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Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and mRI

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World Journal of Gastroenterology 2009年第30期15卷 3748-3756页

作者： Hervé Trillaud jean-michel Bruel Pierre-jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis Department of radiology University of Victor Segalen Bordeaux 2CHU Bordeaux Hospital Saint André1 rue Jean Burguet33075 BordeauxFrance Department of radiology CHU of Montpellier HospitalSaint Eloi34295 MontpellierCedex 5France Department of radiology CHU Lyon University69437 Lyon Cedex 03France Department of radiology Hospital Beaujon92110 ClichyFrance Department of radiology Hospital CaenCaen14033 Caen CedexFrance Department of radiology University Hospitals LeuvenGasthuisbergHerestrat 493000 LeuvenBelgium Department of radiology Zaklad Diagnostyki ObrazowejWojewodzki Zespol Publicznych ZakladowOpieki Zdrowotnejul Kendrtatowicza 803-242 WarszawaPoland Department of Radiology General University HospitalU Nemocnice 212000 Praha 2Czech Republic Department of Radiology University Hospital Brno BohuniceJihlavka 2063900 BrnoCzech Republic Ultrasound medical Department Bracco Imaging Deutschland GmbHMax-Stromeyer-Strasse 11678467 KonstanzGermany

AIm： To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVue-enhancement; and to compare this method with computed tomography （CT） and magnetic resonance imaging （mRI）. mETHODS： One hundred and thirty four patients withone focal liver lesion detected in baseline ultrasound （US） were examined with conventional US, contrastenhanced US （n = 134）, contrast-enhanced CT （n = 115） and/or dynamic contrast-enhanced mRI （n = 70）. The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The final diagnosis based on the combined information of all imaging examinations, clinical information and histology （n = 32） was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions.RESULTS： In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization （malignant/benign） of focal liver lesions. In comparison with CT and/or dynamic mRI, SonoVue -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available （n = 30）, sensitivity was 95.5% （CEUS）, 72.2% （CT） and 81.8% （mRI）, and specificity was 75.0% （CEUS）, 37.5% （CT） and 42.9% （mRI）. The sensitivity and specificity of CEUS for the identification of focal nodular hyperplasia （FNH） and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%.CONCLUSION： SonoVue-enhanced sonography emerges as the most sensitive, ost specific and thus most accurate imaging modality for the characterization of focal liver lesions.

关键词： Contrast-enhanced sonography Contrastmedia Dynamic sonography Liver lesion Liverdisease Liver Oncologic imaging Sonography

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Species and endosymbiont diversity of Bemisia tabaci （Homoptera： Aleyrodidae） on vegetable crops in Senegal

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Insect Science 2015年第3期22卷 386-398页

作者： Delatte Helene Baudin Remy Becker Nathalie Girard Anne-Laure Ramatoulaye Sidebe Traore Lett jean-michel Reynaud Bernard CIRAD UMR PVBMT F-97410 Saint-Pierre La Reunion France museum National d'Histoire Naturelle Institut de Systematique Evolution Biodiversite ISYEB UMR 7205 CNRS UPMC EPHE 75005 Paris France TECHNISEm Zone d'activite Anjou Actiparc de Jumelles 49160 Longue-Jumelles France

Bemisia tabaci-transmitted geminiviruses are one of the major threats on cassava and vegetable crops in Africa. However, to date, few studies are available on the diversity orB. tabaci and their associated endosymbionts in Africa. more than 28 species have been described in the complex ofB. tabaci cryptic species; among them, 2 are invasive pests worldwide： mED and mEAm1. In order to assess the species diversity orB. tabaci in vegetable crops in Senegal, several samplings in different localities, hosts and seasons were collected and analyzed with nuclear （microsatellite） and mitochondrial （COI） markers. The bacterial endosymbiont community was also studied for each sample. Two species were detected： mED Q1 and mEAm1 B. Patterns of mED Q1 （dominance on most of the samples and sites, highest nuclear and mitochondrial diversity and broader secondary endosymbiont community： Hamiltonella, Cardinium, Wolbachia and Rickettsia）, point toward a predominant resident begomovirus vector group for mED Q 1 on market gardening crops. Furthermore, the lower prevalence of the second species mEAm1 B, its lower nuclear and mitochondrial diversity and a narrower secondary endosymbiont community （Hamiltonella/Rickettsia）, indicate that this genetic group is exotic and results from a recent invasion in this area.

关键词： begomovirus vectors endosymbionts diversity mED and mEAm 1 species microsatellites mtCOI phylogeny whitefly

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multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Open Journal of Soil Science（土壤科学期刊） 2024年第4期 237页

作者： Neil-Yohan musadji Rolf Gaël mabicka Obame michel mbina mounguengui jean Aubin Ondo Lydie-Stella Koutika Eric Ravire Claude Geffroy

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Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury

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World Journal of Gastroenterology 2015年第14期21卷 4159-4168页

作者： Donia Tabka mohamed Bejaoui James Javellaud Joan Roselló-Catafau jean-michel Achard Hassen Ben Abdennebi Unité de recherche "Biologie et anthropologie moléculaire appliquées au développe- mentetàla santé" (UR12ES11) University of MonastirFaculty of Pharmacy Experimental Hepatic Ischemia--Reperfusion Unit Institut d’Investigacions Biomèdiques de Barcelona--Consejo Superior de Investigaciones Cientificas INSERm Unité Mixte de Recherche S-8508000 LimogesFrance

AIm: To compare Institut Georges Lopez(IGL-1) and Celsior preservation solutions for hepatic endothelium relaxation and liver cold ischemia reperfusion injury(IRI).mETHODS: Two experimental models were *** the first one, acetylcholine-induced endotheliumdependent relaxation(EDR) was measured in isolated ring preparations of rat hepatic arteries preserved or not in IGL-1 or Celsior solutions(24 h at 4 ℃).To determine nitric oxide(NO) and cyclooxygenase EDR, hepatic arteries were incubated with L-NG-nitroarginine methyl ester(L-NAmE), an inhibitor of endothelium nitric oxide synthase(e NOS), or with L-NAmE plus indomethacin, an inhibitor of *** the second experiment, rat livers were cold-stored in IGL-1 or Celsior solutions for 24 h at 4 ℃ and then perfused "ex vivo " for 2 h at 37 ℃.Liver injury was assessed by transaminase measurements, liver function by bile production and bromosulfophthalein clearance, oxidative stress by malondialdehyde levels and catalase activity and alterations in cell signaling pathways by pA kt, pA mPK, eN OS and mAPKs proteins ***: After cold storage for 24 h with either Celsior or IGL-1, EDR was only slightly *** isolated arteries, EDR was exclusively mediated by ***, cold-stored arteries showed NOand COX-dependent *** decrease in NO-dependent relaxation after cold storage was significantly more marked with *** second study indicated that IGL-1 solution obtained better liver preservation and protection against IRI than *** injury was reduced, function was improved and there was less oxidative ***-1 solution activated Akt and AmPK, which was concomitant with increased eN OS expression and nitrite/nitrate ***, mAPKs kinases were regulated in livers preserved with IGL-1 solution since reductions in p-p38, p-ERK and p-JNK protein levels were ***: IGL-1 solution preserved NO-dependent relaxation better than Celsior storage solutio

关键词： Organ preservation solutions Institut Georges Lope

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Hepatitis C virus: Virology, diagnosis and management ofantiviral therapy

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World Journal of Gastroenterology 2007年第17期13卷 2461-2466页

作者： Stéphane Chevaliez jean-michel Pawlotsky French National Reference Center for Viral Hepatitis B C and deltaDepartment of Virology & INSERM U841 Henri Mondor Hospital University of Paris XII Créteil France

Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection in order to diagnose infection, guide treatment decisions and assess the virological response to antiviral therapy. Anti- HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. The HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment, the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection, and molecular assays are used to assess the end-of-treatment and, most importantly the sustained virological response, i.e. the endpoint of therapy.

关键词： Hepatitis C virus serological tests HepatitisC virus genotype HCV RNA quantification Interferon alpha Ri-bavirin-

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基于氢氧基平面激光诱导荧光法的稀释燃烧机理实验研究

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中国电机工程学报 2008年第32期28卷 61-65页

作者：刘玉英 jean-michel most Philippe Bauer 北京航空航天大学能源与动力工程学院北京市海淀区100083 法国国家科学研究中心燃烧与爆炸实验室

为探讨反应物预热温度和稀释率对稀释燃烧机理的影响,该文以氮气稀释的甲烷–空气对冲扩散火焰为研究对象,采用氢氧基平面激光诱导荧光法(hydroxy radical planar laser induced fluorescence,OH-PLIF)进行实验研究。以OH基反应区厚度... 详细信息

为探讨反应物预热温度和稀释率对稀释燃烧机理的影响,该文以氮气稀释的甲烷–空气对冲扩散火焰为研究对象,采用氢氧基平面激光诱导荧光法(hydroxy radical planar laser induced fluorescence,OH-PLIF)进行实验研究。以OH基反应区厚度表征火焰厚度,实验结果表明,在反应物预热温度较低情况下,当预热温度一定时火焰厚度随反应物稀释率增大(或者浓度减小)而减小,当反应物稀释率一定时火焰厚度随预热温度升高而增大。但进一步分析表明,在反应物预热温度足够高时,火焰厚度将随反应物稀释率增加而增大。根据预热对化学反应速度的增大与稀释对化学反应速度的减小的共同作用,从火焰厚度随反应物预热温度与稀释率的变化情况可推断,在低预热温度稀释燃烧过程中,预热温度是影响火焰结构的主要因素;在预热温度足够高的稀释燃烧过程中,稀释率是火焰结构的主要影响因素,此时由于稀释引起化学反应速度大大降低,因此火焰厚度或体积显著增大。

关键词：对冲火焰稀释燃烧氢氧基平面激光诱导荧光法

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International Oil Price Fluctuations and China's Energy Strategy

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World Economy & China 2001年第2期9卷 35-41页

作者： jean-michel Plassard Professor and Vice-president

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mechanism of friction reduction of unsaturated fatty acids as additives in diesel fuels

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Friction 2013年第3期1卷 252-258页

作者： jean michel mARTIN Christine mATTA maria-Isabel De Barros BOUCHET Cyrielle FOREST Thierry Le mOGNE Thomas DUBOIS michael mAZARIN Laboratory of Tribology and System Dynamics Ecole Centrale de Lyon69134 EcullyFrance TOTAL CReSBP2269360 Solaize CedexFrance

This paper investigates the effect of unsaturated fatty acid additives on the lubricating properties of a biodiesel,composed of a blend of fatty acid methyl esters(FAmEs)and a conventional diesel *** presence of fatty acids as additives for biodiesel improves their lubricating properties at elevated temperature *** formation of a protective lubricating tribochemical film on the steel contact surfaces has been *** temperature conditions and possibly oxygen are needed to form this film that reduces friction and limits *** analytical tools have revealed the insulating nature of the formed tribofilm and its chemical ***-induced reticulation is thought to play a major role in the growth of this insulating film.

关键词： biodiesel low friction fatty acids tribochemistry surface analysis

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Removing harvest residues from hardwood stands affects tree growth, wood density and stem wood nutrient concentration in European beech (Fagus sylvatica) and oak (Quercus spp.)

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Forest Ecosystems 2022年第2期9卷 147-159页

作者： Sanjoy Roy jean-michel Leban Bernhard Zeller Gregory van der Heijden Arnaud Reichard marie-Christine Gehin Philippe Santenoise Laurent Saint-Andre INRAE BEFF-54000 NancyFrance IGN Laboratoire de l’Inventaire ForestierNancyF-54000France Universite de Lorraine AgroParisTechINRAESILVAF-54000 NancyFrance

Background:Higher exportation of harvest residues from forests due to increased demand for woody biomass,has reportedly diminished soil mineral resources and may lead to degraded tree nutrition as well as ***,as nutrients become less available in the soil,the remobilization of nutrients in biomass tissues(plant internal cycling)helps sustain tree *** study aims to quantify the impact of Removing Harvest Residues and Litter(RHRL)during five years on tree growth,wood density,and stem wood nutrient concentrations in young beech and oak forest ***:Our study found that,RHRL significantly decreased tree growth ring width by 14%,and wood density by 3%,in beech trees,in near bark *** also significantly reduced nutrient concentration in near bark and near pith areas of both studied ***,Na and S were found lower by 44%,76%,and 56%,respectively,in near bark area of beech *** near bark area of oak trees,K,Ca,mg,Na,S,and Fe were lower by 20%,25%,41%,48%,41%,and 16%,respectively.K and mg concentrations decreased more strongly in near pith area compared to near bark area suggesting internal translocation of these two ***:In beech trees,wood density proved to be an important factor while quantifying the effect of removing harvest residuals on tree growth and *** nutrient loss intensified the remobilization of nutrients con-tained in older tree rings(close to the pith)towards newly formed rings(close to bark).In our study,in beech trees,K was found to be the most recycled major *** results demonstrate the potential of such analysis for providing valuable insight into the effect of RHRL in premature stands on the physiological adaptive strategies of trees and an indication of soil fertility status.

关键词： Harvest residues Fagus sylvatica Quercus petraea Dendroecology Dendrochemistry Radial growth Wood density Tree growth Ring width Translocation

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moisture-Induced Non-Equilibrium Phase Segregation in Triple Cation mixed Halide Perovskite monitored by In Situ Characterization Techniques and Solid-State NmR

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Energy & Environmental materials 2023年第2期6卷 185-194页

作者： mohammad Ali Akhavan Kazemi Nicolas Folastre Parth Raval michel Sliwa jean marie Vianney Nsanzimana Sema Golonu Arnaud Demortiere jean Rousset Olivier Lafon Laurent Delevoye G.N.manjunatha Reddy Frédéric Sauvage Laboratoire de Réactivité et Chimie des Solides(LRCS) UMR CNRS 7314-Institut de Chimie de Picardie FR 3085Université de Picardie Jules Verne33 rue Saint LeuAmiens Cedex FR-80039France CNRS Centrale LilleUMR 8181UCCSUnitéde Catalyse et Chimie du SolideUniversité de LilleUniversitéd’ArtoisLille F-59000France UmR 8516-LASIRE-Laboratoire de Spectroscopie pour les Interactions la Réactivité et l’EnvironnementCNRSUniversitéde LilleLille F-59000France EDF R&D EDF LabBoulevard Gaspard MongePalaiseau 91120France

Environmental stability is a major bottleneck of perovskite solar *** a handful of studies are investigating the effect of moisture on the structural degradation of the *** mostly rely on ex situ experiments and on completely degraded samples,which restrict the assessment on initial and final *** combining in situ X-ray diffraction under controlled 85%relative humidity,and live observations of the water-induced degradation using liquid-cell transmission electron microscopy,we reveal two competitive degradation paths leading on one hand to the decomposition of state-of-theart mixed cation/anion(Cs_(0.05)(mA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17)I_(0.83))_(3)(CsmAFA)into PbI_(2) through a dissolution/recrystallization mechanism and,on the other hand,to a non-equilibrium phase segregation leading to CsPb_(2)Br_(5) and a Cesium-poor/iodide-rich Cs_(0.05)-x(mA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17-2y)I_(0.83)+2y)_(3) *** degradation mechanism is corroborated at atomic-scale resolution through solid-state ^(1)H and ^(133)Cs NmR *** to moisture leads to a film containing important heterogeneities in terms of morphology,photoluminescence intensities,and *** results provide new insights and consensus that complex perovskite compositions,though very performant as champion devices,are comparatively metastable,a trait that limits the chances to achieve long-term stability.

关键词： liquid-cell transmission electron microscopy moisture degradation perovskite stability phase segregation solid-state NmR

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