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PUMA facilitates EMI 1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1377-1387页

作者： jin Wook Kang Zhiyan Zhan guangzhen ji Youzhou Sang Daohong Zhou Yanxin Li Haizhong Feng Tao Cheng State Key Laboratory of Experimental Hematology Institute of Hematology&Blood Diseases HospitalCenter for Stem Cell MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology&OncologyShanghai Children's Medical CenterShanghai Jiao Tong University School of medicineShanghaiChina Renji-Med X Clinical Stem Cell Research Center Ren Ji HospitalShanghai Cancer InstituteSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Pharmacodynamics College of PharmacyUniversity of Florida at GainesvilleGainesvilleFLUSA

Maintenance of genetic stability via proper DNA repair in stem and progenitor cells is essential for the tissue repair and regeneration,while preventing cell transformation after *** of PUMA dramatically increases the survival of mice after exposure to a lethal dose of ionizing radiation(IR),while without promoting tumorigenesis in the long-term *** finding suggests that PUMA(p53 upregulated modulator of apoptosis)may have a function other than regulates ***,we identify a novel role of PUMA in regulation of DNA repair in embryonic or induced pluripotent stem cells(PSCs)and immortalized hematopoietic progenitor cells(HPCs)after *** found that PUMA-deficient PSCs and HPCs exhibited a significant higher doublestrand break(DSB)DNA repair activity via Rad51-mediated homologous recombination(HR).This is because PUMA can be associated with early mitotic Inhibitor 1(EMI1)and Rad51 in the cytoplasm to facilitate EMI1-mediated cytoplasmic Rad51 ubiquitination and degradation,thereby inhibiting Rad51 nuclear translocation and HR DNA *** data demonstrate that PUMA acts as a repressor for DSB DNA repair and thus offers a new rationale for therapeutic targeting of PUMA in regenerative cells in the context of DNA damage.

关键词： progenitor PUMA repair

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Conservation and characterization of unique porcine interstitial telomeric sequences

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Science China(Life Sciences) 2012年第12期55卷 1029-1037页

作者： ji guangzhen LIU Kai CHEN ChengBin RUAN WeiMin GLYTSOU Christina YANG Yang OKUKA Maja SONG WenQing GAGOS Sarantis LINing LIU Lin State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China" State Key Laboratory far Agrobiotechnology College of Biological Sciences China Agricultural Universi~ Beijing 100193 China" Genettcs Dtvlslon Center of Basic Research H Biomedical Research Foundation of the Academy of Athens Greece Athens 11527 Greece Department of Obstetrics and Gynecology University of South Florida College of Medicine Tampa FL 33612 USA

Telomeres are composed of TTAGGG repeats and located at the ends of chromosomes. Telomeres protect chromosomes from instability in mammals, including mice and humans. Repetitive TTAGGG sequences are also found at intrachromosomal sites, where they are named as interstitial telomeric sequences （ITSs）. Aberrant ITSs are implicated in chromosomal instability and found in cancer cells. Interestingly, in pigs, vertebrate telomere sequences TTAGGG （vlTSs） are also localized at the centro- meric region of chromosome 6, in addition to the end of all chromosomes. Surprisingly, we found that botanic telomere se- quences, TTTAGGG （bITSs）, also localize with vITSs at the centromeric regions of pig chromosome 6 using telomere fluo- rescence in situ hybridization （FISH） and by comparisons between several species. Furthermore, the average lengths of vITSs are highly correlated with those of the terminal telomeres （TTS）. Also, pig ITSs show a high incidence of telomere doublets, suggesting that pig ITSs might be unstable and dynamic. Together, our results show that pig cells maintain the conserved te- lomere sequences that are found at the ITSs from of plants and other vertebrates. Further understanding of the function and regulation of pig ITSs may provide new clues for evolution and chromosomal instability.

关键词： evolution telomere interstitial telomeric sequence (ITS) pig

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基于联合梯度算法的结构可靠寿命预计

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机械工程学报 2017年第10期53卷 187-192页

作者：刘勤孙志礼姬广振李娟东北大学机械工程与自动化学院沈阳110819 中国兵器科学研究院北京100089

基于功能度量法,建立机械结构可靠寿命模型,给出可靠寿命求解方法。该方法将可靠寿命的计算问题转换为一个球面约束的优化问题,只需要进行一次优化迭代求解即可获得可靠寿命;针对寿命函数非线性较高,改进均值法易出现难以收敛问题,在此... 详细信息

基于功能度量法,建立机械结构可靠寿命模型,给出可靠寿命求解方法。该方法将可靠寿命的计算问题转换为一个球面约束的优化问题,只需要进行一次优化迭代求解即可获得可靠寿命;针对寿命函数非线性较高,改进均值法易出现难以收敛问题,在此基础上提出了联合梯度算法,并从理论上证明了该算法的收敛性。对某车用轴进行可靠寿命分析,分析结果表明基于联合梯度算法的结构可靠寿命预计方法具有较好的效率和精度。

关键词：可靠寿命联合梯度算法功能度量法概率功能度量改进均值法

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基于故障物理的复杂机械系统可靠性设计分析技术

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兵工学报 2022年第S1期43卷 189-195页

作者：刘勤姬广振曹璞琳李娟刘英中国兵器科学研究院北京100089 中兵勘察设计研究院有限公司北京100053

武器装备机械系统结构复杂、故障模式多、相关性强,工作过程承受振动、冲击、高温等复杂工作环境应力作用。从复杂机械系统及其关键件的故障机理研究出发,分析工作条件、环境应力及时间对系统退化或故障的影响,利用仿真和试验相结合建... 详细信息

武器装备机械系统结构复杂、故障模式多、相关性强,工作过程承受振动、冲击、高温等复杂工作环境应力作用。从复杂机械系统及其关键件的故障机理研究出发,分析工作条件、环境应力及时间对系统退化或故障的影响,利用仿真和试验相结合建立零部件、系统可靠性模型,提出一套基于故障物理的复杂机械系统可靠性设计分析流程和方法,包括故障物理模型建立、零部件或结构的可靠性设计分析、机械系统或机构可靠性设计分析等。结果表明:该项技术应用于武器装备关键系统,可以有效预测和评估系统的可靠度和寿命,并提高装备的可靠性水平。

关键词：复杂机械系统系统可靠性故障物理可靠性分析

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Research and Development of Cemented Carbide Multifacet Drill for Drilling High Strength Steel

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Journal of Beijing Institute of Technology 1999年第1期8卷 72-76页

作者：庞思勤于启勋姬广振北京理工大学机械工程与自动化学院

Aim To research on a solid cemented carbide multi facet drill for drilling high strength steel. Methods Assimilating some features of multi facet drill edge structures, through systematic drilling experiments, a new type of solid cemented carbide drill was developed and the drill geometry was optimized. Results With the new type drill,the drilling force decreases by 10%-20%, the drilling productivity (drilled holes per hour) increases by 2-3 times, and the drilling precision and surface finish increase by one level. Conclusion The new type drill possesses excellent drilling performance.

关键词： drilling multi facet drill cemented carbide high strength steel

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Novel diagnostic approaches for Fanconi anemia (FA) by single-cell sequencing and capillary nano-immunoassay

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Blood Science 2021年第1期3卷 20-25页

作者： Lixian Chang Xingjie Gao guangzhen ji Xuelian Cheng Yao Zou Tao Cheng Weiping Yuan Xiaofan Zhu State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China

Next-generation sequencing technology has been widely utilized for the diagnosis of Fanconi anemia(FA).However,mixed cell sequencing and chimerism of FA patients may lead to unconfirmed genetic ***,we introduced two novel diagnostic methods,including single-cell sequencing and capillary *** FA case with FANCM c.4931G>A p.R1644Q and FANCD1 c.6325G>A p.V2109I was *** DNA of 28 cells was amplified and eight types of cells were observed after Sanger *** were two homozygous mutations(FANCM/FANCD1).Furthermore,the capillary nano-immunoassay was conducted to analyze the expression profile of FA-associated *** FANCM and FANCD1 expressions simultaneously *** case was thus diagnosed as FA-D1/FA-M dual *** with mixed cell sequencing,single-cell sequencing data shows more accuracy for the FA subtype evaluation,while the capillary nano-immunoassay is a good method to detect the expression profile of abnormal or modified FA protein.

关键词： Capillary nano-immunoassay FANCD1 FANCD2 FANCM Fanconi anemia Single-cell sequencing

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Light People: Professor Fanglin Bao and his cover story

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Light(Science & Applications) 2024年第6期13卷 1015-1020页

作者： ji Wang School of Science Westlake UniversityHangzhouZhejiangPR China

Qu Yuan,a renowned ancient Chinese poet,once pondered in his work Heavenly Inquiry:“If the sun’s light is absent,from where does the radiance of the Hero Flower emanate?”The ability to see clearly in the darkest of nights has long been a sought-after magical power by *** holds not only immense technological significance for computer vision and remote sensing but also profound implications for transcending the dichotomy between day and night in our daily *** Fanglin Bao from Westlake University has made significant breakthroughs in this field,bringing us closer to a world where we can transform night into *** groundbreaking research on Heat-Assisted Detection and Ranging(HADAR)and night vision was featured as the cover story in Nature on July 26,2023.

关键词： bringing breakthrough holds

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引信MEMS微结构可靠性仿真及实现方法

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探测与控制学报 2017年第4期39卷 5-11页

作者：涂宏茂孙志礼姬广振刘勤东北大学机械工程与自动化学院辽宁沈阳110819 中国兵器科学研究院北京100089

针对目前引信MEMS微结构设计中缺乏高效的可靠性量化仿真方法的问题,提出了基于结构性能仿真的可靠性仿真分析及其实现方法。该方法以ANSYS软件为例给出CAE程序的集成方法和实现步骤,解决可靠性分析程序对有限元软件工具的自动调用问题... 详细信息

针对目前引信MEMS微结构设计中缺乏高效的可靠性量化仿真方法的问题,提出了基于结构性能仿真的可靠性仿真分析及其实现方法。该方法以ANSYS软件为例给出CAE程序的集成方法和实现步骤,解决可靠性分析程序对有限元软件工具的自动调用问题;采用试验设计和近似建模相结合的方法,有效降低可靠性分析程序对有限元仿真的调用次数,在此基础上,给出结构可靠度计算和灵敏度分析的基本原理;提出可靠性仿真实现的总体程序框架,给出各主要模块的功能及其主要函数的伪代码。实际验证结果表明,该仿真方法具有可行性和实用性。

关键词：引信可靠性 MEMS微结构可靠性仿真有限元方法可靠度

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Trend of Developing Aqueous Liquid and Gel Electrolytes for Sustainable,Safe,and High‑Performance Li‑Ion Batteries

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Nano-Micro Letters 2024年第1期16卷 17-34页

作者： Donghwan ji Jaeyun Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences&Technology(SAIHST)Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence at SKKU(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Institute of Quantum Biophysics(IQB) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Present Address:Department of NanoEngineering University of California San DiegoLa JollaSan DiegoCA 92093USA

Current lithium-ion batteries(LIBs)rely on organic liquid electrolytes that pose significant risks due to their flammability and *** potential for environmental pollution and explosions resulting from battery damage or fracture is a critical ***-based(aqueous)electrolytes have been receiving attention as an alternative to organic ***,a narrow electrochemicalstability window,water decomposition,and the consequent low battery operating voltage and energy density hinder the practical use of aqueous ***,developing novel aqueous electrolytes for sustainable,safe,high-performance LIBs remains *** Review first commences by summarizing the roles and requirements of electrolytes–separators and then delineates the progression of aqueous electrolytes for LIBs,encompassing aqueous liquid and gel electrolyte development trends along with detailed principles of the *** aqueous electrolytes are progressed based on strategies using superconcentrated salts,concentrated diluents,polymer additives,polymer networks,and artificial passivation layers,which are used for suppressing water decomposition and widening the electrochemical stability window of water of the *** addition,this Review discusses potential strategies for the implementation of aqueous Li-metal batteries with improved electrolyte–electrode interfaces.A comprehensive understanding of each strategy in the aqueous system will assist in the design of an aqueous electrolyte and the development of sustainable and safe high-performance batteries.

关键词： Lithium-ion battery(LIB) Aqueous electrolyte Gel electrolyte Electrochemical stability window Li dendrite

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Photocatalytic activation of sulfite by N-doped porous biochar/MnFe_(2)O_(4) interface-driven catalyst for efficient degradation of tetracycline

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Green Energy & Environment 2024年第3期9卷 481-494页

作者： Long Cheng Yuanhui ji jiangsu Province Hi-Tech Key Laboratory for Biomedical Research School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing211189China

A novel photo-catalytic system composed of N-doped biochars(NBCs),MnFe_(2)O_(4) and sulfite activation under ultraviolet(NBCs/MnFe_(2)O_(4)/sulfite/UV)was constructed to realize the efficient eliminate of tetracycline(TC).As the carrier of MnFe_(2)O_(4),NBCs were synthesized from alfalfa,which has large specific surface area,graphite like structure and hierarchical porous *** adsorption isotherm indicated that NBCs/MnFe_(2)O_(4)-2:1 had the best adsorption performance for TC(347.56 mg g^(-1)).Through synergistic adsorption and photocatalysis,the removal rate of TC reached 84%,which was significantly higher than that of MnFe_(2)O_(4).Electrochemical impedance spectroscopy(EIS)and Photoluminescence(PL)characterization results showed that the introduction of NBCs improved the separation efficiency of photogenerated electron and hole pairs and enhanced the photocatalytic ***,the adsorption,degradation mechanism and degradation path of TC by the catalyst were systematically analyzed by coupling HPLC–MS measurement with the theoretical *** the advantages of excellent degradation performance,low cost,easy separation and environmental friendliness of NBCs/MnFe_(2)O_(4),this work was expected to provide a new path for the practical application of biochar.

关键词： Biochar MnFe_(2)O_(4) Sulfite Adsorption Photocatalysis

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