检索结果-南通市图书馆

SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1890-1907页

作者： xiao-Sheng jin Lu-xi chen Ting-Ting ji Rong-Zhou Li Department of Gastroenterology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Serpin peptidase inhibitor clade H member 1(SERPINH1)was initially recognized as an oncogene implicated in various human ***,the clinical relevance and functional implications of SERPINH1 in colorectal cancer(CRC)remain largely *** To investigate the effects of SERPINH1 on CRC cells and its specific *** Quantitative real-time polymerase chain reaction,western blotting analysis,The Cancer Genome Atlas data mining and immunohistochemistry were employed to examine SERPINH1 expression in CRC cell lines and tissues.A series of in-vitro assays were performed to demonstrate the function of SERPINH1 and its possible mechanisms in *** SERPINH1 demonstrated elevated expression levels in both CRC cells and tissues,manifested at both mRNA and protein *** SERPINH1 levels correlated closely with advanced T stage,lymph node involvement,and distant metastasis,exhibiting a significant association with poorer overall survival among CRC *** investigations unveiled that SERPINH1 overexpression notably bolstered CRC cell proliferation,invasion,and migration in vitro,while conversely,SERPINH1 knockdown elicited the opposite *** set enrichment analysis underscored a correlation between SERPINH1 upregulation and genes associated with cell cycle *** findings underscored the capacity of heightened SERPINH1 levels to expedite G1/S phase cell cycle progression via phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin pathway activation,thereby facilitating CRC cell invasion and *** These findings imply a crucial involvement of SERPINH1 in the advancement and escalation of CRC,potentially positioning it as a novel candidate for prognostic assessment and therapeutic intervention in CRC management.

关键词： Serpin peptidase inhibitor clade H member 1 Colorectal cancer Proliferation Cell cycle Phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin

A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 324-330页

作者： xi chen Yuhu Zhang Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina

The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent but partially *** dopaminergic system acts on the anterior brain and is responsible for executive function,working memory,and *** contrast,the cholinergic system acts on the posterior brain and is responsible for semantic fluency and visuospatial *** from dopaminergic/cholinergic imaging or functional neuroimaging has shed significant insight relating to the involvement of the cerebellum in the cognitive process of patients with Parkinson’s *** research has reported evidence that the cerebellum receives both dopaminergic and cholinergic ***,whether these two neurotransmitter systems are associated with cognitive function has yet to be fully ***,the precise role of the cerebellum in patients with Parkinson’s disease and cognitive impairment remains ***,in this review,we summarize the cerebellar dopaminergic and cholinergic projections and their relationships with cognition,as reported by previous studies,and investigated the role of the cerebellum in patients with Parkinson’s disease and cognitive impairment,as determined by functional *** findings will help us to understand the role of the cerebellum in the mechanisms underlying cognitive impairment in Parkinson’s disease.

关键词： anterior brain system cerebellum cholinergic cognitive impairment dopaminergic dual syndrome hypothesis neuroimage neurotransmitter Parkinson’s disease posterior brain system therapeutic targets

Bio-screening and quantification of methyl paraben in vinegar and coconut juice separated by HPTLC

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1602-1607页

作者： Yisheng chen xingjun xi College of Food Science and Engineering Shanxi Agricultural UniversityTaigu 030801China Insitute of Food Nutrition and Safety Shanxi Agricultural UniversityTaiyuan 030031China Institute of Agricultural Food Standardization China National Institute of StandardizationBeijing 100191China

As a widely used food preservative,methyl paraben was experimentally evidenced with serious hormonelike adverse ***,a high performance thin-layer chromatography platformed bioluminescent bioautography and image analysis for the selective quantification and confirmation of methyl paraben was proposed and validated in vinegar and coconut ***,the detectability of the bioautography to the analyte on different layer materials was estimated,revealing that normal silica gel was the best *** that,the liquid of sample extract and working solution were separated to overcome the background noises due to co-extracted *** separation result was then coupled to the optimized bioautography,enabling instant and straightforward screening of the targeted *** accurate quantification,bioluninescent inhibition pattern caused by the analyte was processed by image analysis,giving useful sensitivity(LOD>16 mg/kg),precision(RSD<10.1%)and accuracy(spike-recovery rate 76.9%-112.2%).Finally,the suspected result was confirmed by determining its MS fingerprint,further strengthening the reliability of screening.

关键词： High performance thin-layer chromatography Bio-screening Bioluminescence Image analysis Methyl paraben

An extended numerical model of the first exothermic peak for three dimensional printed cement-based materials

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第1期18卷 80-88页

作者： Wei jiANG Wenqian LI xi chen School of Materials Science and Engineering Tongji UniversityShanghai 200092China School of Civil Engineering Tongji UniversityShanghai 200092China

The first exothermic peak of cement-based material occurs a few minutes after mixing,and the properties of three dimensional(3D)printed concrete,such as setting time,are very sensitive to *** this background,based on the classical Park cement exothermic model of hydration,we propose and construct a numerical model of the first exothermic peak,taking into account the proportions of C_(3)S,C_(3)A and quicklime in *** calculated parameters are calibrated by means of relevant published exothermic test *** is found that this developed model offers a good simulation of the first exothermic peak of hydration for C_(3)S and C_(3)A proportions from 0 to 100% of cement clinker and reflects the effect of quicklime content at 8%-10%.The unique value of this research is provision of an important computational tool for applications that are sensitive to the first exothermic peak of hydration,such as 3D printing.

关键词： 3D printed cement-based materials cement hydration the first exothermic peak liquid quick-setting agent numerical model

Heterogeneous bimetallic oxides/phosphides nanorod with upshifted d band center for efficient overall water splitting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第9期35卷 414-420页

作者： ji chen Yifan Zhao Shuwen Zhao Hua Zhang Youyu Long Lingfeng Yang Min xi Zitao Ni Yao Zhou Anran chen School of Materials and Energy Yunnan UniversityKunming 650091China School of Engineering The University of EdinburghSouth BridgeEdinburgh EH89YLUnited Kingdom Electron Microscopy Center Yunnan UniversityKunming 650091China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China

Electrocatalytic water splitting is the most directly available route to generate renewable and sustainable ***,we report the design of a composite material in which arrays of square pillar-like NiMoO4nanorods coated with N,P-doped carbon layers are uniformly contained in numerous nested nanoparticle *** catalysts have superior catalytic activity,requiring only 59 mV and 187 mV for HER and OER to attain a current density of 10 mA/cm^(2),*** assembled two-electrode electrolytic cell required a voltage of 1.48 V to reach 10 mA/cm^(2),along with excellent long-term *** calculations reveal that electrons aggregate and redistribute at the heterogeneous interface,with the d-band centers of the Ni and Fe atoms being positively shifted compared to the Fermi level,effectively optimizing the adsorption of intermediates and reducing the Gibbs free energy,thus accelerating the catalytic ***,an integrated solar-driven water-splitting system demonstrated a high and stable solar-to-hydrogen efficiency of 18.20%.This work provides new possibilities for developing non-precious metal-based bifunctional electrocatalysts for large-scale water splitting applications.

关键词： Hydrogen evolution reaction Bimetallic oxides Bimetallic phosphides Overall water splitting Solar-to-hydrogen efficiency

A Systematic Analysis of Early Life Exposure to the Chinese Famine(1959-1961)and the Health of Older Adults-China,2008-2023

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2024年第11期6卷 203-207,I0001-I0003页

作者： Chi Shen xi chen School of Public Policy and Administration Xi’an Jiaotong UniversityXi’an CityShaanxi ProvinceChina Department of Health Policy and Management Yale School of Public HealthNew HavenCTU.S Department of Economics Yale UniversityNew HavenCTU.S

What is already known about this topic?There is mounting evidence indicating that the aging process initiates during early life stages,with in utero the individual’s environment playing a significant ***,it is crucial to comprehend the enduring effects of early life circumstances on health in old *** is added by this report?In this study,we conducted a meta-analysis to examine the effects of the Chinese Famine(1959–1961)on the health of older *** also explored potential mechanisms underlying these *** are the implications for public health practice?The complex interplay between early life circumstances,multiple health-related sectors,and healthy aging necessitates a comprehensive life-course approach and strategic interventions to enhance public health in an aging society.

关键词： life aging mount

Differences in Variations of Long-Lived and Short-Lived Summer Heat Waves during 1981-2020 over Eastern China and Their Corresponding Large-Scale Circulation Anomalies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2024年第3期38卷 414-436页

作者： Liqun ji Haishan chen Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of EducationNanjing University of Information Science&TechnologyNanjing210044China School of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing210044China

Using daily maximum temperature(Tmax)data from 516 observation stations in eastern China from 1981 to 2020,this study employed a relative threshold method to define short-and long-lived heat waves(HWs)by considering regional climate differences to investigate the spatial characteristics and evolution of large-scale circulation during summer *** results demonstrated spatial disparities in the frequency distribution of HWs of different durations and differences in the magnitude of duration and intensity between short-and long-lived *** orthogonal function analysis revealed three dominant spatial modes for both short-and long-lived *** first mode showed that short-lived HWs occur prominently in both northern and southern regions,whereas long-lived HWs mainly occur in the northern *** second mode was characterized by a meridional dipole pattern in both *** third mode exhibited a quadrupole pattern for short-lived HWs and a tripole pattern for long-lived *** in the center locations of anomalies in the 500-hPa geopotential height and 850-hPa wind fields significantly influenced the temperature and precipitation anomaly distribution of typical HWs by affecting the warm column in the lower troposphere,cloud distribution,and moisture ***,the atmospheric circulation evolution processes of typical HWs associated with the different modes of long-and short-lived HWs were linked to distinct teleconnection *** the three modes of long-lived(short-lived)HWs,there was stronger(weaker)wave flux activity with multiple(single)propagation *** westward Atlantic wave train activity at 300 hPa triggered the synergistic action of meridional and zonal wave fluxes,favoring the strengthening and maintenance of positive anomalies in geopotential height of 500 *** may have contributed to the formation of long-lived *** findings provide valuable insights to enhance our understanding and prediction of summer

关键词： short-lived heat waves(HWs) long-lived HWs empirical orthogonal function(EOF)modes large-scale atmospheric circulation

Modeling solubility of oxaprozin and irbesartan in biorelevant complex solutions based on a combination of pH-dependent and micellar solubilization models

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第8期72卷 34-43页

作者： chen Shen Yuanhui ji jiangsu Province Hi-Tech Key Laboratory for Biomedical Research School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

Biological solubility is one of the important basic parameters in the development process of poorly soluble drugs,but the current measurement methods are mainly based on a large number of experiments,which are time-consuming and *** is still a lack of effective theoretical models to accurately describe and predict the biological solubility of drugs to reduce ***,in this study,osaprazole and irbesartan were selected as model drugs,and their solubility in solutions containing surfactants and biorelevant media was measured *** calculating the parameters of each component using the perturbed-chain statistical associating fluid theory(PC-SAFT)model,combined with pH-dependent and micellar solubilization models,the thermodynamic phase behavior of the two drugs was successfully modeled,and the predicted results were in good agreement with the experimental *** results demonstrate that the model combination used provides important basic parameters and theoretical guidance for the development and screening of poorly soluble drugs and related formulations.

关键词： Biorelevant media pH-dependent solubility Micellar solubilization PC-SAFT Active pharmaceutical ingredients

Nondestructive Nonlinear Optical Microscopy Revealed the Blackening Mechanism of Ancient Chinese Jades

在线全文

学校读者我要写书评

暂无评论

Research 2024年第3期2023卷 391-399页

作者： Yaxin chen Rong Wang Minbiao ji State Key Laboratory of Surface Physics and Department of Physics Human Phenome InstituteAcademy for Engineering and TechnologyKey Laboratory of Micro and Nano Photonic Structures(Ministry of Education)Yiwu Research Institute of Fudan UniversityFudan UniversityShanghai 200433China Department of Cultural Heritage and Museology Fudan UniversityShanghaiChina

Jade is most valued in Chinese culture since ancient times. For unearthed jade artifacts, the alteration color resulting from weathering effects and human activities provides information for cultural heritage conservation, archaeology, and history. Currently, the noninvasive 3-dimensional characterization of jade artifacts with high chemical and spatial resolution remains challenging. In this work, we applied femtosecond pump–probe microscopy and second harmonic generation microscopy techniques to study the black alteration of an ancient jade artifact of the late Spring and Autumn period (546 to 476 BC). The direct cause of the “mercury alteration” phenomena was discovered to be the conversion of metacinnabar from buried cinnabar in the tomb. Furthermore, a 3-dimensional optical reconstruction of the black alteration was achieved, providing a high-resolution method for analyzing the blackening mechanism without the need of sample damage. Our approach opens up new opportunities to extract microscopic spatiochemical information for a broad range of alteration colors in jade artifacts.

关键词： pump Nonlinear buried