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Dual specimens increase the diagnostic accuracy and reduce the reaction duration of rapid urease test

World Journal of Gastroenterology 2010年第23期16卷 2926-2930页

作者： Wen-Hung Hsu Sophie SW wang Chiao-Yun Chen Ching-Wen Chang jaw-yuan wang yuan-Chieh Yang Deng-Chyang Wu Ming-Tsang Wu Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Cancer Center Kaohsiung Medical University Hospital Department of Medical Imaging Kaohsiung Medical University Hospital Division of Gastrointestinal and General Surgery Department of SurgeryKaohsiung Medical University Hospital Department of Laboratory Medicine Kaohsi-ung Medical University Hospital Department of Internal Medicine Faculty of MedicineCollege of MedicineKaohsiung Medical University Graduate Institute of Occupational Safety and Health Kaohsiung Medical University

AIM:To evaluate the influence of multiple samplings during esophagogastr oduodenoscopy(EGD) on the accuracy of the rapid urease test,and the validity of newly developed rapid urease tests,HelicotecUT plus test and HelicotecUT test,CLO test and ProntoDry ***:A total of 355 patients undergoing EGD for dyspepsia were *** Helicobacter pylori(***) treatment status was either nave or *** biopsy specimens from antrum and gastric body,respectively,were obtained during *** antral specimens and dual(antrum+body) specimens were *** status of *** was evaluated by three different tests:culture,histology,and four different commercially available rapid urease tests(RUTs)-including the newly developed HelicotecUT plus test and HelicotecUT test,and established CLO test and ProntoDry *** status was defined as positive when the culture was positive or if there were concordant positive results among histology,CLO test and ProntoDry ***:When dual specimens were applied,sensitivity was enhanced and RUT reaction time was signif icantly reduced,regardless of their treatment *** minutes were enough to achieve an agreeable positive rate in all the *** newly developed RUTs showed comparable sensitivity,specif icity and accuracy to the established RUTs,regardless of patient treatment status,RUT reaction duration,and EGD biopsy ***:Combination of antrum and body biopsy specimens greatly enhances the sensitivity of rapid urease test and reduces the reaction duration to 30 min.

关键词： Rapid urease test Helicobacter pylori eradication HelicotecUT plus test HelicotecUT test Esophagogastroduodenoscopy

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Association between Helicobacter pylori seropositivity and digestive tract cancers

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World Journal of Gastroenterology 2009年第43期15卷 5465-5471页

作者： I-Chen Wu Deng-Chyang Wu Fang-Jung Yu jaw-yuan wang Chao-Hung Kuo Sheau-Fang Yang Chao-Ling wang Ming-Tsang Wu Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsitmg 807 Taiwan China Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Department of Pathology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Graduate Institute of Occupational Safety and Health Kaohsiung Medical University Kaohsiung 807 Taiwan China

AIM： To explore the role of Helicobacter pylori （Hpylori） infection on the risk of digestive tract cancers. METHODS： In total, 199 oral squamous-cell carcinoma （SCC）, 317 esophagea! SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of Hpylori infection. Two hospital- and one community-based control groups were used for the comparisons. Hpylori seropositivity was determined by an enzyme linked immunosorbent assay method against Hpylori IgG. RESULTS： Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio （AOR）： 0.315-0.472, all P-value 〈 0.05] but positively associated with gastric adenocarcinoma （both cardia and non-cardia）（AOR： 1.636-3.060, all P-value 〈 0.05） in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon. CONCLUSION： Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.

关键词： Helicobacter pylori infection Oral cancer Esophageal squamous cell carcinoma Gastric cardia adenocarcinoma Colon cancer

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Short-term Celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model

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World Journal of Gastroenterology 2009年第39期15卷 4907-4914页

作者： Chao-Hung Kuo Huang-Ming Hu Pei-Yun Tsai I-Chen Wu Sheau-Fang Yang Lin-Li Chang jaw-yuan wang Chang-Ming Jan Wen-Ming wang Deng-Chyang Wu Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Department of Nursing Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China Department of Pathology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Microbiology Kaohsiung Medical University Kaohsiung 807 Taiwan China Department of Surgery Kaohsiung Medical University Hosoital Kaohsiung 807 Taiwan China

AIM： To evaluate the optimal intervention point of a selective cyclooxygenase-2 （COX-2） inhibitor, Celecoxib, for inhibiting Helicobacter pylori （H pylori-associated gastric carcinogenesis in Mongolian gerbils （MGs）.METHODS： One hundred and twelve MGs were divided into six groups （A-F）. One hundred gerbils were inoculated with H pylor/（groups A-E）. Twelve gerbils were inoculated with vehicle broth only （group F）. After 4 wk, they were given N＇-methyl-N＇ -nitro-N-nitroso-guanidine （MNNG）（50 μg/mL） in the drinking water for 20 wk. in groups B-E, the animals were given the stock Celecoxib （10 mg/kg per day） diet from the 21st, 31st, 21st and 41st week respectively. The periods of administering Celecoxib were 30, 20, 20, and 15 wk respectively. On the 51st week, the animals were sacrificed for histological examination. Local PCNA expression was examined by the immunohistochemistry method. The expression of COX-2 protein was assessed by Western Blot. Analysis used the 2 test. The difference was regarded as significant when P value was less than 0.05. RESULTS： Seventeen percent （17/100） of H pyloriinfected MGs developed gastric cancer. All of these lesions were well-differentiated adenocarcinoma. The incidence rates of adenocarcinoma in groups A-F were 40%, 0%, 0%, 20%, 25%, and 0% respectively. The inflammatory scores were higher in group B than in other groups. There was no inflammatory response noted in group F. Celecoxib treatment resulted in a significant reduction in the proliferation of H pyloriinfected mucosal cells （groups B, C and D）（P 〈 0.01）. The expression of COX-2 protein was significantly attenuated in the groups which were Celecoxib-treated for more than 20 wk （groups B, C, D）. The groups treated with Celecoxib had a significantly lower rate of advanced gastric cancer （34% vs 75%, P 〈 0.001） There were no sudden deaths in any of the groups. CONCLUSION： Short-term treatment with Celecoxib has an anti-carcinogenic effect, and resulted in less severe inflam

关键词： Cyclooxygenase-2 Chemoprevention He/icobacterpylori Mongolian gerbil

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Outcomes of neoadjuvant chemoradiotherapy followed by radical resection for T4 colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第12期12卷 1428-1442页

作者： Chun-Ming Huang Ching-Wen Huang Cheng-Jen Ma Hsiang-Lin Tsai Wei-Chih Su Tsung-Kun Chang Ming-Yii Huang jaw yuan wang Department of Radiation Oncology Kaohsiung Medical University HospitalKaohsiung 80145Taiwan Department of Surgery Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 80145Taiwan Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung 80145Taiwan Department of Surgery and Cancer Center Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 80708Taiwan

BACKGROUND Patients with clinical T4 colorectal cancer(CRC)have a poor prognosis because of compromised surgical *** therapy may be effective in downstaging tumors,thereby rendering possible radical resection with clear *** To evaluate tumor downsizing and resection with clear margins in T4 CRC patients undergoing neoadjuvant concurrent chemoradiotherapy followed by *** This study retrospectively included 86 eligible patients with clinical T4 CRC who underwent neoadjuvant concurrent chemoradiotherapy followed by radical *** therapy consisted of radiation therapy at a dose of 45-50.4 Gy and chemotherapy agents,either FOLFOX or capecitabine.A circumferential resection margin(CRM)of<1 mm was considered to be a positive *** defined pathological complete response(p CR)as the absence of any malignant cells in a specimen,including the primary tumor and lymph nodes.A multivariate logistic regression model was used to identify independent predictive factors for p *** For 86 patients who underwent neoadjuvant chemoradiotherapy and surgery,the rate of p CR was 14%,and the R0 resection rate was 91.9%.Of the 61 patients with rectal cancer,7(11.5%)achieved p CR and 5(8.2%)had positive *** the 25 patients with colon cancer,5(20%)achieved p CR and 2(8%)had positive *** observed that the FOLFOX regimen was an independent predictor of p CR(P=0.046).After a median follow-up of 47 mo,the estimated 5-year overall survival(OS)and disease-free survival(DFS)rates were 70.8%and 61.4%,*** analysis revealed that a tumor with a negative resection margin was associated with improved DFS(P=0.014)and OS(P=0.001).Patients who achieved p CR exhibited longer DFS(P=0.042)and OS(P=0.003)than those who did *** Neoadjuvant concurrent chemoradiotherapy engenders favorable p CR and R0 resection rates among patients with T4 *** R0 resection rate and p CR are independent prognostic factors for pat

关键词： T4 Chemoradiotherapy Pathological complete response R0 resection Colorectal cancer Survival

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Effects of the number of neoadjuvant therapy cycles on clinical outcomes, safety, and survival in patients with metastatic colorectal cancer undergoing metastasectomy

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Oncology Research 2022年第2期30卷 65-76页

作者： YUNG-SUNG YEH HSIANG-LIN TSAI YEN-CHENG CHEN WEI-CHIH SU PO-JUNG CHEN TSUNG-KUN CHANG CHING-CHUN LI CHING-WEN HUANG jaw-yuan wang Division of Trauma and Surgical Critical Care Department of SurgeryKaohsiungMedical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Emergency Medicine Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipeiTaiwanChina Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Center for Cancer Research Kaohsiung Medical UniversityKaohsiungTaiwanChina Pingtung Hospital Ministry of Health and WelfarePingtungTaiwanChina

The controversial outcomes in patients with metastatic colorectal cancer(mCRC)highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical *** optimal treatment cycles in patients with mCRC for metastasectomy remain undeﬁ*** retrospective study compared the efﬁcacy,safety,and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such ***-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April ***-eight patients received 6 cycles of chemotherapy/targeted therapy,whereas 36 patients received≥7 cycles(median,13;range,7–20).Clinical outcomes,including response,progression-free survival(PFS),overall survival(OS),and adverse events,were compared between these two *** the 64 patients,47(73.4%)were included in the response group,and 17(26.6%)were included in the nonresponse *** analysis revealed chemotherapy/targeted therapy cycle and pretreatment serum carcinoembryonic antigen(CEA)level as independent predictors of the response as well as overall survival and chemotherapy/targeted therapy cycle as an independent predictor of progression(all p0.05).The median OS and PFS were 48 months(95%CI,40.855–55.145)and 28 months(95%CI,18.952–37.48)in the≥7-cycle group and 24 months(95%CI,22.038–25.962)and 13 months(95%CI,11.674–14.326)in the 6-cycle group,respectively(both p<0.001).The oncological outcomes in the≥7-cycle group were signiﬁcantly better than those in the 6-cycle group,without signiﬁcant increases in adverse ***,prospective randomized trials are mand

关键词： Metastatic colorectal cancer Neoadjuvant chemotherapy/targeted therapy Treatment cycles Metastasectomy

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Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin wang yuan Lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

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Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： Yi yuan Wen-Long wang Zhi-Wei wang Jin wang Qian-yuan Wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light *** this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called *** Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for *** with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair *** addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species

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Global adaptive output-feedback tracking with prescribed performance for uncertain nonlinear systems

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Science China(Information Sciences) 2024年第5期67卷 150-164页

作者： yuan wang Yungang LIU School of Control Science and Engineering Shandong University

At present, one typical control strategy for guaranteeing transient and steady-state performance is funnel control and prescribed performance control. The strategy features completely discarding the system nonlinearities, even if they are completely known and available. Such an intrinsic feature requires the controller to produce a larger control effect to eliminate the negative impact caused by the high nonlinearities, leading to a conservative controller. In this paper, we fully take advantage of known information on nonlinearities in control design, instead of completely discarding it as done in funnel control. Particularly, we leverage adaptive techniques(i.e., high-gain dynamic compensation) to deal with unknown system nonlinearities. Meanwhile, we integrate the tools of output feedback, tracking control, and the performance *** such, an adaptive output-feedback scheme is developed for global tracking with spatiotemporal performance specifications: arbitrarily given tracking accuracy and accuracy-ensured time. A simulation example supports the developed approach.

关键词： uncertain nonlinear systems output feedback prescribed performance unknown control direction dynamic high gain global tracking

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Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： yuan wang Bing Chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

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Robustness of the octupole collectivity in 144Ba within the cranking covariant density functional theory in 3D lattice

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Nuclear Science and Techniques 2024年第8期35卷 124-131页

作者： Ze‑Kai Li yuan‑yuan wang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice *** reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole *** available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well ***,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).

关键词： Octupole collectivity Cranking covariant density functional theory Rotational spectrum Electric transitional probabilities

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