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MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway

Neural Regeneration Research 2021年第6期16卷 1024-1030页

作者： shi-jia yu Ming-Jun yu Zhong-Qi Bu Ping-Ping He Juan Feng Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurosurgery Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Apoptosis is an important programmed cell death process involved in ischemia/reperfusion *** are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion ***,whether miR-670 can regulate cell growth and death in cerebral ischemia/reperfusion and the underlying mechanism are poorly *** this study,we established mouse models of transient middle artery occlusion and Neuro 2a cell models of oxygen-glucose deprivation and reoxygenation to investigate the potential molecular mechanism by which miR-670 exhibits its effects during cerebral ischemia/reperfusion injury both in vitro and in *** results showed that after ischemia/reperfusion injury,miR-670 expression was obviously *** miR-670 expression was inhibited with an miR-670 antagomir,cerebral ischemia/reperfusion injury-induced neuronal death was obviously *** miR-670 overexpression was induced by an miR-670 agomir,neuronal apoptosis was *** addition,we also found that miR-670 could promote Yap degradation via phosphorylation and worsen neuronal apoptosis and neurological *** of miR-670 reduced neurological impairments after cerebral ischemia/reperfusion *** results suggest that microRNA-670 aggravates cerebral ischemia/reperfusion injury through the Yap pathway,which may be a potential target for treatment of cerebral ischemia/reperfusion *** present study was approved by the Institutional Animal Care and Use Committee of China Medical University on February 27,2017(IRB No.2017PS035K).

关键词： apoptosis cerebral ischemia and reperfusion injury microRNA miR-670 neurological function neuron non-coding RNA pathway

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Plasma brain natriuretic peptide, platelet parameters, and cardiopulmonary function in chronic obstructive pulmonary disease

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World Journal of Clinical Cases 2021年第36期9卷 11165-11172页

作者： Hai-jian Guo Feng jiang Chu Chen jia-yu shi Ya-Wen Zhao Department of Cardiology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Chronic obstructive pulmonary disease(COPD)is a chronic respiratory disease with worldwide occurrence and high disability and mortality *** occurs mostly in the elderly population with pulmonary heart disease,type II respiratory failure,and other serious *** To investigate the correlation of plasma brain natriuretic peptide(BNP)and platelet parameters with cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart *** From June 2016 to June 2019,52 patients with COPD-pulmonary heart disease(pulmonary heart disease group),30 patients with COPD(COPD group),and 30 healthy individuals(control group)in our hospital were enrolled in the *** pulmonary heart disease group was further divided into subgroups according to cardiac function classification and pulmonary artery *** BNP and platelet parameters were estimated and compared among each group and *** correlation of plasma BNP and platelet parameters with cardiac function classification and pulmonary artery pressure was then *** In the pulmonary heart disease group,the COPD group,and the control group,the levels of plasma BNP,platelet distribution width(PDW),and mean platelet volume(MPV)showed a decreasing trend(P0.05).In the cardiac function grade I,II,III,and IV subgroups,the levels of plasma BNP,PDW,and MPV showed an increasing trend(P<0.05),while a decreasing trend was noted in PLT and PCT levels among the four subgroups(P<0.05).Correlation analysis showed that the levels of plasma BNP,PDW,and MPV in patients with pul

关键词： Chronic obstructive pulmonary disease Pulmonary heart disease Plasma brain natriuretic peptide Platelet parameter Cardiac function Pulmonary hypertension Correlation analysis

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Magnetic Properties of Nanometer-Scale NiZnCu Ferrite Thin Films Fabricated by Spray-Spin-Heating-Coating Method

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Journal of Materials Science & Technology 2004年第1期20卷 35-37页

作者： yulan JING, Huaiwu ZHANG, lijun jia, yu shi and Yingli LIUInstitute of Information and Materials, University of Electronic Science and Technology of China, Chengdu 610054, China Inst. of Info. and Mat. Univ. of Electron. Sci. and Technol. Chengdu 610054 China

A new nanometer-scale ferrite thin film with excellent high-frequency characteristics has been developed by the spray-spin-heating-coating method. The effects of the ion synthesis mechanism, chemical stoichiometry, fabrication method, and doping content on the magnetic properties and microstructure of the thin films have been analyzed. The films formed between 75℃ and 90℃ by spray-spin-heating-coating methods was discovered with fine grain size of about 21 nm, high saturation magnetization (4πMs) of about 6.5 kGs, coercivity of about 9.8 Oe, as well as initial permeability of about 14.0. These films can be widely used in radio-frequency integrated circuit devices.

关键词： Nanometer materials Ferrite thin film Spray-spin-heating-coating

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A preliminary study on the key factors contributing to the attractive lips of Chinese children

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Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 318-322页

作者： jia-yu shi Han Zhou Run-Yi Mao Yi Chen Jing-Tao Li Hai-Ying Huo State Key Laboratory of Oral Disease West China College of StomatologySichuan University Department of Cleft Lip and Palate Surgery West China College of StomatologySichuan University Public Health School of Guangxi Medical University

Objective:To explore the aesthetic characteristics of the Chinese children ***: Frontal and profile photographs of 653 healthy children were categorized as the attractive and the unattractive by three laypersons and objectively measured for ***: The attractive group tended to be smaller in the upper paramedian red lip height,the lower paramedian red lip height,the midline upper red lip height,the central bow angle,and the lip angle,while greater in the Cupid’s bow ***:Thinner lips seemed to be more attractive than full ones among Chinese children.

关键词： Lips Aesthetics Chinese children Subjective appeal Photogrammetry

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Pathogenesis and treatment to postoperative bile leakage: report of 38 cases

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 441-444页

作者： jia-Min Zhang,shi-An yu,Wei Shen and Zhang-Dong Zheng Jinhua Centre Hospital, Jinhua 321000 , China Jinhua Centre Hospital Jinhua 321000 China. zhangjiamin 600323@.***

Bile leakage remains a serious complication after biliary surgery. The aim of this study was to assess the etiology, diagnosis and treatment of postoperative biliary leakage. METHODS:Thirty-eight patients with biliary leakage we treated in recent 8 years were analyzed retrospectively. Among them, 8 patients had bilioenterostomy leakage, 7 accessory bile duct leakage, 7 cholecyst bed leakage, 6 leakage after removal of T-tube, 5 leakage after laparoscopic cholecystectomy, 3 leakage around T-tube, and 2 leakage caused by choledochal damage. Drainage was performed in 17 patients, reoperarion in 13, drainage plus percutaneous transhepatic cholangio drainage (PTCD) , endoscopic retrograde cholangiography (ERCP) , endoscopic nasobiliary drainage(ENBD) and endostenting in 5, and drainage plus growth hormone in 3. RESULTS; In this series, 37 patients were cured, and 1 died of multiple organ dysfunction syndrome (MODS). These patients were hospitalized for 2 weeks to 8 weeks. The drainage group was hospitalized shorter than the undrain-age group. CONCLUSIONS; A piece of white gauze can be used to touch surgical area in detecting biliary leakage intraopera-tively. Mucous to mucous suture of the bile duct and appropriate time for removal of T-tube are recommended to prevent biliary leakage. Reoperation is essential to acute peritonitis. Drainage can be used if leakage don t diffuse or it occurs after pulling out T-tube. Drainage plus ERCP, ENBD,PTCD and drainage are effective.

关键词： etiology treatment complication biliary leakage

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基于拉普拉斯特征映射学习的隐匿FDI攻击检测

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自动化学报 2021年第10期47卷 2494-2500页

作者：石家宇陈博俞立浙江工业大学信息工程学院杭州310023 浙江工业大学网络空间安全研究院杭州310023

智能电网中的隐匿虚假数据入侵(False data injection,FDI)攻击能够绕过坏数据检测机制,导致控制中心做出错误的状态估计,进而干扰电力系统的正常运行.由于电网系统具有复杂的拓扑结构,故基于传统机器学习的攻击信号检测方法存在维度过... 详细信息

智能电网中的隐匿虚假数据入侵(False data injection,FDI)攻击能够绕过坏数据检测机制,导致控制中心做出错误的状态估计,进而干扰电力系统的正常运行.由于电网系统具有复杂的拓扑结构,故基于传统机器学习的攻击信号检测方法存在维度过高带来的过拟合问题,而深度学习检测方法则存在训练时间长、占用大量计算资源的问题.为此,针对智能电网中的隐匿FDI攻击信号,提出了基于拉普拉斯特征映射降维的神经网络检测学习算法,不仅降低了陷入过拟合的风险,同时也提高了隐匿FDI攻击检测学习算法的泛化能力.最后,在IEEE57-Bus电力系统模型中验证了所提方法的优点和有效性.

关键词：智能电网隐匿虚假数据入侵攻击拉普拉斯特征映射神经网络

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类石墨烯结构二维层状碳化硅的非线性二次谐波特性的第一性原理研究

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物理学报 2018年第21期67卷 350-359页

作者：施佳妤蓝尤钊浙江师范大学化学与生命科学学院金华321004

二维层状碳化硅(two-dimensional layered silicon carbide, 2d-SiC)是一种类石墨烯结构的半导体,在非线性光学频率转换上具有潜在的应用.本文基于第一性原理高精度全电子势线性缀加平面波结合态求和方法研究了层叠和拉伸下类石墨烯2d-... 详细信息

二维层状碳化硅(two-dimensional layered silicon carbide, 2d-SiC)是一种类石墨烯结构的半导体,在非线性光学频率转换上具有潜在的应用.本文基于第一性原理高精度全电子势线性缀加平面波结合态求和方法研究了层叠和拉伸下类石墨烯2d-SiC结构的非线性二次谐波系数.非线性过程物理源分析表明,三带项构成的单粒子跃迁过程是2d-SiC结构的二次谐波过程的主要微观跃迁机制,电子的带间运动显著受到带内运动的调谐,π电子离域带对非线性过程有重要贡献.理论上给出了2d-SiC结构的二次谐波系数的角度依赖,为实验研究提供理论参考.拉伸可导致不同频率的二次谐波增强.

关键词：二维层状碳化硅非线性光学二次谐波角度依赖拉伸

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Multi-threaded Fast Distance Field Computation Using Spatial Partition

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科技视界 2015年第8期 153-154页

作者： MIN De-heng jia shi-yu ZHANG Xiao-yun Qingdao University

This article describes three algorithms for distance field generation on triangulated model: brute force algorithm, single-threaded algorithm based on spatial partition and multi-threaded algorithm based on spatial partition. Spatial partition algorithm use equidistant network divide the bounding box into equal-sized cubes, calculates the maximum and minimum distances between the sample point and each of the small cubes,taking the minimum value from the maximum distance as the minimum distance from the sample point to the model named d1, comparing d1 with the distance from sample point to every little cube's minimum distance d2, if d1

关键词：三角模型计算方法空间划分单线程

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An Algorithm for Voxelizing Non-manifold Triangle Geometry

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科技视界 2018年第4期 82-83,95页

作者： ZHANG Lu-peng jia shi-yu WANG Ji-qiang College of Computer Science and Technology Qingdao University

Taking advantage of the characteristic of distance field and octree, we brought up a method which can discrete any triangle-geometry into voxel. As many triangles used for cutting simulation are unoriented, non-manifold or self-intersecting, which leads to ambiguity in mathematical terms. The algorithm firstly computes sign distance field and use the threshold value to reconstruct the surface, which is very close to the original mode. At last, the reconstructed surface is voxelized. Also we can produce voxelized model which is suitable for cutting simulation.

关键词： Distance field Octree Non-manifold Self-intersecting Triangle-geometry Voxelization

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人工光环境对雌性豚鼠生殖内分泌的影响及日钟阴阳方的干预作用

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中国中西医结合杂志 2021年第12期41卷 1468-1475页

作者：施加裕谈勇南京中医药大学第一临床医学院南京210029 南京中医药大学附属医院生殖医学科南京210001

目的研究人工光环境对雌性豚鼠生殖内分泌的影响及日钟阴阳方对雌性豚鼠下丘脑中吻素Kisspeptin及吻素受体(KISS1R)的作用机制。方法将3月龄雌性豚鼠按体重的大小从1到36编号,获取随机数字,按余数分为6组,分别为自然光组、自然光食疗组... 详细信息

目的研究人工光环境对雌性豚鼠生殖内分泌的影响及日钟阴阳方对雌性豚鼠下丘脑中吻素Kisspeptin及吻素受体(KISS1R)的作用机制。方法将3月龄雌性豚鼠按体重的大小从1到36编号,获取随机数字,按余数分为6组,分别为自然光组、自然光食疗组、LED灯组、LED灯食疗组、荧光灯组和荧光灯食疗组,每组6只。用日钟阴阳方对自然光食疗组、LED灯食疗组、荧光灯食疗组进行干预12周。饲养12周后,于动情前期取材,HE染色,电镜下观察卵巢形态;ELISA测定豚鼠血清中雌二醇(E2)、促黄体生成素(LH)、促卵泡生成素(FSH)、睾酮(T)、抗苗勒氏管激素(AMH)、泌乳素(PRL)水平;Western Blot测定豚鼠卵巢内雄激素受体(AR)、促黄体生成素受体(LHR)、促卵泡生成素受体(FSHR)及下丘脑中KISS1R的蛋白含量及逆转录聚合酶链式反应法(RT-PCR)测定豚鼠卵巢内AR、LHR、FSHR mRNA及下丘脑中KISS1R mRNA表达水平。结果(1)自然光照组及自然光食疗组可见结构完整的卵母细胞,未见明显病理变化;荧光灯组及LED灯组卵巢卵母细胞消失,见大量炎性细胞浸润;荧光灯食疗组及LED灯食疗组卵巢可见卵母细胞,但卵母细胞周围粒细胞排列疏松,间隙增大。(2)与自然光照组比较,自然光食疗组血清E2、LH、FSH、T、AMH、PRL含量下降,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量下降(P<0.05);与荧光灯组比较,荧光灯食疗组血清血清E2、LH、FSH、T、AMH、PRL含量下降,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量下降(P<0.05);与LED灯组比较,LED灯食疗组血清E2、LH、FSH、T、AMH、PRL含量均下降,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量下降(P<0.05);与自然光照组比较,荧光灯、LED灯组血清E2、LH、FSH、T、AMH、PRL含量上升,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量上升(P<0.05);与自然光食疗组比较,荧光灯食疗、LED灯食疗组血清E2、LH、FSH、T、AMH、PRL含量上升,下丘脑内KISS1R及卵巢内LHR、FSHR、AR蛋白含量上升(P<0.05)。结论人工光环境的改变会对豚鼠生殖内分泌造成影响,日钟阴阳方可有效改善豚鼠生殖内分泌紊乱的结局。其可能机制与通过调控豚鼠下丘脑内KISS1R的表达,影响Kisspeptin的分泌有关。

关键词：光环境日钟阴阳方性激素水平吻素吻素受体

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