检索结果-南通市图书馆

Ratiometrically Designed Nanocarrier to Impact Major Cancer Pathways for Effective Pancreatic Cancer Treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2020年第6期36卷 1143-1144页

作者： ji jian Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027P.R.China

To achieve secured in vivo drug synergy in stroma-rich pancreatic cancer(PDAC)is not an easy *** and Liu et *** the rational development of a ratiometrically designed nanocarrier to co-package a CDK4/6 cel cycle inhibitor palbociclib(PAL)plus an autophagy inhibitor hydroxychloroquine(HCQ)for efficient PDAC treatment The lead formulation was obtained using a computer software aided in vitro screening,followed by a remote drug co-import into a lipid-coated mesoporous silica *** ratiometric nanocarrier led to the synchronized phar-macokinetic(PK)profile and effective intratumoral buildup of the drug pair post intravenous injection,which otherwise exhibited distinctly different biodistribution *** treatment using PAL/HCQ co-delivery nanoparticle:yielded the most effective shrinkage of PDAC in subcutaneous and orthotopic PANCI mouse *** mechanistic investigation also demonstrated the activation of anti-apoptosis pathway after repetitive nanoparticle injection in mice which promoted the authors to introduce a small molecule anti-apoptosis inhibitor to further improve the performance of their already potent nanoparticle in the PDAC mouse *** work has been published online in Nature Communi cations on August 25,2020.

关键词： injection otherwise treatment

An Improved SAR Image Denoising Method Based on Bootstrap Statistical Estimation with ICA Basis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2016年第4期25卷 786-792页

作者： ji jian LI Yang School of Computer Science and Technology Xidian University Shaanxi Automobile Group Co. Ltd

A new method for Synthetic aperture radar(SAR) image denoising is *** prior information of speckle statistical model can be exploited to judge its *** basis of SAR image can be estimated by Independent component analysis(ICA),and these bases can be divided into two different subspaces(noise and real signal subspaces) through a linear *** parametric Bootstrap estimates the parameters of speckle statistical model on the noise signal subspace,and the nonparametric Bootstrap can estimate the distribution of real image on the real signal *** to different results estimated by Bootstrap,corresponding Maximum a posterior probability(MAP) filter will be selected for image denoising,using the noise model’s parameter for adaptive *** show that the image processed by this new method can achieve a better visual perception and objective evaluation results.

关键词： Synthetic aperture radar(SAR) Image denoising Independent component analysis(ICA) basis Bootstrap Maximum a posterior probability(MAP)

A SAR Image Segment Method Using Gray Level Reduction Based on Graph in ICA Space

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2017年第4期26卷 883-888页

作者： ji jian LYU Xiaojia YAO Yafeng School of Computer Science and Technology Xidian University Netease Group

This paper proposes a new SAR image segmentation method based on graph and gray level reduction in Independent component analysis(ICA) space. Firstly,according to the grayscale information of SAR image, effective use of gray level reduction for initial segmentation can group the pixels with same or similar values to the same homogeneous region, which can address the problem of over-segmentation. Secondly, the features of regions are extracted in ICA space, and then the similarity degree can be calculated by Euclidean distance. The initial regions are merged in fully connected graph based on minimum spanning tree in ICA space. The process of region merging is divided into two phases; the first phrase is merging the different regions with the largest similarity degree, the second will focus on updating the fully connected graph for iteration. Finally, experimental and comparative results on synthetic and real SAR images verify the efficiency of the proposed algorithm.

关键词： SAR image segmentation Gray level reduction Independent component analysis(ICA) space Fully connected graph

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Finite NPDM-groups

Acta Mathematica Sinica,English Series 2021年第2期37卷 306-314页

作者： jian ji CAO Xiu Yun GUO School of Applied Mathematics Shanxi University of Finance and EconomicsTaiyuan 030006P.R.China Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

In this paper the classification is given for finite groups in which the normalizer of every non-normal cyclic subgroup of order divided by the minimal prime of |G| is a maximal subgroup.

关键词： Normalizer cyclic subgroup maximal subgroup

维普期刊数据库

A Padé-Aided Analysis of Nonperturbative NN Scattering in ^1S0 Channel

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2007年第4期47卷 699-704页

作者： YANG ji-Feng HUANG jian-Hua Department of Physics East China Normal University Shanghai 200062 China

We carried out a Padé approximant analysis on a compact factor of the T-matrlx for NN scattering to explore the nonperturbative renormalization prescription in a universal manner. The utilities and virtues for this ... 详细信息

关键词： nucleon-nucleon interactions nonperturbative renormalization Padé approximent

维普期刊数据库

Supramolecular Micelles and Reverse Micelles Based on Cyclodextrin Polyrotaxanes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2014年第1期32卷 73-77页

作者： Qiao jin Gongyan Liu jian ji[*] MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Email: jian ji (jijian@***)[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Tel.: 0086-0571-87953729 Fax: 0086-0571-87953729

A new supramolecular self-assembly approach to construct micelles and reverse micelles was ***-hydrophilic block copolymers poly(ethylene oxide)-b-poly(N-isopropylacrylamide) (PEO-b-PNIPAAm) was synthesized via atom transfer radical polymerization (ATRP) using PEO *** of the lower critical solution temperature (LCST) phase behavior of PNIPAAm,PEO-b-PNIPAAm block copolymers self-assembled to form PNIPAAm-core micelles at 40 ℃.The PNIPAAm-core micelles were disassembled to unimers when the temperature was decreased to 25 ℃.But the addition of α-cyclodextrins (α-CDs) could induce the formation of PNIPAAm-shell micelles because of the 'channel-type' crystallities induced by PEO/α-CDs *** assembly and disassembly procedure of micelles and reverse micelles were investigated by dynamic light scattering (DLS),X-ray diffraction (XRD),1H NMR and transmission electron microscopy (TEM).

关键词： cyclodextrin polyrotaxane reverse micelle supramolecular

Modal parameter identification for a roof overflow powerhouse under ambient excitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Water Science and Engineering 2016年第1期9卷 67-80页

作者： Yan Zhang ji-jian Lian Fang Liu State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100038China

Modal parameter identification is a core issue in health monitoring and damage detection for hydraulic structures. For a roof overflow hydropower station with a bulb tubular unit under ambient excitation, a complex unit-powerhouse-dam coupling vibration system increases the difficulties of modal parameter identification. In this study, in view of the difficulties of modal order determination and the noise jamming caused by ambient excitation, along with false mode identification and elimination problems, the ensemble empirical mode decomposition （EEMD） method was used to decrease noise, the singular entropy increment spectrum was used to determine system order, and multiple criteria were used to eliminate false modes. The eigensystem realization algorithm （ERA） and stochastic subspace identification （SSI） method were then used to identify modal parameters. The results show that the relative errors of frequencies in the first four modes were within 10% for the ERA method, while those of SSI were over 10% in the second and third modes. Therefore, the ERA method is more appropriate for identifying the structural modal parameters for this particular powerhouse layout.

关键词： Hydraulic structure Order determination Ensemble empirical mode decomposition Singular entropy Eigensystem realization algorithm Bulb tubular unit

维普期刊数据库

A GPU-accelerated two-phase flow model for fluid-solid interaction using the sharp interface immersed boundary method

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2024年第5期36卷 883-897页

作者： Li-ping Ma ji-jian Lian Dong-ming Liu State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin300072China School of Civil Engineering Tianjin UniversityTianjin300072China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China

A two-phase flow model accelerated by graphical processing unit(GPU)is developed to solve fluid-solid interaction(FSI)using the sharp-interface immersed boundary method(IBM).This model solves the incompressible Navier-Stokes equations using the projection-based fractional step method in a fixed staggered Cartesian grid system.A volume of fluid(VOF)method with second-order accuracy is employed to trace the free *** represent the intricate surface geometry,the structure is discretized using the unstructured triangle ***,a ray tracing method is employed to classify fluid and solid points.A high-order stable scheme has been introduced to reconstruct the local velocity at interface *** FSI problems,including wave evolution around a breakwater,interaction between a periodic wave train and a moving float,and a 3-D moving object interacting with the free surface,were investigated to validate the accuracy and stability of the proposed *** numerical results are in good agreement with the experimental ***,we evaluated the computational performance of the proposed GPU-based *** GPU-based model achieved a 42.29 times speedup compared with the single-core CPU-based model in the three-dimension ***,the results regarding the time cost of each code section indicate that achieving more significant acceleration is associated with solving the turbulence,advection,and diffusion terms,while solving the pressure Poisson equation(PPE)saves the most ***,the impact of grid number on computational efficiency indicates that as Fluid-solid interaction(FSI)immersed boundary method(IBM)graphical processing unit(GPU)two-phase flow moving rigid bodythe number of grids increases,the GPU-based model outperforms the multi-core CPU-based model.

关键词： Fluid-solid interaction(FSI) immersed boundary method(IBM) graphical processing unit(GPU) two-phase flow moving rigid body

The relief of hypoxic microenvironment using an O_(2) self-sufficient fluorinated nanoplatform for enhanced photodynamic eradication of bacterial biofilms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第2期15卷 1636-1644页

作者： Lingyun Zou Dengfeng Hu Fanjin Wang Qiao jin jian ji MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Hypoxia,an important characteristic of bacterial biofilms,can hinder the generation of reactive oxygen species(ROS)in photodynamic therapy(PDT),leading to reduced therapeutic efficacy of *** order to address this issue,fluorinated liposome was fabricated as an oxygen-sufficient nanoplatform for enhanced photodynamic eradication of bacterial *** liposomes(denoted as Lip-Ce6-PFH@O_(2))were prepared by co-encapsulation of O_(2) carrier perfluorohexane(PFH)and photosensitizer chlorin e6(Ce_(6)).Lip-Ce6-PFH@O_(2) could achieve efficient biofilm penetration due to the positively charged *** hypoxic microenvironment of biofilms would then be relieved,leading to the generation of more ROS under laser ***,the bactericidal capability of PDT could be significantly improved because of the co-delivered O_(2) carrier ***-Ce6-PFH@O_(2) exhibited much better antibiofilm ability than that of Lip-Ce6 both in vitro and in ***,Lip-Ce6-PFH@O_(2) also effectively alleviated inflammation symptoms and accelerated wound healing in the mice *** general,this study provides a new paradigm to enhance the therapeutic efficacy of PDT for efficient biofilm eradication.

关键词： biofilm hypoxia perfluorohexane liposome photodynamic therapy