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Journal of Central South University 2017年第10期24卷 2253-2259页

作者： LI Xiao-hui AI Xian-bin HE Li ji shao-shi HU Miao DING jian-nan LI Feng Institute of Biological Resources Jiangxi Academy of ScienceNanchang 330096China Institute of Energy Jiangxi Academy of ScienceNanchang 330096China Kopper Chemical Industrial Corp. Ltd.Chongqing 401221China

Synergistic extraction has been proven to enhance extractability and selectivity for the separation of cadmium and zinc from magnesium and calcium in the sulfuric acid medium with Mextral V10 and Mextral 622H(aromatic hydroxamic)mixtures diluted in *** of Mextral V10 and 622H are highly selective for Zn and Cd over Mg and Ca compared with the single Mextral V10,resulting in larger synergistic shifts for zinc and cadmium with theΔpH_(50(Zn–Ca))values increasing substantially from0.83 to 1.73 pH units andΔpH_(50(Cd–Ca))values increasing from 0.63 to 2.13 p H *** aqueous to organic ratio(A/O ratio),the saponification ratio of Mextral V10 and extracting agent concentration were studied on the effect of metal ions extraction,which helped to increase the organic capacity of metal *** Mc Cabe-Thiele plot for Cd and Zn extraction with 5%(volume fraction)Mextral V10 and 5%Mextral 622H extractants mixture indicate the necessity of only one theoretical stages at an A/O ratio of 1.5:*** stage extraction simulation test conducted at pH 6.50 shows that Cd and Zn reach the extraction of 99.6%and 97.9%,respectively,and only low levels of magnesium and calcium are extracted in the organic *** extracted Zn^(2+)or Cd^(2+)-organic species are Zn(A_1)(A_2)or Cd(A_1)(A_2)with the mixture system by slope analysis.

关键词： synergistic extraction cadmium zinc Mextral V10 aromatic hydroxamic

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磁黄铁矿与磁铁矿分离研究

矿冶工程 2011年第6期31卷 43-46,50页

作者：计少石麦笑宇余永富武汉理工大学资源与环境工程学院湖北武汉430070 长沙矿冶研究院湖南长沙410012

研究了乌拉特后旗欧布乞铁矿磁铁矿和磁黄铁矿的分离技术,采用阶段磨矿-阶段磁选-二磁精浮选脱硫工艺流程,可得到铁精矿品位63.50%、含硫0.210%的合格铁精矿。

关键词：浮选磁选磁黄铁矿磁铁矿捕收剂活化剂脱硫

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian shao Xunming ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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红土铜矿硫酸化浸出工艺研究

矿冶工程 2017年第3期37卷 90-93页

作者：李晓晖艾仙斌胡淼计少石何力丁建南江西省科学院生物资源研究所江西南昌330096 江西省科学院能源研究所江西南昌330096

开发了红土铜矿先硫酸化预处理后浸出的两步工艺,考察了浓硫酸加入量、加水量和硫酸化时间对红土铜矿硫酸化的影响,以及液固比和浸出时间对浸出的影响。结果表明:-0.15 mm粒级红土铜矿,在加水量50%(v/w)、浓硫酸用量276 kg/t、硫酸化时... 详细信息

开发了红土铜矿先硫酸化预处理后浸出的两步工艺,考察了浓硫酸加入量、加水量和硫酸化时间对红土铜矿硫酸化的影响,以及液固比和浸出时间对浸出的影响。结果表明:-0.15 mm粒级红土铜矿,在加水量50%(v/w)、浓硫酸用量276 kg/t、硫酸化时间1.5 h下预处理,然后以水为溶剂,在液固比6∶1、反应温度60℃下浸出3 h,铜浸出率达到87%。与常温硫酸搅拌浸出相比,硫酸化浸出法铜浸出率约提高了14个百分点。

关键词：红土铜矿硫酸化水浸酸浸铜

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铁离子对土状铜矿中铜浸出影响研究

有色金属（冶炼部分） 2015年第7期 5-7页

作者：李晓晖胡淼艾仙斌何力计少石丁建南江西省科学院生物资源研究所南昌330096 江西省科学院能源研究所南昌330096

考察Fe3+浓度、Fe3+/Fe2+对土状铜矿中铜浸出率的影响,分析了酸浸过程中铁离子提高铜浸出率的机理。结果表明,在矿浆浓度30%、酸浓度36.8g/L、12.0g/L硫酸铁溶液浸出土状矿48h后,铜浸出率为62.4%,与无铁时铜浸出率相比提高了10个百分点... 详细信息

考察Fe3+浓度、Fe3+/Fe2+对土状铜矿中铜浸出率的影响,分析了酸浸过程中铁离子提高铜浸出率的机理。结果表明,在矿浆浓度30%、酸浓度36.8g/L、12.0g/L硫酸铁溶液浸出土状矿48h后,铜浸出率为62.4%,与无铁时铜浸出率相比提高了10个百分点。其中有92.6%游离氧化铜、70.3%结合氧化铜、35.6%次生硫化铜和11.8%原生硫化铜被浸出,除原生硫化铜外,均比无铁时有明显提高。并且随着Fe2+/Fe3+的降低,铜浸出率逐渐增加。增加Fe3+浓度提高了溶液电位,从而提高铜浸出率。

关键词：铁离子土状铜矿浸出率机理

饲喂杂交构树对于湖羊瘤胃微生物群落组成的影响

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饲料研究 2021年第6期44卷 6-10页

作者：圣平计少石何力黄江丽张志红王东升江西省科学院生物资源研究所江西南昌330096

试验探讨饲喂杂交构树对于湖羊瘤胃微生物群落组成的影响。试验选取105只湖羊,随机分为7组,每组15只羊。对照组湖羊饲喂基础日粮,试验组湖羊分别饲喂添加30%、60%、100%杂交构树干料和青贮杂交构树的日粮。结果显示,对照组和试验组瘤胃... 详细信息

试验探讨饲喂杂交构树对于湖羊瘤胃微生物群落组成的影响。试验选取105只湖羊,随机分为7组,每组15只羊。对照组湖羊饲喂基础日粮,试验组湖羊分别饲喂添加30%、60%、100%杂交构树干料和青贮杂交构树的日粮。结果显示,对照组和试验组瘤胃细菌主要以拟杆菌门和厚壁菌门细菌为主。在添加青贮杂交构树组以及杂交构树干料添加比例达到60%及以上时,厚壁菌门细菌的相对丰度显著低于对照组(P<0.05)。采用青贮杂交构树全部替代花生秆以外的试验组拟杆菌门细菌的相对丰度显著高于对照组(P<0.05)。试验组拟杆菌门与厚壁菌门的比例均高于对照组。试验表明,日粮中添加杂交构树不会造成湖羊瘤胃微生物紊乱,但是会使得湖羊瘤胃微生物种类组成朝着以降解蛋白质和可溶性碳水化合物进行转变。

关键词：杂交构树湖羊瘤胃微生物

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某高结合率土质氧化铜矿石强化浸出试验研究

中国矿业 2015年第10期24卷 160-163页

作者：胡淼李晓晖张国华何力计少石丁建南江西省科学院江西南昌330096 南昌资环生态科技有限公司江西南昌330096

对云南某黏土质氧化铜矿进行了浸出试验研究,试验结合不同粒级矿石的可浸性能差异,对矿石进行分级强化浸出。+0.074mm添加强化浸出剂ED-1搅拌浸出,-0.074mm加温80℃搅拌浸出。通过搅拌浸出条件试验,确定最佳浸出参数,最佳条件下铜综合... 详细信息

对云南某黏土质氧化铜矿进行了浸出试验研究,试验结合不同粒级矿石的可浸性能差异,对矿石进行分级强化浸出。+0.074mm添加强化浸出剂ED-1搅拌浸出,-0.074mm加温80℃搅拌浸出。通过搅拌浸出条件试验,确定最佳浸出参数,最佳条件下铜综合浸出率81.93%,吨铜综合酸耗13.86t,铜浸出率较现有常温浸出工艺有了大幅提升。

关键词：土状氧化铜矿高结合率强化搅拌浸出

Analysis of Wave Distributions Using the WAVEWATCH-III Model in the Arctic Ocean

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Journal of Ocean University of China 2022年第1期21卷 15-27页

作者： shao Weizeng YU Wupeng jiANG Xingwei shi jian WEI Yongliang ji Qiyan Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316000China National Satellite Ocean Application Service Beijing 100081China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China College of Meteorology and Oceanography National University of Defense TechnologyNanjing 211101China College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China

In this work,we examined long-term wave distributions using a third-generation numerical wave model called WAVE-WATCH-III(WW3)(version 6.07).We also evaluated the influence of sea ice on wave simulation by using eight parametric *** select a suitable ice-wave parameterization,we validated the simulations from the WW3 model in March,May,September,and December 2017 against the measurements from the Jason-2 altimeter at latitudes of up to 60°***,all parameterizations ex-hibited slight differences,i.e.,about 0.6 m root mean square error(RMSE)of significant wave height(SWH)in May and September and about 0.9 m RMSE for the freezing months of March and *** comparison of the results with the SWH from the European Centre for Medium-Range Weather Forecasts for December 2017 indicated that switch IC4_M1 performed most effec-tively(0.68 m RMSE)at high latitudes(60°-80°N).Given this finding,we analyzed the long-term wave distributions in 1999-2018 on the basis of switch IC4_*** the seasonal variability of the simulated SWH was of two types,i.e.,‘U’and‘sin’modes,our results proved that fetch expansion prompted the wave ***,the interannual variability of the specific regions in the‘U’mode was found to be correlated with the decade variability of wind in the Arctic Ocean.

关键词： long-term wave distribution sea ice WAVEWATCH-III Arctic Ocean