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Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai,2018–2021

Virologica Sinica 2023年第5期38卷 671-679页

作者： Lijuan Lu Yuanyun Ao ran jia Huaqing Zhong Pengcheng Liu Menghua Xu Liyun Su Lingfeng Cao Jin Xu Department of Clinical Laboratory Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201100China Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai201100China

Norovirus(NoV)is a major pathogen that causes acute gastroenteritis(AGE)in people of all ages,especially in *** this study,we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to *** overall detection rate of NoV was 11.9%(181/1545),with annual detection rates of 9.4%(36/381),13.6%(29/213),5.8%(13/226)and 14.2%(103/725),*** note,the prevalence of NoV in 2020 was significantly lower than that in 2018-2019(10.9%,65/594)(P=0.023)and 2021(14.2%,103/725)(P=0.000).The 181 NoV strains identified in this study were classified into the GI group(1.1%,2/181),GII group(98.3%,178/181)and GIX group(0.6%,1/181)according to the VP1 *** most common NoV VP1 genotype was GII.4 Sydney_2012(63.5%,115/181),followed by GII.3(19.9%,36/181)and GII.2(9.4%,17/181).For P genotypes,174 strains were sequenced successfully according to the RdRp gene,and the predominant genotype was GII.P16(44.8%,78/174),followed by GII.P31(25.9%,45/174)and GII.P12(21.3%,37/174).Among the 174 cases,GII.4 Sydney_2012[P16](36.8%,64/174)was the dominant genotype,followed by GII.4 Sydney_2012[P31](25.3%,44/174),GII.3[P12](20.1%,35/174)and GII.2[P16](8.0%,14/174).In particular,the dominant genotypes in Shanghai changed from GII.4 Sydney_2012[P31]in 2018-2019 to GII.4 Sydney_2012[P16]in *** is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in *** data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai.

关键词： Norovirus(NoV) Acute gastroenteritis Children Genotype Recombination

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Effectiveness and safety of traditional Chinese medicine decoction for diabetic gastroparesis:A network meta-analysis

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World Journal of Diabetes 2023年第3期14卷 313-342页

作者： Yu-Xin Zhang Yan-jiao Zhang Run-Yu Miao Xin-Yi Fang jia-Hua Wei Yu Wei jia-ran Lin jia-Xing Tian Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate College Beijing University of Chinese MedicineGraduate CollegeBeijing University of Chinese MedicineBeijing 100029China Graduate College Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

BACKGROUND Diabetic gastroparesis(DGP)is a prevalent complication of diabetes that impairs people's quality of life and places a significant financial burden on *** gastrointestinal symptoms of DGP patients can be improved by several Traditional Chinese Medicine(TCM)decoctions that have been shown to be effective in treating the *** are still many unanswered questions regarding the identification of appropriate therapeutic agents for the treatment of DGP in clinical *** To analyze the efficacy of several TCM decoctions in the treatment of DGP using Bayesian network meta-analysis for *** PubMed,EMBASE,Cochrane Library,Web of Science,China National Knowledge Infrastructure,The China Biology Medicine DVD,Wanfang,and CQVIP were searched from inception to September 17,2022,to collect randomized controlled trials(RCTs)about TCM decoctions for *** effects and symptom scores were the primary ***,we assessed motilin(MOT),somatostatin(SS),gastrin(GAS),gastric emptying rate,gastric emptying time,and adverse drug events as secondary *** A total of 67 eligible RCTs involving 4790 DGP patients and 7 TCM decoctions were *** results of network meta-analysis(NMA)and surface under the cumulative ranking curve showed that with western medicine(WM)as a common control,the Banxia Xiexin Decoction(BXXD)+WM was most effective in clinical effects and enhancing early satiety scores;the Simo decoction(SMD)+WM was most effective in improving nausea and vomiting scores and anorexia scores,bloating scores;the Chaishao Liujunzi Decoction(CSLJD)was most effective in MOT,the Zhishi Xiaopi Decoction(ZSXPD)was most effective in SS and upgrading emptying rate;the jianpi Xiaozhi Decoction was most effective in GAS;the CSLJD+WM was most effective in improving gastric emptying *** These NMA results suggest that the BXXD+WM and SMD+WM may be one of the potential optimal *** to various limitations,

关键词： Diabetic gastroparesis Traditional Chinese medicine decoction Network meta-analysis Effectiveness

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基于贝叶斯优化混合核极限学习机的真伪卷烟拉曼光谱预测研究

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承德石油高等专科学校学报 2024年第3期26卷 9-13页

作者：任宝峰祁卫国肖占云撒兴涛贾然承德市烟草专卖局(公司) 河北承德067000

为解决人工鉴别真伪卷烟存在的预测精度低和主观性强的问题,提出一种基于贝叶斯优化混合核极限学习机的真伪卷烟拉曼光谱鉴别方法。该方法通过采用混合核函数提高模型的学习能力和泛化性能,并采用贝叶斯算法对混合核函数的参数进行优化... 详细信息

为解决人工鉴别真伪卷烟存在的预测精度低和主观性强的问题,提出一种基于贝叶斯优化混合核极限学习机的真伪卷烟拉曼光谱鉴别方法。该方法通过采用混合核函数提高模型的学习能力和泛化性能,并采用贝叶斯算法对混合核函数的参数进行优化,使其不仅有良好的局部搜索能力,同时也加强了全局搜索能力。将该方法应用于某品牌的真伪卷烟预测,试验结果表明:该模型拥有更好的预测精度,为真伪卷烟拉曼光谱预测提供了一种新思路。

关键词：卷烟真伪鉴别拉曼光谱混合核极限学习机贝叶斯优化

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Artificial intelligence in individualized retinal disease management

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1519-1530页

作者： Zi-ran Zhang jia-Jun Li Ke-ran Li The Affiliated Eye Hospital of Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina

Owing to the rapid development of modern computer technologies,artificial intelligence(AI)has emerged as an essential instrument for intelligent analysis across a range of *** has been proven to be highly effective in ophthalmology,where it is frequently used for identifying,diagnosing,and typing retinal *** increasing number of researchers have begun to comprehensively map patients’retinal diseases using AI,which has made individualized clinical prediction and treatment *** include prognostic improvement,risk prediction,progression assessment,and interventional therapies for retinal *** have used a range of input data methods to increase the accuracy and dependability of the results,including the use of tabular,textual,or image-based input *** also combined the analyses of multiple types of input *** give ophthalmologists access to precise,individualized,and high-quality treatment strategies that will further optimize treatment outcomes,this review summarizes the latest findings in AI research related to the prediction and guidance of clinical diagnosis and treatment of retinal diseases.

关键词： artificial intelligence artificial intelligence in ophthalmology retinal disease

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针状焦原料对热膨胀性能影响研究

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炭素技术 2024年第2期43卷 59-63页

作者：曹玉亭王路海刘银东李圣平祁传磊王佳冉王琪丁怡中国石油天然气股份有限公司石油化工研究院北京102206

热膨胀系数作为针状焦质量分级的主要依据之一,与原料有着密切的联系。本文通过核磁与喹啉不溶物的测定获得原料的芳烃组成和活性指数,并利用公式与催化油浆、乙烯焦油及其混合物的热膨胀系数相关联。除此之外,本文还依据芳香化合度计... 详细信息

热膨胀系数作为针状焦质量分级的主要依据之一,与原料有着密切的联系。本文通过核磁与喹啉不溶物的测定获得原料的芳烃组成和活性指数,并利用公式与催化油浆、乙烯焦油及其混合物的热膨胀系数相关联。除此之外,本文还依据芳香化合度计算公式,进一步将热膨胀系数与原料的性质关联。结果表明,针状焦原料的最佳密度在1.02~1.08 g/cm^(3)之间,且高芳烃含量与低热反应活性对应低热膨胀系数。

关键词：石墨电极针状焦热膨胀系数

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Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance

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Journal of Integrative Plant Biology 2024年第4期66卷 700-708页

作者： ran Gao Yutian jia Xia Xu Peng Fu jiaqi Zhou Guanghui Yang State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesChina Agricultural UniversityBeijing 100193China

The high-affinity potassium transporters(HKTs),selectively permeable to either Na^(+)alone or Na^(+)/K^(+),play pivotal roles in maintaining plant Na^(+)/K^(+)*** their involvement in salt tolerance is widely reported,the molecular underpinnings of Oryza sativa HKTs remain *** this study,we elucidate the structures of OsHKT1;1 and OsHKT2;1,representing two distinct classes of rice *** dimeric assembled OsHKTs can be structurally divided into four *** the dimer interface,a half-helix or a loop in the third domain is coordinated by the C-terminal region of the opposite ***,we present the structures of OsHKT1;5 salt-tolerant and salt-sensitive variants,a key quantitative trait locus associated with salt *** salt-tolerant variant of OsHKT1;5 exhibits enhanced Na^(+)transport capability and displays a more flexible *** findings shed light on the molecular basis of rice HKTs and provide insights into their role in salt tolerance.

关键词： HKT salt-tolerant structure

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The generalized method for estimating reserves of shale gas and coalbed methane reservoirs based on material balance equation

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Petroleum Science 2022年第6期19卷 2867-2878页

作者： Jun-Tai Shi Yan-ran jia Long-Long Zhang Chang-jiang Ji Guo-Fu Li Xian-Yue Xiong Hong-Xing Huang Xiang-Fang Li Sui-An Zhang State Key Laboratory of Petroleum Resources and Prospecting in China University of Petroleum(Beijing) Beijing102249China Coalbed Methane Research Center China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Coal and CBM Co-Mining in Nancun Town Jincheng048012ShanxiChina Petro China Coalbed Methane Company Limited Beijing100028China China United Coalbed Methane National Engineering Research Center Co.Ltd Beijing100095China

As the main unconventional natural gas reservoirs,shale gas reservoirs and coalbed methane(CBM)reservoirs belong to adsorptive gas reservoirs,i.e.,gas reservoirs containing adsorbed *** gas and CBM reservoirs usually have the characteristics of rich adsorbed gas and obvious dynamic changes of porosity and permeability.A generalized material balance equation and the corresponding reserve evaluation method considering all the mechanisms for both shale gas reservoirs and CBM reservoirs are *** this work,a generalized material balance equation(GMBE)considering the effects of critical desorption pressure,stress sensitivity,matrix shrinkage,water production,water influx,and solubility of natural gas in water is ***,by converting the GMBE to a linear relationship between two parameter groups related with known formation/fluid properties and dynamic performance data,the straight-line reserve evaluation method is *** using the slope and the y-intercept of this straight line,the original adsorbed gas in place(OAGIP),original free gas in place(OFGIP),original dissolved gas in place(ODGIP),and the original gas in place(OGIP)can be quickly ***,two validation cases for shale gas reservoir and CBM reservoir are conducted using commercial reservoir simulator and the coalbed methane dynamic performance analysis software,***,two field studies in the Fuling shale gas field and the Baode CBM field are *** show that the GMBE and the corresponding straight-line reserve evaluation method are rational,accurate,and effective for both shale gas reservoirs and CBM *** detailed information about reserves of shale gas and CBM reservoirs can be clarified,and only the straight-line fitting approach is used to determine all kinds of reserves without iteration,proving that the proposed method has great advantages compared with other current methods.

关键词： Shale gas Coalbed methane Material balance equation Reserve evaluation Dissolved gas Generalized method

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Nab-paclitaxel plus capecitabine as first-line treatment for advanced biliary tract cancers:An open-label,non-randomized,phase II clinical trial

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World Journal of Gastroenterology 2024年第30期30卷 3564-3573页

作者： Ling-Xiao Xu jia-jia Yuan ran Xue Jun Zhou Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Biliary tract cancers(BTCs)are a heterogeneous group of tumors with high malignancy,poor prognosis,and limited treatment *** To explore the efficacy and safety of nab-paclitaxel plus capecitabine as first-line treatment for advanced and metastatic *** This open-label,non-randomized,double-center,phase II clinical trial recruited systemic therapy-naive patients with unresectable or metastatic BTCs between April 2019 and June 2022 at Beijing Cancer Hospital and the First Hospital of China Medical *** patients were administered nab-paclitaxel(150 mg/m2,day 1)and capecitabine(2000 mg/m2,twice daily,days 1-7)in 14-day cycles until experiencing intolerable toxicity or disease *** primary outcome was the objective response rate(ORR).The secondary outcomes included the disease control rate(DCR),overall survival(OS),progression-free survival(PFS),and *** A total of 44 patients successfully completed the trial,with a median age of 64.00 years(interquartile range,35.00-76.00),and 26(59.09%)were *** response assessment was impeded for one patient due to premature demise from tumor *** the remaining 43 patients undergoing at least one imaging assessment,the ORR was 23.26%[95%confidence interval(CI):11.80%-38.60%],and the DCR was 69.77%(95%CI:53.90%-82.80%).The median OS was 14.1 months(95%CI:8.3-19.9),and the median PFS was 4.4 months(95%CI:2.5-6.3).A total of 41 patients(93.18%)experienced at least one adverse event(AE),with 10 patients(22.73%)encountering grade≥3 AEs,and the most frequent AEs of any grade were alopecia(79.50%),leukopenia(54.55%),neutropenia(52.27%),and liver dysfunction(40.91%),and no treatment-related deaths were *** Nab-paclitaxel plus capecitabine may be an effective and safe first-line treatment strategy for patients with advanced or metastatic BTCs.

关键词： Nab-paclitaxel Capecitabine Biliary tract cancer Objective response rate Phase II clinical trial

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Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 54-66页

作者： jiaxin Li Haozhang Zhong Bojun Cao Zhaoyang ran jia Tan Liang Deng Yongqiang Hao Jinglong Yan Department of Orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin150001China Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Institute of Materials Modification and Modeling Shanghai Jiao Tong UniversityShanghai200240China

Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone *** the micro-level,cells can respond to different geometries,and at the macro-level,the geometric design of implants will also affect the biological function of *** this study,three kinds of porous scaffolds with square,triangular and circle rod shapes were designed and 3D *** study observed the proliferation and differentiation of MC3T3-E1 cells during surface culture of the three types of *** also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical *** trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two *** results show that the square rod porous scaffolds have the best proliferative and osteogenic activities,and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1(Piezo1)and Yes-associated protein(YAP)expression caused by the macro-geometric topography.

关键词： Porous titanium scaffolds Geometric morphology Cell proliferation Structural design

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A Class of m-Complex Symmetric Operators on Hardy Space

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Journal of Mathematical Research with Applications 2024年第1期44卷 63-80页

作者： jia FU Xinmei LI ran LI School of Mathematics Liaoning Normal University

In this paper,we study the necessary and sufficient condition that the Toeplitz operators with respect to the conjugations of one permutation are 2-complex ***,we introduce a class of conjugations called the conjugations of one permutations on the classical Hardy ***,Toeplitz operators are completely characterized as 2-complex symmetric structure under this class of *** matrix representation of Toeplitz operators in the classical regular orthogonal basis on Hardy space is used to describe this class of 2-complex symmetric Toeplitz ***,we add two preconditions fn=-f-nand fn=f-nrespectively to the Toeplitz operators,and we get more simplified *** the second condition,we study the 3-complex symmetry of Toeplitz operators,and we get the same result for Tfis a 3-CSO with the conjugation C((i,j)) and 2-CSO’s.

关键词： m-complex symmetric operator Toeplitz operator Hardy space

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