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Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients

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Cell Research 2000年第1期10卷 39-49页

作者： LI NING LI DONG QING ZHANG KUANG YAN ZHOU ANNIE CARTMAN jean yves leroux A ROBIN POOLE YI PING ZHANG ( Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China)(Joint Diseases Laboratory, Shriners Hospital, Dep harmacy.ankara.edu.tr

Our previous work showed that the cartilage proteoglycan aggrecan could induce an erosive polyarthritis and spondylitis in BALB/c mice and the GI globular domain of the aggrecan (GI) contained the arthritogenic region. To elucidate whether autoreactive T cells to G1 are expressed in rheumatoid arthritis patients, we analyzed the frequency of human G1-specific T cells in the peripheral blood of five rheumatoid arthritis patients and tried to establish G1-reactive T cell lines from these rheumatoid arthritis patients. The results showed that the G1-specific T cells in PBL were detectable at the range of 4.97 ±0.5 ×10-6 in peripheral blood lymphocytes. We have also generated 15 G1-specific T lymphocyte lines from these pateints with a standard split-well method. All these cells expressed fine specificity to human recombinant G1, but not to unrelated antigen. All the 15 lines expressed a panT cell marker and 13 of them selectively used the αβ T cell receptor. Two of them used rye T cell receptor. The 13 of these T cell lines was CD4 positive. One line expressed CD8. One line expressed both CD4 and CD8. Moreover, 14 out of 15 lines expressed the Th-1 cytokine profile, characterized by interferon-γpositivity and IL-4 negativity. No Th-2 type cell line was generated. These data provide strong evidence in favor of the presence of autoreactive T cells in the rheumatoid arthritis pateints. What is the mechanism(s) that these autoreactive T cells attack self-target and whether these G1-specific, Th-1 type T cell lines can induce arthritis in immune deficiency mice are currently under investigation.

关键词： rG1-specific T cell lines T cell receptor cytokine profile rheumatoid arthritis.

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Gravity tectonics controls on reservoir-scale sandbodies:Insights from 3D seismic geomorphology of the canyons buried in the upper slope of the Eastern Niger delta basin

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Energy Geoscience 2024年第3期5卷 244-260页

作者： Vivian O.Oguadinma jean-yves Reynaud Vincent Delhaye-Prat Tony Akpi Scott Thackrey Ademola Lanisa Massimo Dall’Asta Univ.Lille CNRSUniv.Littoral Côte d'OpaleUMR 8187LOGLaboratoire d'Océanologie et de GéosciencesF 59000 LilleFrance Total Energies E&P Africa-HUB CSTJFAvenue Larribau64000PauFrance

High-resolution 3D seismic data analysis was integrated with a calibrated well and biostratigraphy data to present the first overview of a buried Pleistocene canyon system on the upper slope of the eastern Niger Delta,the Galabor *** maps of specific horizons allow documenting the changing morphologies and infill lithologies of two main branches of the canyon through two stages of activity separated by a reference horizon dated at 0.99 Ma based on well *** the upper slope,growth faults dissect the canyon heads,the catchment of which encroaches a network of valleys incised on the outer *** canyon fill is composed of muddy channels and mass-transport deposits,largely derived from the collapse of canyon walls and sand-rich bodies forming a tract sourced by shelf-edge deltas at the outlet of the incised ***-density turbiditic processes likely control the distribution of sand bodies along the canyon,ranging from tributary fans on the upper slope to 6 km-wide meander belts on the middle *** sandy deposits accumulate in minibasins formed along the canyon path,downstream of the subsiding hanging wall of the growth faults and upstream of shale ridges that damp the flow in the *** results show that canyons can be major targets for sand reservoir exploration on the upper slope of large muddy deltas.

关键词： Geomorphology Submarine canyon 3D seismic Fault Shale ridge Reservoir Channel

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Fatty Acid Composition of Hazelnut Kernel Oil from Coula edulis Collected in the Republic of Congo

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Food and Nutrition Sciences 2024年第4期15卷 290-297页

作者： Josiane Enzonga Yoca jean Paul Latran Ossoko yves Okandza Michel Didace Mvoula Tsieri Laboratoire de Contrô le et Qualit&#233 des Aliments de l&#8217Ecole Nationale Sup&#233rieure d&#8217Agronomie et de Foresterie Universit&#233 Marien NGOUABI Brazzaville Congo Université Denis Sassou NGUESSO Brazzaville Congo

Coula edulis is non-timber forest product (NTFP) used in Africa for its hazelnuts, which contain edible seeds with a demonstrated nutritional potential. However, there have been very few scientific studies of this species in the Republic of Congo. Thus, the aim of the current study was therefore to determine the fatty acid composition of the oil extracted from Coula edulis hazelnut seeds collected at random in the Republic of Congo. The oil was extracted using the Soxhlet method and its fatty acid composition was determined by gas chromatography. The extracted oil from Coula edulis hazelnut kernels is rich in monounsaturated fatty acids (95.28%), particularly oleic acid (94.5%), which classifies it as an oleic oil and gives it interesting nutritional and therapeutic properties. On the other hand, saturated fatty acids (4.15%) and polyunsaturated fatty acids (0.35%) are not well represented. Its low poly-unsaturated fatty acid content makes it more stable when stored at room temperature.

关键词： Coula edulis Fatty Acids Oil Seeds Hazelnuts Republic of Congo NTFP

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Lighting up aggregate emission of perylene diimide by leveraging polymerization-mediated through-space charge transfer and π-π stacking

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Science China Chemistry 2024年

作者： Suiying Ye Désirée Füglistaller Tian Tian Anjay Manian Sudhir Kumar Celine Nardo Andrew J.Christofferson Salvy P.Russo Chih-Jen Shih jean-Christophe leroux Yinyin Bao Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of Excellence in Exciton Science School of Science RMIT University School of Science STEM College RMIT University

The molecular engineering of fluorescent organic/polymeric materials, specifically those emitting in the deep red to near-infrared spectrum, is vital for advancements in optoelectronics and biomedicine. Perylene diimide(PDI), a well-known fluorescent scaffold, offers high thermal and photophysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simple and versatile methods for strong PDI aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we report a straightforward strategy to enhance the solid-state emission of PDI by introducing certain degree of through-space charge transfer(TSCT) via controlled radical polymerization,which can efficiently distort the typical face-to-face PDI stacking, enabling greatly enhanced deep red emission. This is achieved by growing electron-donating star-shape styrenic(co)polymers from a multidirectional electron-accepting PDI initiator. The incorporation of polycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the PDI-based TSCT polymers can be systematically manipulated by leveraging the balance between PDI stacking and the TSCT degree, as confirmed by both experimental study and theoretical calculations. Our approach circumvents complex synthetic procedures, offering highly emissive materials with large Stokes shifts and showing broad potential for optoelectronic technology.

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Optical gravitational wave detectors on the ground and in space:theory and technology

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Research in Astronomy and Astrophysics 2010年第10期10卷 956-1004页

作者： jean-yves Vinet ARTEMIS Observatoire de la Cte d'Azur Université de Nice-Sophia Antipolis 06304 NICE France

Major predictions of General Relativity, unforeseen at the beginning of the preceding century, are now under investigation. The existence of black holes of any mass from tens to billions of solar masses is now established, and the physics around these objects begins to be studied through direct observations in a wide electromagnetic spectrum from visible light to X-rays. General relativity, however, provides an extra medium which carries more information on the regions of intense gravitational field, namely gravitational waves （GWs）. Due to their extremely weak coupling to matter, GWs are precisely generated in those regions of spacetime undergoing strong curvature, which is very exciting for modern astrophysics. On the other hand, this weak coupling makes it difficult for GWs to cause appreciable effects in human made instruments. This is why technology of GW detectors took such a long time to reach a sensitivity level consistent with GW amplitudes predicted by theoretical models of sources. In the present status, apart from resonant solid detectors, two large interferometric antennas （LIGO in the USA and the French-Italian Virgo） are beginning to produce data, and a joint ESA-NASA space mission, resulting from a wide effort of European and American groups, is reaching a crucial approval phase. The aim of the present review is to give the theoretical bases of GW detectors using light.

关键词： gravitation -- gravitational waves -- interferometry

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Wellposedness of some quasi-linear Schrdinger equations

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Science China Mathematics 2015年第5期58卷 891-914页

作者： CHEMIN jean-yves SALORT Delphine Laboratoire J.-L. Lions UMR 7598 Universit'e Pierre et Marie Curie Laboratoire de Biologie Computationnelle et Quantitative UMR 7238Sorbonne Universit'es L'Institut Jacques Monod UMR 7592 Universit'e Paris Diderot

This article is devoted to the study of a quasilinear Schrodinger equation coupled with an elliptic equation on the metric g. We first prove that, in this context, the propagation of regularity holds which ensures local wellposedness for initial data small enough in H1/2 and belonging to the Besov space B3/2 2,1. In a second step, we establish Strichartz estimates for time dependent rough metrics to obtain a lower bound of the time existence which only involves the B1＋ε 2,∞ norm on the initial data.

关键词： quasilinear Schrodinger equation Strichartz estimates paradiffential calculus stationary phase method

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Concept and application of ideal protein for pigs

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Journal of Animal Science and Biotechnology 2015年第3期6卷 269-279页

作者： Jaap van Milgen jean-yves Dourmad INRA Agrocampus Ouest

Knowledge about the amino acid requirements and the response of pigs to the amino acid supply is essential in feed formulation. A deficient AA supply results in a reduction in performance while an oversupply is costly and leads to excessive nitrogen excretion with a potentially negative environmental impact. Amino acid requirements are determined to a large extent by the protein deposition in the body and, for lactating sows, by the protein exported in the milk. The concept of ideal protein was developed more than 50 years ago and refers to a protein with an amino acid profile that exactly meets the animal＇s requirement so that all amino acids are equally limiting for performance. Because Lys typically is the first-limiting amino acid, the ideal amino acid profile is often expressed relative to Lys. Although the ideal protein profile is often assumed to be constant for a given production stage, （small） changes in the ideal protein profile can occur within a production stage. This can be caused by changes in the relative contribution of the different components of amino acid requirements during the productive life on the animal （e.g. changes in the relative contribution of growth and maintenance）. Amino acids requirements can be determined experimentally using dose-response studies. The design of the study, the chosen response criterion, and the statistical model affect the requirement estimate. Although considerable experimental work has been carried out to determine the requirements for Lys, Met, Thr, and Trp in growing pigs （and to a lesser extent in sows）, little is known about the requirements for the other essential amino acids. Experimental dose-response studies generally focus on the requirement and less on the overall response （i.e. what are the consequences of an amino acid deficiency？）. This latter aspect is, to some extent, accounted for in modelling approaches that quantify the response of the animal to the amino acid supply in a dynamic way. The paper d

关键词： Amino acids Gestation Growth Ideal protein Lactation Modeling Pigs

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Transient Ablation Regime in Circuit Breakers

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Plasma Science and Technology 2007年第6期9卷 653-656页

作者： Alexandre MARTIN jean-yves TREPANIER Marcelo REGGIO Ecole Polytechnique MontrealQuebecCanada

Nozzle wall ablation caused by high temperature electric arcs is studied in the context of high voltage SF6 circuit breakers. The simplified ablation model used in litterature has been updated to take into account the unsteady state of ablation. Ablation rate and velocity are now calculated by a kinetic model using two layers of transition, between the bulk plasma and the ablating wall. The first layer （Knudsen layer）, right by the wall, is a kinetic layer of a few mean-free path of thickness. The second layer is collision dominated and makes the transition between the kinetic layer and the plasma bulk. With this new coupled algorithm, it is now possible to calculate the temperature distribution inside the wall, as well as more accurate ablation rates.

关键词： circuit breakers electric arc ablation Teflon radiation

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In situ chemical fabrication of polyaniline/multi-walled carbon nanotubes composites as supports of Pt for methanol electrooxidation

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Science China Chemistry 2010年第9期53卷 2006-2014页

作者： GAL jean-yves UMR Laboratoire Hydrosciences Maison des Sciences de l'Eau de MontpellierUniversite Montpellier Ⅱ

In this study,platinum(Pt)-polyaniline(PANI)/MWNTs catalysts were synthesized by two sequential ***,coreshell structural PANI/MWNTs composites were fabricated by in-situ chemical oxidation polymerization,in which MWNTs act as the core and PANI as the ***,Pt particles were deposited on the PANI/MWNTs composites by a chemical reduction *** morphology and constitution of the products were characterized by FT IR,scanning electron microscopy,transmission electron microscopy and *** was observed that the Pt particles were smaller in size and more uniformly distributed on these composite supports than those on the reference,pure MWNT *** results showed higher Pt(111) content in the catalyst deposited on PANI/MWNTs supports than that on *** cyclic voltammeter(CV) tests demonstrated that the electrode modified by Pt-PANI/MWNTs ternary composite catalyst showed a higher catalytic stability than Pt-MWNT binary catalyst did,due to the synergic interaction between Pt and the composite support.

关键词： polyaniline multi-walled carbon nanotubes in situ polymerization methanol electrooxidation

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Kant's,Hegel's and Cousin's Perceptions of China and Non-European Cultures:Racialism,Historicism and Universalism,and the Methodology of Comparative Philosophy

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Frontiers of Philosophy in China 2018年第4期13卷 554-573页

作者： jean-yves Heurtebise Department of French Language and Culture Fu Jen Catholic UniversityNew Taipei City 24205TaiwanChina

The aim of this paper is to discuss some assumptions of comparative philosophy by providing a critical analysis of Hegel's perception of China and other non-European cultures in relation to Kant's anthropological works. The main assumption of comparative philosophy is that the temporal-cognitive distance between Plato and Diderot is irrelevant compared to the geographic-cultural distance between Plato and Confucius or Diderot and Dai Zhen. This paper will demonstrate that this culturalist assumption is also a legacy of Hegel's history of philosophy, whose anthropological basis and historicist framework needs to be deconstructed. Finally, this paper will make reference to Victor Cousin, the French philosopher who introduced German philosophy in France, to show how this thinker's adaptation of Hegel's history of philosophy allows us to propose a more inclusive conception of the value of non-European cultures' intellectual productions and to elaborate, on this basis, a radically non-culturalist framework for comparative philosophy.

关键词： Hegel Kant Victor Cousin China anthropology Volksgeist (national spirit) culturalism methodology

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