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YZ-145原油破乳剂的研制

石油化工应用 2011年第5期30卷 16-20,26页

作者：史党伟么丽媛章文荣姬文玉王军燕中国石油长庆油田分公司西安长庆化工集团有限公司陕西西安710021 中国石油长庆油田分公司长庆(宁夏)精细化工公司宁夏银川750200

白于山作业区针对长_(4+5)层开发过程中见水井多、含水上升快及产能损失严重等开发矛盾,进行了大量注水井深部调驱,在现场取得了良好效果,成为白于山作业区长_(4+5)油藏控水稳油的有效手段;但同时暴露出白于山联合站沉降罐在该类型措施... 详细信息

白于山作业区针对长_(4+5)层开发过程中见水井多、含水上升快及产能损失严重等开发矛盾,进行了大量注水井深部调驱,在现场取得了良好效果,成为白于山作业区长_(4+5)油藏控水稳油的有效手段;但同时暴露出白于山联合站沉降罐在该类型措施之后,乳化层呈规律上升态势,同时乳化层非常规形态的油水乳状液形态,组分复杂,含有大量非油质组分,并凝聚一定量的机杂,乳状液成连续相O/W/O稳定状态,具备较大粘度,常温下流动性差的特点,常规破乳剂对其较难实现破乳。针对白于山长_(4+5)层原油,研制了一种新型YZ-145原油破乳剂,可满足现场需要。

关键词：破乳剂沉降罐乳化层投加浓度

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船舶SCR系统还原剂制备、存储系统的设计

船舶标准化工程师 2021年第2期54卷 44-49页

作者：计雯钰李虎生陈纪赛支晓欢徐海涛南京工业大学环境科学与工程学院南京211816 南京中船绿洲机器有限公司南京210000

船舶柴油机产生氮氧化物对大气环境造成严重污染,针对该问题,采用模块化设计一种使用AUS40船用尿素溶液作为还原剂的船舶SCR系统,还原剂系统由纯水制备模块、尿素溶解模块、尿素溶液存储模块和电控系统组成。使用该系统制备的尿素溶液... 详细信息

船舶柴油机产生氮氧化物对大气环境造成严重污染,针对该问题,采用模块化设计一种使用AUS40船用尿素溶液作为还原剂的船舶SCR系统,还原剂系统由纯水制备模块、尿素溶解模块、尿素溶液存储模块和电控系统组成。使用该系统制备的尿素溶液质量分数始终保持在39%~41%,且能在5℃~35℃范围内长时间低温保质存储。所设计的船舶SCR系统是在常规船舶尿素的存储和液化系统上做出的优化,实现船舶SCR系统中尿素溶液的制备及长时间安全稳定保存。

关键词：尿素溶液存储选择性催化还原

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五里湾二区破乳剂性能优化及现场应用

石油化工应用 2018年第3期37卷 52-56页

作者：章文荣周春林谯夫姬文钰么丽媛长庆(宁夏)精细化工有限公司宁夏银川750200 中国石油长庆油田西安长庆化工集团研究所陕西西安710018

随着我国原油开采进入中后期,原油中胶质、沥青质含量增加,使得原油乳状液更加稳定,加上采油技术的不断开发与应用,大量的表面活性剂用来驱油,使得原油的组成变得更加复杂,油田采出的原油含水量逐年增加,本文针对五里湾二区生产过程中... 详细信息

随着我国原油开采进入中后期,原油中胶质、沥青质含量增加,使得原油乳状液更加稳定,加上采油技术的不断开发与应用,大量的表面活性剂用来驱油,使得原油的组成变得更加复杂,油田采出的原油含水量逐年增加,本文针对五里湾二区生产过程中出现破乳剂脱水水质发黑,加药浓度持续偏高现象进行分析,对该区块现使用破乳剂进行了室内性能优化,并进行现场实验取得良好效果。

关键词：破乳剂性能优化脱水率现场应用

急诊PTCA治疗急性下壁心肌梗死高危患者临床意义

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上海铁道大学学报 1999年第9期20卷 27-29页

作者：于萍徐文俊王春明黄岚季文宇张代富浙江省丽水地区人民医院心内科浙江丽水323000

目的　急诊经皮冠状动脉腔内成型术（ＥｍｅｒｇｅｎｃｅＰＴＣＡ）能改善急性前壁心梗患者的预后已成定论，但急诊ＰＴＣＡ是否对急性下壁心梗患者有益尚有争论。本文总结了我院１９９６～１９９８年入院治疗３３例... 详细信息

目的　急诊经皮冠状动脉腔内成型术（ＥｍｅｒｇｅｎｃｅＰＴＣＡ）能改善急性前壁心梗患者的预后已成定论，但急诊ＰＴＣＡ是否对急性下壁心梗患者有益尚有争论。本文总结了我院１９９６～１９９８年入院治疗３３例急性下壁心梗高危患者的治疗效果，旨在探讨急诊ＰＴＣＡ对急性下壁心梗高危患者的治疗意义。方法　３３例经体表心电图确诊为急性下壁心梗高危患者根据治疗方法的不同分为Ａ、Ｂ两组。Ａ组１５例，均在发病６ｈ内行急诊ＰＴＣＡ；Ｂ组１８例，予药物治疗。结果　研究结果发现Ａ组住院天数、ＳＴ段恢复正常时间、ＣＰＫ峰值及到达峰值的时间、心脏事件发生率与Ｂ组均有显著性差异。Ａ、Ｂ两组死亡率、左室射血分数无显著性差异。结论　急诊ＰＴＣＡ对急性下壁心梗高危患者有益。

关键词：下壁高危患者心肌梗塞 PTCA

Organic dye assemblies with aggregation-induced photophysical changes and their bio-applications

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Aggregate

Aggregate 2021年第4期2卷 57-71页

作者： Chendong ji Liming Lai Pengyu Li Zhen Wu wenyu Cheng Meizhen Yin State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijingChina

Phototheranostics provide a safe,effective,and noninvasive way for the diagnosis and treatment of contemporary diseases,and organic dyes play a vital *** example,chemical modification endowed dyes with powerful reactive oxygen species or heat generation ability,favoring for photodynamic therapy and photoacoustic(PA)imaging guided photothermal therapy(PTT)of serious ***,photophysical properties manipulation of dyes has become the focus in current dye chemistry *** development of aggregate science has made great effort to solve this *** recent years,a large number of studies have focused on molecular aggregation behavior and its effect on photophysical *** most famous example is the discovery of aggregation-induced emission(AIE)*** on AIE theory,more theories for revealing the relationship between molecular aggregation behavior and photophysical properties were proposed and *** photophysical property changes caused by dye aggregation have become a unique discipline,guiding the development of molecular science and material *** the help of molecular self-assembly,controllable aggregation of dyes can be realized,and stable nano-theranostic reagents can be ***,constructing dye assemblies with various photophysical properties will greatly reduce the cost of theranostic reagents,thus,expanding biomedical applications of organic ***,this review focuses on the photophysical characteristic changes caused by dye aggregation and their biological applications including,fluorescence/phosphorescence/PA imaging as well as photodynamic and *** review will provide guidance for the design of organic dyes,the development of controllable aggregation methods,and the construction of multifunctional phototheranostic reagents.

关键词： aggregation-induced photophysical changes fluorescence imaging organic dye assemblies phosphorescence photodynamic therapy photothermal therapy

Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins

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Synthetic and Systems Biotechnology 2022年第3期7卷 880-886页

作者： Wanlu Li wenyu Zhang Yijia Cheng Yaoyao Shen jianzhao Qi Hou-Wen Lin Yongjun Zhou Research Center for Marine Drugs State Key Laboratory of Oncogenes and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling712100ShaanxiChina

Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude *** backbones of piericidins are derived fromβ,δ-diketo carboxylic acids,which are offloaded from a modular polyketide synthase(PKS)and putatively undergo a carbonyl amidation beforeα-pyridone ring *** tailoring modifications to theα-pyridone structure mainly include the verified hydroxylation and O-methylation of the C-4′position and an unidentified C-5′***,we describe a piericidin producer,terrestrial Streptomyces conglobatus,which contains a piericidin biosynthetic gene cluster in two different *** of the amidotransferase gene pieD resulted in the accumulation of two fatty acids that should be degraded from the nascent carboxylic acid released by the PKS,supporting the carbonyl amidation function of PieD duringα-pyridone ring *** of the O-methyltransferase gene pieB1 led to the production of three piericidin analogues lacking C-5′O-methylation,therefore confirming that PieB1 specifically catalyses the tailoring ***,bioactivity analysis of the mutant-derived products provided clues regarding the structure-function relationship for antitumor *** work addresses two previously unidentified steps involved in pyridyl pharmacophore formation during piericidin biosynthesis,facilitating the rational bioengineering of the biosynthetic pathway towards valuable antitumor agents.

关键词： Polyketide Pyridine Polyketide synthase(PKS) Natural product biosynthesis

Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase

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Synthetic and Systems Biotechnology 2023年第3期8卷 349-356页

作者： Ming Yang Wanlu Li Lin Zhou Xiao Lin wenyu Zhang Yaoyao Shen Hai Deng Hou-wen Lin Yongjun Zhou Research Center for Marine Drugs Department of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Institute of Marine Drugs Guangxi Key Laboratory of Marine DrugsGuangxi University of Chinese MedicineNanning530200PR China Department of Chemistry University of AberdeenAberdeenAB243UEUK

The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123(1),veramycin A(2),NFAT-133(3)and benwamycin I(4),which were discovered from Streptomyces species and demonstrated with antidiabetic and immunosuppressant *** the biosynthetic pathway of 1-3 was reported as a type I polyketide synthase(PKS),the PKS assembly line was interpreted inconsistently,and it remains a mystery how the compound 3 was ***,the PKS assembly logic of 1-4 was revised by site-mutagenetic analysis of the PKS dehydratase *** on gene deletion and complementation,the putative P450 monooxygenase nftE1 and metallo-beta-lactamase(MBL)fold hydrolase nftF1 were verified as essential genes for the biosynthesis of *** absence of nftE1 led to abolishment of 1-4 and accumulation of new products(5-8).Structural elucidation reveals 5-8 as the non-aromatic analogs of 1,suggesting the NftE1-catalyzed aromatic core *** of nftF1 resulted in disappearance of 3 and 4 with the compounds 1 and 2 *** a rare MBL-fold hydrolase from type I PKSs,NftF1 potentially generates the compound 3 through two strategies:catalyze premature chain-offloading as a trans-acting thioesterase or hydrolyze the lactone-bond of compound 1 as an esterase.

关键词： Thioesterase Metallo hydrolase Metallo-beta-lactamase Aromatic polyketide Polyketide synthase P450 monooxygenase

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不同术式对婴儿脑积水的治疗效果对比

中国医药导报 2018年第12期15卷 82-85页

作者：吉文玉蔡宁图柯拜汪永新范雁东更.党木仁加甫新疆医科大学第一附属医院神经外科新疆乌鲁木齐830054

目的探讨脑积水患儿不同治疗术式的临床效果。方法选择2014年2个月~2017年3月新疆医科大学第一附属医院收治70例脑积水患儿,依据治疗方法分为第三脑室造瘘术(ETV)组(20例)、脑室-腹腔分流术(VPS)组(27例)和对照组(23例),随访6个月,统计... 详细信息

目的探讨脑积水患儿不同治疗术式的临床效果。方法选择2014年2个月~2017年3月新疆医科大学第一附属医院收治70例脑积水患儿,依据治疗方法分为第三脑室造瘘术(ETV)组(20例)、脑室-腹腔分流术(VPS)组(27例)和对照组(23例),随访6个月,统计患儿临床症状改善情况,评估不同组间和两手术组中不同年龄段患儿手术前后的发育商(DQ),CT/MRI测量两手术组术前和术后患儿的脑室宽度各指标值。结果 ETV组、VPS组分别有18和27例患儿临床症状改善;ETV组术后6个月和VPS组术后2、6个月的DQ值与术前比较明显升高(P1岁患儿(P<0.05)。结论两种术式治疗脑积水患儿的临床效果显著,脑室-腹腔分流术对婴儿认知功能的改善更为明显。

关键词：脑积水第三脑室底造瘘术脑室腹腔分流术脑认知功能

Liquid-liquid phase separation in biology: mechanisms,physiological functions and human diseases

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Science China(Life Sciences) 2020年第7期63卷 953-985页

作者： Hong Zhang Xiong ji Pilong Li Cong Liu jizhong Lou Zheng Wang wenyu Wen Yue Xiao Mingjie Zhang Xueliang Zhu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education School of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Structural Biology Beijing Frontier Research Center for Biological StructureTsinghua-Peking Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China Key Laboratory of RNA Biology CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Biomedical SciencesSchool of Basic Medical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China Division of Life Science State Key Laboratory of Molecular NeuroscienceHong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking and membrane contactmediated inter-organelle interactions, have been extensively characterized. However, the molecular details of the assembly and functions of membraneless compartments remain elusive. Mounting evidence has emerged recently that a large number of membraneless compartments, collectively called biomacromolecular condensates, are assembled via liquid-liquid phase separation(LLPS). Phase-separated condensates participate in various biological activities, including higher-order chromatin organization,gene expression, triage of misfolded or unwanted proteins for autophagic degradation, assembly of signaling clusters and actin-and microtubule-based cytoskeletal networks, asymmetric segregations of cell fate determinants and formation of pre-and post-synaptic density signaling assemblies. Biomacromolecular condensates can transition into different material states such as gel-like structures and solid aggregates. The material properties of condensates are crucial for fulfilment of their distinct functions, such as biochemical reaction centers, signaling hubs and supporting architectures. Cells have evolved multiple mechanisms to ensure that biomacromolecular condensates are assembled and disassembled in a tightly controlled manner. Aberrant phase separation and transition are causatively associated with a variety of human diseases such as neurodegenerative diseases and cancers. This review summarizes recent major progress in elucidating the roles of LLPS in various biological pathways and diseases.

关键词： phase separation phase transition transcription asymmetric division postsynaptic density autophagy