检索结果-南通市图书馆

A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

引用

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan Zhang jia-Jie Zhu Zong-Ming Liu yu-Xuan Zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:Hepatocellular carcinoma(HCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC ***-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： Hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

球冠型入射光学系统中等效辐射平面位置的计算

引用

计量学报 2006年第3期27卷 236-240页

作者：代彩红于家琳于靖殷纯永中国计量科学研究院清华大学精密仪器与机械学系

为了满足包括太阳直射和天空散射在内的2π球面度立体角范围的入射光线的测量需求,要求太阳紫外光谱辐射测量装置的入射光学系统必须具备较好的余弦响应特性。研制的入射光学系统由聚四氟乙烯积分球、磨砂石英球冠型余弦漫射器和修正环... 详细信息

为了满足包括太阳直射和天空散射在内的2π球面度立体角范围的入射光线的测量需求,要求太阳紫外光谱辐射测量装置的入射光学系统必须具备较好的余弦响应特性。研制的入射光学系统由聚四氟乙烯积分球、磨砂石英球冠型余弦漫射器和修正环组成。

关键词：计量学光谱学太阳紫外光谱辐射等效辐射平面入射光学系统光谱辐射照度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Filling the gaps in icosahedral superatomic metal clusters

引用

National Science Review 2024年第7期11卷 168-176页

作者： Wei-Miao He jia-Hua Hu yu-jia Cui Jing Li yu-Bing Si Shuai-Bo Wang yu-Jing Zhao Zhan Zhou Lu-Fang Ma Shuang-Quan Zang College of Chemistry Zhengzhou University School of Science Xuchang University College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal University

Chemically modified superatoms have emerged as promising candidates in the new periodic table, in which Au13and its doped M_nAu13-nhave been widely studied. However, their important counterpart, Ag13artificial element, has not yet been synthesized. In this work, we report the synthesis of Ag13nanoclusters using strong chelating ability and rigid ligands, that fills the gaps in the icosahedral superatomic metal clusters. After further doping Ag13template with different degrees of Au atoms, we gained insight into the evolution of their optical properties. Theoretical calculations show that the kernel metal doping can modulate the transition of the excited-state electronic structure, and the electron transfer process changes from local excitation（LE） to charge transfer（CT） to LE. This study not only enriches the families of artificial superatoms, but also contributes to the understanding of the electronic states of superatomic clusters.

关键词： icosahedral superatomic metal clusters analog clusters photoluminescence alloying near-infrared quantum yield

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

新生儿机械通气相关性肺炎

引用

临床儿科杂志 2007年第3期25卷 166-169页

作者：余加林重庆医科大学儿童医院新生儿科重庆400014

新生儿机械通气所致的肺炎已逐渐受到重视,发生率高,尤其是上机3d以上的新生儿。其易感因素包括通气时间、污染的通气管路、抗酸剂的应用、体位及滥用抗生素等。常见致病菌主要是肺炎克雷伯菌、铜绿假单胞菌、不动杆菌属及大肠杆菌等。... 详细信息

新生儿机械通气所致的肺炎已逐渐受到重视,发生率高,尤其是上机3d以上的新生儿。其易感因素包括通气时间、污染的通气管路、抗酸剂的应用、体位及滥用抗生素等。常见致病菌主要是肺炎克雷伯菌、铜绿假单胞菌、不动杆菌属及大肠杆菌等。必须采用综合的防治措施,有依据地选用抗生素,并注意全身支持治疗。

关键词：机械通气肺炎新生儿院内感染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nomogram prediction of vessels encapsulating tumor clusters in small hepatocellular carcinoma≤3 cm based on enhanced magnetic resonance imaging

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1808-1820页

作者： Hui-lin Chen Rui-lin He Meng-Ting Gu Xing-yu Zhao Kai-Rong Song Wen-Jie Zou Ning-Yang jia Wan-Min Liu School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology The Third Affiliated Hospital of Shanghai Naval Military Medical UniversityShanghai 200438China Department of Radiology Tongji University Affiliated Tongji HospitalShanghai 200065China

BACKGROUND Vessels encapsulating tumor clusters(VETC)represent a recently discovered vascular pattern associated with novel metastasis mechanisms in hepatocellular carcinoma(HCC).However,it seems that no one have focused on predicting VETC status in small HCC(sHCC).This study aimed to develop a new nomogram for predicting VETC positivity using preoperative clinical data and image features in sHCC(≤3 cm)*** To construct a nomogram that combines preoperative clinical parameters and image features to predict patterns of VETC and evaluate the prognosis of sHCC *** A total of 309 patients with sHCC,who underwent segmental resection and had their VETC status confirmed,were included in the *** patients were recruited from three different hospitals:Hospital 1 contributed 177 patients for the training set,Hospital 2 provided 78 patients for the test set,and Hospital 3 provided 54 patients for the validation *** predictors of VETC were identified through univariate and multivariate logistic *** independent predictors were then used to construct a VETC prediction model for *** model’s performance was evaluated using the area under the curve(AUC),calibration curve,and clinical decision ***,Kaplan-Meier survival analysis was performed to confirm whether the predicted VETC status by the model is associated with early recurrence,just as it is with the actual VETC status and early *** Alpha-fetoprotein_lg10,carbohydrate antigen 199,irregular shape,non-smooth margin,and arterial peritumoral enhancement were identified as independent predictors of *** model incorporating these predictors demonstrated strong predictive *** AUC was 0.811 for the training set,0.800 for the test set,and 0.791 for the validation *** calibration curve indicated that the predicted probability was consistent with the actual VETC status in all three ***,the decision curve analysis demonstr

关键词： Small hepatocellular carcinoma Vessels encapsulating tumor clusters Nomogram Magnetic resonance imaging Multicenter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

产前感染与早产

引用

实用儿科临床杂志 2005年第12期20卷 1169-1171页

作者：余加林重庆医科大学附属儿童医院重庆400014

早产分为自发性(spontaneous)早产和诱发性(indicated)早产两种,自发性包括未足月分娩发作和未足月胎膜早破(PPROM),诱发性则为医源性或复杂的病理产科因素使孕母或胎儿处于不利情况造成.在美国,自发性早产占2/3,而后者仅占1/3.故防止... 详细信息

早产分为自发性(spontaneous)早产和诱发性(indicated)早产两种,自发性包括未足月分娩发作和未足月胎膜早破(PPROM),诱发性则为医源性或复杂的病理产科因素使孕母或胎儿处于不利情况造成.在美国,自发性早产占2/3,而后者仅占1/3.故防止早产的策略重点应放在自发性早产上.大量基础和临床研究表明,导致自发性早产的原因中,产前感染起了很大的作用[1].调查发现,出生体质量<1 kg的早产儿中1/3以上其母亲都有绒毛膜羊膜炎,经组织学证实的绒毛膜羊膜炎发生率,在20～36周早产中为18.7%(123/679),对照非早产者为5.2%(392/7505),而更早的早产(20～28周)中则为23%,较33～37周早产的绒毛膜羊膜炎发生率(11%)更高[2],可见孕龄越早的早产感染因素越重要.在妊娠最后阶段,几乎任何有能力建立胎儿感染的致病因子都可引起早产[3].

关键词：感染婴儿,早产病因学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新生儿败血症的诊断和治疗

引用

实用儿科临床杂志 2005年第2期20卷 100-102页

作者：余加林重庆医科大学儿童医院重庆400014

新生儿败血症(neonatal sepsis或septicemia)是新生儿期细菌侵入血液循环并在其中生长繁殖,产生毒素所造成的全身性感染[1].发生率占活产儿的0.1%～1.0%,占极低体质量儿的16.4%,长期住院者可更高达300%[1,2].病死率为10%～50%,存活者有... 详细信息

新生儿败血症(neonatal sepsis或septicemia)是新生儿期细菌侵入血液循环并在其中生长繁殖,产生毒素所造成的全身性感染[1].发生率占活产儿的0.1%～1.0%,占极低体质量儿的16.4%,长期住院者可更高达300%[1,2].病死率为10%～50%,存活者有相当一部分发生后遗症,所以应高度重视.

关键词：婴儿,新生败血症诊断治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Furan-derived Schiff base covalent adaptable thermosets with recyclability and anti-flammability

引用

Green Chemical Engineering 2024年第3期5卷 364-373页

作者： Ping Zhang Shuyu jia Ruishi Xie lin Chen Ying Xiong State Key Laboratory of Environment-friendly Energy Materials School of Materials Science and EngineeringSouthwest University of Science and TechnologyMianyang621010China

Conventional thermosetting polymers,mostly derived from nonrenewable petroleum resources,are not reprocessable and recyclable due to their highly cross-linked three-dimensional networks and face the disadvantage of high *** solve these issues,in this study,we synthesized a novel Schiff base covalent adaptable thermoset from a furan-derived tri-aldehyde monomer(TMFP)and a furan-derived di-amine monomer(DFDA).The as-prepared TMFP-DFDA-Vitrimer exhibited superior anti-flammability with a high limiting oxygen index(LOI)of 35.0%and a UL-94 V-0 rating,which was attributed to the excellent charring ***,TMFPDFDA-Vitrimer could also be conveniently recycled by chemical decomposition under a mixed hydrochloric acid/tetrahydrofuran(HCl/THF)*** recycling for 5 times,the thermal,mechanical,and flame retardant properties of the recycled TMFP-DFDA-Vitrimer retained almost unchanged compared to the original *** work provides a prime instance to develop advanced thermosetting polymers from abundant furan-based compounds.

关键词： Furan-based compounds Vitrimer Recyclability Flame retardancy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The effect of Ti and Zr content on the structure,mechanics and energy-release characteristics of Ti—Zr—Ta alloys

引用

Defence Technology（防务技术） 2024年第1期31卷 343-350页

作者： jia-yu Meng Jing-zhi He Bin Zhang Jin Chen Shun Li Dun Niu yu Tang Xi’an Modern Chemistry Research Institute Xi'an710065China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China

Energetic structural materials(ESMs)are a new type of structural materials with bearing and damage *** this work the microstructure,mechanical properties and energy release characteristics of multi-element Ti-Zr-Ta alloys with good casting performance were *** microstructure of the Ti_(x)ZrTa alloys gradually change from BCC+HCP to single BCC structure with the increase of *** the Ti_(2)Zr_(y)Ta alloys was still uniform and single BCC structure with the increase of *** evolution of microstructure and composition then greatly affect the mechanical properties and energy-release characteristics of Ti-Zr-Ta *** synergistic effect of dual phase structure increases the fracture strain of Ti_(x)ZrTa(x=0.2,0.5)with the Ti content decreases,while the fracture strain of Ti_(x)ZrTa(x=2.0,3.0,4.0)gradually increase with the Ti content increases caused by the annihilation of the obstacles for dislocation *** as Zr content increases,the fracture strain of Ti_(2)Zr_(y)Ta alloys decrease,then the oxidation reaction rate and fragmentation degree gradually *** higher oxidation rate and the lager exposed oxidation area jointly leads the higher releasing energy efficiency of Ti_(x)ZrTa alloys with low Ti content and Ti_(2)Zr_(y)Ta alloys with high Zr content.

关键词： Energetic structural materials Ti-Zr-Ta Multi-element alloy Energy release characteristics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cluster DetectionMethod of Endogenous Security Abnormal Attack Behavior in Air Traffic Control Network

引用

Computers, Materials & Continua 2024年第5期79卷 2523-2546页

作者： Ruchun jia jianwei Zhang Yi lin yunxiang Han Feike Yang College of Computer Science Sichuan UniversityChengdu610065China Equipment Management and Unmanned Aerial Vehicle College of Air Force Engineering University Air Force Engineering UniversityXi’an710051China

In order to enhance the accuracy of Air Traffic Control(ATC)cybersecurity attack detection,in this paper,a new clustering detection method is designed for air traffic control network security *** feature set for ATC cybersecurity attacks is constructed by setting the feature states,adding recursive features,and determining the feature *** expected information gain and entropy of the feature data are computed to determine the information gain of the feature data and reduce the interference of similar feature *** autoencoder is introduced into the AI(artificial intelligence)algorithm to encode and decode the characteristics of ATC network security attack behavior to reduce the dimensionality of the ATC network security attack behavior *** on the above processing,an unsupervised learning algorithm for clustering detection of ATC network security attacks is ***,determine the distance between the clustering clusters of ATC network security attack behavior characteristics,calculate the clustering threshold,and construct the initial clustering ***,the new average value of all feature objects in each cluster is recalculated as the new cluster ***,it traverses all objects in a cluster of ATC network security attack behavior feature ***,the cluster detection of ATC network security attack behavior is completed by the computation of objective *** experiment took three groups of experimental attack behavior data sets as the test object,and took the detection rate,false detection rate and recall rate as the test indicators,and selected three similar methods for comparative *** experimental results show that the detection rate of this method is about 98%,the false positive rate is below 1%,and the recall rate is above 97%.Research shows that this method can improve the detection performance of security attacks in air traffic control network.

关键词： Air traffic control network security attack behavior cluster detection behavioral characteristics information gain cluster threshold automatic encoder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：