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不同禾本科植物对矿区重金属污染土壤的修复效果研究

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陕西科技大学学报 2025年第1期43卷 23-28页

作者：贾红磊安昊东王晴李成涛陕西科技大学环境科学与工程学院陕西西安710021

以秦岭腹地凤县典型铅锌尾矿区周边的农田土壤为研究对象,采用黑麦草、剪股颖、百慕大草三种类型的草本植物进行室内盆栽实验,阐述了干旱胁迫对植物生长的影响,探究不同禾本科植物在干旱半干旱地区对重金属污染土壤的修复效果,以期筛选... 详细信息

以秦岭腹地凤县典型铅锌尾矿区周边的农田土壤为研究对象,采用黑麦草、剪股颖、百慕大草三种类型的草本植物进行室内盆栽实验,阐述了干旱胁迫对植物生长的影响,探究不同禾本科植物在干旱半干旱地区对重金属污染土壤的修复效果,以期筛选出能够适合在金属矿区修复中种植的耐旱性草本植物.结果表明:相比剪股颖和百慕大草,黑麦草在该土壤条件下能够具有较高的生物量累积,且在干旱条件下生物量降低的较少(P<0.05),黑麦草的丙二醛(MDA)含量与电导率(EC)较低,说明其具有较好的耐旱能力和较高的重金属耐受能力(P<0.05).在重金属污染土壤修复中,黑麦草中Cd、Pb和Zn的含量最高,且对Cd的富集系数可达到0.98,种植黑麦草对土壤中Cd的去除效率高达50%以上,Pb的去除效率为15.5%.因此,研究认为黑麦草对于凤县矿区Pb、Zn和Cd污染土壤具有更好的修复潜力.

关键词：重金属干旱土壤修复植物筛选

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Hypocretin neuron hyperexcitability in the hypothalamus:a newly discovered culprit in aging-related sleep impairment

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2648-2649页

作者： Tianbai Li Congcong jia Weidong le Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases the First Affiliated HospitalDalian Medical University116021 DalianChina Institute of Neurology Sichuan Academy of Medical SciencesSichuan Provincial Hospital610072 ChengduChina

The recent research published in Science by Li et al.1 provides compelling evidence that the hyperexcitability of arousalpromoting hypocretin(Hcrt,also called orexin)neurons is closely associated with sleep instabilit... 详细信息

关键词： sleep impairment al.

Saddle pulmonary embolism is not a sign of high-risk deterioration in non-high-risk patients: A propensity score-matched study

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World Journal of Emergency Medicine 2021年第4期12卷 261-267页

作者： dong jia Chao Ji Min Zhao Department of Emergency Medicine Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Clinical Epidemiology Shengjing Hospital of China Medical UniversityShenyang 110004China

BACKGROUND: There is controversy regarding whether saddle main pulmonary artery(MPA) embolism represents a high risk of deterioration in non-high-risk acute pulmonary embolism(PE) patients. This study aims to address this issue by conducting a propensity score matching(PSM) ***: A total of 727 non-high-risk acute PE patients were retrospectively evaluated. We evaluated the Bova score and risk stratification to examine the risk of deterioration. Deterioration defined as any adverse event within 30 days after admission. Computed tomographic pulmonary angiography was used to identify the embolism type. All patients were matched into four subgroups by PSM according to age, sex, Bova score, and risk stratification:(1) MPA and non-MPA embolism;(2) non-saddle MPA and non-MPA embolism;(3) saddle MPA and non-saddle MPA embolism;(4) saddle MPA and non-MPA embolism. Correlations were analyzed using Cox regression analysis, and deterioration risk was compared between subgroups using Kaplan-Meier ***: Cox regression analysis revealed that MPA embolism was correlated with deterioration, regardless of whether saddle MPA embolism was included or excluded. Saddle MPA embolism was not correlated with deterioration, regardless of comparison with non-saddle MPA embolism or non-MPA embolism. Patients with MPA and non-saddle MPA embolism presented a high risk for deterioration(logrank test=5.23 and 4.70, P=0.022 and 0.030, respetively), while patients with saddle MPA embolism were not at a high risk of deterioration(log-rank test=1.20 and 3.17, P=0.729 and 0.077, respetively).CONCLUSIONS: Saddle MPA embolism is not indicative of a high risk of deterioration in nonhigh-risk acute PE patients.

关键词： Main pulmonary artery Pulmonary embolism Computerized tomography pulmonary arteriography

Changes in Spring Snow Cover over the Eastern and Western Tibetan Plateau and Their Associated Mechanism

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Advances in Atmospheric Sciences 2024年第5期41卷 959-973页

作者： Fangchi LIU Xiaojing jia Wei dong Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhouZhejiang 310058China

The spring snow cover(SC)over the western Tibetan Plateau(TP)(TPSC)(W_TPSC)and eastern TPSC(E_TPSC)have displayed remarkable decreasing and increasing trends,respectively,during 1985–*** current work investigates the possible mechanisms accounting for these distinct TPSC *** results indicate that the decrease in W_TPSC is primarily attributed to rising temperatures,while the increase in E_TPSC is closely linked to enhanced *** circulation analysis shows that the essential system responsible for the TPSC changes is a significant anticyclonic system centered over the northwestern *** anomalous descending motion and adiabatic heating linked to this anticyclone leads to warmer temperatures and consequent snowmelt over the western ***,anomalous easterly winds along the southern flank of this anticyclone serve to transport additional moisture from the North Pacific,leading to an increase in snowfall over the eastern *** analysis reveals that the anomalous anticyclone is associated with an atmospheric wave pattern that originates from upstream *** warming of the subtropical North Atlantic(NA)sea surface temperature(SST)induces an atmospheric pattern resembling a wave train that travels eastward across the Eurasian continent before reaching the ***,the decline in winter sea ice(SIC)over the Barents Sea exerts a persistent warming influence on the atmosphere,inducing an anomalous atmospheric circulation that propagates southeastward and strengthens the northwest TP anticyclone in ***,an enhancement of subtropical stationary waves has resulted in significant increases in easterly moisture fluxes over the coastal areas of East Asia,which further promotes more snowfall over eastern TP.

关键词： snow cover Tibetan Plateau long-term changes spring

How online ADHD-related information affects Chinese parents' decisions?

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World Journal of Pediatrics 2019年第1期15卷 57-65页

作者： Xiao-He Yu le Zhong jia Huang Department of Pediatrics Xiangya HospitalCentral South UniversityNo.87 Xiangya RoadChangsha 410008China Department of Pediatrics Distinct HealthcareShenzhen 518000China

Background Attention deficit hyperactivity disorder (ADHD) is a major public health problem in *** of children with confirmed,or suspected ADHD often face a difficult process in making decisions concerning diagnosis and *** internet is a major source of information for *** purpose of this study is to survey Chinese parental motivation and experience in using the internet to retrieve ADHD-related information,and how well online information is associated with making *** Parents were recruited to fill out an online questionnaire in the health portal.A total of 404 valid questionnaires were *** A total of 47.8% of parents agree that the internet helps them to understand the potential treatment options,but 77.7% of all parents still have conflict during *** Parents search for ADHD-related information online,but their acquisition skills need to be *** information affects their health *** still have highly conflicting *** the ability of parents to obtain information on the Internet may reduce the conflict in decision-making.

关键词： Attention deficit hyperactivity disorder Decision-making conflict Parents

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang jia-Qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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Broad-spectrum rescue compounds for structural p53 mutations: perspective on ‘Arsenic trioxide rescues structural p53 mutations through a cryptic allosteric site’

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Journal of Molecular Cell Biology 2021年第2期13卷 155-157页

作者： jia-le Wu Shuo Chen Min Lu Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine(Shanghai)Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Precision medicine targeting gene mutations holds the promise of changing the landscape of cancer care and prognosis,but currently approved drugs in this category are efficacious in only a very small percentage of all cancer patients(Tannock and Hickman,2016).TP53,encoding the tumor suppressor and transcription factor p53,is the most frequently mutated gene in human cancers(Joerger and Fersht,2016;Sabapathy and Lane,2018;levine,2019).Pharmacologically rescuing mutant p53 by restoring wild-type function could therefore potentially be widely applicable in cancer treatment and is considered to be a holy grail of cancer research(Joerger and Fersht,2010).Indeed,at least 17 compounds that can rescue mutant p53 variants were reported by 2018(Sabapathy and Lane,2018).Unfortunately,p53 mutations still remain therapeutically nonactionable due to challenges such as heterogeneous mechanisms of inactivation by different mutations and the absence of obvious targetable drug-binding pockets(except Y220C mutant).In a recent publication(Chen et al.,2021),we reported the identification of small-molecule compounds that rescue a broad class of p53 ***,these include arsenic trioxide(ATO),which is used to treat acute promyelocytic leukemia(de Théet al.,2017).The study differentiates itself from previous reports in:(i)rescuing mutant p53 at striking levels when benchmarked against previously reported rescue compounds;(ii)providing a structural mechanism,wherein the arsenic atom binds to a cryptic allosteric site connecting the loop–sheet–helix(LSH)motif with theβ-sandwich skeleton to increase the thermostability of mutant p53;(iii)offering a largely defined spectrum of applicable p53 mutations—the structural mutations that compromise the wild-type structure of p53 and collectively account for more than half of all clinically relevant p53 alterations.

关键词： structural spectrum collective

Cleavage/cross-coupling strategy for converting β-O-4 linkage lignin model compounds into high valued benzyl amines via dual C–O bond cleavage

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Chinese Chemical letters 2022年第3期33卷 1519-1523页

作者： le jia Chao-Jun Li Huiying Zeng The State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China Department of Chemistry FQRNT Centre for Green Chemistry and CatalysisMcGill UniversityMontrealQuebec H3A 0B8Canada

Lignin is the most recalcitrant of the three components of lignocellulosic biomass. The strength and stability of the linkages have long been a great challenge for the degradation and valorization of lignin biomass to obtain bio-fuels and commercial chemicals. Up to now, the selective cleavage of C–O linkages of lignin to afford chemicals contains only C, H and O atoms. Our group has developed a cleavage/crosscoupling strategy for converting 4-O-5 linkage lignin model compounds into high value-added compounds. Herein, we present a palladium-catalyzed cleavage/cross-coupling of the β-O-4 lignin model compounds with amines via dual C–O bond cleavage for the preparation of benzyl amine compounds and phenols.

关键词： β-O-4 Linkage Lignin C-O bond cleavage Cross-coupling reaction Palladium-catalyzed

Efficient optimization method for variable-specific-impulse low-thrust trajectories with shutdown constraint

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Science China(Technological Sciences) 2022年第3期65卷 581-594页

作者： jia FeiDa QIAO dong HAN HongWei LI XiangYu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Autonomous Navigation and Control for Deep Space Exploration Ministry of Industry and Information TechnologyBeijing 100081China

This paper develops a sequential convex programming(SCP)-based method to solve the minimum-fuel variable-specific-impulse low-thrust transfer problem considering shutdown constraint,with emphasize on improving the computational *** variable parameter engine is more applicable for many low-thrust scenarios,therefore,both a continuously variable model and a ladder variable model are ***,the original problem is convexified by processing the constraint feasible domain,which is composed of the nonlinear dynamic equations and second-order equality constraint,into convex ***,the approximation is generated to close the optimal solution of the low-thrust problem by iteratively solving the convexified ***,the switching self-detection and adaptive node refinement methods are presented,which can improve the accuracy of the solution and accelerate the convergence during the approximation process and is especially necessary and effective in the scenarios with shutdown *** numerical simulations,the comparison with the homotopic approach shows that the proposed method only needs 4%computational time as that of the homotopic approach,and two variable-specificimpulse examples further demonstrate the effectiveness and efficiency of the proposed method.

关键词： low-thrust trajectory variable-specific-impulse shutdown constraint sequential convex programming switching self-detection and adaptive node refinement