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Friction 2024年第7期12卷 1564-1579页

作者： Linlin DUAN dan jia jian LI jianfang LIU Haitao DUAN State Key Laboratory of Special Surface Protection Materials and Application Technology Wuhan Research Institute of Materials ProtectionWuhan 430030China Hubei Longzhong Laboratory Xiangyang 441000China College of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430030China

In this work,the advantage of Coulomb repulsion in the intermolecular forces experienced by molecules on the solid–liquid nanosized contact interface is taken,and the superior friction-reducing property of Cu_(3)(PO_(4))2·3H_(2)O(CuP)oil-based additives has been confirmed for titanium ***-dimensional(3D)CuP nanoflowers(CuP-Fs)with a strong capillary absorption effect are prepared to achieve the homogeneous mixing of solid CuP and lubricating *** by CuP-Fs additives for titanium alloy,friction coefficient(COF)can be reduced by 73.68%,and wear rate(WR)reduced by 99.69%.It is demonstrated that the extraordinary friction-reducing property is due to the repulsive solid–liquid interface with low viscous shear force originating from Coulomb repulsion between polar water molecules in CuP and non-polar oil ***,any steric hindrance or connection between this repulsive solid–liquid interface will trigger the adhesion and increase the viscous shear force,for example,dispersant,hydrogen bondings,and shaky adsorbed water ***,the lamellar thickness of CuP and the molecular size of lubricant both have a great influence on tribological *** the lubrication mechanism based on interface Coulomb repulsion is proposed that may help broaden the scope of the exploration in low-friction nanomaterial design and new lubricant systems.

关键词： lubrication nanomaterial additive solid-liquid interface wear

Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： Jingyi Tan jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang jia dan Zexin Zeng Jun Hu Wenbo Zhu jiankai Liang Jing Cai Ying Liu Guangmei Yan Yuan Lin Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China Department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical Technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer

在不同养殖背景下鳜mc1r组织表达差异和启动子转录调控分析

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水生生物学报 2024年第1期48卷 149-156页

作者：贾晓丹梁旭方何珊华中农业大学水产学院华中农业大学鳜鱼研究中心武汉430070 农业农村部淡水生物繁育重点实验室/农业动物遗传育种与繁殖教育部重点实验室武汉430070

为探究鳜(Siniperca chuatsi)黑素皮质素1受体基因mc1r在不同养殖背景下的组织表达差异及转录调控机制,研究以在黑白养殖背景下产生的深、浅色体表鳜为研究对象,通过实时荧光定量PCR测定mc1r基因的组织表达差异;其次以鳜基因组DNA为模板... 详细信息

为探究鳜(Siniperca chuatsi)黑素皮质素1受体基因mc1r在不同养殖背景下的组织表达差异及转录调控机制,研究以在黑白养殖背景下产生的深、浅色体表鳜为研究对象,通过实时荧光定量PCR测定mc1r基因的组织表达差异;其次以鳜基因组DNA为模板,通过PCR扩增mc1r基因5′侧翼区不同长度的缺失片段并克隆至pGL3-Basic载体,之后将重组质粒转染到HEK 293T细胞,检测双荧光素酶的相对活性并预测其存在潜在的转录因子。结果显示,黑色背景养殖所产生的深色体表鳜与野生型更为相似;RT-qPCR检测显示深色体表鳜mc1r在背部皮肤和腹部皮肤表达量最高,而浅色体表鳜脑中表达量最高;双荧光素酶活性检测发现,构建的5个缺失片段启动子活性之间存在显著差异,且−159∽−+292启动子活性最高,推测其为mc1r核心启动子区域,并且通过在线软件预测出存在MITF、SP1等转录因子。研究克隆了鳜mc1r基因启动子区域并进行了转录活性分析,并且对潜在的转录因子进行了预测,为鱼类mc1r基因分子机制表达调控及表皮颜色可控性研究提供了理论依据。

关键词： mc1r 组织表达启动子活性转录因子鳜

甘遂炮制前后HPLC指纹图谱及主要成分含量变化研究

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解放军药学学报 2024年第4期37卷 386-390页

作者：沈佳丹杭州市第一人民医院浙江杭州311227

目的建立甘遂炮制前后(生甘遂、醋甘遂)的HPLC指纹图谱,并对大戟二烯醇进行定量分析,为甘遂质量控制及炮制提供参考。方法采用HPLC法建立生甘遂和醋甘遂的HPLC指纹图谱。通过相似度评价对甘遂炮制前后指纹图谱进行分析,并对大戟二烯醇... 详细信息

目的建立甘遂炮制前后(生甘遂、醋甘遂)的HPLC指纹图谱,并对大戟二烯醇进行定量分析,为甘遂质量控制及炮制提供参考。方法采用HPLC法建立生甘遂和醋甘遂的HPLC指纹图谱。通过相似度评价对甘遂炮制前后指纹图谱进行分析,并对大戟二烯醇进行含量测定。结果建立了甘遂炮制前后的HPLC指纹图谱,生甘遂和醋甘遂分别确定了14个和12个共有峰,与各自对照指纹图谱的相似度均大于0.950。大戟二烯醇在生甘遂和醋甘遂中的质量分数分别为0.249%和0.222%。甘遂HPLC指纹图谱在炮制前后发生了显著变化,共有峰减少3个,新增加1个,大戟二烯醇的含量显著降低。结论建立的HPLC指纹图谱对甘遂及其炮制品的质量控制及整体性评价具有重要意义,能够为甘遂的炮制及药理研究提供参考。

关键词：甘遂醋甘遂炮制方法 HPLC指纹图谱相似度评价

血液透析血管通路医患共同决策的核心障碍和解决方法

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中华全科医师杂志 2024年第2期23卷 106-111页

作者：李禾婷蒲丽嘉廖笑天贾丹四川大学华西公共卫生学院、四川大学华西第四医院成都610041 四川大学华西医院肾脏内科成都610041 成都市第三人民医院药学部成都610031 四川大学华西医院门诊部成都610041

文章阐述血液透析血管通路决策的现状和医患共同决策的障碍,并提出可能的解决方案,包括进行高质量的研究、血管通路建立与维护、共同决策技巧培训、改革绩效考核制度、设立血管通路团队,以及开发患者友好的决策辅助工具等,并探讨了不同... 详细信息

文章阐述血液透析血管通路决策的现状和医患共同决策的障碍,并提出可能的解决方案,包括进行高质量的研究、血管通路建立与维护、共同决策技巧培训、改革绩效考核制度、设立血管通路团队,以及开发患者友好的决策辅助工具等,并探讨了不同层级医疗单位在血液透析血管通路医患共同决策中的作用。

关键词：血液透析共同决策肾病

聚苯胺-碳化硅复合材料在膨胀型防火涂料中的应用

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消防科学与技术 2024年第2期43卷 261-264,270页

作者：王晓明朱耿增贾丹金义杰国网山东省电力公司电力科学研究院山东济南250003 武汉材料保护研究所特种表面保护材料及应用技术国家重点实验室湖北武汉430030

膨胀型防火涂料在阻隔基材迅速升温方面具有明显效果。试验合成了聚苯胺-碳化硅(PANI-SiC)复合材料,通过SEM、FTIR、XRD等手段分析了复合材料的形貌、组成和结构,考察了单组分膨胀型防火涂料乳液的种类及复合材料含量对涂层防火耐火性... 详细信息

膨胀型防火涂料在阻隔基材迅速升温方面具有明显效果。试验合成了聚苯胺-碳化硅(PANI-SiC)复合材料,通过SEM、FTIR、XRD等手段分析了复合材料的形貌、组成和结构,考察了单组分膨胀型防火涂料乳液的种类及复合材料含量对涂层防火耐火性能的影响。结果表明:醋酸乙烯-乙烯(VAE)乳液相比于苯丙乳液和丙烯酸乳液可以更好地提升涂层的膨胀倍率和耐火性能。随着PANI-SiC含量的增加,涂层的膨胀倍率增加,背面温度降低,10%含量复合材料的防火涂层表现出优异的耐火性能。

关键词：钢结构膨胀型防火涂料聚苯胺碳化硅

Coincidence of abandoned settlements and climate change in the Xinjiang oases zone during the last 2000 years

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Journal of Geographical Sciences 2017年第9期27卷 1100-1110页

作者： jia dan FANG Xiuqi ZHANG Chengpeng Faculty of Geographical Science Beijing Normal University Beijing 100875 China

The study on the relationship of abandoned settlements and climate change in the oases could provide a historical reference for understanding human responses to present and future global warming in the arid zone. A total of 554 abandoned historical settlements in Xinjiang Uygur Autonomous Region, China, were used to examine the relationship between abandoned settlements and temperature change over the past 2000 years. The analysis covered dynastic epochs from the Han Dynasty （206BC-220AD） to the Qing Dynasty （1644AD- 1911AD） in the oases of Xinjiang. Greater density of settlements was found at the oases larger than 2000 km^2, which were more stable and less sensitive to climate change compared to smaller oases. Settlements flourished at small oases and the middle and lower reaches of rivers during warm periods and shrank back to piedmont basins and upstream alluvial fans during cold periods. These results demonstrated responses of oasis agriculture to climate change.

关键词： abandoned settlements climate change oasis Xinjiang the last 2000 years

Dynamic recrystallization behavior of GH4169G alloy during hot compressive deformation

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Journal of Materials Science & Technology 2019年第9期35卷 1851-1859页

作者： dan jia Wenru Sun Dongsheng Xu Fang Liu University of Chinese Academy of Sciences Beijing100049China Institute of Metal Research Chinese Academy of SciencesShenyang110016China

The microstructure evolutions and nucleation mechanisms of GH4169G alloy were studied by optical microscope, electron backscatter diffraction (EBSD) and transmission electron microscope (TEM). The hot compression tests were performed different imposed reductions in the range of true strain from 0.12 to 1.2 at the temperatures of 930 °-1050 ° with strain rates of 0.01 s^-1-l s^-1. It is found that cumulative and local misorientation increase firstly and then decrease when the strain is increased due to the progress of dynamic recrystallization (DRX). The low angle boundaries (LAGBs) rapidly develop to high angle boundaries (HAGBs) at relatively high deformation temperature or the low strain rate. There are three DRX mechanisms observed for GH4169 G alloy during hot deformation. Discontinuous dynamic recrystallization (DDRX) as the dominant mechanism for GH4169 G alloy is characterized by typical necklace structures and bulged-original boundaries. Besides, different deformation bands with dislocation cells formed in deformed matrix at low temperature and large strain, which indicates that continuous dynamic recrystallization (CDRX) contributed to the DRX process. The twin boundaries lost their coherent characteristics and provide sites for nucleation, which also accelerates the nucleation of DRX.

关键词： GH4169G alloy Dynamic recrystallization Nucleation mechanism

激光表面织构技术调控材料摩擦学性能的研究进展

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表面技术 2024年第9期53卷 85-101,157页

作者：李文轩段海涛李国政詹胜鹏章武林马利欣贾丹武汉材料保护研究所有限公司特种表面保护材料及应用技术国家重点实验室武汉430030 湖北隆中实验室湖北襄阳441000

表面织构是提高工程材料摩擦学性能有效的表面改性方法之一。近年来多种表面织构技术已被应用于提高材料表面减摩耐磨性能,而在众多表面织构化技术中,激光表面织构技术由于具有加工速度快、生产效率高、可控性好等优点而被广泛应用。综... 详细信息

表面织构是提高工程材料摩擦学性能有效的表面改性方法之一。近年来多种表面织构技术已被应用于提高材料表面减摩耐磨性能,而在众多表面织构化技术中,激光表面织构技术由于具有加工速度快、生产效率高、可控性好等优点而被广泛应用。综述了激光表面织构的最新进展及应用,讨论了目前激光表面织构技术存在的问题及解决方法,总结了3种不同加工原理下的激光处理方法存在的问题,包括形状参数难控制、精度较差及灵活性较低等,并介绍了液相辅助加工技术在激光表面织构技术中的应用,同时分析了不同工艺参数包括密度、形状及深度等对材料摩擦学性能的影响。综述了激光表面织构技术复合涂层技术的研究现状,其中激光表面织构与非金属或金属涂层复合,包括氧化石墨烯填充PTFE涂层复合激光表面织构、复合热丝化学气相沉积增强激光表面织构、复合电液雾化增强激光表面织构及复合激光熔覆技术增强激光表面织构。总结了激光表面织构技术结合不同润滑技术对材料摩擦学性能的影响。最后展望了激光表面织构在各个领域的未来发展方向。

关键词：激光加工表面织构摩擦性能涂层复合工艺参数

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An Approximation Algorithm for the Generalized Prize-Collecting Steiner Forest Problem with Submodular Penalties

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Journal of the Operations Research Society of China 2022年第1期10卷 183-192页

作者： Xiao-dan jia Bo Hou Wen Liu School of Mathematical Sciences Hebei Normal UniversityShijiazhuang 050024HebeiChina

In this paper,we consider the generalized prize-collecting Steiner forest problem with submodular penalties(GPCSF-SP problem).In this problem,we are given an undirected connected graph G=(V,E)and a collection of disjoint vertex subsets V={V_(1),V_(2),…,V_(l)}.Assume c:E→R_(+)is an edge cost function andπ:2^(V)→R_(+)is a submodular penalty *** objective of the GPCSF-SP problem is to find an edge subset F such that the total cost including the edge cost in F and the penalty cost of the subcollection S containing these Vi not connected by F is *** using the primal-dual technique,we give a 3-approximation algorithm for this problem.

关键词： Generalized prize-collecting Steiner forest problem Submodular function Primal-dual algorithm