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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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FleXURAL-GRAVITY WAVES DUE TO TRANSIENT DISTURBANCES IN AN INVISCID FLUID OF FINITE DEPTH

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Journal of Hydrodynamics 2008年第2期20卷 131-136页

作者： LU dong-qiang le jia-chun DAI Shi-qiang Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China Shanghai Key Laboratory of Mechanics in Energy and Environment Engineering Shanghai 200072 China

The dynamic response of an ice-covered fluid to transient disturbances was analytically investigated by means of integral transforms and the generalized method of stationary phase. The initially quiescent fluid of finite depth was assumed to be inviscid, incompressible, and homogenous. The thin ice-cover was modeled as a homogeneous elastic plate. The disturbances were idealized as the fundamental singularities. A linearized initial-boundary-value problem was formulated within the framework of potential flow. The perturbed flow was decomposed into the regular and the singular components. An image system was introduced for the singular part to meet the boundary condition at the fiat bottom. The solutions in integral form for the vertical deflexion at the ice-water interface were obtained by means of a joint Laplace-Fourier transform. The asymptotic representations of the wave motion were explicitly derived for large time with a fixed distance-to-time ratio. The effects of the finite depth of fluid on the resultant wave pattems were discussed in detail. As the depth increases from zero, the critical wave number and the minimal group velocity first increase to their peak values and then decrease to constants.

关键词： waves ice-cover transient disturbances asymptotic group velocity

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： X ray photoelectron spectroscopy

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Integration Operators on Spaces of Dirichlet Series

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Acta Mathematica Sinica,English Series 2023年第10期39卷 1919-1938页

作者： jia le CHEN Mao Fa WANG School of Mathematics and Statistics Shaanxi Normal UniversityXi’an 710119P.R.China School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

We first study the Volterra operator V acting on spaces of Dirichlet *** prove that V is bounded on the Hardy space H_(0)^(p)for any 0 详细信息

We first study the Volterra operator V acting on spaces of Dirichlet *** prove that V is bounded on the Hardy space H_(0)^(p)for any 0

关键词： Integration operator Dirichlet series Hardy space Bergman space

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Effects of water adsorption on active site-dependent H_(2)activation over MgO nanoflakes

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Nano Research 2023年第7期16卷 9059-9064页

作者： Aiyi dong Kun Li Rentao Mu Conghui Liu Rongtan Li Haoran jia le Lin Qiang Fu School of Science Dalian Maritime UniversityDalian 116026China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Understanding the effect of H_(2)O adsorption on reactant activation is of great importance in heterogeneous catalysis,which remains a grand challenge particularly in oxide catalyst systems with structural ***,the effect of D_(2)O adsorption on D_(2)activation over MgO nanocatalysts at different temperatures has been investigated by transmission Fourier transform infrared(FT-IR)and temperature-programmed desorption(TPD).Two sets of hydride and hydroxyl species produced from D_(2)dissociation at more active and less active Mg-O pairs can be observed by FT-IR,which all desorb via the product of D_(2)as confirmed by TPD *** find that the physically adsorbed D_(2)O overlayer does not affect the dissociation of D_(2)since D_(2)may pass through the molecular layer and access the surface-active *** D_(2)O is partially dissociated on the MgO surface,D_(2)can only dissociate at the remaining active sites until that dissociated-ODw groups from D_(2)O occupy all active *** findings provide a fundamental understanding of the effect of water adsorption on D_(2)activation on oxide catalysts.

关键词： H_(2)activation MgO hydride hydroxyl H_(2)O

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小儿肺炎支原体感染82例临床分析

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蚌埠医学院学报 2005年第5期30卷 427-429页

作者：孔少云程正平李晓春乐嘉东王飞安徽省安庆市立医院儿科 246003

目的:分析肺炎支原体(Mycoplasma pneumoniae,MP)感染肺及肺外器官受累的临床特征和治疗效果。方法:采用ELISA法检测血MP-IgM及冷凝集试验。对确诊为MP感染的82例患儿进行回顾性分析。结果:82例患儿52.4%有呼吸道症状,26.8%肺外器官受累... 详细信息

目的:分析肺炎支原体(Mycoplasma pneumoniae,MP)感染肺及肺外器官受累的临床特征和治疗效果。方法:采用ELISA法检测血MP-IgM及冷凝集试验。对确诊为MP感染的82例患儿进行回顾性分析。结果:82例患儿52.4%有呼吸道症状,26.8%肺外器官受累,其中以消化、神经、心血管系统受累多见。82例患儿均给予大环内酯类抗生素治疗,80例治愈好转,2例死亡。实验室检查中72例血MP-IgM阳性,冷凝集试验≥1∶32阳性率12.2%。结论:MP感染临床特征及胸片缺乏特异性,对于治疗不理想及多器官受累的呼吸道感染,应注意有无MP感染可能,及时进行相关检查,早期确诊,对因治疗。

关键词：肺炎支原体呼吸道疾病肺和肺外器官儿童

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Design for structural flexibility using connected morphable components based topology optimization

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Science China(Technological Sciences) 2016年第6期59卷 839-851页

作者： DENG jia dong CHEN Wei Department of Mechanical Engineering Northwestern University

In topology optimization of structures considering flexibility, degenerated optimal solutions, such as hinges, gray areas and disconnected structures may appear. In this paper, built upon the newly developed morphable component based topology optimization approach, a novel representation using connected morphable components(CMC) and a linkage scheme are proposed to prevent degenerating designs and to ensure structure integrity. A lower bound condition of the thickness of each component is also incorporated to completely remove the smallest components in an optimal configuration. Designs of flexible structures, such as compliant mechanism design, maximum compliance structure design, and design of low-frequency resonating micro devices are studied to validate the proposed methodology. Our work demonstrates that the new methodology can successfully prevent degeneration solutions and possesses other advantages, such as minimum member size control in topology optimization of flexible structures.

关键词： topology optimization connected component degenerated designs

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai Li-Hui Cao Xu-Yong Chen jia-Yu Wang Zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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Metal organophosphates:electronic structure tuning from inert materials to universal alkali-metal-ion battery cathodes

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Rare Metals 2023年第1期42卷 122-133页

作者： Wu-Jie dong jia-Bo le Yan Jin Guo-Qing Zhang Bin Ye Peng Qin Fu-Qiang Huang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Beijing National Laboratory for Molecular Sciences and State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China

Organic cathodes for alkali-metal-ion batteries attract great attentions in recent years,but the ion storage sites are limited to some finite functional *** is because an organic cathode must have proper lowest unoccupied molecular orbitals(LUMO) to accept electrons at high ***,a novel type of organophosphate-based cathode has successfully been explored by tuning the LUMO energy level of organophosphates through metal ions with an inert electron *** the first time,the P=O of phytate(PA),N,N,N’,N’-ethylenediaminetetrakis(methylene phytate)(EDTMP),and diethylenetriaminepentakis(methyl phytate)(DTPMP) is activated by lead/bismuth(with 6s2electron pair) to storage Li/Na/K ions ***,density functional theory calculations indicate that the LUMO energy of Bi-PA is greatly reduced from-0.99(PA) to-4.61 eV,which shows the first discharge capacity of 173,182 and 206mAh·g-1and the reversibly capacity of 102,102 and 101mAh·g-1with the discharge platform of 2.4,2.1 and 2.4 V for Li/Na/K-ion battery cathodes,***,with proper LUMO energy level,Pb-PA(-4.63 eV),Pb-EDTMP(-3.71 eV),and Pb-DTPMP(-4.45 eV) all exhibit admirable *** unique strategy of organic materials to alkali-metal-ion battery cathodes offers a new avenue for future energy storage systems.

关键词： Organic cathodes Alkali-metal-ion battery Lowest unoccupied molecular orbitals(LUMO) Organophosphates

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