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SERPINh1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1890-1907页

作者： Xiao-Sheng jin Lu-Xi Chen Ting-Ting ji Rong-Zhou Li Department of Gastroenterology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Serpin peptidase inhibitor clade h member 1(SERPINh1)was initially recognized as an oncogene implicated in various human ***,the clinical relevance and functional implications of SERPINh1 in colorectal cancer(CRC)remain largely *** To investigate the effects of SERPINh1 on CRC cells and its specific *** Quantitative real-time polymerase chain reaction,western blotting analysis,The Cancer Genome Atlas data mining and immunohistochemistry were employed to examine SERPINh1 expression in CRC cell lines and tissues.A series of in-vitro assays were performed to demonstrate the function of SERPINh1 and its possible mechanisms in *** SERPINh1 demonstrated elevated expression levels in both CRC cells and tissues,manifested at both mRNA and protein *** SERPINh1 levels correlated closely with advanced T stage,lymph node involvement,and distant metastasis,exhibiting a significant association with poorer overall survival among CRC *** investigations unveiled that SERPINh1 overexpression notably bolstered CRC cell proliferation,invasion,and migration in vitro,while conversely,SERPINh1 knockdown elicited the opposite *** set enrichment analysis underscored a correlation between SERPINh1 upregulation and genes associated with cell cycle *** findings underscored the capacity of heightened SERPINh1 levels to expedite G1/S phase cell cycle progression via phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin pathway activation,thereby facilitating CRC cell invasion and *** These findings imply a crucial involvement of SERPINh1 in the advancement and escalation of CRC,potentially positioning it as a novel candidate for prognostic assessment and therapeutic intervention in CRC management.

关键词： Serpin peptidase inhibitor clade h member 1 Colorectal cancer Proliferation Cell cycle Phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin

Simulation of deuterium pellet ablation and deposition in the EAST tokamak with hPI2 code

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Chinese Physics B 2024年第4期33卷 561-569页

作者：李大正张洁侯吉磊李懋孙继忠 Key Laboratory of Materials Modification by Laser Ionand Electron BeamsSchool of PhysicsDalian University of TechnologyDalian 116024China Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

Pellet injection is a primary method for fueling the plasma in magnetic confinement *** that goal the knowledges of pellet ablation and deposition profiles are *** the present study,the pellet fueling code hPI2 was used to predict the ablation and deposition profiles of deuterium pellets injected into a typical h-mode discharge on the EAST *** ablation and deposition profiles were evaluated for various pellet injection locations,with the aim at optimizing the pellet injection to obtain a deep fueling *** this study,we investigate the effect of the injection angle on the deposition depth of the pellet at different velocities and *** ablation and deposition of the injected pellet are mainly studied at each injection position for three different injection angles:0°,45°,and 60°.The pellet injection on the high field side(hFS)can achieve a more ideal deposition depth than on the low field side(LFS).Among these angles,horizontal injection on the middle plane is relatively better on either the hFS or the *** the injection location is 0.468 m below the middle plane on the hFS or 0.40 m above the middle plane of the LFS,it can achieve a similar deposition depth to the one of its corresponding *** the pre-cooling effect is taken into account,the deposition depth is predicted to increase only slightly when the pellet is launched from the *** findings of this study will serve as a reference for the update of pellet injection systems for the EAST tokamak.

关键词： pellet injection pellet ablation hPI2 pellet deposition

纳米光子结构软膜紫外光固化纳米压印(英文)

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纳米技术与精密工程 2006年第3期4卷 225-229页

作者： ShI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M h ZhANG B ji h OUYANG Q ChEN Y 北京大学物理学院北京100871 法国巴黎高等师范学院巴黎75005 法国国家科研中心光子与纳米结构实验室马库锡91460

紫外光固化纳米压印是实现纳米结构批量复制的一种新技术．其特点是低成本和高分辨,而且可以达到极高的套刻精度．为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板．其母版图案可由高分辨率电子束曝光和反... 详细信息

紫外光固化纳米压印是实现纳米结构批量复制的一种新技术．其特点是低成本和高分辨,而且可以达到极高的套刻精度．为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板．其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上．本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术．该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成．对光胶层的压印可用普通的光学曝光仪实现．然后再将图案用反应离子刻蚀的方法转移到PMMA层中．为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验．相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的．

关键词：纳米压印纳米加工纳米光子学

Evaluating the efficacy of immunotherapy in gastric cancer:Insights from immune checkpoint inhibitors

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World Journal of Gastroenterology 2024年第32期30卷 3726-3729页

作者： Yu-Nuo Yang Li-Sheng Wang Yan-Qi Dang Guang ji Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Biochemistry University of OttawaOttawa K1H 8M5ONCanada

The emergence of immunotherapy,particularly immune checkpoint inhibitors(ICIs),represents a groundbreaking approach to treating gastric cancer(GC).however,the prognosis of GC patients receiving ICI treatment is influenced by various *** manuscript identified sarcopenia and myosteatosis as independent prognostic factors impacting the outcomes of GC patients treated with ***,this study introduced a visual predictive model to estimate the prognosis of GC *** confirmed by further studies,this observation could provide valuable insights to propel the advancement of personalized clinical medicine and the integration of precision medicine practices.

关键词： Gastric cancer Immune checkpoint inhibitors Sarcopenia Myosteatosis Prediction model

Stabilizing high-Nickel Cathodes via Interfacial hydrogen Bonding Effects Using a hydrofluoric Acid-Scavenging Separator

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Engineering 2024年第8期39卷 117-126页

作者： Shijie Zhong Liwei Dong Botao Yuan Yueyao Dong Qun Li Yuanpeng ji Yuanpeng Liu jiecai han Weidong he National Key Laboratory of Science and Technology on Advanced Composites in Special Environments &Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401151China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Nickel-rich layered Li transition metal oxides are the most promising cathode materials for high-energydensity Li-ion ***,they exhibit rapid capacity degradation induced by transition metal dissolution and structural reconstruction,which are associated with hydrofluoric acid(hF)generation from lithium hexafluorophosphate *** potential for thermal runaway during the working process poses another *** are promising components to alleviate the aforementioned ***,an ultrathin double-layered separator with a 10 lm polyimide(PI)basement and a 2 lm polyvinylidene difluoride(PVDF)coating layer is designed and fabricated by combining a nonsolvent induced phase inversion process and coating *** PI skeleton provides good stability against potential thermal shrinkage,and the strong PI-PVDF bonding endows the composite separator with robust structural integrity;these characteristics jointly contribute to the extraordinary mechanical tolerance of the separator at elevated ***,unique hF-scavenging effects are achieved with the formation of-CO…h-F hydrogen bonds for the abundant hF coordination sites provided by the imide ring;hence,the layered Ni-rich cathodes are protected from hF attack,which ultimately reduces transition metal dissolution and facilitates long-term cyclability of the Ni-rich ***||NCM811 batteries(where“NCM”indicates LiNi_(x)Co_(y)Mn_(1-x-y)O_(2))with the proposed composite separator exhibit a 90.6%capacity retention after 400 cycles at room temperature and remain sustainable at 60℃with a 91.4%capacity retention after 200 *** adopting a new perspective on separators,this study presents a feasible and promising strategy for suppressing capacity degradation and enabling the safe operation of Ni-rich cathode materials.

关键词： Nickel-rich cathodes Composite separator hF scavenging Transition metal dissolution Long-term cyclability

Chalcogen-dependent catalytic properties of RuX2 (X = S/Se/Te) nanoparticles decorated carbon nanofibers for hydrogen evolution in acidic and alkaline media

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Nano Research 2024年第4期17卷 2528-2537页

作者： Chengkai he Yue Wei jia Xu Yujie Wei Tao Wang Rongfei Liu Lvlv ji Zhun Liu Sheng Wang School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Physics Shaoxing UniversityShaoxing 312000China Zhejiang Kangjiesi New Material Technology Co. LTDZhuji 311800China

Transition metal dichalcogenides(TMDs),with the general formula MX_(2)(M=Mo/W/Fe/Co/Ni,etc.;X=S/Se/Te),have attracted extensive research interests for hydrogen evolution reaction(hER).Compared with numerous studies on noble-metal-free TMDs,the chalcogen-dependent hER catalytic properties of noble-metal-based TMDs are lack of sufficient research ***,a facile electrospinning-assisted synthetic strategy is proposed to synthesize ruthenium dichalcogenides(RuX_(2),X=S/Se/Te)nanoparticles decorated carbon nanofibers(CNFs).Benefiting from the identical nanofibrous morphology and exposed crystal planes of RuX_(2)(111),the catalytic activities of RuX_(2)@CNFs samples were investigated and compared in a fair and direct *** electrochemical measurements coupled with density functional theory calculations were carried out to probe their intrinsic hER catalytic activities,resulting in the catalytic activity order of RuS_(2)@CNFs>RuSe_(2)@CNFs>RuTe_(2)@CNFs in acidic media and that of RuS_(2)@CNFs>RuTe_(2)@CNFs>RuSe_(2)@CNFs in alkaline *** superior catalytic performance of RuS_(2)@CNFs mainly stems from the relative lower hER energy barriers and thereby the higher intrinsic catalytic activity of RuS_(2)(111),leading to ultralow overpotentials of 44 and 9 mV at 10 mA·cm^(-2) in acidic and alkaline media,***_(2)(111)is endowed with the more optimized Gibbs free energy of hydrogen adsorption(ΔGh*)than RuTe_(2)(111),but RuTe_(2)(111)shows enhanced catalytic property for h_(2)O dissociation and Oh-desorption than RuSe_(2)(111),therefore,resulting in the altered catalytic activity sequences for RuSe_(2) and RuTe_(2) in acidic and alkaline media.

关键词： hydrogen evolution reaction transition metal dichalcogenides carbon nanofibers electrocatalysis catalytic activity

Design and preparation of a crosslinkable,oil-resistant,and bio-based elastomer from fumarate

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Science China Chemistry 2024年第2期67卷 622-631页

作者： hui Yang haijun ji Xinxin Zhou Shihan Yang Liwei Li Chaoying Sun Weiwei Lei Runguo Wang Liqun Zhang Beijing State Key Laboratory of Organic-Inorganic Composites&Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing100029China hubei Key Laboratory of Polymer Materials Faculty of Materials Science and EngineeringHubei UniversityWuhan430062China

Poly(diethyl fumarate-co-methoxyethyl acrylate-co-vinyl chloroacetate)(PDEFMV),a novel bio-based elastomer with a saturated structure,was synthesized via redox emulsion *** glass-transition temperatures of PDEFMV,adjusted through the variation of the diethyl fumarate-to-methoxyethyl acrylate feeding ratio,ranged from-36.1 to-14.8 ℃.The number-average molecular weights of PDEFMV ranged from 384,000 to 46,000 g/*** designing the molecular structure,vinyl chloroacetate was used to provide active sites for subsequent vulcanization and *** active chlorine groups within the PDEFMV chain reacted with the crosslinking agent trithiocyanuric acid under high temperature and pressure to form a nonsulfur crosslinked three-dimensional network *** achieve the desired properties,carbon black(CB,N330) was incorporated to reinforce PDEFMV,leading to the formation of PDEFMV/CB composites.A comprehensive study was conducted on the high-temperature oil resistance of PDEFMV/CB *** immersion in IRM903 oil at temperatures of 150 and 200 ℃ for 72 h,the mass and volume changes in PDEFMV/CB were lower than those observed in commercially available acrylate rubber(AR)/CB,indicating that PDEFMV exhibited superior oil ***,the aging characteristics and mechanisms of oil resistance in the PDEFMV/CB and AR/CB composites were investigated at different temperatures(150,200,and 250 ℃).The results provide insights into the operational temperature ranges suitable for PDEFMV/CB and offer valuable guidance for potential industrial applications.

关键词： diethyl fumarate molecular design bio-based elastomer solvent-free synthetic route high-temperature oil resistance

Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 426-440页

作者： SI jianchao ChEN Xue QI Kerong LI Dongli LIU Bingbing ZhENG Yuying ji Ensheng YANG Shengchang Department of Physiology Hebei University of Chinese MedicineShijiazhuang 050000China hebei Technology Innovation Center of TCM Combined hydrogen Medicine Shijiazhuang 050000China Department of Geriatrics First People’s Hospital of XiaoganXiaogan 432000China

Chronic intermittent hypoxia(CIh),a principal pathophysiological aspect of obstructive sleep apnea(OSA),is associated with cognitive *** evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions(SMS-LD)can enhance cognitive function by nourishing yin and strengthening the *** study aimed to assess the efficacy and underlying mechanisms of SMS-LD in addressing cognitive impairments induced by *** exposed C57BL/6N mice to CIh for five weeks(20%-5%O_(2),5 min/cycle,8 h/day)and administered SMS-LD intragastrically(15.0 or 30 g·kg^(-1)·day)30 min before each CIh ***,AG490,a JJanus kinase 2(JAK2)inhibitor,was administered via intracerebroventricular *** function was evaluated using the Morris water maze,while synaptic and mitochondrial structures were examined by transmission electron *** stress levels were determined using DhE staining,and the activation of the erythropoietin(ER)/ER receptor(EPOR)/JAK2 signaling pathway was analyzed through immunohistochemistry and Western *** further investigate molecular mechanisms,hT22 cells were treated in vitro with either SMS-LD medicated serum alone or in combination with AG490 and then exposed to CIh for 48 *** results indicate that SMS-LD significantly mitigated CIh-induced cognitive impairments in ***,SMS-LD treatment enhanced dendritic spine density,ameliorated mitochondrial dysfunction,reduced oxidative stress,and activated the EPO/EPOR/JAK2 signaling ***,AG490 negated SMS-LD’s neuroprotective and cognitive improvement effects under CIh *** findings suggest that SMS-LD’s beneficial impact on cognitive impairment and synaptic and mitochondrial integrity under CIh conditions may predominantly be attributed to the activation of the EPO/EPOR/JAK2 signaling pathway.

关键词： Chronic intermittent hypoxia Cognitive impairment Shengmaisan Liuwei Dihuang Decoction Oxidative stress EPO/EPOR/JAK2 signaling pathway