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Intranasal Immunization Using CTA1-DD as a Mucosal Adjuvant for an Inactivated Influenza Vaccine

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Biomedical and Environmental Sciences 2019年第7期32卷 531-540页

作者： FAN Xue Ting WANG Yun Long SU Qiu Dong QIU Feng YI Yao jia zhi yuan WANG Da Yan QIN Kun ZOU Ye Ning BI Sheng Li SHEN Li Ping National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Henan Bioengineering Research Center Zhengzhou 4500466 Henan China Sinovac Biotech Co. Ltd. Beijing 100085 China

Objective To evaluate the effect of intranasal immunization with CTA1-DD as mucosal adjuvant combined with H3N2 split vaccine. Methods Mice were immunized intranasally with PBS(negative control), or H3N2 split vaccine(3 μg/mouse) alone, or CTA1-DD(5 μg/mouse) alone, or H3N2 split vaccine(3 μg/mouse) plus CTA1-DD(5 μg/mouse). Positive control mice were immunized intramuscularly with H3N2 split vaccine(3 μg/mouse) and alum adjuvant. All the mice were immunized twice, two weeks apart. Then sera and mucosal lavages were collected. The specific HI titers, IgM, IgG, IgA, and IgG subtypes were examined by ELISA. IFN-γ and IL-4 were test by ELISpot. In addition, two weeks after the last immunization, surivival after H3N2 virus lethal challenge was measured. Results H3N2 split vaccine formulated with CTA1-DD could elicit higher Ig M, Ig G and hemagglutination inhibition titers in sera. Furthermore, using CTA1-DD as adjuvant significantly improved mucosal secretory Ig A titers in bronchoalveolar lavages and vaginal lavages. Meanwhile this mucosal adjuvant could enhance Th-1-type responses and induce protective hemagglutination inhibition titers. Notably, the addition of CTA1-DD to split vaccine provided 100% protection against lethal infection by the H3N2 virus. Conclusion CTA1-DD could promote mucosal, humoral and cell-mediated immune responses, which supports the further development of CTA1-DD as a mucosal adjuvant for mucosal vaccines.

关键词： Adjuvants H3N2 Influenza Mucosal immunization Split vaccine

Toward Analytical Homogenized Relaxation Modulus for Fibrous Composite Material with Reduced Order Homogenization Method

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Computers, Materials & Continua 2025年第1期82卷 193-222页

作者： Huilin jia Shanqiao Huang Zifeng yuan HEDPS Center for Applied Physics and Technology(CAPT)Department of Mechanics and Engineering SciencePeking UniversityBeijing100871China State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100871China

In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational *** method is based on the reduced-order homogenization(ROH)*** ROH method typically involves solving multiple finite element problems under periodic conditions to evaluate elastic strain and eigenstrain influence functions in an‘off-line’stage,which offers substantial cost savings compared to direct computational homogenization *** to the unique structure of the fibrous unit cell,“off-line”stage calculation can be eliminated by influence functions obtained *** the standard solid model to the ROH method enables the creation of a comprehensive analytical homogeneous viscoelastic constitutive *** method treats fibrous composite materials as homogeneous,anisotropic viscoelastic materials,significantly reducing computational time due to its analytical *** approach also enables precise determination of a homogenized anisotropic relaxation modulus and accurate capture of various viscoelastic responses under different loading *** sets of numerical examples,including unit cell tests,three-point beam bending tests,and torsion tests,are given to demonstrate the predictive performance of the homogenized viscoelastic ***,the model is validated against experimental measurements,confirming its accuracy and reliability.

关键词： Homogenized relaxation modulus viscoelastic standard solid model reduced order homogenization fibrous composite material

Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li zhi-Xin Liu jia-Wei Su Ya-Zhou yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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基于滑模学习神经网络的开关磁阻电动机位置控制

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控制与决策 2017年第6期32卷 1133-1136页

作者：王家军孙嘉豪郑致远杭州电子科技大学自动化学院杭州310018

为了解决开关磁阻电动机的位置控制问题,提出一种滑模学习神经网络控制方法.滑模学习算法可以加快自适应线性单元权值训练的速度,采用磁链分配方法实现虚拟参考磁链在不同相之间的合理分配.经过与PD控制器、梯度下降法和转矩分配方法的... 详细信息

为了解决开关磁阻电动机的位置控制问题,提出一种滑模学习神经网络控制方法.滑模学习算法可以加快自适应线性单元权值训练的速度,采用磁链分配方法实现虚拟参考磁链在不同相之间的合理分配.经过与PD控制器、梯度下降法和转矩分配方法的仿真对比,验证了所设计方法在开关磁阻电动机位置控制方面具有更好的响应速度和控制精度.

关键词：开关磁阻电动机滑模学习算法自适应线性单元磁链分配方法

Effect of deposition rate on microstructure and mechanical properties of wire arc additive manufacturing of Ti-6Al-4V components

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Journal of Central South University 2021年第4期28卷 1100-1110页

作者： ZHANG Pei-lei jia zhi-yuan YAN Hua YU zhi-shui WU Di SHI Hai-chuan WANG Fu-xin TIAN Ying-tao MA Song-yun LEI Wei-sheng School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China Shanghai Collaborative Innovation Center of Laser Advanced Manufacturing Technology Shanghai 201620China Fraunhofer Institute for Laser Technology ILT Aachen 52074Germany Department of Engineering Lancaster UniversityLancaster LA14YWUnited Kingdom Institute of General Mechanics RWTH Aachen UniversityAachen 52062Germany

Wire arc additive manufacturing(WAAM)is a novel manufacturing technique by which high strength metal components can be fabricated layer by layer using an electric arc as the heat source and metal wire as feedstock,and offers the potential to produce large dimensional structures at much higher build rate and minimum waste of raw *** the present work,a cold metal transfer(CMT)based additive manufacturing was carried out and the effect of deposition rate on the microstructure and mechanical properties of WAAM Ti-6Al-4V components was *** microstructure of WAAM components showed similar microstructural morphology in all deposition *** the deposition rate increased from 1.63 to 2.23 kg/h,the ultimate tensile strength(UTS)decreased from 984.6 MPa to 899.2 MPa and the micro-hardness showed a scattered but clear decline trend.

关键词： wire and arc additive manufacturing titanium alloys cold metal transfer deposition rate

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： Cell engineering

U-OFDM可见光通信系统的高性能符号同步算法

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北京邮电大学学报 2016年第6期39卷 62-66页

作者：霍佳皓周娴皇甫伟涂佳静杜志远北京科技大学先进网络技术与新业务研究所北京100083

为了提高可见光通信系统的传输效率和抵抗自由空间的多径效应,对单极性正交频分复用技术(U-OFDM)进行了研究.由于U-OFDM信号具有单极性特点,现有的同步算法中还没有针对U-OFDM系统结构的同步算法.鉴于此,提出了一种新的基于负镜像训练... 详细信息

为了提高可见光通信系统的传输效率和抵抗自由空间的多径效应,对单极性正交频分复用技术(U-OFDM)进行了研究.由于U-OFDM信号具有单极性特点,现有的同步算法中还没有针对U-OFDM系统结构的同步算法.鉴于此,提出了一种新的基于负镜像训练序列的符号同步算法,该算法在很低信噪比的情况下也能取得良好的同步效果.

关键词：可见光通信单极性正交频分复用技术同步算法负镜像算法

水-空气耦合介质中冰载荷对闸墩的撞击影响研究

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工程力学 2024年第6期41卷 177-187页

作者：贡力杨腾腾靳春玲贾治元董洲全兰州交通大学土木工程学院甘肃兰州730070 兰州交通大学调水工程及输水安全研究所甘肃兰州730070

西北干寒地区长距离输水工程中河道修建的闸墩受到冰载荷撞击破坏,为确保冬季安全稳定供水,需进行冰载荷对闸墩撞击破坏力学特性研究。该文采用任意拉格朗日-欧拉(arbitrary Lagrangian-Eulerian, ALE)流固耦合(fluid structure interac... 详细信息

西北干寒地区长距离输水工程中河道修建的闸墩受到冰载荷撞击破坏,为确保冬季安全稳定供水,需进行冰载荷对闸墩撞击破坏力学特性研究。该文采用任意拉格朗日-欧拉(arbitrary Lagrangian-Eulerian, ALE)流固耦合(fluid structure interaction, FSI)方法模拟不同碰撞工况下冰体楔入闸墩碰撞过程,并通过对比实验,验证了冰材料模型参数和ALE算法的适用性,分析了网格尺寸对撞击力的影响。研究结果表明:计算得到冰载荷对闸墩撞击力极值与实验值具有良好的吻合性,表明该模拟所采用的冰材料模型参数、ALE算法和网格尺寸能够较准确模拟冰载荷对闸墩的作用力;闸墩损伤变形与冰排破损主要集中在碰撞接触区,接触区撞击力大小受到“水垫效应”的影响,空气介质对撞击力影响较小;不同冰厚和冰速工况下撞击力时程曲线呈现“Sawtooth”(上下波动)现象,撞击力加载-卸载时间较短;冰排楔入闸墩的过程中,撞击力极值出现在0°正碰接触区,在冰速1.2 m/s~3.0 m/s范围内,撞击力逐渐减小,在不改变冰速工况下,随着冰厚的增加,墩体结构响应越大,冰速和冰厚两种影响工况下闸墩顶端位移均为周期性振动。其仿真结果拟为西北干寒地区冰期河道中墩体结构安全提供指导。

关键词：数值模拟流固耦合任意拉格朗日-欧拉冰载荷撞击力闸墩

微量硼对Ti-Fe-Cu-Sn-Nb合金力学性能的影响

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材料工程 2021年第11期49卷 156-162页

作者：甘致聪王硕山圣峰张兵贾元智马明臻燕山大学亚稳材料制备技术与科学国家重点实验室河北秦皇岛066004 济宁学院物理与信息工程系山东曲阜273155

基于细晶强化和第二相强化原理,通过在一种近β钛合金中加入微量硼(B)元素,以强化该合金。首先设计不同含硼量的Ti_(85)Fe_(6)Cu_(5)Sn_(2)Nb_(2)合金,并用真空非自耗电弧炉制备,随后对合金在800℃下进行多道次热轧及最终淬火。通过组... 详细信息

基于细晶强化和第二相强化原理,通过在一种近β钛合金中加入微量硼(B)元素,以强化该合金。首先设计不同含硼量的Ti_(85)Fe_(6)Cu_(5)Sn_(2)Nb_(2)合金,并用真空非自耗电弧炉制备,随后对合金在800℃下进行多道次热轧及最终淬火。通过组织观察、拉伸力学性能测试、断口观察及透射电子显微分析,考察不同硼含量对Ti_(85)Fe_(6)Cu_(5)Sn_(2)Nb_(2)合金组织及力学性能的影响。结果表明,微量硼元素可以使合金的晶粒细化,强度明显提高,但伴随着塑性下降。添加质量分数为0.15%硼可以使合金具有较好的综合力学性能(σ_(0.2)=1105 MPa,δ_(b)=4.5%)。随着硼含量的增加,合金的强度升高,最高可达115_(6)MPa。硼的加入在合金中形成正交结构的TiB相,分布于β钛基体中。变形过程中,TiB断裂、TiB割裂基体及其与基体脱粘,产生裂纹源,导致合金塑性下降。

关键词：钛合金 TiB 力学性能显微组织