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Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage

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Chinese Journal of Integrative Medicine 2022年第3期28卷 272-280页

作者： jiaNG Yu-hang HE jia-kai LI Ran CHEN Ze-hao jia bao-hui Department of Acupuncture Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China

Alzheimer's disease(AD)is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80%of all *** pathogenesis of AD is complicated and enigmatic thus *** mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate,drive,or contribute to a variety of AD pathologies and may be the main factor in late-onset ***,there are no widely recognized drugs able to attenuate mitochondrial damage in ***,increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in *** review reports the mechanisms by which acupuncture regulates mitochondrial dynamics,energy metabolism,calcium homeostasis and *** conclusion,these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.

关键词： acupuncture Alzheimer's disease mitochondrial damage review

Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice

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Chinese Journal of Integrative Medicine 2018年第2期24卷 133-139页

作者： HE Xiao-li ZHAO Shi-hui YOU Wei CAI Yu-ying WANG Yan-yun YE Yong-ming jia bao-hui Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193China Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing100010 China

Objective： To investigate the preventive treatment effects of electroacupuncture（EA） on cognitive changes and brain damage in senescence-accelerated mouse prone 8（SAMP8） mice. Methods： The 5-month-old male SAMP8 and age-matched homologous normal aging mice（SAMR1） were adopted in this study. EA stimulation at Baihui（GV 20） and Yintang（EX-HN 3） was performed every other day for 12 weeks, 4 weeks as a course. Morris water maze test and Nissl-stained with cresyl violet were used for cognitive impairments evaluation and brain morphometric analysis. Amyloid-β（Aβ） expression in hippocampus and parietal cortex was detected by immunohistochemistry, and apoptosis was observed by TUNEL staining. Results： After 3 courses of EA preventive treatment, the escape latencies of 8-month-old SAMP8 mice in EA group were significantly shortened than those of un-pretreated SAMP8 mice. Compared with SAMR1 mice, extensive neuronal changes were visualized in the CA1 area of hippocampus in SAMP8 mice, while these pathological changes and attenuate cell loss in hippocampal CA1 area of SAMP8 mice markedly reduced after EA preventive treatment. Furthermore, Aβ expression in hippocampus and parietal cortex of SAMP8 mice decreased significantly after EA treatment, and neuronal apoptosis decreased as well. Conclusion： EA preventive treatment at GV 20 and EX-HN 3 might improve cognitive deficits and neuropathological changes in SAMP8 mice, which might be, at least in part, due to the effects of reducing brain neuronal damage, decreasing neuronal apoptosis and inhibiting Aβ-containing aggregates.

关键词： electroacupuncture senescence-accelerated mouse prone 8 mice prevention learning and memory cognitive impairment brain damage

Phospholamban Antisense RNA Improves SR Ca^(2+)-ATPase Activity and Left Ventricular Function in STZ-induced Diabetic Rats

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Biomedical and Environmental Sciences 2013年第7期26卷 577-583页

作者： LI jiang jia bao hui SUN jian LOU Xiao Liang HU Shen jiang Department of Emergency and ICU Fourth Affiliated Hospital of Nanchang University Zhengzhou Railway Vocational Technical College Institute of Cardiology First Affiliated Hospital Zhejiang University Medical College

Objective To study the effect of phospholamban antisense RNA （asPLB） on sarcoplasmic reticulum Ca2＋-ATPase activity and cardiac function in rats with diabetes mellitus （DM） mediated by recombinant adeno-associated virus （rAAV） vector. Methods Six weeks after the induction of DM by streptozotocin injected intraperitoneally, the rats were divided into three groups, namely： DM-rAAV-asPLB group, DM-saline group and DM group （control group）. The rats in the DM-rAAV-asPLB group were intramyocardially injected with rAAV-asPLB, the rats in the DM-saline group were injected with saline, and those in the control group did not receive any treatment. Six weeks after gene transfer, the expressions of PLB protein and PLB phosphorylation were detected by Western-blot, while the activity of sarcoplasmic reticulum （SR） Ca2＋-ATPase and left ventricular function were measured. Results The PLB protein expression level was significantly higher whereas the PLB phosphorylation, SR Ca2＋-ATPase activity and left ventricular function were significantly lower in the DM-saline group than in the control group. No significant difference was found in PLB protein expression level, PLB phosphorylation or SR Ca2＋-ATPase activity between the DM-rAAV-asPLB group and the control group. The left ventricular function in the DM-rAAV-asPLB group was poorer than in the control group and was better than in the DM-saline group. Conclusion rAAV-asPLB can down-regulate PLB protein expression and up-regulate phosphorylation and SR Ca2＋-ATPase activity, thus contributing to the improvement of in vivo ventricutar function. PLB left

关键词： Diabetes mellitus Phospholamban Sarcoplasmic reticulum Ca2+-ATPase, Gene therapy

基于辛积分法的复合材料层合板的应力分析(英文)

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船舶力学 2012年第6期16卷 692-704页

作者：贾宝慧王艳丽中国民航大学航空工程学院天津300300

文章介绍了线弹性体的修正H-R变分原理,并建立了矩形单元的可分型正则方程。然后在辛差分格式的基础上应用显式辛格式得到了单层板的可分型正则控制方程,并应用了多尺度迭代技术以获得高精度的数值解。最后基于层间的应力及位移协调性条... 详细信息

文章介绍了线弹性体的修正H-R变分原理,并建立了矩形单元的可分型正则方程。然后在辛差分格式的基础上应用显式辛格式得到了单层板的可分型正则控制方程,并应用了多尺度迭代技术以获得高精度的数值解。最后基于层间的应力及位移协调性条件,通过几个层合板静力响应的数值实验证明了文中方法的显著优点。

关键词：广义哈密顿系统可分型辛格式层合板静力响应

Protective Effects of Ginsenoside Rb1 on Septic Rats and Its Mechanism

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Biomedical and Environmental Sciences 2014年第4期27卷 300-303页

作者： WU Li Li jia bao hui SUN jian CHEN Jun Xi LIU Zhong Ying LIU Yuan Department of Emergency and ICU Fourth Affiliated Hospital of Nanchang University School of Life Sciences and Food Engineering Nanchang University

This study aims to observe the protective effects of ginsenoside Rbl on liver and lung in rats with septic shock and reveal its mechanism. Rats were randomly divided into three groups： sham, cecal ligation and puncture （CLP）, and CLP with ginsenoside Rb1. Then, the survival rate, arterial blood pressure, TLR4 mRNA, and TNF-α levels were determined. The liver and lung tissues were stained with hematoxylin-eosin （HE）. The overall survival rate of the Rb1 group was significantly higher than that of the CLP group. Mean arterial blood pressure went down in both the CLP and Rb1 groups after CLP, and there was a significant difference both in the sham and Rb1 groups when compared with the CLP group. The Rb1 treatment group had markedly lower TLR4 mRNA expression and TNF-a levels than the CLP group. In the CLP group, pathology showed swelling, degeneration, necrosis, and neutrophii infiltration in the liver and alveolar epithelial cells. However, in the Rb1 group, there was mild degeneration and slight neutrophil infiltration, but no obvious necrosis. Rb1 may improve the survival rate, ameliorate arterial blood pressure, and protect the liver and lung in septic shock rats by downregulating the expression of TLR4 mRNA and inhibiting the production of TNF-α.

关键词： Rb CLP Protective Effects of Ginsenoside Rb1 on Septic Rats and Its Mechanism

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai jian hui jia Yu Wang Chun Cheng Yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

非概率响应面法在起落架结构安全性评估中的应用

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安全与环境学报 2021年第3期21卷 1005-1011页

作者：贾宝惠廖文辉卢翔中国民航大学航空工程学院天津300300

由于起落架结构的安全性分析参数多为区间变量,随机分布较难获得,采用传统的概率分析方法受到一定的制约。基于此,针对起落架运营事件的严重度分析,提出了基于区间理论的起落架结构非概率可靠性方法,在只知道不确定参量的界限而不知其... 详细信息

由于起落架结构的安全性分析参数多为区间变量,随机分布较难获得,采用传统的概率分析方法受到一定的制约。基于此,针对起落架运营事件的严重度分析,提出了基于区间理论的起落架结构非概率可靠性方法,在只知道不确定参量的界限而不知其分布情况的条件下,即可求得结构的可靠度。以非概率可靠性理论为基础,结合响应面法建立结构的非概率模型,并通过改进的解析方法求解非概率可靠性指标。以某型飞机起落架结构为研究对象,对起落架结构进行数值分析获取建立非概率模型所需的数据样本,进而进行结构的安全性评估。算例分析表明,非概率可靠性方法能够有效评估起落架结构的安全状态,可为飞机结构的运营安全性分析提供参考。

关键词：安全工程起落架非概率可靠性区间分析响应面法

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民机直接维修成本优化模型研究

机械设计与制造 2019年第6期 264-267页

作者：贾宝惠吴婧中国民航大学航空工程学院

针对民机研制阶段直接维修成本(Direct Maintenance Cost,DMC)优化问题进行研究,建立可靠性、维修性协同优化(Collaborative Optimization,CO)模型。模型以DMC最小化为目标,以可靠性参数MTBUR、MTBF和维修性参数MTPM为设计变量。为了求... 详细信息

针对民机研制阶段直接维修成本(Direct Maintenance Cost,DMC)优化问题进行研究,建立可靠性、维修性协同优化(Collaborative Optimization,CO)模型。模型以DMC最小化为目标,以可靠性参数MTBUR、MTBF和维修性参数MTPM为设计变量。为了求解模型,将遗传算法与反向传播神经网络组合,通过BP神经网络预测输出,再采用遗传算法寻求最优解。根据设计变量确定网络结构为3-5-1,采用实数编码,通过选择、交叉、变异求解最优解及对应设计变量值。最后以冲洗包和压缩机为例通过Matlab仿真研究,验证协同优化在民机研制中的可行性。

关键词：直接维修成本可靠性维修性协同优化遗传算法研制阶段

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民机隐性功能系统预防性维修策略优化研究

机械设计与制造 2016年第5期 257-260页

作者：贾宝惠杨杭中国民航大学航空工程学院天津300300

针对民机隐性功能系统预防性维修策略优化的问题,假设隐性故障的检查和修理效果是"最小维修"、翻修效果是"完美维修"的基础上,运用威布尔分布建立民机隐性功能系统"翻修期"区间内的可靠度函数约束模型下的成本率函数(CRF)优化模型,并基... 详细信息

针对民机隐性功能系统预防性维修策略优化的问题,假设隐性故障的检查和修理效果是"最小维修"、翻修效果是"完美维修"的基础上,运用威布尔分布建立民机隐性功能系统"翻修期"区间内的可靠度函数约束模型下的成本率函数(CRF)优化模型,并基于"数值模拟法"对比分析出可靠度函数和成本率函数随维修间隔的变化趋势,分析结果表明,民机隐性功能系统预防性维修策略优化模型能够较好地实现维修间隔最优化的目标,可为航空公司制定维修决策和优化维修方案提供参考。

关键词：预防性维修策略隐性故障威布尔分布成本率函数(CRF) 维修间隔