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Bullous pemphigoid associated with acquired hemophilia A: A case report

World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-jia hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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SiS_(2)/ZnO范德华异质结光催化水分解第一性原理研究

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原子与分子物理学报 2025年第6期42卷 31-36页

作者：李家豪黄欣杨志红南京邮电大学电子与光学工程学院、柔性电子(未来技术)学院南京210023 南京邮电大学理学院南京210023

基于第一性原理方法,研究了SiS_(2)/ZnO范德华异质结的电子结构和光催化性质.结果表明,SiS_(2)/ZnO异质结是带隙值为1.32 eV的半导体材料,表现出交错排列的能带结构.在异质结界面处,形成了从ZnO指向SiS_(2)的内置电场,该内置电场的存在... 详细信息

基于第一性原理方法,研究了SiS_(2)/ZnO范德华异质结的电子结构和光催化性质.结果表明,SiS_(2)/ZnO异质结是带隙值为1.32 eV的半导体材料,表现出交错排列的能带结构.在异质结界面处,形成了从ZnO指向SiS_(2)的内置电场,该内置电场的存在使得SiS_(2)/ZnO异质结中形成了特殊的“Z-型”载流子迁移模式,有利于电子空穴对的有效分离,同时增强了载流子的氧化还原能力.异质结构具有良好的热力学稳定性,且带边位置跨越水的氧化还原电位.与单层材料相比,SiS_(2)/ZnO异质结光吸收谱出现红移现象,表现出更宽的光吸收范围(从可见光到紫外光)及更强的光吸收强度(达到10~5 cm^(-1)量级).另外,通过施加双轴应变,可以有效调控SiS_(2)/ZnO异质结的带隙值.以上结果表明SiS_(2)/ZnO异质结有潜力成为新型光催化剂用于全解水.

关键词： SiS_(2)/ZnO Z-型范德华异质结光催化电子结构第一性原理

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gem-Difluorinative 1,2-azide migration of vinyl azides enables an expedient synthesis of β-difluoroalkyl azides

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Science China Chemistry 2020年第8期63卷 1019-1020页

作者： jia hao Pang Shunsuke Chiba Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

Organic azides have shown versatile reactivity to induce various organic transformations for the synthesis of nitrogencontaining organic molecules such as 1,3-dipolar cycloadditions with unsaturated bonds,the Curtius rearrangement,and formation of nitrogen-centered radicals,most of which are driven by the entropic loss of molecular dinitrogen[1].

关键词： azide synthesis enable

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基于遥感和社交媒体数据的城市洪涝灾害监测

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郑州大学学报（工学版） 2025年第1期46卷 82-89页

作者：张会潘晓宁贾浩许德合华北水利水电大学测绘与地理信息学院河南郑州450046

城市洪涝监测对灾害管理与应急响应至关重要,单一数据源往往存在各自的缺陷,不利于多维度、全方位地分析城市复杂洪涝灾害灾情。结合不受云雨影响且覆盖范围大的GF-3 SAR影像与实时性较强的社交媒体数据,建立“7·20”特大暴雨郑州市中... 详细信息

城市洪涝监测对灾害管理与应急响应至关重要,单一数据源往往存在各自的缺陷,不利于多维度、全方位地分析城市复杂洪涝灾害灾情。结合不受云雨影响且覆盖范围大的GF-3 SAR影像与实时性较强的社交媒体数据,建立“7·20”特大暴雨郑州市中心城区洪涝监测方法,采用阈值分割、随机森林对GF-3 SAR影像进行多方案的灾前灾中水体提取,获取精度最高的水体提取与洪涝监测结果,分析典型区域的水体提取效果;利用Python工具获取城市内涝的社交媒体数据,对其进行处理、可视化与空间分析;结合GF-3 SAR影像与社交媒体数据洪涝监测结果探讨二者优势互补性。结果表明:SAR影像的水体总体提取效果为随机森林最优,HV次之,HV优于HH,HH优于水体指数SAR水体总体提取精度从高到低依次为随机森林、Otsu阈值法、水体指数法,但是在一些典型区域分析中,随机森林的提取效果低于其他方法;基于SAR影像提取的洪涝淹没范围主要集中在三环外的城市边缘地区与大型水体周围,基于社交媒体数据提取的洪涝信息主要集中在城市人口和建筑密集的三环内。

关键词：洪涝灾害高分三号阈值分割随机森林社交媒体数据

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Comparison of the Photo-thermal Energy Conversion Behavior of Polar Bear Hair and Wool of Sheep

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Journal of Bionic Engineering 2017年第4期14卷 616-621页

作者： hao jia jiansheng Guo Jingjing Zhu Key Laboratory of Textile Science and Technology Ministry of Education College of Textiles Donghua University Shanghai 201620 China

The unique photo-thermal energy conversion property of polar bear hairs has long been regarded as an essential element to enable this creature to survive in extremely cold conditions. However, the relevant research was ineffectual to provide sufficient evidence of its solar energy harvesting property. In this paper, the properties of polar bear hairs were analyzed and compared systematically with those of domestic sheep wool through the measurements in the aspects of photo-thermal conversion effi- ciency, scanning electron microscope, fluorescence spectral and transmission of UV-visible spectra. Moreover, this study was much more focused on exploring ultraviolet utilization property of polar bear hair than previous research. The research results demonstrated that the photo-thermal property of polar bear hair was superior to those of wool fiber, especially in harvesting ultraviolet part. The potential benefits of this research lie in the development of bionic solar energy collective devices, especially in artificial solar energy collection fibers and textile products.

关键词： photo-thermal conversion efficiency polar bear hair sheep wool fiber ultraviolet utilization fluorescence spectra

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Asymptotics of Stationary Navier Stokes Equations in Higher Dimensions

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Acta Mathematica Sinica,English Series 2018年第4期34卷 598-611页

作者： hao jia Vladimír ?VERáK Department of Mathematics University of Minnesota

We show that the asymptotics of solutions to stationary Navier Stokes equations in 4, 5 or 6 dimensions in the whole space with a smooth compactly supported forcing are given by the linear Stokes equation. We do not need to assume any smallness condition. The result is in contrast to three dimensions, where the asymptotics for steady states are different from the linear Stokes equation, even for small data, while the large data case presents an open problem. The case of dimension n = 2 is still harder.

关键词： Navier Stokes equations steady states asymptotics

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A real-time calibration method based on time-to-digital converter for accelerator timing system

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Nuclear Science and Techniques 2024年第9期35卷 127-140页

作者： Qi-hao Duan Liang Ge Yan-hao jia Jie-Yu Zhu Wei Zhang Institute of modern physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed over a certain range of 2 km,involving over a hundred *** white rabbit,a technology-enhancing Gigabit Ethernet,has shown the capability of scheduling distributed timing devices but still faces the challenge of obtaining real-time synchronization calibration param-eters with high *** study presents a calibration system based on a time-to-digital converter implemented on an ARM-based System-on-Chip(SoC).The system consists of four multi-sample delay lines,a bubble-proof encoder,an edge controller for managing data from different channels,and a highly effective calibration module that benefits from the SoC *** performance was evaluated with an average RMS precision of 5.51 ps by measuring the time intervals from 0 to 24,000 ps with 120,000 data for every *** design presented in this study refines the calibration precision of the HIAF timing *** eliminates the errors caused by manual calibration without efficiency loss and provides data support for fault *** can also be easily tailored or ported to other devices for specific applications and provides more space for developing timing systems for particle accelerators,such as white rabbits on HIAF.

关键词： HIAF White rabbit Calibration system Time-to-digital converter(TDC)

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Simulation annealing diagnosis algorithm method for optimized forecast of the dynamic response of floating offshore wind turbines

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Journal of Hydrodynamics 2021年第2期33卷 216-225页

作者： Peng Chen Lei Song jia-hao Chen Zhiqiang Hu School of Engineering Newcastle UniversityNewcastle upon TyneNE17RUUnited Kingdom School of Naval Architecture and Ocean Engineering Huazhong University of Science and TechnologyWuhan 430074China Guangdong Electric Power Design Institute Co. Ltd.China Energy Engineering GroupGuangzhou 510663China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China

Design of floating offshore wind turbines(FOWTs)needs reliable and innovative technologies to overcome the challenges on how to better predict the dynamic responses in terms of aero-hydro-servo-elastic *** paper aims to demonstrate the optimized prediction of the dynamic response of FOWTs by Simulation annealing diagnosis algorithm(SADA).SADA is an Artificial Intelligence technology-based method,which utilizes the advantages of numerical simulation,basin experiment and machine learning *** actor network in deep deterministic policy gradient(DDPG)is adopted to take actions to adjust the Key disciplinary parameters(KDPs)in each loop according to the feedback of 6DOF motions of platform in dynamic response *** results demonstrated that the mean values of the platform's motions and rotor axial thrust force could be predicted with higher *** this basis,other physical quantities that designers are more concerned about but cannot be obtained from experiments and actual measurements will be predicted by SADA with more *** SADA method differs from traditional supervised learning applications in renewable energy,which do not need to be provided physical quantities with strong direct *** targets can be artificially set for SADA to obtain a better self-learning *** general,designers can use SADA to get a more accurate and optimized prediction of the dynamic response of FOWTs,especially those physical quantities that cannot be directly obtained through the basin experiments.

关键词： Floating offshore wind turbine simulation annealing diagnosis algorithm(SADA) AI-based DARwind artificial intelligence basin experiment

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Uncertain Multidisciplinary Design Optimization on Next Generation Subsea Production System by Using Surrogate Model and Interval Method

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China Ocean Engineering 2021年第4期35卷 609-621页

作者： WU jia-hao ZHEN Xing-wei LIU Gang HUANG Yi School of Naval Architecture and Ocean Engineering Dalian University of TechnologyDalian 116024China

The innovative Next Generation Subsea Production System(NextGen SPS)concept is a newly proposed petroleum development solution in ultra-deep water *** definition of NextGen SPS involves several disciplines,which makes the design process *** this paper,the definition of NextGen SPS is modeled as an uncertain multidisciplinary design optimization(MDO)*** deterministic optimization model is formulated,and three concerning disciplines—cost calculation,hydrodynamic analysis and global performance analysis are *** model technique is applied in the latter two *** optimization(CO)architecture is utilized to organize the concerning disciplines.A deterministic CO framework with two disciplinelevel optimizations is proposed *** the uncertainties of design parameters and surrogate models are incorporated by using interval method,and uncertain CO frameworks with triple loop and double loop optimization structure are established *** optimization results illustrate that,although the deterministic MDO result achieves higher reduction in objective function than the uncertain MDO result,the latter is more reliable than the former.

关键词： next generation subsea production system multidisciplinary design optimization uncertain optimization collaborative optimization surrogate model interval method

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Challenges in the noninvasive detection of body composition using near-infrared spectroscopy

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Journal of Innovative Optical Health Sciences 2014年第6期7卷 16-24页

作者： Wenliang Chen hao jia Chenli Li Kexin Xu State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072P.R.China Key Laboratory of Micro-Optical-Electro-Mechanical System Technology Tianjin University Ministry of EducationTianjin 300072P.R.China

Noninvasive detection of body composition plays a significant role in the improvement of life quality and reduction in complications of the patients,and the near-infrared(NIR)spectroscopy,with the advantages of painlessness and convenience,is considered as the most promising tool for the online noninvasive monitoring of body ***,quite different from other fields of online detection using NIR spectroscopy,such as food safety and environment monitoring,noninvasive detection of body composit ion demands higher precision of the instruments as well as more rigor-ousness of measurement ***,new challenges emerge when NIR spectroscopy is applied to the noninvasive detection of body composition,which,in this paper,are first concluded from the aspects of measurement methods,measurement conditions,instrument precision,multi-component influence,individual difference and novel weak signal extraction method based on our previous research in the cutting edge field of NIR noninvasive blood glucose ***,novel ideas and approaches of our group to solve these problems are introduced,which may provide evidence for the future development of noninvasive blood glucose detection,and further contibute to the noninvasive detection of other body compositions using NIR spectroscopy.

关键词： Near-infrared spectroscopy noninvasive detection body composition blood glucose

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