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Calcium Glucarate Prevents Tumor Formation in Mouse Skin

Biomedical and Environmental Sciences 2003年第1期16卷 9-16页

作者： jayasingh KRISHNAP.GUPTA Environmental Carcinogenesis Division Industrial Toxicology Research CenterPost Box No.80Mahatma Gandhi Marg Lucknow-226001IndiaEnvironmental Carcinogenesis DivisionIndustrial Toxicology Research CenterPost Box No.80Mahatma Gandhi Marg Lucknow-226001India

Objective Calcium Glucarate (Cag), Ca salt of D-glucaric acid is a naturally occurring non-toxic compound present in fruits, vegetables and seeds of some plants, and suppress tumor growth in different models. Due to lack of knowledge about its mode of action its uses are limited in cancer chemotherapy thus the objective of the study was to study the mechanism of action of Cag on mouse skin tumorigenesis. Methods We have estimated effect of Cag on DMBA induced mouse skin tumor development following complete carcinogenesis protocol. We measured, epidermal transglutaminase activity (TG), a marker of cell differentiation after DMBA and/or Cag treatment and [3H] thymidine incorporation into DNA as a marker for cell proliferation. Results Topical application of Cag suppressed the DMBA induced mouse skin tumor development. Topical application of Cag significantly modifies the critical events of proliferation and differentiation TG activity was found to be reduced after DMBA treatment. Reduction of the TG activ

关键词： Cag Skin tumor Chemoprevention TG DNA synthesis Skin Transglutaminase

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Neurobehavioral Analysis of Ethanolic Extract of Roots and Rhizomes of Acorus calamus in 6-hydroxydopamine Hydrobromide-induced ADHD Neonatal Rat Model——An Observational Study

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World Journal of Traditional Chinese Medicine 2024年第3期10卷 316-321页

作者： Mariyappan Kousalya Palayyan Muralidharan Hanish Singh jayasingh Chellammal Department of Pharmacology C.L.Baid Metha College of Pharmacy Affiliated to the Tamil Nadu Dr.M.G.R.Medical University Department of Pharmacology Faculty of Pharmacy University Technology MARA

Background: An imbalance in Nor-adrenaline and Dopamine neurotransmitter levels in the brain is the reason for the development of Attention Deficit Hyperactivity Disorder(ADHD) which is a neurodevelopmental disorder. 6-Hydroxy Dopamine hydrobromide injection in the brain destroys catecholamine receptors thereby inducing, ADHD and expressing ADHD symptoms such as hyperactivity, inattention, anxiety, and impaired cognitive function. Aims and Objectives: Our aim is to analyze the antagonistic effect of 6-Hydroxy Dopamine by the ethanolic extract of the Acorus calamus in Neonatal rats. Settings and Design: The study was conducted in neonatal rats and analyzed the three main signs of ADHD-like behaviour in 6-OHDAHBr rats on attention, and impairment. The model identified distinct co-occurring symptoms, marble burying behaviour. The animals were sacrificed and histopathological analysis was performed. Materials and Methods: Rats were divided into 5 groups. Control, Induced control, Standard, test drug of low and high dose. The behavioural analysis was studied on days 7, 14, and 21using pole climbing, water maze, marble burying. Statistical Analysis Used: One-way ANOVA with multiple Graphpad prism version ***: The extract shows significant improvement in reducing ADHD symptoms in dose-dependent manner. The model's validity is further supported by a histological investigation that reveals dopamine depletion, changes in cortical thickness, and anomalies in the neurons of the anterior cingulate cortex. Conclusions: The study concludes that neonatal dopamine deprivation causes behavioural abnormalities that are comparable to those seen in patients, making it a useful model for researching the pathophysiological mechanisms underlying ADHD and discovering potential treatment targets.

关键词： 6-Hydroxy dopamine anxiety cognitive hyperactivity intracerebroventricular

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