检索结果-南通市图书馆

Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis

Journal of Rare Earths 2024年第3期42卷 621-628,I0007页

作者： Dandan Zou Runlian Lin yu Han Juan jia Guoqiang Zhou Haisong Zhang Kun Ge Hebei Key Laboratory of Chronic Kidney Diseases and Bone Metabolism Affiliated Hospital of Hebei UniversityBaoding071000China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding071002China

With lanthanum(La) in agriculture, medicine, and the chemical industry, La shows accumulation in the body, especially in the bone, because of its similar structure to calcium. Moreover, La has a direct role in bone formation regulating osteoblasts and osteoclasts. Nevertheless, bone formation is complex under the regulation of osteogenesis, osteoclastogenesis, and angiogenesis in the bone microenvironment. It is difficult to comprehensively understand the regulation of bone homeostasis from a single kind of ***, some bone microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-based compound-lanthanum nitrate(La(NO_(3))_(3)) on bone ***(NO_(3))_(3) has good biological safety, and the osteogenic differentiation is significantly increased under La(NO_(3))_(3) treatment for bone marrow mesenchymal stem cells(BMMSC). In contrast, the differentiation,maturation, and bone erosion ability of osteoclasts are significantly decreased. Meanwhile, the angiogenesis ability of human umbilical vein endothelial cells(HUVEC) is significantly promoted when treated with La(NO_(3))_(3). Furthermore, bone metabolism and angiogenesis are improved under La(NO_(3))_(3) treatment in the calvaria ex vivo culture model and BMMSC-HUVEC co-culture system. These results suggest that La has the beneficial effect of promoting bone metabolism and improving bone formation in the bone microenvironment.

关键词： Lanthanum Bone microenvironment Osteogenic differentiation Angiogenesis Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Megafossils of Betulaceae from the Oligocene of Qaidam Basin and their paleoenvironmental and phytogeographic implications

引用

Plant Diversity 2024年第1期46卷 101-115页

作者： Tao Yang jia-Hao Cai Yan-Zhi Dai Hong-yu Chen Lei Han Li Zhang Wei-yu liang Xu-Jun Li Wen-jia Li Jing-yu Wu San-Ping Xie De-Fei Yan School of Earth Sciences and Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou UniversityLanzhou 730000China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Center for Research and Education on Biological Evolution and Environments School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China

Understanding the paleoenvironment and phytogeographical history of the Tibetan Plateau,China relies on discovering new plant *** Qaidam Basin has long been regarded as an ideal‘field laboratory’to investigate the paleoclimate and paleobiological evolution of the northern Tibetan ***,fossil angiosperms from the Qaidam Basin are rare,and our knowledge of its paleovegetation is ***,we report fossil leaves and fruits of Betulaceae found from the Oligocene Shangganchaigou Formation of northwestern Qaidam Basin(Huatugou area).Comparative morphological analysis led us to assign the fruits to the Betula subgenus Betula and the leaves to Carpinus *** findings,together with other reported fossil plants from the same locality,reveal a close floristic linkage between the Qaidam Basin and Europe during the *** northern pathway of this floristic exchange may have crossed through the Qaidam Basin during the late *** floristic linkage may have been facilitated by the continuous narrowing of the Turgai Strait and stronger westerlies,which transported moisture and provided favorable climatic ***,fossil plants collected from the Qaidam Basin suggest that during the Oligocene this region had warm and humid deciduous broad-leaf forest,which differs from the region’s modern vegetation and indicates that the Qaidam Basin may have been a suitable region for these plants to flourish and spread during the Oligocene.

关键词： Paleoenvironment Biogeography Betulaceous fossil Qaidam basin Tibetan Plateau Oligocene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An efficient labeled memory system for learned indexes

引用

Fundamental Research 2024年第3期4卷 651-659页

作者： yuxuan Mo Jingnan jia Pengfei Li yu Hua Huazhong University of Science and Technology Wuhan 430074China

The appearance and wide use of memory hardware bring significant changes to the conventional vertical memory hierarchy that fails to handle contentions for shared hardware resources and expensive data *** deal with these problems,existing schemes have to rely on inefficient scheduling strategies that also cause extra temporal,spatial and bandwidth *** on the insights that the shared hardware resources trend to be uniformly and hierarchically offered to the requests for co-located applications in memory systems,we present an efficient abstraction of memory hierarchies,called Label,which is used to establish the connection between the application layer and underlying hardware *** on labels,our paper proposes LaMem,a labeled,resource-isolated and cross-tiered memory system by leveraging the way-based partitioning technique for shared resources to guarantee QoS demands of applications,while supporting fast and low-overhead cache repartitioning ***,we customize LaMem for the learned index that fundamentally replaces storage structures with computation models as a case study to verify the applicability of *** results demonstrate the efficiency and efficacy of LaMem.

关键词： Heterogeneous memory system Cache hierarchy Data movement Resource contention Learned index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Vertex-Centered Arbitrary Lagrangian-Eulerian Finite Volume Method with Sub-Cells for Two-Dimensional Compressible Flow

引用

Advances in Applied Mathematics and Mechanics 2024年第1期16卷 181-207页

作者： Xiaolong Zhao Xijun yu Zupeng jia Shijun Zou Meilan Qiu School of Mathematics and Statistics Zhengzhou UniversityZhengzhouHenan 450001China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China School of Mathematics and Statistics Huizhou UniversityHuizhouGuangdong 516007China Institute of Applied Physics and Computational Mathematics Beijing 100088China

In this paper,we present a new vertex-centered arbitrary LagrangianEulerian(ALE)finite volume scheme for two-dimensional compressible *** our scheme,the momentum equation is discretized on the vertex control volume,while the mass equation and the energy equation are discretized on the sub-cells which are included in the vertex control *** attain the average of the fluid velocity on the vertex control volume directly by solving the conservation *** we can obtain the fluid velocity at vertex with the reconstructed polynomial of the *** fluid velocity is chosen as the mesh velocity,which makes the mesh move in a Lagrangian *** WENO(Weighted Essentially Non-Oscillatory)reconstructions for the density(the total energy)and the velocity are used to make our scheme achieve the anticipated *** with the general vertexcentered schemes,our scheme with the new approach for the space discretization can simulate some multi-material flows which do not involve large *** addition,our scheme has good robustness,and some numerical examples are presented to demonstrate the anticipated accuracy and the good properties of our scheme.

关键词： Vertex-centered arbitrary Lagrangian-Eulerian sub-cells multi-material flows

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black hole

引用

Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 55-75页

作者： Li-Ming Cao jia-Ning Chen liang-Bi Wu Libo Xie yu-Sen Zhou School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Peng Huanwu Center for Fundamental Theory Hefei 230026China Interdisciplinary Center for Theoretical Study and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

In this study,we investigate the pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black ***,we use the hyperboloidal framework to cast the quasinormal mode(QNM)problem into an eigenvalue problem associated with a non-selfadjoint operator,and then the spectrum and pseudospectrum are ***,the invariant subspace method is exploited to improve the computational efficiency for *** investigation into the spectrum(in)stability entails two main *** the one hand,we calculate the spectra of the quantum corrected black hole,then by the means of the migration ratio,the impact of the quantum correction effect on the Schwarzschild black hole has been *** results indicate that the so-called“migration ratio instability”will occur for small black holes with small angular momentum number *** the eikonal limit,the migration ratios remain the same for each *** the other hand,we study the spectrum(in)stability of the quantum corrected black hole by directly adding some particular perturbations into the effective potential,where perturbations are located at the event horizon and null infinity,*** are two interesting observations under the same perturbation energy ***,perturbations at infinity are more capable of generating spectrum instability than those at the event ***,we find that the peak distribution can lead to the instability of QNM spectrum more efficiently than the average distribution.

关键词： quasinormal modes pseudospectrum hyperboloidal coordinate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel heterozygous USH1C mutation impacts hair cell mechanotransduction and causes progressive hearing loss

引用

Science Bulletin 2024年第2期69卷 167-172页

作者： Yanyan jia Gaogan jia Luo Guo Nan Song yu-Meng Wang Luoying jiang Yilai Shu Yan Chen Shujia Zhu Huawei Li Wenyan Li ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200031China The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200032China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular MedicineXinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China

Hearing loss is one of the most common sensory disorders worldwide,affecting approximately 466 million people,including 34 million children[1].Genetic mutations accounts for approximately 60%of inherited hearing loss cases[2,3].These genetic changes result in a wide variety of clinical manifestations,ranging from nonsyndromic hearing loss(NSHL)to over 400 syndromes involving hearing loss and from mild adult-onset hearing loss to profound congenital deafness,covering the entire spectrum of Mendelian inheritance.

关键词： mec hearing approximate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LAMDA-SSL:a comprehensive semi-supervised learning toolkit

引用

Science China(Information Sciences) 2024年第1期67卷 306-307页

作者： Lin-Han jia Lan-Zhe GUO Zhi ZHOU yu-Feng LI National Key Laboratory for Novel Software Technology Nanjing University

Machine learning, particularly deep learning, has achieved remarkable success across a wide range of tasks. However,most of these tasks demand a substantial amount of labeled training data, which can be challenging to obtain in many real-world applications due to difficulties, costs, or time constraints associated with labeling. In this context,semi-supervised learning (SSL) has emerged as a promising paradigm to alleviate the dependency on large labeled datasets by harnessing the power of unlabeled data [1–3].

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Distributionally robust optimization configuration method for island microgrid considering extreme scenarios

Energy and AI

引用

Energy and AI 2024年第3期17卷 179-194页

作者： Qingzhu Zhang yunfei Mu Hongjie jia Xiaodan yu Kai Hou Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin300072China Key Laboratory of Smart Energy&Information Technology of Tianjin Municipality Tianjin UniversityTianjin300072China

The marine climate conditions are intricate and variable. In scenarios characterized by high proportions of wind and solar energy access, the uncertainty regarding the energy sources for island microgrid is significantly exacerbated, presenting challenges to both the economic viability and reliability of the capacity configuration for island microgrids. To address this issue, this paper proposes a distributionally robust optimization (DRO) method for island microgrids, considering extreme scenarios of wind and solar conditions. Firstly, to address the challenge of determining the probability distribution functions of wind and solar in complex island climates, a conditional generative adversarial network (CGAN) is employed to generate a scenario set for wind and solar conditions. Then, by combining k-means clustering with an extreme scenario selection method, typical scenarios and extreme scenarios are selected from the generated scenario set, forming the scenario set for the DRO model of island microgrids. On this basis, a DRO model based on multiple discrete scenarios is constructed with the objective of minimizing the sum of investment costs, operation and maintenance costs, fuel purchase costs, penalty costs of wind and solar curtailment, and penalty costs of load loss. The model is subjected to equipment operation and power balance constraints, and solved using the columns and constraints generation (CCG) algorithm. Finally, through typical examples, the effectiveness of this paper’s method in balancing the economic viability and robustness of the configuration scheme for the island microgrid, as well as reducing wind and solar curtailment and load loss, is verified.

关键词： Island microgrid Extreme scenario Distributionally robust optimization Conditi onal generative adversarial network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rate transient analysis methods for water-producing gas wells in tight reservoirs with mobile water

引用

Energy Geoscience 2024年第1期5卷 311-320页

作者： Qingyan yu Ying jia Pengcheng Liu Xiangyang Hu Shengye Hao Research Institute of Petroleum Exploration and Development of SINOPEC Beijing100083China School of Energy Resources China University of GeosciencesBeijing100083China

Tight gas reservoirs with mobile water exhibit multi-phase flow and high stress *** analyzing the reservoir and well parameters using conventional single-phase rate transient analysis methods proves *** study introduces novel rate transient analysis methods incorporating evaluation processes based on the conventional flowing material balance method and the Blasingame type-curve method to examine fractured gas wells producing *** positing a gas-water two-phase equivalent homogenous phase that considers characteristics of mobile water,gas,and high stress sensitivity,the conventional single-phase rate transient analysis methods can be applied by integrating the phase's characteristics and defining the phase's normalized parameters and material balance *** rate transient analysis methods based on the equivalent homogenous phase can be used to quantitatively assess the parameters of wells and gas reservoirs,such as original gas-in-place,fracture half-length,reservoir permeability,and well drainage *** facilitates the analysis of production dynamics of fractured wells and well-controlled areas,subsequently aiding in locating residual gas and guiding the configuration of well *** specific evaluation processes are ***,a numerical simulation mechanism model was constructed to verify the reliability of the developed *** methods introduced have been successfully implemented in field water-producing gas wells within tight gas reservoirs containing mobile water.

关键词： Gas reservoirs with mobile water Gas-water two phase flow High stress sensitivity Equivalent homogenous phase Rate transient analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

引用

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： yu Zhang Fang Zhou Ming-yu Zhang Li-Na Feng jia-Lun Guan Ruo-Nan Dong yu-Jie Huang Su-Hong Xia jia-Zhi Liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,RNA binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(P<0.05).The overall survival rate of EBVaGC patients with a lower expression level of IGFBP1 was significantly higher(P=0.046).GO and KEGG functional enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： N6-methyladenosine methylation Tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：