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社会性别视角下的女大学生平等就业平台搭建

河北学刊 2009年第4期29卷 189-191页

作者：吉朝珑石家庄学院政法系河北石家庄050035

传统社会性别观念的困扰、现行法律规定的缺失以及经济因素的制约是当前女大学生平等就业的三大障碍。在社会性别视角下实现女大学生的平等就业,需要重构平等的社会性别意识、修正现行法律规定的缺失以及利用经济的杠杆手段进行调节。... 详细信息

传统社会性别观念的困扰、现行法律规定的缺失以及经济因素的制约是当前女大学生平等就业的三大障碍。在社会性别视角下实现女大学生的平等就业,需要重构平等的社会性别意识、修正现行法律规定的缺失以及利用经济的杠杆手段进行调节。社会性别主流化才能为女大学生平等就业搭建广阔的平台。

关键词：社会性别女大学生平等就业平台搭建

Efficacy and safety of 0.4 percent sodium hyaluronate for endoscopic submucosal dissection of gastric neoplasms

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World Journal of Gastroenterology 2013年第20期19卷 3069-3076页

作者： Young Dae Kim Jun Lee Ju Yeon Cho Seok Won Kim Seong Hwan Kim Young Kwan Cho jin Seok Jang ji Sun Han Joo Young Cho Division of Gastroenterology and Hepatology Department of Internal MedicineMedical SchoolChosun UniversityGwangju 501-717South Korea Department of Internal Medicine Eulji HospitalEulji UniversitySeoul 139-872South Korea Department of Internal Medicine Dong A University College of MedicineBusan 602-715South Korea Department of Internal Medicine Institute for Digestive ResearchDigestive Disease CenterSoonchunhyang University College of MedicineSeoul 140-743South Korea

AIM:To evaluate the efficacy and safety of sodium hyaluronate solution(sh) in endoscopic submucosal dissection(ESD) of gastric ***:A prospective multicenter randomized,double blind,controlled trial was designed and utilized in this study.A total of 76 patients with 5-20 mm sized gastric neoplasms were enrolled at three academic hospitals in South Korea from June 2011 to October *** were randomly assigned to the 0.4% sodium hyaluronate or control *** lesions underwent endoscopic *** was performed with 0.4%sh and normal saline(NS) solution for submucosal *** was assessed using en bloc resection and the number of additional *** evaluation variables were the volume of injection material,steepness of mucosal elevation,bleeding rate,procedural time and operator ***,the safety was assessed by analyzing adverse events during the ***:The usefulness rate in the 0.4%sh group and the controlled group had statistically significant difference under intention to treat(ITT) analysis(90.91% vs 61.11% P = 0.0041).Under per protocol(PP),the usefulness rate is statistically significant different(93.10% vs 61.76%,P = 0.0036).The difference in volume of the solution injected between 0.4%sh group and the controlled group and NS group was also statistically significant under intention to treat and per protocol analysis(ITT:0.03 ± 0.02 mL vs 0.06 ± 0.03 mL,P = 0.0003,PP:0.03 ± 0.02 mL vs 0.06 ± 0.03 mL,P = 0.0004).Satisfaction above the grade good was significantly higher in the sh group under intention to treat and per protocol analysis(ITT:90.91% vs 61.11%,P = 0.0041,PP = 93.11% vs 61.77%,P = 0.0022).Adverse events above grade 3 were not noticed in either *** adverse events were treated and were judged as not associated with the submucosal injection ***:0.4%sh solution is a safe and effective agent that doesn't cause any significant adverse events and is useful for submucos

关键词： Sodium hyaluronate Endoscopic submucosal dissection Gastric neoplasm Endoscopic mucosal resection

地下圆形衬砌洞室对sh波的动应力集中(Ⅱ):数值结果

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世界地震工程 2013年第3期29卷 46-51页

作者：纪晓东杜修力大连大学建筑工程学院辽宁大连116622 北京工业大学建筑工程学院北京100124

利用地下圆形衬砌洞室在入射平面sh波作用下动应力集中问题的级数解,定量分析了入射波长、入射角度、洞室直径及衬砌刚度等因素对动应力集中系数的影响。数值结果表明:(1)衬砌刚度对动应力集中系数有重要影响,刚性衬砌情形的动应力集中... 详细信息

利用地下圆形衬砌洞室在入射平面sh波作用下动应力集中问题的级数解,定量分析了入射波长、入射角度、洞室直径及衬砌刚度等因素对动应力集中系数的影响。数值结果表明:(1)衬砌刚度对动应力集中系数有重要影响,刚性衬砌情形的动应力集中系数最大,无衬砌情形次之,柔性衬砌情形最小;环向与轴向动应力集中系数最大可分别达到83.49与85.31;(2)入射频率和入射角度对动应力集中系数也有很大的影响。

关键词：衬砌洞室 sh波动应力集中数值结果

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HY5-HDA9 orchestrates the transcription of HsfA2 to modulate salt stress response in Arabidopsis

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Journal of Integrative Plant Biology 2023年第1期65卷 45-63页

作者： jiaheng Yang Xiao Qu Tao Li Yixiang Gao Haonan Du Lanjie Zheng Manchun ji Paifeng Zhang Yan Zhang jinxin Hu Liangyu Liu Zefu Lu Zijian Yang Huiyong Zhang jianping Yang Yongqing jiao Xu Zheng College of Agronomy State Key Laboratory of Wheat and Maize Crop Scienceand Center for Crop Genome EngineeringLongzi Lake Campus Henan Agricultural UniversityZhengzhou 450046 China College of Life Science Henan Agricultural University Zhengzhou 450002 China College of Life Sciences Capital Normal University Beijing 100048 China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China

Integration of light signaling and diverse abiotic stress responses contribute to plant survival in a changing *** reports have indicated that light signals contribute a plant’s ability to deal with heat,cold,and ***,the molecular link between light signaling and the saltresponse pathways remains *** demonstrate here that increasing light intensity elevates the salt stress tolerance of *** of HY5,a key component of light signaling,causes Arabidopsis thaliana to become salinity ***,the small heat shock protein(shsp)family genes are upregulated in hy5-215 mutant plants,and HsfA 2 is commonly involved in the regulation of these sh *** found that HY5directly binds to the G-box motifs in the HsfA2promoter,with the cooperation of HISTONE DEACETYLASE 9(HDA9),to repress its ***,the accumulation of HDA9 and the interaction between HY5 and HDA9 are significantly enhanced by salt *** the contrary,high temperature triggers HY5 and HDA9 degradation,which leads to dissociation of HY5-HDA9from the HsfA2 promoter,thereby reducing salt *** salt and heat stress conditions,fine tuning of protein accumulation and an interaction between HY5 and HDA9 regulate HsfA2 *** implies that HY5,HDA9,and HsfA2play important roles in the integration of light signaling with salt stress and heat shock response.

关键词： HDA9 heat shock HsfA2 HY5 light signaling salt stress small Hsps temperature

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数据挖掘中采样技术的研究

系统工程与电子技术 2005年第11期27卷 1946-1949页

作者：郑吉平秦小麟南京航空航天大学信息科学与技术学院江苏南京210016

针对日益增长的海量数据和信息,通常采取有效的采样技术对大数据集进行采样,然后通过对样本的分析得到数据总体的相关模式。首先论述了关于样本的一些基本概念:利用采样技术对大数据集和海量数据进行分析处理,讨论了普通抽样技术与数据... 详细信息

针对日益增长的海量数据和信息,通常采取有效的采样技术对大数据集进行采样,然后通过对样本的分析得到数据总体的相关模式。首先论述了关于样本的一些基本概念:利用采样技术对大数据集和海量数据进行分析处理,讨论了普通抽样技术与数据挖掘中的采样技术的异同。然后对目前普遍采用的采样技术进行了分类,重点研究了简单随机采样和分层随机采样,并对不同采样技术进行了比较。最后给出数据挖掘中利用采样技术的一个实现。

关键词：样本简单随机采样分层随机采样数据挖掘模式

sh-SAW IN LAYERED PIEZOELECTRIC/PIEZOMAGNETIC STRUCTURES LOADED WITH VISCOELASTIC LAYER

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SH-SAW IN LAYERED PIEZOELECTRIC/PIEZOMAGNETIC STRUCTURES LOA...

猪繁殖与呼吸综合征病毒GS株结构蛋白基因的克隆及结构特征分析

2013全国压电和声波理论及器件技术研讨会

作者： Lili YUAN jianke DU Tingfeng MA ji WANG School of Mechanical Engineering and Mechanics Ningbo University School of Civil Engineering and Environment Ningbo University

sh surface acoustic wave（sh-SAW）propagation in perfectly bonded piezoelectric/piezomagnetic structures loaded with viscoelastic layer has been *** on the three-dimensional piezoelectricity theory,the coupling wave equations have been obtained and solved by analytical method with consideration of both magnetoelectrically open and short *** effects of viscoelasticity on the phase velocity and attenuation of the waves are analyzed and discussed in *** the results we can find that the effects of viscoelasticity on the properties of sh-SAW are remarkable,the phase velocity decreases with the viscous coefficient,the attenuation increases with the *** analytical method and the Tesults can be useful for the design of the biosensors and chemical sensors made of magnetoelectric materials for liquid application.

关键词： sh-SAW waves piezoelectric viscoelastic layer piezomagnetic

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甘肃农业大学学报 2010年第6期45卷 1-5,17页

作者：马友记柳纪省张利甘肃农业大学动物科技学院甘肃兰州730070 中国农业科学院兰州兽医研究所甘肃兰州730046 中农威特生物科技股份有限公司甘肃兰州730046

根据GenBank中猪繁殖与呼吸综合征病毒(PRRSV)VR-2332毒株基因序列设计合成了6对引物,应用RT-PCR方法对PRRSVGS株部分片段进行基因的扩增、克隆和测序,将测序结果应用Blast和DNAStar软件进行拼接,并与国内外分离毒株进行核苷酸以及推导... 详细信息

根据GenBank中猪繁殖与呼吸综合征病毒(PRRSV)VR-2332毒株基因序列设计合成了6对引物,应用RT-PCR方法对PRRSVGS株部分片段进行基因的扩增、克隆和测序,将测序结果应用Blast和DNAStar软件进行拼接,并与国内外分离毒株进行核苷酸以及推导氨基酸序列同源性比较.结果发现PRRSVGS毒株结构蛋白基因全长3819bp,包括ORF2、ORF3、ORF4、ORF5、ORF6和ORF7共6个阅读框,分别编码GP2、GP3、GP4、GP5、M和N蛋白;与BJ-4、CH-1a、HB-2(sh)/2002和VR-2332美洲株等核苷酸的同源性在87.9%～97.1%,推导的氨基酸同源性在88.3%～97.1%;而与LV和Euro毒株的同源性差异显著,核苷酸同源性在56.0%～70.0%,氨基酸同源性在54.9%～77.6%.构建的系统发育树证明该毒株在基因型上属于美洲型.

关键词：猪繁殖与呼吸综合征结构蛋白基因同源性序列分析

Protective effects of β-dihydroagarofuran-type sesquiterpene against Aβ_(25-35)-induced neuronal apoptosis and oxidative damage

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Journal of Chinese Pharmaceutical Sciences 2016年第8期25卷 582-589页

作者： shasha ji Yun Lei Xiaotian Huang Zhiqin Gao School of Biological Science and Technology Weifang Medical University Weifang 261053 China CAS Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Excessive beta-amyloid （Aβ） plays a detrimental role in the pathogenesis of Alzheimer＇s disease （AD）, which is closely associated with apoptosis and oxidative stress in neurons. Therefore, identification of active small molecules with potent effects on neutralizing Aβ-induced neurotoxicity would be a promising strategy for delaying or preventing AD progression. In the present study, we discovered that pretreatment with CF-1 （（1R,2S,4R,5S,7R,9S, IOS）-1,15-diacetoxy-2-benzoyloxy-9-cinnamoyloxy- β-di-hydroagarofuran）, a sesquiterpene isolated from the seeds of Celastrus flagellaris, attenuated Aβ25_35-induced reduction in cell viability in a concentration-dependent manner, as evaluated by the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay. Above neuroprotective effect of CF-1 was associated with a significant decrease of apoptotic cells as measured by 4,6-diamidino-2-phenylindole （DAPI） staining, which concurrently happened with marked inhibition in the level of cleaved Caspase-3, an apoptotic executive protein. CF-1 pretreatment also markedly reduced the intracellular accumulation of reactive oxygen species （ROS） following Aβ exposure in sh-SY5Y neuroblastoma cells, but such pretreatment had no notable influence on 2,2-diphenyl-l-picrylhydrazyl （DPPH） scavenging. In conclusion, we demonstrated that a novel natural product, CF-1, possessed promising effects against Aβ-induced neuronal apoptosis and oxidative stress, which could be a potential drug lead or candidate for the treatment of Aβ-associated neurotoxicity.

关键词： Alzheimer's disease Aβ Neuroprotection Apoptosis Oxidative stress

Emerging role of protein modification in inflammatory bowel disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第3期23卷 173-188页

作者： Gaoying WANG jintao YUAN ji LUO Dickson Kofi Wiredu OCANSEY Xu ZHANG Hui QIAN Wenrong XU Fei MAO Key Laboratory of Medical Science and Laboratory Medicine of jiangsu Province School of MedicineJiangsu UniversityZhenjiang212013China Clinical Laboratory Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical UniversityWuxi214002China Clinical Laboratory the People’s Hospital of DanyangAffiliated Danyang Hospital of Nantong UniversityZhenjiang212300China Directorate of University Health Services University of Cape CoastCape Coast02630Ghana

The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune *** research on IBD continues to expand,the specific pathogenesis mechanism is still *** modification refers to chemical modification after protein biosynthesis,also known as post-translational modification(PTM),which causes changes in the properties and functions of *** proteins can be modified in different ways,such as acetylation,methylation,and phosphorylation,the functions of proteins in different modified states will also be *** between different states of protein or changes in modification sites can regulate protein properties and *** modifications like neddylation,sumoylation,glycosylation,and acetylation can activate or inhibit various signaling pathways(e.g.,nuclear factor-κB(NF-κB),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT))by changing the intestinal flora,regulating immune cells,modulating the release of cytokines such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ),and ultimately leading to the maintenance of the stability of the intestinal epithelial *** this review,we focus on the current understanding of PTM and describe its regulatory role in the pathogenesis of IBD.

关键词： Inflammatory bowel disease(IBD) Protein modification Neddylation Sumoylation Glycosylation Acetylation