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Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro

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World Journal of Gastroenterology 2015年第25期21卷 7764-7776页

作者： Fu-Cai Wang Jing-Xuan Pei Jun Zhu Nan-Jin Zhou dong-Sheng Liu Hui-Fang Xiong Xiao-Qun Liu dong-jia lin Yong Xie Department of Gastroenterology the First Affiliated Hospital of Nanchang University Gastro-enterology Institute of Jiangxi Province Key Laboratory of Digestive Diseases of Jiangxi Province Department of Immunology Medical College of Nanchang University Department of Pathophysiology Medical College of Nanchang University Institute of Immunology and Biological Therapy Jiangxi Academy of Medical Sciences

AIM: To investigate the inhibitory effects and mechanism of high mobility group box(HMGB)1 A-box in lipopolysaccharide(LPS)-induced intestinal ***: Overexpression of HMGB1 A-box in human intestinal epithelial cell lines(SW480 cells) was achieved using the plasmid p EGFP-N1. HMGB1 A-box-overexpressing SW480 cells were stimulated with LPS and co-culturing with human monocyte-like cell lines(THP-1 cells) using a Transwell system, compared with another HMGB1 inhibitor ethyl pyruvate(EP). The m RNA and protein levels of HMGB1/toll-like receptor(TLR) 4 signaling pathways [including HMGB1, TLR4, myeloid differentiation factor88(MYD88), Phosphorylated Nuclear Factor κB(p NF-κB) p65] in the stimulated cells were determined by realtime polymerase chain reaction and Western blotting. The levels of the proinflammatory mediators [including HMGB1, interleukin(IL)-1β, IL-6 and tumor necrosis factor(TNF)-α] in the supernatants of the stimulated cells were determined by ***: EP downregulated the m RNA and protein levels of HMGB1, inhibited the TLR4 signaling pathways(TLR4, MYD88 and p NF-κB p65) and reduced the secretion of proinflammatory mediators(HMGB1, IL-1β, IL-6 and TNF-α) in the SW480 and THP-1 cells activated by LPS but not in the unstimulated cells. Activated by LPS, the overexpression of HMGB1 A-box in the SW480 cells also inhibited the HMGB1/TLR4 signaling pathways and reduced the secretion of these proinflammatory mediators in the THP-1 cells but not in the transfected and unstimulated cells. CONCLUSION: HMGB1 A-box, not only EP, can reduce LPS-induced intestinal inflammation through inhibition of the HMGB1/TLR4 signaling pathways.

关键词： High mobility group box 1 Toll-like receptor 4 HMGB1 A-box Ethyl pyruvate Inflammatory bowel disease

Brnsted Acidic Ionic Liquids: Efficient and Recyclable Catalytic Systems for Beckmann Rearrangement

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Chemical Research in Chinese Universities 2011年第6期27卷 973-976页

作者： WU Mao-cheng DUAN Hai-feng CAO Jun-gang LIANG Da-peng jiaNG Feng GAO Han jia Xu-dong lin Ying-jie College of Chemistry Jilin University Changchun 130012 P. R. China

Six Brnsted acidic ionic liquids（ILs） 1a―1f were synthesized and used as the dual solvent-catalyst systems for Beckmann rearrangement reactions. Among ILs 1a―1f, IL 1a exhibited the highest catalytic activity and successfully catalyzed the Beckmann rearrangement of ketoximes, and the corresponding amides were obtained in good to excellent yields（74%―92%）. In addition, IL 1a could be recovered easily and reused at least three times without any loss of catalytic activity.

关键词： Brnsted acidic ionic liquid Beckmann rearrangement Oxime

Use of ultrasound to facilitate femoral nerve block with stimulating catheter

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Chinese Medical Journal 2011年第4期124卷 519-524页

作者： LI Min XU Ting HAN Wen-yong WANG Xue-dong jia dong-lin GUO Xiang-yang Department of Anesthesiology Peking University Third HospitalBeijing 100191 China

Background The adjunction of ultrasound to nerve stimulation has been proven to improve single-injection peripheral nerve block quality. However, few reports have been published determining whether ultrasound can facilitate continuous nerve blocks. In this study, we tested the hypothesis that the addition of ultrasound to nerve stimulation facilitates femoral nerve blocks with a stimulating *** In this prospective randomized study, patients receiving continuous femoral nerve blocks for total knee replacement were randomly assigned to either the ultrasound guidance combined with stimulating catheter group （USNS group; n=60） or the stimulating catheter alone group （NS group; n=60）. The primary end point was the procedure time （defined as the time from first needle contact with the skin until correct catheter placement）. The numbers of needle passes and catheter insertions, onset and quality of femoral nerve blocks, postoperative pain score, and early knee function were also *** The procedure time was significantly less in the USNS group than in the NS group （9.0 （6.0-22.8） minutes vs.13.5 （6.0-35.9） minutes, P=0.024）. The numbers of needle passes and catheter insertions were also significantly less in the USNS group. A greater complete block rate was achieved at 30 minutes in the USNS group （63.3% vs. 38.3%;P=0.010）. The postoperative pain score, the number of patients who required bolus local anesthetic and intravenous patient-controlled analgesia, and knee flexion on the second postoperative day were not significantly different between the two groups of *** Ultrasound-assisted placement of a stimulating catheter for femoral nerve blocks decreases the time necessary to perform the block compared with just the nerve-stimulating technique. In addition, a more complete blockade is achieved using the ultrasound-assisted technique.

关键词： ultrasonography nerve block catheterization

A small-dose naloxone infusion alleviates nausea and sedation without impacting analgesia via intravenous tramadol

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Chinese Medical Journal 2010年第13期123卷 1695-1698页

作者： jia dong-lin NI Cheng XU Ting ZHANG Li-ping GUO Xiang-yang Department of Anesthesiology Peking University Third Hospital Beijing 100191 China

Background Early studies showed that naloxone infusion decreases the incidence of morphine-related side effects from intravenous patient-controlled analgesia. This study aimed to determine whether naloxone preserved analgesia while minimizing side effects caused by intravenous tramadol administration. Methods Eighty patients undergoing general anesthesia for cervical vertebrae surgery were randomly divided into four groups. All patients received 1 mg/kg tramadol 30 minutes before the end of surgery, followed by a continuous infusion with 0.3 mg-kg1.h^-1 tramadol with no naloxone （group I, n=20）, 0.05 μ***.^-1.h^-1 naloxone （group Ⅱ, n=20）, 0.1 ***^-1.h^-1 naloxone （group Ⅲ, n=-20） and 0.2 μ***^-1.h^-1 naloxone （group Ⅳ, n=20）. Visual analog scales （VAS） for pain during rest and cough, nausea five-point scale （NFPS） for nausea and vomiting, and ramsay sedation score （RSS） for sedation were assessed at 2, 6, 12, 24 and 48 hours postoperatively. Analgesia and side effects were evaluated by blinded observers. Results Seventy-eight patients were included in this study. The intravenous tramadol administration provided the satisfied analgesia. There was no significant difference in either resting or coughing VAS scores among naloxone groups and control group. Compared with control group, sedation was less in groups Ⅱ, Ⅲ, and Ⅳ at 6, 12, and 24 hours （P 〈0.05）; nausea was less in groups Ⅱ, Ⅲ and Ⅳ than group I at 2, 6, 12, 24 and 48 hours postoperatively （P 〈0.05）. The incidence of vomiting in the control group was 35% vs. 10% for the highest dose naloxone group （group Ⅳ）（P 〈0.01）. Conclusion A small-dose naloxone infusion could reduce tramadol induced side effects without reversing its analgesic effects.

关键词： tramadol naloxone analgesia nausea sedation

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu lin He lin-Sen Ye Xiao-Feng Yang jia-jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

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基于神经网络的拉曼光谱波长选择方法

光谱学与光谱分析 2020年第11期40卷 3457-3462页

作者：沈东旭洪明坚董家林重庆大学大数据与软件学院重庆401331

血液鉴别对于检验检疫、刑侦以及动物保护领域具有非常重要的意义,传统的的血液鉴别方法在鉴别的过程中存在分析周期长、对血液样本造成损害等缺点。而拉曼光谱可以通过分析与入射光频率不同的散射光谱得到分子振动、转动方面的信息,进... 详细信息

血液鉴别对于检验检疫、刑侦以及动物保护领域具有非常重要的意义,传统的的血液鉴别方法在鉴别的过程中存在分析周期长、对血液样本造成损害等缺点。而拉曼光谱可以通过分析与入射光频率不同的散射光谱得到分子振动、转动方面的信息,进而得到物质的组成成分,并且具有零污染非接触的特点,为血液的无损鉴别提供了可能,但是在拉曼光谱中,各个波长点之间存在严重的多重共线性,直接使用全光谱进行建模会增加模型的复杂性和降低模型的稳定性。针对拉曼光谱的特点,提出了一种基于神经网络的波长选择方法。该方法利用神经网络学习到各个波长点对校正模型的贡献权重,并将权重的均值作为阈值,去除权重低于阈值的波长点,以达到波长选择的目的。为了更容易确定筛选的阈值,在权重学习的过程中加入了稀疏约束,极大的减少了用于筛选的波长点。利用动物与人血清的拉曼光谱数据集对所提方法进行了验证,实验结果表明,利用该方法得到的光谱建立的校正模型,相比于全光谱数据在分类准确率和AUC值都有一定的提升,人工神经网络(NN)的准确率达到了94.495%, AUC值达到了0.9850,偏最小二乘(PLS-DA)的准确率达到了92.661%, AUC值达到了0.9760。与传统的波长选择方法UVE相比,该方法选择的波长点更少,仅选择了42个波长点用于建模,而且得到的校正模型的分类准确率和AUC值更高,证明该波长选择方法能有效的筛选出对建模有贡献的波长点,提高了模型的分类准确率和稳定性,为血液的无损鉴别提供了可能,具有一定的实用价值。

关键词：光谱分析拉曼光谱波长选择神经网络校正模型

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie jia-lin Li ling Gong Xiang-Li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

新型承托式纵肋与横肋交叉构造细节疲劳性能研究

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桥梁建设 2018年第6期48卷 29-34页

作者：张清华余佳田启贤贾东林西南交通大学桥梁工程系四川成都610031 桥梁结构健康与安全国家重点试验室湖北武汉430034 中铁大桥科学研究院有限公司湖北武汉430034

为改善传统正交异性钢桥面板纵肋与横肋交叉构造细节的疲劳性能,提高其疲劳抗力,提出一种新型承托式横肋开孔形式,采用ANSYS软件建立大纵肋组合桥面板节段有限元模型,基于热点应力法和线性损伤累积理论分析纵肋与横肋交叉构造细节的疲... 详细信息

为改善传统正交异性钢桥面板纵肋与横肋交叉构造细节的疲劳性能,提高其疲劳抗力,提出一种新型承托式横肋开孔形式,采用ANSYS软件建立大纵肋组合桥面板节段有限元模型,基于热点应力法和线性损伤累积理论分析纵肋与横肋交叉构造细节的疲劳性能,并与4种典型横肋开孔形式进行对比。结果表明:在不考虑残余应力的情况下,相对于4种典型横肋开孔形式,新型承托式横肋开孔形式的疲劳性能显著提高;纵肋与横肋交叉构造细节最大应力幅的出现位置转移至纵肋底部与横肋焊趾对应处内侧,应力幅为30.2MPa,满足设计要求;纵肋底部焊趾处应力为压应力。新型承托式横肋开口形式能够改善纵肋与横肋交叉构造细节的疲劳性能。

关键词：正交异性钢桥面板纵肋横肋交叉构造疲劳性能应力幅有限元法