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Solid pseudopapillary tumor of the pancreas:A review of 553 cases in Chinese literature

World Journal of Gastroenterology 2010年第10期16卷 1209-1214页

作者： yu, Peng-Fei Hu, Zhen-Hua Wang, Xin-Bao Guo, jian-min Cheng, Xiang-Dong Zhang, yun-Li Xu, Qi Zhejiang Canc Hosp Dept Abdominal Surg Hangzhou 310022 Zhejiang Peoples R China Zhejiang Univ Coll Med Affiliated Hosp 1 Dept Hepatobiliary & Pancreat Surg Hangzhou 310003 Zhejiang Peoples R China Zhejiang Canc Hosp Dept Chemotherapy Ctr Hangzhou 310022 Zhejiang Peoples R China

AIM:To sum up the clinical and pathological characte- ristics of solid pseudopapillary tumor (SPT) and the experience with ***: A total of 553 SPT patients reported in Chinese literature between January 1996 and January 2009 were retrospectively reviewed and analyzed. RESULTS: The mean age of the 553 SPT patients included in this review was 27.2 years, and the male to female ratio was 1:8.37. Their symptoms were non-specific, and nearly one third of the patients were asymptomatic. Computed tomography and ultraso-nography were performed to show the nature and location of SPT. Most of the tumors were distributed in the pancreatic head (39.8%), tail (24.1%), body andtail (19.5%). Forty-five patients (9.2%) were diagnosed as malignant SPT with metastasis or invasion. None of the clinical factors was closely related to the malignant potential of SPT. Surgery was the main therapeutic modality for SPT. Local resection, distal pancreatectomy and pancreatoduodenectomy were the most common surgical procedures. Local recurrence and hepatic metastasis were found in 11 and 2 patients, respectively, after radical resection. Four patients died of tumor progression within 4 years after palliative resection of SPT. The prognosis of SPT patients was good with a 5-year survival rate of 96.9%.CONCLUSION: SPT of the pancreas is a rare indolent neoplasm that typically occurs in young females. It is a low-grade malignancy and can be cured with extended resection. The prognosis of such patients is good although the tumor may recur and metastasize.

关键词： Pancreatic neoplasm Solid pseudopapillary tumor Diagnosis Treatment Prognosis

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Risk factors for persistent epiphora following successful canalicular laceration repair

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 106-111页

作者： Ying-Yan Qin Zuo-Hong Li Feng-Bin Lin yu jia Jun Mao Cong-Yao Wang Xuan-Wei Liang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To identify the risk factors of epiphora in patients with anatomical patency after surgical repair of canalicular ***:This retrospective case series included 178 cases of canalicular laceration repair from 2005 to *** data collected from each patient included age,sex,type of injury,distance from the distal lacerated end of the canaliculus to the punctum,the severity score for the structural abnormity of the medial canthus,the duration of stent placement,and the timing of *** risk factors for epiphora were evaluated using Logistic regression ***:Among the 178 cases,45(25.3%)with lacrimal patency after irrigation had symptomatic epiphora at the final ***'sex,age,type of injury,duration of stent placement,timing of surgery,and concurrent trauma were not found to be significantly associated with symptomatic epiphora after surgical repair of the lacerated canaliculus(P>0.05).A distance of more than 5 mm from the distal cut end to the punctum was closely and significantly associated with symptomatic epiphora after surgical repair of the lacerated canaliculus(P<0.01).Symptomatic epiphora was significantly more frequent in patients with higher severity scores for structural abnormities of the medial canthus(P<0.01).CONCLUSION:Our results indicate that the risk factors for postoperative symptomatic epiphora include a further distance between the distal cut end and the lacrimal punctum and a higher severity score for structural abnormities of the medial *** findings could be used to prognosticate postoperative symptomatic epiphora.

关键词： canalicular laceration patency irrigation epiphora abnormity of the medial canthus

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Small nucleolar RNA and its potential role in the oncogenesis and development of colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 115-127页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen Ze-Xuan Fang Xin-Ning yu Hua-Tao Wu Jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Small nucleolar RNAs(snoRNAs)represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification,thereby contributing significantly to the maintenance of cellular functions related to protein *** have been discovered to possess the ability to influence cell fate and alter disease progression,holding immense potential in controlling human *** is suggested that the dysregulation of snoRNAs in cancer exhibits differential expression across various cancer types,stages,metastasis,treatment response and/or prognosis in *** the other hand,colorectal cancer(CRC),a prevalent malignancy of the digestive system,is characterized by high incidence and mortality rates,ranking as the third most common cancer *** research indicates that snoRNA dysregulation is associated with CRC,as snoRNA expression significantly differs between normal and cancerous ***,assessing snoRNA expression level and function holds promise for the prognosis and diagnosis of ***,current comprehension of the potential roles of snoRNAs in CRC remains *** review offers a comprehensive survey of the aberrant regulation of snoRNAs in CRC,providing valuable insights into the discovery of novel biomarkers,therapeutic targets,and potential tools for the diagnosis and treatment of CRC and furnishing critical cues for advancing research into CRC and the judicious selection of therapeutic targets.

关键词： Small nucleolar RNAs Colorectal cancer Dysregulation Biomarker

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Autoimmune enteropathy and primary biliary cholangitis after proctocolectomy for ulcerative colitis:A case report and review of the literature

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World Journal of Gastroenterology 2021年第29期27卷 4929-4938页

作者： Qing-Yang Zhou Wei-Xun Zhou Xi-yu Sun Bin Wu Wei-Yang Zheng yue Li jia-ming Qian Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Autoimmune enteropathy(AIE)and primary biliary cholangitis(PBC)are both immune-mediated *** or PBC complicated with ulcerative colitis(UC)are *** are no cases of AIE and PBC diagnosed after proctocolectomy for UC reported before,and the pathogenesis of these comorbidities has not been *** SUMMARY A middle-aged woman diagnosed with UC underwent subtotal colectomy and ileostomy due to the steroid-resistant refractory disease,and a restorative proctectomy with ileal pouch-anal anastomosis and proximal neoileostomy was postponed due to active residual rectal inflammation in January 2016.A few months after the neoileostomy,she began to suffer from recurrent episodes of watery *** was diagnosed with postcolectomy enteritis and stoma closure acquired a good therapeutic ***,her symptoms of diarrhea relapsed in 2019,with different histological features of endoscopic biopsies compared with 2016,which showed apoptotic bodies,a lack of goblet and Paneth cells,and villous blunting.A diagnosis of AIE was established,and the patient’s stool volume decreased dramatically with the treatment of methylprednisolone 60 mg/d for 1 wk and tacrolimus 3 mg/d for 4 ***,her constantly evaluated cholestatic enzymes and high titers of antimitochondrial antibodies indicated the diagnosis of PBC,and treatment with ursodeoxycholic acid(16 mg/kg per day)achieved satisfactory *** Some immune-mediated diseases may be promoted by operation due to microbial alterations in UC *** follow-up is essential for UC patients with postoperative complications.

关键词： Autoimmune enteropathy Primary biliary cholangitis Ulcerative colitis Proctocolectomy Bacterial translocation Case report

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新型钴基高温合金中W元素对蠕变组织和性能的影响

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金属学报 2023年第9期59卷 1209-1220页

作者：陈佳郭敏杨敏刘林张军西北工业大学凝固技术国家重点实验室西安710072

以γ’相强化的Co-Al-W高温合金(Co-9Al-xW,x=8、9、10,原子分数,%)为研究对象,耦合CALPHAD和晶体塑性本构关系,建立了高温加载时微观组织演化的三元弹塑性相场模型,考察了W含量对蠕变过程中γ’相演化行为和蠕变性能的影响。结果表明,... 详细信息

以γ’相强化的Co-Al-W高温合金(Co-9Al-xW,x=8、9、10,原子分数,%)为研究对象,耦合CALPHAD和晶体塑性本构关系,建立了高温加载时微观组织演化的三元弹塑性相场模型,考察了W含量对蠕变过程中γ’相演化行为和蠕变性能的影响。结果表明,随W含量增加,γ’相体积分数增加,γ基体塑性变形降低,筏化形成并提前,导致蠕变性能提高。不变矩分析表明,9W和10W合金中筏组织形成是出现稳态蠕变阶段的主要原因。应力/应变分析表明,高W合金γ基体中较大的错配应力减小了塑性变形。

关键词：钴基高温合金相场模拟蠕变筏化

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Sarcomatoid intrahepatic cholangiocarcinoma mimicking liver abscess: A case report

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World Journal of Clinical Cases 2020年第1期8卷 208-216页

作者： Yan Wang jia-Lei ming Xing-yu Ren Lu Qiu Li-Juan Zhou Shu-Dong Yang Xiang-ming Fang Department of Radiology The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Department of Pathology The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina

BACKGROUND Sarcomatoid intrahepatic cholangiocarcinoma(SICC) is an extremely rare and highly invasive malignant tumor of the liver. To our knowledge, the imaging findings of sarcomatous cholangiocarcinoma have been rarely reported; and radiological features of this tumor mimicking liver abscess have not yet been *** SUMMARY We present a case of SICC mimicking liver abscess. The patient, a 43-year-old male, complained of repeated upper right abdominal discomfort and intermittent distension over a period of one month. Radiology examination revealed a huge focal lesion in the right liver. The lesion was hypointense on computed tomography with honeycomb enhancement surrounded by enhanced peripheral areas. It showed a hypo-signal on non-contrast T1-weighted images and a hypersignal on non-contrast T2-weighted images. Radiologists diagnosed the lesion as an atypical liver abscess. The patient underwent a hepatectomy. After surgery, he survived another 2.5 mo before passing away. A search of Pub Med and Google revealed 43 non-repeated cases of SICC reported in 20 published studies. The following is a short review in order to improve the diagnostic and therapeutic skills in cases of *** This report presents the clinical and radiological features of SICC and imaging features which showed hypovascularity and progressive enhancement. SICC can present as a multilocular cyst on radiological images and it is necessary to distinguish this lesion from an atypical abscess. Simple surgical treatment is not the best treatment option for this disease.

关键词： Sarcomatoid intrahepatic cholangiocarcinoma Liver abscess Radiological features Case report

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支持透明离线TTP的多方非否认协议

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吉林大学学报（工学版） 2009年第4期39卷 1099-1104页

作者：李磊杨加喜王育民西安电子科技大学综合业务网国家重点实验室西安710071 郑州大学信息工程学院郑州450052

针对电子商务中已提出的多方非否认协议不支持透明TTP,提出了一种新的协议,该协议的非否认证据不需使用TTP的签名,实现了对透明TTP的支持。协议由Exchange、Cancel和Finish三个子协议以及争议处理方案组成,在正常执行情况下,仅需3个消... 详细信息

针对电子商务中已提出的多方非否认协议不支持透明TTP,提出了一种新的协议,该协议的非否认证据不需使用TTP的签名,实现了对透明TTP的支持。协议由Exchange、Cancel和Finish三个子协议以及争议处理方案组成,在正常执行情况下,仅需3个消息交换步骤。对协议的分析表明,协议满足公平性、时限性和机密性。

关键词：通信技术安全协议非否认多方协议透明TTP

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Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3585-3599页

作者： De-Gang Li jia-Peng jiang Fan-Ye Chen Wei Wu Jun Fu Gong-He Wang yu-Bo Li Department of Gastrointestinal and Anorectal Surgery The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are typical gastrointestinal tract *** is the first-line therapy for GIST *** resistance limits the long-term effectiveness of *** regulatory effect of insulin-like growth factor 2(IGF2)has been confirmed in various cancers and is related to resistance to chemotherapy and a worse *** To further investigate the mechanism of IGF2 specific to *** IGF2 was screened and analyzed using Gene Expression Omnibus(GEO:GSE225819)*** IGF2 knockdown or overexpression by transfection,the phenotypes(proliferation,migration,invasion,apoptosis)of GIST cells were characterized by cell counting kit 8,Transwell,and flow cytometry *** used western blotting to evaluate pathway-associated and epithelial-mesenchymal transition(EMT)-associated *** injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of *** Data from the GEO indicated that IGF2 expression is high in GISTs,associated with liver metastasis,and closely related to drug *** cells with high expression of IGF2 had increased proliferation and migration,invasiveness and *** of IGF2 significantly inhibited those *** addition,OEIGF2 promoted GIST metastasis in vivo in nude ***2 activated IGF1R signaling in GIST cells,and IGF2/IGF1R-mediated glycolysis was required for GIST with liver *** cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib ***,2-deoxy-D-glucose(a glycolysis inhibitor)treatment reversed IGF2 overexpressionmediated imatinib resistance in *** IGF2 targeting of IGF1R signaling inhibited metastasis and decreased imatinib resistance by driving glycolysis in GISTs.

关键词： Insulin-like growth factor 2 Gastrointestinal stromal tumors IGF1R Glycolysis Imatinib resistance

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Distribution of airborne SARS-CoV-2 and possible aerosol transmission in Wuhan hospitals,China

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National Science Review 2020年第12期7卷 1865-1867页

作者： jia Hu Chengfeng Lei Zhen Chen Weihua Liu Xujuan Hu Rongjuan Pei Zhengyuan Su Fei Deng yu Huang Xiulian Sun Junji Cao Wuxiang Guan Wuhan Institute of Virology Center for Biosafety Mega-ScienceChinese Academy of Sciences Wuhan Jinyintan Hospital Key Lab of Aerosol Chemistry and Physics SKLLQGInstitute of Earth EnvironmentChinese Academy of Sciences

The novel severe acute respiratory syndrome coronavirus 2 (SARS-Co V-2) has caused an outbreak of COVID-19 (2019coronavirus infectious disease) that has led to a global public health *** spread of SARS-Co V-2 can be rapid,but there is still considerable controversy about its main route of transmission[1,2];that is,

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Slow-pull and different conventional suction techniques in endoscopic ultrasound-guided fine-needle aspiration of pancreatic solid lesions using 22-gauge needles

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World Journal of Gastroenterology 2016年第39期22卷 8790-8797页

作者： jia-Ying Chen Qing-yu Ding Yang Lv Wen Guo Fa-Chao Zhi Si-De Liu Tian-ming Cheng Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University Department of Gastroenterology Shenzhen Hospital of Southern Medical University Hui Qiao Medical Center Nanfang Hospital Southern Medical University

AIM To evaluate the cytological diagnostic capacity and sample quality of the slow-pull technique and compare them with different suction *** From July 2010 to December 2015, 102 patients with pancreatic solid lesions who underwent endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) with 22-gauge needles were retrospectively evaluated. EUS-FNA diagnosis was based on a cytological examination, and final diagnosis was based on a comprehensive standard of cytological diagnosis, surgical pathology and clinical or imaging follow-up. Cytological specimens were characterized for cellularity and blood contamination. The cytological diagnostic capacity and sample quality of the slow-pull technique and suction techniques with 5-m L/10-m L/20-m L syringes were *** Of all of the EUS-FNA procedures, the slow-pull technique and suction techniques with 5-m L/10-m L/20-m L syringes were used in 31, 19, 34 and 18 procedures, respectively. There were significant differences between these four suction techniques in terms of cytological diagnostic accuracy(90.3% vs 63.2% vs 58.8% vs 55.6%, P = 0.019), sensitivity(88.2% vs 41.7% vs 40.0% vs 36.4%, P = 0.009) and blood contamination(score ≥ 2 for 29.0% vs 52.6% vs 70.6% vs 72.2%, P = 0.003). The accuracy and sensitivity of the slow-pull technique were significantly higher than those of the suction techniques using 5-m L(P = 0.03, P = 0.014), 10-m L(P = 0.005; P = 0.006) and 20-mL syringes(P = 0.01, P = 0.01). Blood contamination was significantly lower in the slow-pull technique than in the suction techniques with 10-m L(P = 0.001) and 20-mL syringes(P = 0.007).CONCLUSION The slow-pull technique may increase the cytological diagnostic accuracy and sensitivity with slight blood contamination during EUS-FNA when using 22-gauge needles for solid pancreatic masses.

关键词： Endoscopic ultrasound-guided fine-needle aspiration Pancreatic solid lesion Slow-pull technique Suction Negative pressure Cytology

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