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Lipid Accumulation and IL-6 Production in L02 Hepatocytes Induced by Sodium Oleate:Dose and Time Dependence

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Biomedical and Environmental Sciences 2021年第12期34卷 998-1004页

作者： CHEN Chen HUO Jun Sheng ZHUO Qin LI Yan MA Yan WANG Jing Bo jia xu dong Key Laboratory of Trace Element Nutrition of National Health Commission(NHC) National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Key Laboratory of Food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk AssessmentBeijing 100021China

To explore interleukin-6(IL-6)production and characterize lipid accumulation in L02 hepatocytes induced by sodium oleate.L02 hepatocytes were incubated with 0,37.5,75,150,300,600,or 1,200μmol/L sodium oleate for 24 h,and the supernatant was collected to detect the concentration of IL-6.L02 hepatocytes were incubated with 300,150,75,or 0μmol/L sodium oleate for 0–24 *** supernatant was collected for detection of IL-6 and free fatty acids.L02 hepatocytes treated with 300μmol/L sodium oleate for 0–24 h were stained with Oil Red *** extended sodium oleate incubation time,IL-6 levels increased,and free fatty acids *** 24 h incubation,IL-6 levels increased as sodium oleate increased from 37.5 to 300μmol/L(P<0.05 for 37.5μmol/L,P<0.01 for 75μmol/L and P<0.001 for concentrations 150μmol/L or higher).Lipid accumulation increased as the sodium oleate concentration and incubation time *** Red O staining intensified with incubation time extending beyond 2 ***-6 production and lipid accumulation in L02 hepatocytes are influenced by sodium oleate in a dose-and time-dependent manner.

关键词： L02 intensified Lipid

One-pot Three-component Synthesis of 4,4'-Arylidene-bis(3-methyl-pyrazolones) Derivatives in Water

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Chemical Research in Chinese Universities 2012年第6期28卷 999-1002页

作者： jia xu-dong DUAN Hal-feng LIN Ylng-jle CAO Jun-gang LIANG Da-peng WU Mao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changehun 130012 P. R. China

Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4＇-arylidene-bis（3-methyl-pyrazolones） derivatives in *** this green synthetic protocol,the solvent water itself catalyzed the reaction via hydrogen bonding,thus avoiding the use of any other catalyst to make the work up procedure ***-pot,environmental friendly and convenient are the highlights.

关键词： 4 4'-Arylidene-bis(3-methyl-pyrazolones) Catalysis Multi-component reaction

Simple and Mild Syntheses of Optically Active 2-(N,N-Dialkylamino)oxazolines

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Chemical Research in Chinese Universities 2010年第3期26卷 394-397页

作者： jia xu-dong DUAN Hai-feng LIN Ying-jie CAO Jun-gang LIANG Da-peng LUO xu-yang jiaNG Feng GAO Han WU Mao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Chloroamidinium salts and a-amino alcohols derived from commercially available tetraalkyl ureas and α-amino acids, respectively, can be used for the syntheses of optically active 2-（N,N-dialkylamino）oxazolines in moderate to excellent yields without any catalyst. It is a simple and mild method for the syntheses of optically active oxazolines

关键词： Amino alcohol Oxazoline Chloroamidinium salt Guanidine

A gravity-spatial entropy model for the measurement of urban sprawl

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Science China Earth Sciences 2016年第2期59卷 207-213页

作者： LI Ji Hong QIU Rong xu XIONG Le xu jia dong Forestry College Northeast Forestry University Geography Department University of Lethbridge Tourism Department Fudan University

Since the mid-twentieth century, most cities worldwide have undergone a rapid expansion in urban land use. Along with the expansion, several problems, such as excessive loss of prime agricultural land and increasing traffic congestion have arisen. Thus, understanding and measurements of the expansion scale and its speed are crucial to planners and officials during urban planning and management processes. To measure such geographic phenomena, Shannon first devised entropy theory, and then Batty developed it into spatial entropy. The recently developed spatial entropy model, which was used to measure urban sprawl, introduced area to represent spatial asymmetry. However, most models did not consider spatial discretization, particularly the impact of distance. This study attempted to construct an integrated gravity-spatial entropy model to delineate distance and spatial diffusion impacts on population distribution. Then, we tested the model using Shanghai's temporal land use and community statistical data. Application results for the new gravity-spatial model show that it is a useful tool for identifying spatial and temporal variations of urban sprawl.

关键词： Entropy Spatial entropy Gravity model Urban sprawl

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Efficient One-pot Synthesis of 12-Aryl-8, 9, 10, 12- tetrahydrobenzo [a]anthen-11-ones Under Solvent-free Conditions

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Chemical Research in Chinese Universities 2013年第1期29卷 82-86页

作者： jia xu-dong HAN Song-yang DUAN Hai-feng LIN Ying-jie CAO Jun-gang LIANG Da-peng WUMao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Multi-component condensation of 2-naphthol, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by ionic liquid [NSPTEA][HSO4] was accomplished for the synthesis of a series of 12-aryl-8,9,10,12- tetrahydrobenzo[a]xanthen-11-ones under solvent-free conditions. High yields, ease recovery, short reaction time and reusability of catalyst are significant advantages. ZrOC12＂8H20 was also found to act as an effective catalyst towards this transformation.

关键词： Aldehyde Ionic liquid ZrOCI28HzO Multi-component reaction Solvent-free condition

Immunotoxicity of Acrylamide in Female BALB/c Mice

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Biomedical and Environmental Sciences 2014年第6期27卷 401-409页

作者： FANG Jin LIANG Chun Lai jia xu dong LI Ning Key Laboratory of Food Safety Risk Assessment Ministry of Health National Center for Food Safety Risk Assessment National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention

Objective To investigate the immunotoxicity of acrylamide （ACR） in female BALB/c mice.Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weight-based cluster included five groups （10 mice per group）： negative control, positive control （cyclophosphamide）, low, intermediate, and high dose ACR groups, and all the groups were administered ACR by gavage for 30 days. At the end of the study, the immunotoxicological effects of the ACR were evaluated through immunopathology, humoral immunity, cellular immunity, and non-specific immunity. Results The terminal body weight, spleen and thymus weights, lymphocyte counts in the ACR-H group were decreased, pathological changes were observed in lymph glands, thymus and spleen. %T cells in blood lymphocytes were significantly increased in all ACR-treated groups, and a significant reduction of % natural killer（NK） cells and increase of %Th cells were observed in the ACR-H group. interleukin-6（IL-6）, Concanavalin A（ConA）-induced splenocyte proliferation and serum half hemolysis value （HCso） were also significantly suppressed in the ACR-H group. Conclusion ACR elicited an inhibitory effect on cellular and humoral immunity of mice after 30 day feeding.

关键词： Acrylamide(ACR) Immunotoxicity Female BALB/c mice

Highly Efficient and Recyclable Catalyst HBF_4·SiO_2 Catalyzed Synthesis of β-Enamino Compounds Under Solvent-free Conditions

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Chemical Research in Chinese Universities 2011年第5期27卷 792-794页

作者： GAO Han jia xu-dong DUAN Hai-feng LIN Ying-jie GAO Jun-gang LIANG Da-peng WU Mao-cheng Department of Organic Chemistry College of Chemistry dilin University Changchun 130012 l~ R. China

Fluoroboric acid adsorbed on silica-gel（HBF4·SiO2） has been found to be an extremely efficient and recyclable catalyst for the preparation of β-enaminones and β-enamino esters under solvent-free conditions.

关键词： β-Enaminone β-Enamino ester HBF4·SiO2 Solvent-free condition

A Subchronic Toxicity Study on Lactobacillus Fermentum GM 090 in Rat

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Biomedical and Environmental Sciences 2013年第8期26卷 680-683页

作者： jia xu dong ZHANG Xiao Peng LI Ning Key Laboratory of Food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk Assessment

Lactobacillus fermentum （L. fermentum） is one of seven species in the genus Lactobacillus[1]. With a long history of safe use in fermented food production, Lactobacillus is considered as one of the most beneficial probiotics[23]. The most well-known potential health benefit is improving digestion and immune function[4.s]. Other beneficial functions of Lactobacillus strains include managing lactose intoleranceIs], lowering cholesterol and blood pressureIs], reducing inflammation[~], and prevention of cancerIs＇7]. L. fermentum is usually found during malt whisky fermentation]8]. L. fermentum CP34 was found to have the significant effect of decreasing the serum antigen-specific IgE levels compared to a control group[9].

关键词： A Subchronic Toxicity Study on Lactobacillus Fermentum GM 090 in Rat body GM

Immunotoxicological Evaluation of Wheat Genetically Modified with TaDREB4 Gene on BALB/c Mice

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Biomedical and Environmental Sciences 2013年第8期26卷 663-670页

作者： LIANG Chun Lai ZHANG Xiao Peng SONG Yan jia xu dong Key Laboratory of Food Safety Risk Assessment Ministry of Health (China National Center for Food Safety Risk Assessment)

Objective To evaluate the immunotoxicological effects of genetically modified wheat with TaDREB4 gene in female BALB/c mice. Methods Female mice weighing 18-22 g were divided into five groups （10 mice/group）, which were set as negative control group, common wheat group, parental wheat group, genetically modified wheat group and cyclophosphamide positive control group, respectively. Mice in negative control group and positive control group were fed with AIN93G diet, mice in common wheat group, non-genetically modified parental wheat group and genetically modified wheat group were fed with feedstuffs added corresponding wheat （the proportion is 76%} for 30 days, then body weight, absolute and relative weight of spleen and thymus, white blood cell count, histological examination of immune organ, peripheral blood lymphocytes phenotyping, serum cytokine, serum immunoglobulin, antibody plaque-forming cell, serum half hemolysis value, mitogen-induced splenocyte proliferation, delayed-type hypersensitivity reaction and phagocytic activities of phagocytes were detected. Results No immunotoxicological effects related to the consumption of the genetically modified wheat were observed in BALB/c mice when compared with parental wheat group, common wheat group and negative control group. Conclusion From the immunotoxicological point of view, results from this study demonstrate that genetically modified wheat with TaDREB4 gene is as safe as the parental wheat.

关键词： Genetically modified wheat Immunotoxicological effects BALB/c mice