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Protective effect of pioglitazone on kidney injury in diabetic rats

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 819-822页

作者： Xiao-Hui Peng Pei-Yu Liang Shan-ji ou Xiong-Bing Zu Urology Department Hainan Medical University Affiliated Hospital Urology Department. Xiangya Hospital

Objective:To investigate the protective effect of pioglitazone on kidney injury in diabetic rat model and its ***:Forty healthy Sprague Dawley rats were selected and randomly divided into five groups,with 8 rats in each *** A served as control group and were administered with sterile citrate buffer(i.p.)as *** B.C,D and E rats were injected(i.p.)with streptozotocin to induce type I diabetes,Diabetic rats in Group B were intragastrically administered with sterile saline solution *** C,D and E rats were iutragastrically given pioglitazone hydrochloride suspension at doses of 10,20,30 mg/kg per *** eight weeks of treatment,all rats were anesthetized and blood was withdrawn from the abdominal aortic ofr detection of hemoglobin A_(1c),serum creatinine(SCr)and blood ures nitrogen(BUN)*** were then sacrificed and the left kidney was excised for calculation of kidney hypertrophy index(KHI),observation of renal pathological changes using light microscope and electron *** glomerular cross-sectional areas(MGA).mean glomerular volume(MGV).glomerular basement membrane thickness and foot process fusion ratio were ***-PCR was employed for detection of podocalyxin(PCX)protein ***:Results showed that levels of hemoglobin A_(1c),*** in Groups B,C.D and E rats were significantly higher than those in Group A(Poups C,D and E were significantly lower than those in Group B(Poups B.C,D and E rats than those in Group A(Poup B rats were significantly higher than those in Groups C.D and E(Poups D and E was significantly lower than that in Gtoups B and C(Poup A *** mesan

关键词： Pioglitazone Diabetic nephropathy Kidney Protection

A new technology for controlling in-situ oxygen fugacity in diamond anvil cells and measuring electrical conductivity of anhydrous olivine at high pressures and temperatures

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Chinese Physics B 2020年第1期29卷 186-191页

作者： Wen-Shu Shen Lei Wu Tian-ji ou Dong-Hui Yue Ting-Ting ji Yong-Hao Han Wen-Liang Xu Chun-Xiao Gao State Key Laboratory for Superhard Materials Jilin UniversityChangchun 130012China School of Mechatronics Engineering Guizhou Minzu UniversityGuiyang 550002China College of Earth Sciences Jilin UniversityChangchun 130061China

We present a novel technique for controlling oxygen fugacity,which is broadly used to in-situ measure the electrical conductivities in minerals and rocks during diamond anvil cell *** electrical conductivities of olivine are determined under controlled oxygen fugacity conditions(Mo–MoO2)at pressures up to 4.0 GPa and temperatures up to 873 *** advantages of this new technique enable the measuring of the activation enthalpy,activation energy,and activation bulk volume in the Arrhenius *** provides an improved understanding of the mechanism of conduction in *** conduction in olivine is best explained by small polaron movement,given the oxygen fugacity-dependent variations in conductivity.

关键词： high pressure high temperature oxygen fugacity

The Landau-level structure of a single polaron in a nanorod under a non-uniform magnetic field

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Communications in Theoretical Physics 2023年第9期75卷 168-172页

作者： Tian-ji ou Ran An Wei Zhang Shuang Han Yong Sun Hamid-Reza Rastegar-Sedehi Xin-Jun Ma jing-Lin Xiao Institute of Condensed Matter Physics College of Physics and Electronic InformationInner Mongolia Minzu UniversityTongliao 028043China Department of Physics College of SciencesJahrom UniversityJahrom 74137-66171Iran

Nanorod is a unique low-dimensional nanometer structure in which the Landau level arrangement of polaron is essential for understanding its quasiparticle system. However, the stability of the polaron level is susceptible to external factors, such as changing magnetic *** this manuscript, the Pekar variational method is employed to calculate the external magnetic field's effect on the nanorod's polaron Landau level. It was found that different magnetic fields have different effects on the polaron energy levels of the nanorod, which demonstrated that the external environment had critical effects on the polaron energy levels. This study provides a theoretical basis for regulating the interaction between electrons and phonons in low-dimensional nanomaterials.

关键词： single polaron energy-levels non-uniform magnetic field nanorod

提高GPS单频相位模糊度解算成功率的新方法

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南京航空航天大学学报 2005年第3期37卷 279-283页

作者：阳仁贵欧吉坤中国科学院测量与地球物理研究所

相位模糊度的成功解算是应用单频接收机进行高精度快速定位的关键。为了提高整周模糊度解算成功率,本文提出了一种新的算法,包括两项措施:(1)针对仅由几个历元组成的双差法方程系数阵存在着较严重病态性的结构特性,合理设计正则化矩阵,... 详细信息

相位模糊度的成功解算是应用单频接收机进行高精度快速定位的关键。为了提高整周模糊度解算成功率,本文提出了一种新的算法,包括两项措施:(1)针对仅由几个历元组成的双差法方程系数阵存在着较严重病态性的结构特性,合理设计正则化矩阵,并在此基础上运用截断奇异值法求解模糊度实数解,使模糊度实数解更稳定和可靠,接近真实值;(2)在用最小二乘降相关平差(Least-squaresambiguitydecorrelationadjustment,LAMBDA)方法进行模糊度搜索时,在Ratio检验的基础上,应用2个分析和比较的准则,对输出的多组候选整数模糊度向量进行分析和比较,甄别出正确的整数模糊度向量。算例表明,新方法不但缩短了模糊度解算所需要的观测时间,提高了模糊度实数解的可靠性和精度,而且显著地提高了整周模糊度解算的成功率。本文为单频接收机在高精度快速动态定位甚至实时定位等方面的广泛应用,提供了新的研究思路。

关键词： GPS相位模糊度成功率病态问题正则化截断奇异值解

增加Doppler观测值实现实时动态PPP快速重新初始化

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宇航学报 2013年第6期34卷 795-800页

作者：丁文武欧吉坤大地测量与地球动力学国家重点实验室武汉430077 中国科学院研究生院北京100049

针对实时动态PPP中常常会遇到卫星信号中断或大部分卫星发生周跳而导致重新初始化的问题,可以将GNSS信号短时间中断看作是全部卫星发生周跳,通过研究Doppler观测值在快速重新初始化中的观测模型,进而提出联合伪距、相位、Doppler观测值... 详细信息

针对实时动态PPP中常常会遇到卫星信号中断或大部分卫星发生周跳而导致重新初始化的问题,可以将GNSS信号短时间中断看作是全部卫星发生周跳,通过研究Doppler观测值在快速重新初始化中的观测模型,进而提出联合伪距、相位、Doppler观测值及电离层延迟变化约束信息的数学模型,对于发生周跳的卫星,通过将周跳参数固定为整数以实现动态PPP快速重新初始化。根据实际算例,从多个角度进行统计分析表明引入Doppler观测值能够提高周跳修复的成功率,从而加快PPP快速重新初始化的过程。

关键词：精密单点定位(PPP) 多普勒观测快速重新初始化实时动态定位周跳修复

单频GPS进行高精度线路测量和有轨车辆定位的有效方法

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中国铁道科学 2006年第4期27卷 22-26页

作者：阳仁贵欧吉坤袁运斌中国科学院测量与地球物理研究所湖北武汉430077

轨道线路测量和有轨车辆的定位常采用GPS定位技术。利用GPS单频接收机实现高精度快速定位的关键是提高GPS单频相位模糊度解算的效率和成功率。基于轨道线路垂直方向变化不大和有轨车辆沿一定线路行驶的特点,提出一种有效的单频相位模糊... 详细信息

轨道线路测量和有轨车辆的定位常采用GPS定位技术。利用GPS单频接收机实现高精度快速定位的关键是提高GPS单频相位模糊度解算的效率和成功率。基于轨道线路垂直方向变化不大和有轨车辆沿一定线路行驶的特点,提出一种有效的单频相位模糊度解算方法。对GPS单频接收机提供的定位观测值进行粗差探测、修正和剔除等数据预处理,用低噪声和低多路径效应的载波相位观测值对码伪距观测值进行平滑处理,再用附加约束的方法估计双差模糊度实数解,以此为基础进行模糊度搜索固定。算例显示,该方法可提高模糊度实数解估计的精度和可靠性,缩小模糊度的搜索空间,使模糊度解算效率和成功率得到提高,有利于单频GPS接收机在高精度的线路测量和有轨车辆的定位中得到更广泛的应用。

关键词：线路测量车辆定位 GPS单频接收机相位模糊度约束法

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起算数据精度的测量参数估计的新解算

辽宁工程技术大学学报（自然科学版） 2007年第3期26卷 348-350页

作者：宁伟梁勇欧吉坤中国科学院测量与地球物理研究所湖北武汉430077 山东农业大学信息科学与工程学院山东泰安271018

针对起算数据具有误差时现有处理方法的不足,利用广义最小二乘原理,提出了一种新的顾及起算数据精度的参数估计方法,推导了基于广义最小二乘原则的顾及起算数据精度的参数估计公式,与将起算数据视为无误差的传统测量平差方法,或虽考虑... 详细信息

针对起算数据具有误差时现有处理方法的不足,利用广义最小二乘原理,提出了一种新的顾及起算数据精度的参数估计方法,推导了基于广义最小二乘原则的顾及起算数据精度的参数估计公式,与将起算数据视为无误差的传统测量平差方法,或虽考虑起算数据精度,但将其与观测值一起进行整体平差的方法相比,在理论和方法上都有较好的改进。算例表明:给出的参数估计模型较传统平差解算方法,其参数估计的精度有明显提高。

关键词：起始数据精度广义最小二乘法参数估计

GPS接收机仪器偏差的短期时变特征提取与建模

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地球物理学报 2016年第1期59卷 101-115页

作者：张宝成袁运斌欧吉坤 GNSS Research Centre Department of Spatial SciencesCurtin University 中国科学院测量与地球物理研究所动力大地测量学国家重点实验室武汉430077

卫星和接收机仪器偏差（Differential Code Biases,DCB）是利用GPS（Global Positioning System）研究电离层的两类主要误差源.由于所处的空间环境恒定,且可被全球跟踪站连续观测,GPS卫星的DCB具备长期稳定性和较高的估计精度.但针对各... 详细信息

卫星和接收机仪器偏差（Differential Code Biases,DCB）是利用GPS（Global Positioning System）研究电离层的两类主要误差源.由于所处的空间环境恒定,且可被全球跟踪站连续观测,GPS卫星的DCB具备长期稳定性和较高的估计精度.但针对各类型接收机而言,受测站环境、硬件设施等影响,其DCB可能会呈现明显的短期变化.精确地模型化接收机DCB的短期变化特征,将有助于提高GPS电离层产品的可靠性,以及基于这些产品反演空间和地球科学现象的准确性.采用零/短基线GPS数据,本文改进了提取和分析接收机DCB变化的现有方案.随后,本文推导了一种能直接估计接收机DCB的函数模型.当检验出接收机DCB的短期变化服从随机游走时,通过对比接收机DCB的直接估值与间接提取值之间的符合程度,可＂试探出＂过程噪声标准差的最优经验值.实验分析选用4台双频接收机（共形成1条零基线和2条短基线,间距最大为15m）多天的观测数据,主要结论包括：1）改进的接收机DCB提取方案能较好地克服低频伪距噪声和多路径效应的影响;2）针对零基线,其接收机DCB在各天内的变化量级小于1TECu,变化趋势则可采用过程噪声标准差为1.0～1.5mm的随机游走加以描述;3）对应于某短基线的接收机DCB在某天内的变化可达12TECu,当采用随机游走描述其趋势时,过程噪声标准差的经验值超过2mm.

关键词： GPS 精密单点定位电离层接收机仪器偏差零/短基线

Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

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World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： jian-Ping Wen Shuan-ji ou jia-Bao Liu Wei Zhang Yu-Dun Qu jia-Xuan Li Chang-Liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGRouND Diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were China,Shanghai jiao Tong University of China,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： Diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation