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Soil application of Trichoderma asperellum GDFS1009 granules promotes growth and resistance to Fusarium graminearum in maize

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Journal of Integrative Agriculture 2019年第3期18卷 599-606页

作者： HE An-le LIU jia WANG Xin-hua ZHANG Quan-guo SONG Wei CHEN Jie School of Agriculture and Biology Shanghai Jiao Tong University/State Key Laboratory of Microbial Metabolites/Key Laboratory of Urban Agriculture(South)Ministry of Agriculture Institute of Cereal and Oil Crops Hebei Academy of Agriculture and Forestry Sciences

Of diseases affecting maize(Zea mays), Fusarium graminearum is one of the most common pathogenic fungi that cause stalk rot. In the present study, the Trichoderma asperellum GDFS1009 strain was shown to be an effective biocontrol agent against stalk rot. In a confrontation culture test, Trichoderma strain displayed an approximately 60% inhibition rate on the mycelial growth of F. graminearum. In pot trials, the application of 2 g/pot of T. asperellum GDFS1009 granules had the best control effect on stalk rot at the seedling stage(up to 53.7%), while the average plant height and fresh weight were also significantly improved. Additionally when fertilizer was added at 8 g/pot, the application of 3 g/pot of Trichoderma granules had the best control effect on maize stalk rot(40.95%). In field trials, when inoculating F. graminearum alone, the disease index for inoculating was 62.45, but only 31.43 after treatment with T. asperellum GDFS1009 granules, suggesting a control efficiency of 49.67%. Furthermore, in a naturally F. graminearum-infected field, Trichoderma granules, when applied for 3 consecutive years, showed significant control of stalk rot and increased yields.

关键词： Trichoderma asperellum maize Fusarium graminearum stalk rot biocontrol agent

GSK3β inhibitor promotes myelination and mitigates muscle atrophy after peripheral nerve injury

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Neural Regeneration Research 2018年第2期13卷 324-330页

作者： jian Weng Yan-hua Wang Ming Li Dian-ying Zhang Bao-guo jiang Department of Orthopedics and Trauma Peking University People's Hospital

Delay of axon regeneration after peripheral nerve injury usually leads to progressive muscle atrophy and poor functional recovery. The Wnt/β-catenin signaling pathway is considered to be one of the main molecular mechanisms that lead to skeletal muscle atrophy in the elderly. We hold the hypothesis that the innervation of target muscle can be promoted by accelerating axon regeneration and decelerating muscle cell degeneration so as to improve functional recovery of skeletal muscle following peripheral nerve injury. This process may be associated with the Wnt/β-catenin signaling pathway. Our study designed in vitro cell models to simulate myelin regeneration and muscle atrophy. We investigated the effects of SB216763, a glycogen synthase kinase 3 beta inhibitor, on the two major murine cell lines RSC96 and C2C12 derived from Schwann cells and muscle satellite cells. The results showed that SB216763 stimulated the Schwann cell migra- tion and myotube contraction. Quantitative polymerase chain reaction results demonstrated that myelin related genes, myelin associated glycoprotein and cyclin-D1, muscle related gene myogenin and endplate-associated gene nicotinic acetylcholine receptors levels were stimulated by SB216763. Immunocytochemical staining revealed that the expressions of ^-catenin in the RSC96 and C2C12 cytosolic and nuclear compartments were increased in the SB216763-treated cells. These findings confirm that the glycogen synthase kinase 3 beta in- hibitor, SB216763, promoted the myelination and myotube differentiation through the Wnt/β-catenin signaling pathway and contributed to nerve remyelination and reduced denervated muscle atrophy after peripheral nerve injury.

关键词： nerve regeneration glycogen synthase kinase 3 beta inhibitor SB216763 myelination myotube differentiation denervated muscle atrophy Wnt/^-catenin Schwann cell muscle cells peripheral nerve injury neural regeneration

灵芝康爱芝宝增强环磷酰胺抑制小鼠乳腺癌肺转移的增效减毒作用

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中国药理学通报 2024年第7期40卷 1335-1342页

作者：练殊吴挺键陈婕钟春莲卢余盛李晔吴长辉张昆贾力解晓东闽江学院材料与化学工程学院闽港澳台科技合作基地福州海洋研究院福建福州350108 福建仙芝楼生物科技有限公司福建福州350108

目的探讨灵芝康爱芝宝(GanoExtra)与环磷酰胺(cyclophosphamide,CTX)联用对抑制小鼠乳腺癌肺转移的增效减毒作用以及对免疫功能的影响。方法通过CCK-8实验验证GanoExtra对肿瘤细胞MCF-7和4T1的毒性;尾静脉注射4T1细胞建立小鼠乳腺癌肺... 详细信息

目的探讨灵芝康爱芝宝(GanoExtra)与环磷酰胺(cyclophosphamide,CTX)联用对抑制小鼠乳腺癌肺转移的增效减毒作用以及对免疫功能的影响。方法通过CCK-8实验验证GanoExtra对肿瘤细胞MCF-7和4T1的毒性;尾静脉注射4T1细胞建立小鼠乳腺癌肺转移模型,设立4T1模型组、CTX组、GanoExtra组和GanoExtra+CTX组,另设对照组。21 d后麻醉处死小鼠,记录小鼠体重、肺转移灶数;肺和脾脏系数;测定小鼠脾脏细胞的活性和NK细胞的活性;测定小鼠血样中各细胞数量;流式细胞术测定血样中CD4^(+)和CD8^(+)T细胞的含量;ELISA法检测血清中TNF-α和IL-6含量;HE染色法观察肿瘤及各组织病理形态学变化;CFSE染色测定GanoExtra对CD8^(+)T细胞的增殖作用。结果在体外,GanoExtra可明显抑制MCF-7和4T1肿瘤细胞活性;在乳腺癌肺转移模型中,与模型组相比,GanoExtra组小鼠脾脏系数和血液WBCs含量明显降低,RBCs、NK细胞、脾细胞活性、CD3^(+)和CD8^(+)细胞比例明显升高;治疗结束后,与CTX组相比较,GanoExtra+CTX组肺转移灶数和肺脏系数明显降低,小鼠血液HGB、CD8^(+)细胞、IL-6和TNF-α明显升高。在体外10 mg·L^(-1)的GanoExtra可明显促进CD8^(+)T细胞增殖。结论GanoExtra可以提高CTX对肿瘤转移的抑制作用,减少由于CTX导致的不良反应,具有促进CD8^(+)T细胞增殖以增强机体免疫疗效的保健功能。

关键词：灵芝康爱芝宝环磷酰胺增效减毒 CD8^(+)T细胞肿瘤转移免疫功能

维普期刊数据库博看期刊

Modeling in-network caching and bandwidth sharing performance in information-centric networking

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The Journal of China Universities of Posts and Telecommunications 2013年第2期20卷 99-105页

作者： WANG guo-qing HUANG Tao LIU jiang CHEN jian-ya LIU Yun-jie Key Laboratory of Universal Wireless Communications of Ministry of Education Beijing University of Posts and Telecommunications School of Telecommunication Engineering Beijing University of Posts and Telecommunications

Information-centric networking （ICN） proposes a content-centric paradigm which has some attractive advantages, such as network load reduction, low dissemination latency, and energy efficiency. In this paper, based on the analytical model of ICN with receiver-driven transport protocol employing least-recently used （LRU） replacement policy, we derive expressions to compute the average content delivery time of the requests＇ arrival sequence of a single cache, and then we extend the expressions to a cascade of caches＇ scenario. From the expressions, we know the quantitative relationship among the delivery time, cache size and bandwidth. Our results, analyzing the trade-offs between performance and resources in ICN, can be used as a guide to design ICN and to evaluation its performance.

关键词： ICN LRU miss probability content delivery time

Variation Characteristics of Hydrothermal Resources Effectiveness Under the Background of Climate Change in Southern Rice Production Area of China

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Journal of Integrative Agriculture 2013年第12期12卷 2260-2279页

作者： YE Qing YANG Xiao-guang DAI Shu-wei LI Yong guo jian-ping College of Resources and Environmental Science China Agricultural University Forestry Institute Jiangxi Agricultural University School of Natural Resources University of Nebraska-Lincoln Guizhou Key Laboratory of Mountainous Climate and Resources Chinese Academy of Meteorological Sciences

The spatiotemporal characteristics of hydrothermal resources in southern rice production area of China have changed under the background of climate change,and this change would affect the effectiveness of hydrothermal resources during local rice growing *** to the cropping system subdivision in southern rice production area of China during 1980s,this study used climate data from 254 meteorological stations and phonological data from 168 agricultural observation stations in the south of China,and adopted 6 international evaluation indices about the effectiveness of hydrothermal resources to analyze the temporal and spatial characteristics of hydrothermal resources during the growing period of single cropping rice system and double cropping rice system for 16 planting zones in the whole study *** results showed that：in southern rice production area of China,the effectiveness of thermal resources of single cropping rice area（SCRA） was less than that of double cropping rice area（DCRA）,whereas the effectiveness of thermal resources of both SARA and DCRA showed a decreasing *** index value of effective precipitation satisfaction of SCRA was higher than that of DCRA,nevertheless the index value of effective precipitation satisfaction of both SCRA and DCRA showed a decreasing *** was a significant linear relationship between effective thermal resource and water demand,likely water demand increased by 18 mm with every 100°C d increase of effective *** precipitation satisfaction index（EPSI） showed a negative correlation with effective heat,yet showed a positive correlation with effective *** reduced by 1% when effective heat resource increased by 125°C *** study could provide insights for policy makers,land managers or farmers to improve water and heat resource uses and rationally arrange rice production activities under global climate change condition.

关键词： climate change rice production area effectiveness of hydrothermal resources spatiotemporal characteristics

Monitoring the Expression of Maize Genes in Developing Kernels under Droug ht Stress usingOligo-microarray

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Journal of Integrative Plant Biology 2010年第12期52卷 1059-1074页

作者： Meng Luo jia Liu R. Dewey Lee Brian T. Scully Baozhu guo The University of Georgia Department of Crop and Soil Sciences Tifton GA 31793 USA J. Craig Venter Institute Rockville MD 20850 USA US D-epartment of Agriculture Agricultural Research Service Crop Protection and Management Research Unit Tifton GA 31793 USA

Preharvest aflatoxin contamination of grain grown on the US southeastern Coast Plain is provoked and aggravated by abiotic stress. The primary abiotic stress is drought along with high temperatures. The objectives of the present study were to monitor gene expression in developing kernels in response to drought stress and to identify drought-responsive genes for possible use in germplasm assessment. The maize breeding line Tex6 was used, and gene expression profiles were analyzed in developing kernels under drought stress verses well-watered conditions at the stages of 25, 30, 35, 40, 45 d after pollination （DAP） using the 70 mer maize oligo-arrays. A total of 9 573 positive array spots were detected with unique gene IDs, and 7 988 were common in both stressed and well-watered samples. Expression patterns of some genes in several stress response-associated pathways, including abscisic acid, jasmonic acid and phenylalanine ammonia-lyase, were examined, and these specific genes were responsive to drought stress positively. Real-time quantitative polymerase chain reaction validated microarray expression data. The comparison between Tex6 and B73 revealed that there were significant differences in specific gene expression, patterns and levels. Several defense-related genes had been downregulated, even though some defense-related or drought responsive genes were upregulated at the later stages.

关键词： CORN GENETICS GENETIC regulation in plants EFFECT of drought on plants EFFECT of stress on plants DNA microarrays AFLATOXINS CROPS -- Postharvest technology

相变储热材料相变过程对含瓦斯煤解吸特性的影响研究

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山西煤炭 2024年第3期44卷 81-86页

作者：郭军斌秦兴林贾雪祺李闯何承毅山西晋煤集团阳城晋圣上孔煤业有限公司山西阳城048100 中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿安全技术国家重点实验室辽宁抚顺113122 重庆大学资源与安全学院重庆400044

煤体瓦斯解吸速率慢易引起煤与瓦斯突出事故,且温度对瓦斯的解吸过程有重要的影响,提高温度能够明显提高瓦斯解吸率。基于此规律,选取相变温度为58℃的无机相变蓄能材料,采用对比实验,研究不同含量相变材料的相变过程对煤体的温度影响范... 详细信息

煤体瓦斯解吸速率慢易引起煤与瓦斯突出事故,且温度对瓦斯的解吸过程有重要的影响,提高温度能够明显提高瓦斯解吸率。基于此规律,选取相变温度为58℃的无机相变蓄能材料,采用对比实验,研究不同含量相变材料的相变过程对煤体的温度影响范围,同时,将相变材料应用到吸附解吸实验中,获得相变过程中温度变化对煤体瓦斯解吸量与解吸速率的影响。结果表明:加入相变材料后,已完成解吸过程的含瓦斯煤会重新解吸出瓦斯,最终稳定的解吸量为1.709 cm^(3)/g,增加了0.185 cm^(3)/g,占正常条件下解吸量的12.14%,说明相变材料的加入可提高煤样的解吸率。

关键词：瓦斯吸附解吸相变材料吸附量温度变化

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城市建筑垃圾填埋区地下水水质对比和溯源

中国环境科学 2024年第7期44卷 3843-3857页

作者：魏晓倩姜建芳冯肖嘉文许明明李蒴刘冰白凯文侯丽丽赵文吉首都师范大学资源环境与旅游学院北京100048 首都师范大学地面沉降机理与防控教育部重点实验室北京100048 首都师范大学水资源安全北京实验室北京100048 中国地质大学(武汉)地理与信息工程学院湖北武汉430074

从我国两个典型中小型城市各选取一处建筑垃圾填埋场,采用熵权指数法(EWQI)对两场地周边地区地下水水质进行综合评价分析,基于聚类分析等手段进行初步污染源识别,并在此基础上采用正定矩阵分解(PMF)模型进行源解析计算,定量解析和对比... 详细信息

从我国两个典型中小型城市各选取一处建筑垃圾填埋场,采用熵权指数法(EWQI)对两场地周边地区地下水水质进行综合评价分析,基于聚类分析等手段进行初步污染源识别,并在此基础上采用正定矩阵分解(PMF)模型进行源解析计算,定量解析和对比两处建筑垃圾填埋场地对周边区域地下水水质变化的贡献.结果表明,建筑垃圾的填埋处理可能会引起周边地下水水质恶化,其影响程度与场地性质、填埋历史、介质防污性能等因素有关.两处研究场地中,场地1周边地下水水质恶化情况更严重,有7种检测组分的浓度超过了地下水质量标准(GB/T 1448-2017)中的III类标准限值,而场地2有1种组分超标.对地下水化学组分进行源解析的结果表明,两处场地均识别出岩土矿物溶解、溶质运移、农业、建筑垃圾和工业活动这5种自然和人为来源,场地1周边区域各来源贡献占比分别为18.2%、18.0%、25.9%、19.5%、9.8%,场地2占比分别为19.8%、23.5%、18.9%、12.6%和15.1%.人类活动和建筑垃圾填埋污染对场地1周边地下水的影响大于对场地2的影响.

关键词：源解析相关性分析 EWQI PMF 层次聚类

Nitrogen Cycling and Losses Under Rice-Wheat Rotations with Coated Urea and Urea in the Taihu Lake Region

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Pedosphere 2007年第1期17卷 62-69页

作者： WANG Xiao-Zhi ZHU jian-guo GAO Ren H. YASUKAZU FENG Ke State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） Environment Science and Engineering College Yangzhou University Yangzhou 225009 （China） Fujian Normal University Fuzhou 350007 （China） Japan International Research Center for Agricultural Sciences 1-2 Ohwashi Tsukuba Ibaraki 305-8686 （Japan）

A lysimeter experiment with undisturbed soil profiles was carried out to study nitrogen cycling and losses in a paddy soll with applications of coated urea and urea under a rice-wheat rotation system in the Taihu Lake region from 2001 to 2003. Treatments for rice and wheat included urea at conventional, 300 （rice） and 250 （wheat） kg N ha^-1, and reduced levels, 150 （rice） and 125 （wheat） kg N ha^-1, coated urea at two levels, 100 （rice） and 75 （wheat） kg N ha^-1, and 150 （rice） and 125 （wheat） kg N ha^-1, and a control with no nitrogen arranged in a completely randomized design. The results under two rice-wheat rotations showed that N losses through both NH3 volatilization and runoff in the coated urea treatments were much lower than those in the urea treatments. In the urea treatments N runoff losses were significantly （P 〈 0.001） positively correlated （r = 0.851） with applied N. N concentration in surface water increased rapidly to maximum two days after urea application and then decreased quickly. However, if there was no heavy rain within five days of fertilizer application, the likelihood of N loss by runoff was not high. As the treatments showed little difference in N loss via percolation, nitrate N in the groundwater of the paddy fields was not directly related to N leaching. The total yield of the two rice-wheat rotations in the treatment of coated urea at 50% conventional level was higher than that in the treatment of urea at the conventional level. Thus, coated urea was more favorable to rice production and environmental protection than urea.

关键词： ammonia volatilization coated urea N cycling percolation runoff