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韧性城市视角下惠州国土空间综合防灾规划策略研究

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价值工程 2024年第28期43卷 152-156页

作者：刘博文王征贾晓强广东省科学院广州地理研究所广州510070 中晋环境科技有限公司太原030000

在实施国土空间规划背景下,加快构建适应新时代发展要求和人民群众期盼的防灾减灾救灾体系成为未来一段时期规划和防灾管理领域的紧迫任务,也是学术界的研究热点。文章在韧性理念的引领下,以“问题和风险识别-安全韧性战略引导-防灾减... 详细信息

在实施国土空间规划背景下,加快构建适应新时代发展要求和人民群众期盼的防灾减灾救灾体系成为未来一段时期规划和防灾管理领域的紧迫任务,也是学术界的研究热点。文章在韧性理念的引领下,以“问题和风险识别-安全韧性战略引导-防灾减灾空间布局-应急救援空间资源配置”为主线,探讨韧性城市角度下国土空间综合防灾规划策略和思路,丰富国土空间综合防灾规划理论和方法。

关键词：城市韧性国土空间综合防灾规划惠州

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Recent advances in electrocatalytic generation of indole-derived radical cations and their applications in organic synthesis

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Chinese Chemical Letters 2024年第4期35卷 106-123页

作者： Wei Zhou Xi Chen Lin Lu Xian-Rong Song Mu-jia Luo qiang xiao Key Laboratory of Organic Chemistry of jiangxi Province Jiangxi Science&Technology Normal UniversityNanchang 330013China

Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines. Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles. Remarkable achievements in electrocatalytic indolederived radical cation-mediated indole functionalization have been realized so far. This review comprehensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp~2)–H functionalization, dearomative 2,3-difunctionalization, and ring-opening reaction, emphasizing the vital single electron oxidation steps of indoles, the substrates scope and limitations, and the reaction mechanisms.

关键词： Electrocatalysis Indole radical cation C-H functionalizatin Dearomative 2 3-difunctionalization

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畅舟通便、调畅三焦法论治功能性便秘

中国肛肠病杂志 2024年第2期44卷 78-80页

作者：王芳贾小强赫兰晔崔春辉曹威巍权隆芳李佳兴云南中医药大学云南昆明650500 中国中医科学院西苑医院北京100091

功能性便秘(functional constipation, FC)是临床上常见的病证,临床表现为持续或可缓解的排粪困难、排粪次数减少或排粪不尽感,粪质干硬或不干。随着社会节奏加快,生活压力增加,饮食结构精细化等原因,FC的患病率呈逐年上升趋向。长期便... 详细信息

功能性便秘(functional constipation, FC)是临床上常见的病证,临床表现为持续或可缓解的排粪困难、排粪次数减少或排粪不尽感,粪质干硬或不干。随着社会节奏加快,生活压力增加,饮食结构精细化等原因,FC的患病率呈逐年上升趋向。长期便秘不仅会影响患者生活质量、加重患者经济负担,还可引发患者焦虑、抑郁,或导致混合痔、结肠黑变病等疾病;此外,近年来研究显示FC亦是老年人心脑血管疾病常见诱因^([1])。

关键词：三焦理论功能性便秘中医药治疗

Current understanding of ELF4 deficiency:a novel inborn error of immunity

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World Journal of Pediatrics 2024年第5期20卷 444-450页

作者： Hong-qiang Du xiao-Dong Zhao Department of Rheumatology&Immunology National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Rare Diseases in Infection and ImmunityChildren’s Hospital of Chongqing Medical UniversityZhongshan Er Road 136Yuzhong DistrictChongqingChina

Background ELF4 deficiency has been recently recognized as a novel disorder within the spectrum of inborn errors of immunity(IEIs),specifically categorized as a“disease of immune dysregulation.”Cases of this condition,reported by our team and others,are very limited *** such,our current knowledge of this new disease remains *** review aims to provide a brief overview of the clinical manifestations,pathogenesis,and treatment strategies for this novel *** sources A comprehensive review was conducted after an extensive literature search in the PubMed/Medline database and websites concerning transcriptional factor ELF4 and reports concerning patients with ELF4 *** search strategy was“ELF4 OR ETS-related transcription factor Elf-4 OR EL4-like factor 4 OR myeloid Elf-1-like factor”as of the time of manuscript *** The current signature manifestations of ELF4 deficiency disorder are recurrent and prolonged oral ulcer,abdominal pain,and diarrhea in pediatric *** some cases,immunodeficiency and autoimmunity can also be *** Sanger sequencing or whole exome sequencing can be used to detect variation in ELF4 *** blotting for ELF4 expression of the patient’s cells can confirm the pathogenic effect of the *** fully confirm the pathogenicity of the variant,further functional test is strongly *** and biologics are the mainstream management of ELF4 deficiency *** Pediatric males presenting with recurring ulcerations in digestive tract epithelium with or without recurrent fever should be suspected of *** atypical presentations are prominent,variations in ELF4 gene should be carefully evaluated functionally due to the complex nature of ELF4 *** of treating DEX includes use of glucocorticoid and biologics and more precise treatment needs more patients to identify and further mechanistic study.

关键词： ELF4 transcription factor Immune dysregulation Inborn errors of immunity Mechanism Recurrent infections

Pancreatic cancer with gastrointestinal obstruction as an initial symptom

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 545-547页

作者： jia-Ren Xu Xing-Nan Wu Yong-qiang Si Jin-Pu Yang xiao-Sun Liu Department of Gastrointestinal Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor: Pancreatic cancer is the fourth leading cause of cancer mortality in the United States [ 1, 2 ]. Risk factors of pancreatic cancer include smoking, family history of chronic pancreatitis, advanced age, male, diabetes mellitus, and obesity [1]. Most of patients have no obvious symptoms in the early stage, and are often diagnosed in the late stage and accompanied by invasion of surrounding tissues and distant metastasis, such as local lymph nodes, liver, lung and peritoneum [ 1, 3 ]. Therefore, the prognosis is poor.

关键词： cancer Pancreatic invasion

Infinitely Many Solutions for a Class of Quasi-linear Elliptic Problem

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 728-743页

作者： xiao-yao jia Zhen-luo LOU School of Economics and Management Zhongyuan University of TechnologyZhengzhou 450007China Mathematics and Statistics School Henan University of Science and TechnologyLuoyang 471023China

In this paper,we study the following quasi-linear elliptic equation:■where Ω?R^(N) is a bounded domain,λ>0 is a *** function ψ(|t|)t is the subcritical term,and φ(|t|)t is the critical Orlicz-Sobolev growth term with respect to φ.Under appropriate conditions on φ,ψ and φ,we prove the existence of infinitely many weak solutions for quasi-linear elliptic equation,for λ∈(0,λ_(0)),where λ_(0)> 0 is a fixed constant.

关键词： quasi-linear elliptic equations variational methods Orlicz-Sobolev spaces

Resilience assessment and optimization method of city road network in the post-earthquake emergency period

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 765-779页

作者： Wang Haoran xiao jia Li Shuang Zhai Changhai Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150090China

The post-earthquake emergency period,which is a sensitive time segment just after an event,mainly focuses on saving life and restoring social *** improve the seismic resilience of city road networks,a resilience evaluation method used in the post-earthquake emergency period is *** road seismic damage index of a city road network can consider the influence of roads,bridges and buildings along the roads,*** road capacity after an earthquake.A function index for a city road network is developed,which reflects the connectivity,redundancy,traffic demand and traffic function of the *** optimization model for improving the road repair order in the post-earthquake emergency period is also developed according to the resilience evaluation,to enable decision support for city emergency management and achieve the best seismic resilience of the city road *** optimization model is applied to a city road network and the results illustrate the feasibility of the resilience evaluation and optimization method for a city road network in the post-earthquake emergency period.

关键词： city road network post-earthquake emergency period traffic demand resilience evaluation optimization model

Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： qiang-qiang Liu Shu-Ting Liu Ying-Guang Li Xu Liu xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao Feng Hua Zou Yuan-qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury