power

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Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies

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Journal of Molecular Cell Biology 2021年第2期13卷 79-90页

作者： Ziyan Xie Junye Chen Chenyu Wang jiahao zhang Yanxiang Wu Xiaowei Yan Department of Cardiology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100730China Department of Vascular Surgery Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100730China

Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders.

关键词： Krüppel-like factor 5(KLF5) vascular remodeling inflammation angiogenesis drug development microRNA

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Experimental study on permeability evolution of deep high-stressed coal under major horizontal stress unloading paths

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International Journal of Mining Science and Technology 2024年第11期34卷 1495-1508页

作者： Liu, Chao zhang, jiahao Wu, Songwei Qi, Jinghua Yu, Beichen Wang, Liang School of Mechanics and Civil Engineering China University of Mining and Technology Xuzhou 221116 China State Key Laboratory of Mining Disaster Prevention and Control Ministry of Education Shandong University of Science and Technology Qingdao 266590 China School of Safety Engineering China University of Mining and Technology Xuzhou 221116 China State Key Laboratory of Coal Mine Disaster Prevention and Control China University of Mining and Technology Xuzhou 221116 China Key Laboratory of Theory and Technology on Coal and Rock Dynamic Disaster Prevention and Control National Mine Safety Administration China University of Mining and Technology Xuzhou 221116 China

Both bulk stress (σii) and stress path (SP) significantly affect the transportation characteristics of deep gas during reservoir pressure depletion. Therefore, the experimental study of horizontal stress unloading on seepage behavior of gas-bearing coal under constant σii-constraints is performed. The results show that coal permeability is affected by horizontal stress anisotropy (σH≠σh), and the contribution of minor horizontal stress to permeability is related to the differential response of horizontal strain. The slippage phenomenon is prominent in deep high-stress regime, especially in low reservoir pressure. σii and SP jointly determine the manifestation of slippage effect and the strength of stress sensitivity (γ) of permeability. Deep reservoir implies an incremental percentage of slip-based permeability, and SP weakens the slippage effect by changing the elastic–plastic state of coal. However, γ is negatively correlated with slippage effect. From the Walsh model, narrow (low aspect-ratio) fractures within the coal under unloading SP became the main channel for gas seepage, and bring the effective stress coefficient of permeability (χ) less than 1 for both low-stress elastic and high-stress damaged coal. With the raise of the effective stress, the effect of pore-lined clay particles on permeability was enhanced, inducing an increase in χ for high-stress elastic coal. © 2024

关键词： Aspect ratio

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